Category Archives: DNA

VANCOUVER - Scientists have decoded the DNA of the Western painted turtle, and hope that unravelling the mystery of the reptiles may lead to medical breakthroughs for humans.

They are the most abundant turtle in North America, with a northernmost range from Ontario west to British Columbia, where they are listed as endangered on the Pacific Coast and of special concern in the rest of the province.

The shelled reptile, named for the bright yellow stripes that adorn its body, is a fresh water species that can freeze solid and return to life when thawed.

It can also hold its breath for up to four days at room temperature without suffering oxygen deprivation and up to four months when hibernating, said Brad Shaffer of UCLA's Institute of the Environment and Sustainability and one of the lead authors of the study published in the latest edition of the journal Genome Biology.

"Those are fascinating ecological, physiological features that have evolved in turtles ... so as a biologist those are fascinating things to learn more about, more about the genes that allow them to do that," Shaffer said.

Shaffer and his colleagues hope solving the DNA puzzle may one day lead to innovations in treating hypothermia, frostbite, heart attacks or strokes.

The DNA confirmed for scientists that the turtles have evolved at a ... turtle's pace, and have in fact changed little in design over the past 210 million years.

"Turtles are nothing short of an enigma," Richard K. Wilson, director of Washington University's Genome Institute and one of the authors, said in a statement. "We could learn a lot from them."

In addition to their ability to freeze and thaw without suffering organ or tissue damage, they have longevity and continue to reproduce at advanced ages, he said.

Western painted turtles can live for more than 40 years, while other species of turtle live well over a century. Females can grow up to 25 centimetres long, while males grow up to 17 centimetres.

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Scientists hope turtle DNA could lead to treatment for hypothermia, stroke

DNA VS K-SHINE REVIEW (MY OPINION)
HEY CHECK OUT MY REVIEW ON K-SHINE VS DNA! PLEASE LIKE, SUB AND COMMMENT ON WHO U THINK WON! THANKS 4 WATCHING! PEACE! DNA VS K-SHINE REVIEW (MY OPINION) DNA...

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DNA VS K-SHINE REVIEW (MY OPINION) - Video

Genome sequencing is cheap, fast, and poised to revolutionize health care. In the one-hour radio special Mapping Eliza: Decoding DNA Secrets, IEEE Spectrum editor Eliza Strickland gets a glimpse of the medical future by getting her own genome sequenced. She takes listeners on her personal journey as she explores her genes, and investigates just how much they can reveal about her medical destiny.

This radio program is presented byPRX, the Public Radio Exchange, and received support fromfrom theAlfred P. Sloan Foundationenhancing public understanding of science, technology, and economic performance.

Jump to: Segment One / Segment Two / Segment Three

Segment One

Eliza Strickland: Have you ever lain awake in the middle of the night and wondered what will kill you in the end? I did a bit of that recently. I mentally scrolled through my family history and counted up the relatives who had died of heart diseaseand then I vowed to go to the gym more often. I thought of an aunt who died of breast cancer and a grandfather who had kidney failure, and I sent internal messages to those body parts: How you doing in there? Stay strong. I need you!

I think most of us would agree that these kinds of midnight ruminations arent very useful. But what if there were a way to find out, with much more precision, what your biological weak points are? Would you want to know? And what would you do with that information?

I was lying in bed playing the mortality guessing game because the next morning I was flying to Texas to get all that precise information. In the name of journalism, science, and self-discovery, Id had my genome sequenced. And Im not talking about the mail-order genetic tests you can get from companies like 23andMe these days. Those companies send consumers a very limited set of results about their ancestry and possible health risks. Im talking about a full, medical-grade genome scan that doctors interpreted for me.

I had given blood a few months before, and doctors at Baylor College of Medicine extracted my DNA and ran it through a cutting-edge genetic sequencing machine. The doctors analyzed the data, and I had to fly to Houston to get their predictions about my medical future.

JetBlue pilot: Ladies and gentlemen, JetBlue Airways welcomes you to Houston, Texas.

Eliza Strickland: But lets leave me there on the runway for a minute. Before we go to Texas, lets go to genetics class to talk over some of the basic science here. Im lucky in that I have an on-call genetic tutor. Really, hes on speed-dial, and I can go see him whenever I want.

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Mapping Eliza: Decoding DNA Secrets

The D.C. Court of Appeals has overturned the convictions of a man who had been found guilty of raping a woman in her Northeast apartment building.

Robert C. Young was linked to the violent 2006 attackby DNA evidence. But the appeals court ordered a new trial because one of Young's constitutional rights was violated by an expert's testimony about the evidence.

On Oct. 11, 2006, a 19-year-old woman was followed into her apartment building and grabbed from behind as she was about to enter her unit. Her attacker dragged her to the basement of the building, where he sexually assaulted her, prosecutors said.

After the attack, the woman was then taken to a hospital, where a nurse examined her and took swabs from her body. A team of scientists at an FBI lab in Quantico developed a DNA profile of the woman's attacker based on the swabs and entered the information into a database.

In November 2007, a search of databases found that Young -- who had been required to provide a DNA sample when he was convicted of burglary in 1985 -- matched the DNA profile of the attacker. In 2009, D.C. police obtained another tissue sample from Young, and scientists determined that the DNA profile from that sample matched the DNA of the attacker.

During Young's trial, FBI examiner Rhonda Craig testified that she had compared the DNA profiles of Young's 2009 sample and the attacker and found them to be a match.

Craig supervised scientists at the lab, but she did not personally perform the testing and computer analysis that generated the DNA profiles that she was comparing. She also did not claim to have witnessed the testing. None of the scientists who were involved in preparing the DNA profiles testified.

The Sixth Amendment of the U.S. Constitution guarantees the right of a criminal defendant to confront the witnesses against him. The appeals court ruled that this right of Young's was violated when D.C Superior Court Judge Herbert Dixon allowed prosecutors to have Craig testify about the DNA match without also having testimony from scientists whose work formed the basis for Craig's testimony.

Craig's testimony was considered hearsay that should have been barred because "she admittedly relied throughout her testimony ... on the documentation, testing and analysis written or produced by other employees of the FBI laboratory in connection with this particular case."

njagoda@washingtonexaminer.com

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D.C. rape conviction reversed over testimony about DNA evidence

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/tf2vsq/dna_sequencing) has announced the addition of Jain PharmaBiotech's new report "DNA Sequencing - Technologies, Markets and Companies" to their offering.

Current large and small sequencers are described as well as companies developing them. Various applications of sequencing are described including those for genetics, medical diagnostics, drug discovery and cancer. Next generation sequencing technologies, both second and third generations, are reviewed. Companies developing software for analysis of sequencing data are also included. Selected academic institutes conducting research in sequencing are also listed.

Current market is mostly for research applications and future markets will be other applications related to healthcare. The value of DNA sequencer market in 2012 is described with estimates for 2017 and 2022. Various methods and factors on which market estimates depend are described briefly. Markets are tabulated according to geographical areas as well as applications. Small sequencers form the basis of SWOT (strengths, weaknesses, opportunities, threats) analysis. Several marketing strategies have been outlined.

The report includes profiles of 108 companies involved in sequencing and their 106 collaborations. The report text is supplemented by 36 tables, 12 figures and 320 selected references to the literature.

Key Topics Covered:

Executive Summary

1. Introduction

2. DNA Sequencing Technologies

3. Comparative Analysis of Sequencing Technologies

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Research and Markets: DNA Sequencing - Technologies, Markets and Companies - Updated 2013 Report

Apr. 4, 2013 Scientists from the University of Notre Dame, The Nature Conservancy, and Central Michigan University presented their findings of Asian carp DNA throughout the Great Lakes in a study published in the Canadian Journal of Fisheries and Aquatic Sciences. "The good news is that we have found no evidence that Asian carp are widespread in the Great Lakes basin, despite extensive surveys in Southern Lake Michigan and parts of lakes Erie and St Clair," said Dr. Christopher Jerde, the paper's lead author and a scientist at the University of Notre Dame, "Looking at the overall patterns of detections we remain convinced that the most likely source of Asian carp DNA is live fish."

Some recent reports regarding environmental DNA have suggested that birds, boats, and other pathways, but not live fish, are spreading the bighead and silver carp DNA. Jerde points out, "It's really very telling that the only places DNA has been recovered are where Asian carp have been captured. If birds or boats were commonly spreading the DNA, then we should be detecting DNA in other places we have surveyed in the Great Lakes. "

According to the USGS, in 2010 commercial fishermen captured a 20 lb. bighead carp in Lake Calumet, 30 miles above the electric barrier meant to block the advancing carp from the Illinois River. Lake Calumet is 7 miles of river away from Lake Michigan. Likewise, in 1995 and twice in 2000, USGS records indicate that bighead carp were captured in the western basin of Lake Erie. "It shouldn't be surprising that we found evidence of Asian carp in these areas where Asian carp were already known to exist from captures, " said Lindsay Chadderton, co-author on the paper and Director of The Nature Conservancy's Great Lakes Aquatic Invasive Species program.

This study builds upon a growing area of research to find invasive species when they are at low abundance and when they can be potentially managed. Professor David Lodge, Director of the University of Notre Dame's Environmental Change Initiative and author on the paper said, "Catching these fish by net, hook, or electrofishing is ineffective when the fish are at low abundance -- that's why we were asked to deploy this eDNA approach in the first place. If we wait for the tell-tale signs of Asian carp jumping out of the water, then we are likely too late to prevent the damages. Environmental DNA allows for us to detect their presence before the fish become widespread."

Dr. Andrew Mahon, co-author and Assistant Professor at Central Michigan University, said "when we first discovered DNA from Asian carp at the Calumet Harbor and Port of Chicago, we were concerned that Asian carp may already be widespread in the Great Lakes. But because of our collaborations with State and Federal partners, we now have a better picture of the Asian carp distribution, and we are optimistic that with continued vigilance, it will be possible to prevent Asian carp becoming established in the Great Lakes."

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Asian carp DNA not widespread in the Great Lakes

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/466nfj/dna_microarray) has announced the addition of the "DNA Microarray 2013: A Focus on Sales Growth" report to their offering.

DNA Microarray 2013 presents the findings of a global market study of DNA Microarray, involving the participation of 201 buyers and end-users in this field. With a focus on market development, sales growth and commercial opportunities, the study profiled current and evolving areas of this market, as outlined below. Its findings provide valuable product and market information, and decision-making support to suppliers in the DNA Microarray field.

From the early use of miniaturised microarrays for the analysis of gene expression in the mid 1990s, this technique has established markets that are expected to reach $3 billion by 2015. However, these are also changing as new applications are developed and new competitive strategies, such as PCR, grow. This report, based on an analysis of current and evolving developments in the DNA microarray field, has been produced to assist marketing and sales in this field, and the identification of new opportunities. It is the outcome of an extensive global study involving more than 200 experienced DNA microarray buyers and end-users. It's findings provide a focus on sales growth to developers and vendors in the microarray field, and the changes that are driving these developments.

Key Topics Covered:

Chapter 1 Introduction

Chapter 2 Study Participants

Chapter 3 DNA Microarray Methods

Chapter 4 DNA Microarray Applications

Chapter 5 Companies

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Research and Markets: DNA Microarray 2013 Market Report: A Focus on Sales Growth

STONY BROOK, NY--(Marketwired - Apr 4, 2013) - Applied DNA Sciences, Inc. (OTCBB: APDN), (Twitter: @APDN), a provider of DNA-based anti-counterfeiting technology and product authentication solutions, announced today a Letter of Intent (LOI) with Markem-Imaje Corporation (Keene, NH), establishing Applied DNA Sciences as an authorized reseller of Markem-Imaje Fluid inks. The LOI is specifically related to the application of SigNature DNA botanical markers added into Markem-Imaje inks. This supports suppliers in meeting the Defense Logistics Agency (DLA) requirement for SigNature DNA marking on a class of electronics provided to the Agency.

Markem-Imaje is a top supplier of inks to the electronics industry, both military and commercial, and is said to be the world's largest provider of product identification solutions.

"This expanded relationship will create new opportunities for Applied DNA Sciences to support the DLA requirement for the use of DNA on microcircuits, and will provide additional synergies with other Markem-Imaje products," said Dr. James A. Hayward, CEO and President of Applied DNA Sciences. "Markem-Imaje is interested in further expanding its product line with SigNature DNA, and feels that a working relationship with Applied DNA Sciences would provide the best solution to accomplish that goal."

The Authorized Reseller agreement will enable APDN to resell a set of Markem-Imaje Fluid inks, which APDN then inoculates with its proprietary SigNature DNA unique to each customer. Markem-Imaje and APDN are also looking at the possible development of other ink products suitable for application on a broad range of substrates that will provide APDN customers access to the increased line of Markem-Imaje products and printing solutions. The DLA requirement stipulates that the Agency will only procure FSC 5962 (microcircuits) that use SigNature DNA marking.

"With Applied DNA Sciences as an authorized seller of Markem-Imaje inks, I believe the supply of SigNature DNA for electronics will be simpler, faster, and more easily meet the DLA requirement. This will facilitate usage for customers already using SigNature DNA in Markem-Imaje inks, as well as those future SigNature DNA-customers who have experience with Markem-Imaje inks," continued Dr. Hayward.

"We are working with APDN to make available SigNature DNA-marked inks, and to develop new solutions for Markem-Imaje inks that incorporate this dynamic technology. The innovative nature of SigNature DNA technology provides our Fluid ink customers with a unique value for ensuring that products and supply chains are protected," said Markem-Imaje Vice President of Marketing Christophe Lopez.

About Applied DNA SciencesAPDN is a provider of botanical-DNA based security and authentication solutions that can help protect products, brands and intellectual property of companies, governments and consumers from theft, counterfeiting, fraud and diversion. SigNature DNA and smartDNA, our principal anti-counterfeiting and product authentication solutions that essentially cannot be copied, provide a forensic chain of evidence and can be used to prosecute perpetrators.

The statements made by APDN may be forward-looking in nature. Forward-looking statements describe APDN's future plans, projections, strategies and expectations, and are based on assumptions and involve a number of risks and uncertainties, many of which are beyond the control of APDN. Actual results could differ materially from those projected due to our short operating history, limited financial resources, limited market acceptance, market competition and various other factors detailed from time to time in APDN's SEC reports and filings, including our Annual Report on Form 10-K, filed on December 20, 2012 and our subsequent quarterly reports on Form 10-Q. APDN undertakes no obligation to update publicly any forward-looking statements to reflect new information, events or circumstances after the date hereof to reflect the occurrence of unanticipated events.

About Markem-ImajeMarkem-Imaje, a wholly owned subsidiary of the New York-based Dover Group is a trusted world manufacturer of product identification and traceability solutions, offering a full line of reliable and innovative inkjet, thermal transfer, laser, and print and apply label systems. Markem-Imaje delivers fully integrated solutions that enable product quality and safety, regulatory and retailer compliance, better product recalls and improved manufacturing processes. Headquartered in Bourg-ls-Valence, France, Markem-Imaje provides more than 40,000 customers with optimal product marking and coding solutions. Additionally, Markem-Imaje customers are supported by 30 subsidiaries, 6 R&D centers, several equipment repair centers and manufacturing plants strategically located around the globe.

About DoverDover, traded on the NYSE, is a world-wide diversified manufacturer of industrial products, with $ 7.9 billion in annualized revenue in 2011. Dover encompasses 34 reporting companies and nearly 34,000 employees around the world. Visit http://www.dovercorporation.com for further information.

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Applied DNA Sciences and Markem-Imaje Sign Letter of Intent for Authorized Reseller Agreement

GH3 - DNA 2 - *PREVIEW*
Third original song in this pack. (I really hope you guys enjoyed this pack!) 😀 46 Hours in FL Studio on this one! =) Download here: https://www.dropbox.com...

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GH3 - DNA 2 - *PREVIEW* - Video

Washington, April 2 (ANI): For the first time, scientists have "discovered how a key step in human DNA replication is performed."

Part of the DNA replication process-in humans and in other life forms-involves loading of molecular structures called sliding clamps onto DNA.

This crucial step in DNA replication had remained somewhat mysterious and had not been well studied in human DNA replication.

Mark Hedglin, a post-doctoral researcher in Penn State University's Department of Chemistry and a member of Benkovic's team, explained that the sliding clamp is a ring-shaped protein that acts to encircle the DNA strand, latching around it like a watch band.

The sliding clamp then serves to anchor special enzymes called polymerases to the DNA, ensuring efficient copying of the genetic material. "Without a sliding clamp, polymerases can copy very few bases-the molecular 'letters' that make up the code of DNA-at a time.

But the clamp helps the polymerase to stay in place, allowing it to copy thousands of bases before being removed from the strand of DNA," Hedglin said.

Hedglin explained that, due to the closed circular structure of sliding clamps, another necessary step in DNA replication is the presence of a "clamp loader," which acts to latch and unlatch the sliding clamps at key stages during the process.

"The big unknown has always been how the sliding clamp and the clamp loader interact and the timing of latching and unlatching of the clamp from the DNA," said Hedglin.

"We know that polymerases and clamp loaders can't bind the sliding clamp at the same time, so the hypothesis was that clamp loaders latched sliding clamps onto DNA, then left for some time during DNA replication, returning only to unlatch the clamps after the polymerase left so they could be recycled for further use," he added.

The study was recently published in the journal eLife. (ANI)

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Elusive step in human DNA replication process demystified