Category Archives: DNA

DNA Funk - Qual é o Estilo Musical do Rio?
Samba, Bossa Nova ou Funk? Qual o estilo musical que, atualmente, representa o Rio de Janeiro?

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DNA Funk - Qual é o Estilo Musical do Rio? - Video

30 September 2013 Last updated at 16:07 ET

The Italian judge hearing the retrial of Amanda Knox and and Raffaele Sollecito for the murder of Meredith Kercher has ordered a new DNA test on a knife allegedly used in the killing.

The two suspects spent four years in jail for the 2007 murder, but their convictions were overturned on appeal.

That ruling was itself overturned in March by Italy's highest court.

A separate trial convicted Rudy Guede from Ivory Coast of Miss Kercher's murder. He is serving 16 years in jail.

Neither the American Amanda Knox, nor her Italian former boyfriend Raffaele Sollecito, were in court for the start of the hearing in Florence.

Ms Knox was the housemate of Miss Kercher - a 21-year-old Briton who was found in their student lodgings in Perugia with her throat slashed.

Miss Kercher's sister Stephanie wrote to the court to express the family's feelings, nearly six years on from the brutal killing.

"We desperately want to discover the truth," she wrote, "and find justice for Meredith."

Miss Kercher, from Coulsdon in south London, was an undergraduate at the University of Leeds and was studying on an exchange programme at the University of Perugia at the time of her death.

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Kercher judge orders new DNA test

Florence (Italy) (AFP) - Judges at the retrial of Amanda Knox for the murder of a British student on Monday ordered new DNA testing on the alleged murder weapon, a kitchen knife, on the first day of hearings.

The court in Florence also said it would re-hear the testimony of Luciano Aviello, a jailed mafia turncoat who at one point had accused his own brother of the grisly murder but then retracted.

Lawyers for the US student and her Italian former lover Raffaele Sollecito told the court the fresh tests were essential in clearing the defendants, as the victim's lawyer said the truth behind one of Italy's most notorious crimes was long overdue.

Knox and Sollecito spent four years behind bars for the murder of Meredith Kercher, who was found in a pool of blood in the house she shared with Knox in 2007, her body riddled with stab wounds.

An appeals court overturned their convictions in 2011 and Knox quickly returned to Seattle, but Italy's Supreme Court in March ordered a retrial following an appeal by prosecutors against what they slammed a "superficial ruling."

"We need a key step forward on the DNA evidence... We want the truth," Knox's lawyer Luciano Ghirga told the retrial's presiding judge Alessandro Nencini.

The knife, recovered from a kitchen drawer in Sollecito's house, bore tiny traces of Knox's DNA on the handle, and Meredith's DNA on the blade.

A third DNA trace had gone unexamined because it was seen as too low to produce conclusive results but the defence hopes it could help clear the pair.

I'm not coming back

Knox, 26, has insisted she will not return to Italy for any part of the retrial.

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Defence wants new DNA tests in Knox murder retrial

Public release date: 30-Sep-2013 [ | E-mail | Share ]

Contact: Sarah Avery sarah.avery@duke.edu 919-660-1306 Duke University Medical Center

DURHAM, N.C. By detailing a process required for repairing DNA breakage, scientists at the Duke Cancer Institute have gained a better understanding of how cells deal with the barrage of damage that can contribute to cancer and other diseases.

The insights, reported online the week of Sept. 30, 2013, in the journal Proceedings of the National Academy of Sciences, build on earlier work by the research team and identify new prospects for developing cancer therapies.

The researchers have focused on a complex series of events that cells routinely undertake to repair DNA damaged by sun exposure, smoking and even normal metabolism. If not correctly repaired, DNA breakages can result in cellular damage leading to cancer.

"We never had good assays to measure how DNA breaks are repaired, and there were few good tools to study how that repair unfolds at the molecular level," said senior author Michael Kastan, M.D., PhD, executive director of the Duke Cancer Institute. "Our work for the first time enables us to both sensitively measure the repair of DNA breaks and study the molecular mechanisms by which they occur."

DNA inside the cell faces a challenge for repairing itself because it is so compacted in the cell nucleus. Tightly wrapped in a complex of proteins called chromatin, the DNA is spooled like thread around a protein structure called a nucleosome. DNA could suffer a breakage that would go unheeded if it remained deep within the reel.

The system developed by Kastan and colleagues induced DNA breakage at defined points on the DNA strands, enabling researchers to chronicle events as the cells launched the repair process.

What they described for the first time was a choreographed interaction in which the tightly wound DNA was temporarily loosened when a key protein, called nucleolin, was recruited to the breakage site, disrupting the nucleosome spool. The process was then reversed when the nucleosome was re-formed after repair was complete.

"Our study demonstrates for the first time the functional importance of nucleosome disruption in DNA repair," Kastan said. "This nucleosome disruption allows DNA repair proteins to access the DNA lesion and begin the process of mending the breakage."

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New insights into DNA repair process may spur better cancer therapies

September 30, 2013 Sophie Langley

Genes in mitochondria, the powerhouses that turn sugar into energy in human cells, shape a persons risk for heart disease and diabetes, according to a study from researchers at the University of Alabama at Birmingham (UAB).

The findings may have implications for diet-planning and the ongoing debates surrounding added sugars in foods and beverages.

Researchers said the findings, published in the Biochemical Journal 8 August 2013, may explain why some people get sick and others do not despite having the same traditional risk factors like ageing, obesity and smoking.

Research in recent years has shown that miscues in mitochondrial energy production create too many particles called oxidants and free radicals that cause cells to self-destruct as part of heart disease, diabetes and cancer.

Having been in this field for decades, I remember when mitochondrial DNA variations were thought to play a role only in the rarest of genetic syndromes, said Scott Ballinger, PhD, Professor in the Division of Molecular and Cellular Pathology at the UAB School of Medicine and corresponding study author. Today there is a growing consensus that variation in mitochondrial DNA alone make a substantial contribution to each persons risk for heart disease, and ours is the first study to directly confirm it in a living mammal, he said.

Evolution of mitochondria in humans

The UAB study reflects the theory that humans ancient one-celled ancestors swallowed the bacterial forebears of what are now mitochondria. These gave their hosts the ability to convert sugar from food into about 15 times as much cellular energy as the hosts could by using oxygen. As the evolutionary process continued, the mitochondria became permanent sub-compartments of human cells.

Each human cell has two genomes, the long stretches of DNA that encode the blueprint for the human body: one set inherited from both parents in a central nucleus, and a separate, smaller set in each mitochondrion. The mitochondria genes are inherited from a childs mother.

Researchers have struggled to genetically engineer mice that would enable them to separate the impact of one gene set from the other, making the theory that mitochondria DNA shape disease risk difficult to prove. Additionally, the human nuclear genome contains more than 30,000 genes, compared to just 13 energy-related genes in the mitochondria.

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DNA link to sugar impact risk for heart disease and diabetes

DNA Live @Smash Beat All [008]
This is DNA , This is Madness, This is too crazy. Thank you Guys . . http://www.youtube.com/myDNAOficial https://www.facebook.com/myDNA3D https://soundcloud....

By: DNA Live

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DNA Live @Smash Beat All [008] - Video

Let #39;s Play Pokemon: White 2 - Part 20 - DNA Splicers
We help Drayden take on Team Plasma who are in search of the DNA Splicers!! Enjoy!! -- Stay connected with me! Twitter: http://www.twitter.com/PurpleRodri Fa...

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Let's Play Pokemon: White 2 - Part 20 - DNA Splicers - Video

DNA 2 of 5) Playing God

By: Documentary Pack

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DNA 2 of 5) Playing God - Video

DNA 3 of 5) The Human Race

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DNA 3 of 5) The Human Race - Video

TATA to launch SUV in 2016 with Land Rover DNA
Tata Motors, having lost to Mahindra in SUV space, is planning two models to be rolled out in 2016. In the price range of Rs10-15 lakhs, the SUVs will be dev...

By: livemintvideos

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TATA to launch SUV in 2016 with Land Rover DNA - Video