Category Archives: DNA

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CORSICANA, Texas A 58-year-old Texas man walked free Monday after serving years for a crime he didn't commit -- the repeated stabbing of a woman whose body was found on a dirt road in rural North Texas.

Randolph Arledge was sentenced to 99 years in prison in 1984 for killing Carolyn Armstrong. But a state district judge in Corsicana, about 50 miles southeast of Dallas, agreed with prosecutors and Arledge's attorneys that he could no longer be considered guilty after new DNA tests tied someone else to the crime.

Judge James Lagomarsino agreed to release Arledge on bond while the process of overturning his conviction is pending. The Texas Court of Criminal Appeals must accept Lagomarsino's recommendation for the conviction to be formally overturned, a process that is considered a formality.

Arledge wore shackles around his wrists and ankles at the start of the hearing, but was later taken into a back room by two deputies to have them removed. When he returned, Arledge hugged his two children. His daughter was 4 years old and his son 7 when he was sent to prison.

"They suffered more than anybody," Arledge told reporters afterward. He gestured to his daughter, Randa Machelle Arledge. "She's always talking about, she wanted me to come pick her up from school. Now she's picking me up."

His children said they remained hopeful through the years, not doubting his innocence.

"Every time he came up for parole, it was broken, shattered hopes," his daughter said.

Armstrong's body was found in August 1981 on a rural dirt road in Navarro County, according to a court filing by Arledge's attorneys. She had been stripped naked from the waist down and stabbed more than 40 times.

Her abandoned car was found miles away with several pieces of evidence, including a black hairnet on the left side of the driver's seat. Hair taken from that net was preserved for three decades. In 2011, more advanced DNA testing linked samples from the hair net and elsewhere to someone else.

Navarro County District Attorney Lowell Thompson said authorities are searching for the person matched to the DNA and believe they know where he is. The case "will stay open until we solve it," he said in an interview.

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DNA evidence clears Texas man convicted in '81 killing

CORSICANA, Texas A 58-year-old Texas man was allowed to walk free Monday after spending half his life behind bars for a crime he didn't commit -- the repeated stabbing of a woman whose body was found on a dirt road in rural North Texas.

Randolph Arledge, left, speaks to one of his attorneys, Innocence Project co-director Barry Scheck, before a court hearing in Corsicana, Texas, Feb. 11, 2013.

Randolph Arledge was sentenced to 99 years in prison in 1984 for killing Carolyn Armstrong. But a state district judge in Corsicana, about 50 miles southeast of Dallas, agreed with prosecutors and Arledge's attorneys that he could no longer be considered guilty after new DNA tests tied someone else to the crime.

Judge James Lagomarsino agreed to release Arledge while the process of overturning his conviction is pending. The Texas Court of Criminal Appeals must accept Lagomarsino's recommendation for the conviction to be formally overturned, a process that is considered a formality.

Arledge was wearing shackles around his wrists and ankles at the start of the hearing. He later was taken into a back room by two deputies to have the shackles removed. When he returned, Arledge hugged his two children. His daughter was 4 years old and his son 7 when he was sent to prison.

Armstrong's body was found in August 1981 on a rural dirt road in Navarro County, according to a court filing by Arledge's attorneys. She had been stripped naked from the waist down and stabbed more than 40 times.

Her abandoned car was found miles away with several pieces of evidence, including a black hairnet on the left side of the driver's seat. Hair taken from that net was preserved for three decades. In 2011, more advanced DNA testing linked a hair sample to someone else.

Armstrong's relatives declined to comment Monday.

Like many wrongfully convicted inmates, Arledge was sent to prison with the help of faulty eyewitness testimony. Two co-conspirators in an armed robbery testified at his trial that he had admitted to stabbing someone in Corsicana and that he had blood on his clothes and knife, according to the filing by Arledge's attorneys.

One of those witnesses has since admitted to lying about Arledge due to a personal dispute, the filing said.

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DNA evidence frees Texas man convicted in '81 stabbing death

Researchers have created a way to store data in the form of DNA and retrieve it without errors.

The researchers, from the European Bioinformatics Institute (EMBL-EBI) in Hinxton, England, claim to have used such a method to store versions of an MP3 of Martin Luther King Jr.'s "I Have a Dream" speech, along with a JPG photo and several text files.

Their research was published in the journal Nature in late January.

"We already know that DNA is a robust way to store information because we can extract it from woolly mammoth bones, which date back tens of thousands of years, and make sense of it," said Nick Goldman, co-author of the EMBL-EBI study. "It's also incredibly small, dense and does not need any power for storage, so shipping and keeping it is easy."

Last fall, Harvard University researchers were able to store 70 billion copies of an HTML-formatted book in DNA binary code.

The difference between the two studies is that EMBL-EBI invented an error-correcting code that was "specially tailored to deal with the types of errors" that both reading and writing DNA tend to make, Goldman said.

Goldman and his co-author, Ewan Birney, associate director of EMBL-EBI, set out to create a code that overcomes both problems. The new method requires synthesizing DNA from the encoded information. The lab worked with Santa Clara, Calif.-based Agilent Technologies, a maker of measurement instruments such as oscilloscopes, to transmit the data and encode it in DNA.

Agilent synthesized hundreds of thousands of pieces of DNA to represent the data, then mailed the sample to EMBL-EBI. There, researchers were able to decode the file.

Goldman's team analyzed the cost-effectiveness of the technology and suggested that, for now, using DNA as a storage medium would be best suited for archival purposes, such as preserving personal photos or videos.

This version of this story was originally published in Computerworld's print edition. It was adapted from an article that appeared earlier on Computerworld.com.

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DNA an option for data storage

CORSICANA, Texas A 58-year-old Texas man walked free Monday after serving years for a crime he didn't commit -- the repeated stabbing of a woman whose body was found on a dirt road in rural North Texas.

Randolph Arledge was sentenced to 99 years in prison in 1984 for killing Carolyn Armstrong. But a state district judge in Corsicana, about 50 miles southeast of Dallas, agreed with prosecutors and Arledge's attorneys that he could no longer be considered guilty after new DNA tests tied someone else to the crime.

Judge James Lagomarsino agreed to release Arledge on bond while the process of overturning his conviction is pending. The Texas Court of Criminal Appeals must accept Lagomarsino's recommendation for the conviction to be formally overturned, a process that is considered a formality.

Arledge wore shackles around his wrists and ankles at the start of the hearing, but was later taken into a back room by two deputies to have them removed. When he returned, Arledge hugged his two children. His daughter was 4 years old and his son 7 when he was sent to prison.

"They suffered more than anybody," Arledge told reporters afterward. He gestured to his daughter, Randa Machelle Arledge. "She's always talking about, she wanted me to come pick her up from school. Now she's picking me up."

His children said they remained hopeful through the years, not doubting his innocence.

"Every time he came up for parole, it was broken, shattered hopes," his daughter said.

Armstrong's body was found in August 1981 on a rural dirt road in Navarro County, according to a court filing by Arledge's attorneys. She had been stripped naked from the waist down and stabbed more than 40 times.

Her abandoned car was found miles away with several pieces of evidence, including a black hairnet on the left side of the driver's seat. Hair taken from that net was preserved for three decades. In 2011, more advanced DNA testing linked samples from the hair net and elsewhere to someone else.

Navarro County District Attorney Lowell Thompson said authorities are searching for the person matched to the DNA and believe they know where he is. The case "will stay open until we solve it," he said in an interview.

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DNA evidence clears Texas man convicted in '81 stabbing death

Genetic products company, Affymetrix Inc. (AFFX), inked a Powered by Affymetrix (PbA) Program agreement with Korea-based biotechnology company, DNA Link Inc. Following the terms of the deal, DNA Link acquired a global license to use Affymetrixs GeneChip System 3000Dx v.2 along with other microarray technologies to develop a forensic test for human identification.

The GCS 3000Dx v.2 from Affymetrix is a second-generation solution for DNA and RNA analysis. It has received the U.S. Food and Drug Administration (FDA) approval as well as the European CE Mark for in vitro diagnostic (IVD) uses. The system has also been cleared by the Korean FDA.

DNA Link intends to combine Affymetrixs leading GeneChip technology with its cutting-edge forensic test, AccuID Chip, to develop innovative molecular diagnostic tests for personalized healthcare in the field of genomics.

Earlier, in Aug 2012, Affymetrix had signed a PbA Program agreement with a Singapore-based molecular diagnostics company, PathGEN Dx Pte. Ltd. Apart from PathGEN Dx, the company shares its technology with Roche Diagnostics, a unit of Roche Holdings Ltd. (RHHBY), and Pathwork Diagnostics.

Our Take

Affymetrix is a leading provider of microarray-based products and services to the global research community. Apart from Illumina Inc. (ILMN), it is one of the two major providers of microarray technologies, primarily serving the field of genetic research.

The latest agreement is in accordance with Affymetrixs strategy to expand its customer base through strategic alliances. Moreover, the company is pursuing a number of strategies (including acquisitions and expansion into new markets) aimed at expanding its top line.

The Powered by Affymetrix Program is an initiative by Affymetrix, which allows other companies to gain access to its GeneChip technology in order to develop new microarray products and solutions. The collaboration with DNA Link marks Affymetrixs first partnership venture in Korea. The agreement further allows Affymetrixs other PbA partners to enter Koreas personalized genomics market.

However, research and development spending by Affymetrixs customers have fallen considerably due to a weak macroeconomic environment coupled with stringent government actions including budget cuts.

The company currently carries a Zacks Rank #3 (Hold). Biotechnology company, Alkermes plc. (ALKS), carrying a Zacks Rank #1 (Strong Buy), is expected to do well in the Medical-Biomed/Gene industry.

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Affymetrix Links Up with DNA Link

LONDON (Reuters) - Tesco, Britain's biggest retailer, said on Monday it had found horse DNA exceeding 60 percent in some of its own-brand frozen spaghetti bolognese meals withdrawn from stores last week.

Tesco said tests carried out since pulling the product last Wednesday had identified the presence of horse DNA, with most positive results at a trace level of less than one percent. However, three tests showed horse DNA levels of over 60 percent.

None of its tests were positive for the potentially harmful drug known as bute - a common, anti-inflammatory painkiller for sporting horses but banned for animals intended for eventual human consumption, it said.

The news is the latest installment in a scandal that has rocked the food industry in Britain and across Europe. Investigations into suppliers have been launched in recent weeks after the discovery that beef products sold to some of Britain's major supermarkets and fast-food chain Burger King contained horsemeat.

Tesco had already dropped an Irish supplier of frozen beef burgers that had also tested positive for horse DNA.

The firm had pulled its frozen Everyday Value Spaghetti Bolognese product last week as a precaution after the manufacturer Findus withdrew its beef products on the advice of its French supplier Comigel, which also supplies Tesco.

Findus said last week that some of its beef lasagne meals had contained horse meat.

On Monday, Tesco said the source of the horse meat was still under investigation by the relevant authorities, but added that it would not take food from Comigel's facility again.

"The level of contamination suggests that Comigel was not following the appropriate production process for our Tesco product and we will not take food from their facility again," Tesco said, adding that it had let customers down.

(Reporting by Neil Maidment; Editing by Peter Griffiths)

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Tesco's spaghetti bolognese tests positive for horse DNA

Cup Song -- DNA by Little Mix
DNA by Little Mix

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