Category Archives: DNA

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DNA contains genetic segments inherited from groups that interbred in the past. Scientists have mapped some of the intermixing.

STORY HIGHLIGHTS

(CNN) -- Most people are carrying around historical records in their DNA, with clues to how people from genetically distinct groups intermingled over the last 4,000 years. That's the conclusion of a new study in the journal Science.

Researchers set out to pinpoint which groups intermixed, and when, over thousands of years, using modern DNA. They thought this information could complement other historical records.

"The results suggest DNA is indeed a powerful means of reconstructing history, which then might be used to identify the genetic legacies of historically well-attested events ... and highlight surprising events with a less clear historical context," authors Garrett Hellenthal and Simon Myers wrote in an e-mail.

The scientists have created an interactive map showcasing their findings. You can explore the map in detail on the researchers' website, admixturemap.paintmychromosomes.com.

The technical term for people from genetically different groups having babies together is "genetic admixture." This has happened throughout history when people migrated into a new geographic region where others were already living.

Researchers say there have been many such admixture events among people from populations that were separated by thousands of miles. Sometimes populations adjacent to each other have distinct ancestry and history.

Did you know that your DNA contains genetic segments you've inherited from groups that intermingled in the past? Researchers can look at these signatures for clues about major historical mixings of populations.

DNA from a person today can also give scientists an idea of how long ago two groups genetically mixed.

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How your DNA can reconstruct history

DNA contains genetic segments inherited from groups that interbred in the past. Scientists have mapped some of the intermixing.

STORY HIGHLIGHTS

(CNN) -- Most people are carrying around historical records in their DNA, with clues to how people from genetically distinct groups intermingled over the last 4,000 years. That's the conclusion of a new study in the journal Science.

Researchers set out to pinpoint which groups intermixed, and when, over thousands of years, using modern DNA. They thought this information could complement other historical records.

"The results suggest DNA is indeed a powerful means of reconstructing history, which then might be used to identify the genetic legacies of historically well-attested events ... and highlight surprising events with a less clear historical context," authors Garrett Hellenthal and Simon Myers wrote in an e-mail.

The scientists have created an interactive map showcasing their findings. You can explore the map in detail on the researchers' website, admixturemap.paintmychromosomes.com.

The technical term for people from genetically different groups having babies together is "genetic admixture." This has happened throughout history when people migrated into a new geographic region where others were already living.

Researchers say there have been many such admixture events among people from populations that were separated by thousands of miles. Sometimes populations adjacent to each other have distinct ancestry and history.

Did you know that your DNA contains genetic segments you've inherited from groups that intermingled in the past? Researchers can look at these signatures for clues about major historical mixings of populations.

DNA from a person today can also give scientists an idea of how long ago two groups genetically mixed.

More:
How DNA can rebuild history

Researchers are testing whether high-throughput DNA sequencing can help screen out abnormal embryos during in vitro fertilization.

A reproductive clinic in New Jersey is testing whether DNA sequencing can help make in vitro fertilization less risky.

In the trial, researchers will use DNA sequencing to count the number of chromosomes in each of the embryos they create by fertilizing a womans eggs in a dish. An abnormal number of chromosomes is the most common reason for IVF to fail, experts say, and as many as 30 percent of fertilized human eggs have such abnormalities. By selecting only those embryos with the normal number of chromosomes to transfer into the uterus, doctors hope to improve the success rate of IVF.

Traditionally in an IVF procedure, doctors visually inspect embryos and then transfer those that appear healthy after a few days of growthoften more than one at a time, because many of the embryos wont result in a successful pregnancy. If multiple embryos do implant successfully, however, it can be risky for both them and the mother, says Richard Scott, a reproductive endocrinologist and lead researcher in the trial, which is being conducted at Reproductive Medicine Associates of New Jersey.

To reduce such risks, some clinics, including Scotts, are moving toward transferring only a single embryo, and new DNA analysis technologies are helping to ensure that they pick the most viable and healthy one. Researchers have already shown that other methods of chromosome screening can improve the success rate of IVF. DNA sequencing offers a more affordable way to do such tests because samples from multiple embryos can be analyzed simultaneously. That gain in efficiency lowers the cost of the procedure and could make chromosome screening feasible for more couples.

Lower-cost testing is especially important for IVF because its often necessary to screen many embryos for one couple, says Dagan Wells, an IVF researcher at the University of Oxford. One patient does not equal one test, he says. Many patients who may want to use this kind of screening are denied because of the cost of the method.

Last summer, Wells, who works with another New Jersey-based fertility clinic, called Reprogenetics, announced the birth of the first child whose chromosome content had been checked using next-generation sequencing during IVF embryo selection (see Baby Born After Genome Analyzed in IVF Test).

Several companies already sell prenatal blood tests that detect abnormalities such as Down syndrome by using sequencing to count chromosomes in a mothers blood, which contains DNA from both mother and baby (see A Brave New World of Prenatal DNA Sequencing). Researchers have also shown that it is possible to determine the genome sequence of a fetus using DNA gathered from the mothers blood and the fathers saliva (see Using Parents Blood to Decode the Genome of a Fetus). Scientists can even read the genome of a human egg before it is fertilized (see Single-Cell Genomics Could Improve IVF Screening).

Both New Jersey clinics are testing whether using DNA sequencing to count embryo chromosomes does indeed improve the success of IVF. The trial by Reproductive Medicine Associates will transfer two embryos into each participating mother, whereas the Reprogenetics trial will transfer just one.

In addition to asking whether screening for abnormal chromosome numbers can improve IVF conception rates, Reproductive Medicine Associates is also testing whether sequencing can successfully screen for genetic diseases known to affect a family, says Scott. For instance, if both parents carry a copy of the mutation responsible for cystic fibrosis, they have a one in four chance of passing the disease on to their child. Embryos could be analyzed for the mutation so that only those without it would be transferred.

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DNA Sequencing of IVF Embryos

DNA Diet Webcast
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DJ Shog - DNA (Official Video HD)
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HOW TO PLAY DEFENSE! #39;The DNA of Defense #39; with Coach Tet Shot Science Basketball

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Diagnosis by DNA: Entering the Era of Personalized Medicine
Personalized medicine is an emerging practice that uses an individual #39;s detailed genomic data to guide decisions made in preventing, diagnosing and treating disease. Genomics expert Howard...

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