Category Archives: DNA

STONY BROOK, NY--(Marketwired - May 7, 2013) - Applied DNA Sciences, Inc. (OTCBB: APDN), (Twitter: @APDN), a provider of DNA-based anti-counterfeiting technology and product authentication solutions today issued its latest progress update to its program for SigNature DNA-marking of electronics supplied to the U.S. Defense Logistics Agency (DLA).APDN lists forty-two electronics companies that are either under contract, have entered into contract negotiation, or have requested and received a SigNature DNA quotation.The companies include Original Equipment Manufacturers (OEMs), Original Component Manufacturers (OCMs), and as designated by DLA, Qualified Manufacturers (QML), including both qualified independent and authorized distributors.

DLA announced in late January that it would subsidize costs for companies implementing SigNature DNA marks.Once the reimbursement policy was instituted, and initial DNA-marking customers trained and certified, APDN began incremental DNA shipments in March.

APDN noted that both the number and rate of contract signings have increased since the reimbursement policy was announced.The accelerated sales cycle is a sign of additional momentum in the DNA-compliant electronics vertical.Other developments include the recruitment of a second company providing third party SigNature DNA marking services and increased efficiency in the certification times for onboarding customers.

APDN stated that 10 companies have now signed contracts to provide SigNature DNA marking on parts provided to DLA, while 9 more have contracts under negotiation, and 23 possess requested quotations for DNA.(APDN noted that the negotiation process does not guarantee or automatically lead to a signed agreement.) These suppliers also support U.S. Department of Defense prime contractors and other military/aerospace companies.Many are looking to expand their SigNature DNA-marking capabilities beyond DLA and offer the forensically secured supply-chain platform to their existing and new OEM and Contract Manufacturer (CM) customers.

Manufacturers using the SigNature DNA platform will use an Authentication Mark, forensically verifying originality of a component anywhere along the supply chain.Distributors are assigned a SigNature DNA Provenance Mark, verifying the immediate source of the part.The Provenance Mark assures the identity of the distributor and verifies that the distributor possesses original component manufacturer traceability or test method paperwork using the widely accepted anti-counterfeiting standard SAE AS6081.

The company notes that SigNature DNA is approved only for companies certified by DLA as trusted sources.As such, the APDN platform is closely linked to DLA quality programs, and is one piece in the effort to prevent counterfeit parts from entering the supply chain.Certifications of the DNA-compliance include the Qualified Manufacturers List (QML), the Qualified Products List (QPL), and the Qualified Testing Suppliers List (QTSL.)In order to qualify for QTSL, companies are required by DLA to implement SigNature DNA marking on designated parts.

Some members of the electronics industry resisted the requirement for DNA marking due to concerns over increased costs or process impact. Early adopters are seeing a rapid return on their investment, with increasing sales to DLA. APDN views the contract increment as evidence of increasing industry acceptance.

Dr. James A. Hayward, CEO and President of Applied DNA Sciences, stated, "I believe that our company's significant commitment of resources to aid the military electronics program is bearing fruit.Our road map for implementation began with the independent distributors, and continues systematically through authorized distributors, OCMs and the prime contractors. We are seeing steady progress in all categories."

Janice Meraglia, APDN Vice President for Military and Government Programs, stated, "We are now strongly branded in the electronics industry, and that brand is recognized and bringing more companies to us.We believe there is a large potential for this technology to transition to other high reliability supply, beyond defense, such as medical and automotive equipment."

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Applied DNA Sciences Expands Base for Signature DNA Marking of Electronics: Forty-Two Companies Rally to DNA Mark

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Featured Article Academic Journal Main Category: Cancer / Oncology Also Included In: Genetics Article Date: 06 May 2013 - 3:00 PDT

Current ratings for: DNA Housekeeping Proteins May Also Prevent Cancer

Senior author Gerald Crabtree, who is also of the Howard Hughes Medical Institute in Chevy Chase, Maryland, and colleagues, write about their findings in a paper published online in Nature Genetics on 5 May.

"Somehow these chromatin-regulatory complexes manage to compress nearly two yards of DNA into a nucleus about one one-thousandth the size of a pinhead. And they do this without compromising the ability of the DNA to be replicated and selectively expressed in different tissues - all without tangling."

More recently, in the journal Nature, they reported that switching subunits in the BAF complexes can transform human fibroblasts to neurons, suggesting they also play an instructive role in cell development, and possibly, cancer.

In this latest study, they show that BAF complexes "are mutated in nearly 20 percent of all human malignancies thus far examined," says Crabtree.

The results also show that the mutations have a broad reach, comparable to that of another well-known tumor suppressor, p53.

"Although we knew that this complex was likely to play a role in preventing cancer, we didn't realize how extensive it would be," says co-first author and postdoctoral scholar Cigall Kadoch.

The team discovered that certain patterns of mutations in the subunits of the BAF complexes seem to precede specific cancers. For example, one pattern suggests ovarian rather than colon cancer will follow.

When they found that in some cases even just one mutation in a subunit was enough to trigger cancer, they realized how important a role BAF complexes must play in tumor suppression.

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DNA Housekeeping Proteins May Also Prevent Cancer

May 6, 2013 Take a swab of saliva from your mouth and within minutes your DNA could be ready for analysis and genome sequencing with the help of a new device.

University of Washington engineers and NanoFacture (http://nano-facture.com/), a Bellevue, Wash., company, have created a device that can extract human DNA from fluid samples in a simpler, more efficient and environmentally friendly way than conventional methods.

The device will give hospitals and research labs a much easier way to separate DNA from human fluid samples, which will help with genome sequencing, disease diagnosis and forensic investigations.

"It's very complex to extract DNA," said Jae-Hyun Chung, a UW associate professor of mechanical engineering who led the research. "When you think of the current procedure, the equivalent is like collecting human hairs using a construction crane."

This technology aims to clear those hurdles. The small, box-shaped kit now is ready for manufacturing, then eventual distribution to hospitals and clinics. NanoFacture, a UW spinout company, signed a contract with Korean manufacturer KNR Systems last month at a ceremony in Olympia, Wash.

The UW, led by Chung, spearheaded the research and invention of the technology, and still manages the intellectual property.

Separating DNA from bodily fluids is a cumbersome process that's become a bottleneck as scientists make advances in genome sequencing, particularly for disease prevention and treatment. The market for DNA preparation alone is about $3 billion each year.

Conventional methods use a centrifuge to spin and separate DNA molecules or strain them from a fluid sample with a micro-filter, but these processes take 20 to 30 minutes to complete and can require excessive toxic chemicals.

UW engineers designed microscopic probes that dip into a fluid sample -- saliva, sputum or blood -- and apply an electric field within the liquid. That draws particles to concentrate around the surface of the tiny probe. Larger particles hit the tip and swerve away, but DNA-sized molecules stick to the probe and are trapped on the surface. It takes two or three minutes to separate and purify DNA using this technology.

"This simple process removes all the steps of conventional methods," Chung said.

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New device can extract human DNA with full genetic data in minutes

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