Category Archives: DNA

Little Mix- "DNA" 3/4/14
Little Mix performing "DNA" on the Neon Lights Tour at the Sands Event Center in Bethlehem, PA.

By: slightlygabbi

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Little Mix- "DNA" 3/4/14 - Video

BERKELEY -- Every day, up to 10 double-strand DNA breaks occur in each of the 70 trillion cells making up your body. It's a natural part of aging and the body has a built-in repair kit. But eat too many french fries, get an X-ray, breathe truck exhaust during a morning traffic jam or just lose out on the genetic lottery: your body's natural repair mechanism could go haywire, leaving trillions of broken helixes, potentially causing havoc.

Scientists know that genetic, lifestyle and environmental forces trigger the DNA damage linked to diseases like cancer and neurodegenerative disorders, including Alzheimer's. What they do not know, is which factors are most important and how much any one person can do to control the damage.

Exogen Biotechnology, a Lawrence Berkeley National Laboratory spinoff led by biophysicist Sylvain Costes, thinks it has a way to find the answers. Although the 43-year-old scientist's expertise in radiation risk modeling, a Ph.D. from UC Berkeley in nuclear engineering and his tendency to see a home tiling project as "mathematics on the floor" are key to the startup company's novel breakthroughs, Costes predicts the answers will come from a unique source: you.

Enrolling citizen scientists in the quest to map geographic patterns and better determine individual DNA damage risk factors, Costes and EB co-founder Jonathan Tang are building the world's first DNA damage database. A $70,000 Berkeley Lab Innovation Grant refined the six-piece kit Exogen developed in the lab's biohacker location. Costes, in an interview at LBNL, said a large cohort is necessary -- up to 100,000 people, if big data is to track patterns correlating to big problems, like cancer. For that, EB will need angel investors with seed money and, eventually, FDA approval.

In the meantime, an Indiegogo crowdfunding campaign raised $50,000 in under 10 days and is ongoing.

Individuals pay $99 ($204 for international participants; $999 for one-year monthly tracking) for the kit that safely collects three drop-sized blood samples.

Using a sterilized lancet, participants place the samples in vessels filled with fixative solution, answer a few questions at EB's secure, online registry and drop the package in a FedEx box.

"Voil," says Costes, a native of France, "It's like a home cholesterol test. We analyze and make the results available to you via a secure login." Results show the participating citizen scientists where they fall in their demographic. Exogen provides no medical advice and, at this point, none of the researchers make any money. "It's a scientific endeavor, not a business," Costes says.

If it's that easy, one wonders, why hasn't it been done before? Costes says the current DNA damage assessment system is not easy: it's time-intensive and subjective. Lab workers use eight-prong, hand-held dispensers, laboriously pumping samples into tiny indentations in a tablet.

Under the microscope, images are fuzzy, leading to human error.

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Berkeley startup wants to read your DNA crystal ball

Updated: Wednesday, March 5 2014, 10:43 PM CST Reported by Ewa Roman:

HARRISBURG -- An alleged serial rapist is behind bars in Dauphin County thanks to DNA evidence linking him to the sexual assault of three women in Harrisburg.

The alleged acts happened in Harrisburgs Allison Hill area last summer and fall.

CBS 21 found out how crucial DNA test kits are in cases like this one and we wanted to know the size of the kit testing backlog, and whats being done to change things.

Dauphin County District Attorney Ed Marsico tells us that there is a back log of DNA kits waiting to be tested, because not enough people are on the job.

Right now, hes working to get more funding to change that.

Theres been a move to have more funding put towards rape kits and processing of DNA , we can get those done more rapidly, stated Ed Marsico, Dauphin County District Attorney.

DA Marsico says three DNA matches got an accused serial rapist in Harrisburg off the streets. Jyrell Selvey, 23, is accused of raping three women last year.

Police say he robbed two of them. One was 17 and the other two were in their 20s.

Police say he threaten them with a knife.

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DNA links man to three rapes in Harrisburg

PUBLIC RELEASE DATE:

6-Mar-2014

Contact: Katrine Sonne-Hansen katrine.sonne@bric.ku.dk 45-21-32-90-40 University of Copenhagen

Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature Communications.

Interdisciplinary research team finds cellular high-speed shuttle

An interdisciplinary team of researchers from BRIC, University of Copenhagen and University of Southern Denmark have identified a cellular transport mechanism so fast and finely tuned that it compares to an Asian fast-speed train.

"Using advanced laboratory techniques, we have revealed how an enzyme called TLK1 regulates the transport of histones to DNA copying hubs in our cells. Such a devoted supply of histones, is crucial to maintain the genomic architecture when our cells divide", says Ilnaz Klimovskaia who has been spearheading the experimental work as part of her PhD-studies at BRIC.

The new results show that TLK1 controls the activity of a molecule called Asf1. Asf1 act as a freight train that transports histones to the nuclei of our cells where the DNA is copied during cell divisions. The enzymatic activity of TLK1 turn Asf1 into a fast-speed train, capable of precise, fast and timely transport of histones to newly formed DNA.

TLK1 contribute to cellular identity

Histones play an important role for the activity of our genes, as they contain information that can turn on or off genes. The information is communicated only when DNA is wrapped around the histones, to form the ordered genomic architecture called chromatin. As all our cells contain exactly the same genes, the histone information is crucial to activate only the sub-set of genes necessary to maintain a certain cellular identity. For example, heart genes needs only to be turned on in heart cells, but turned off in other cell types.

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Enzyme controls transport of genomic building blocks

Test: Glide Gear DNA-5050
This is a quick test of the Glide Gear DNA-5050 stabilizer. MUSIC: Boyce: Excerpts from Symphonies Sigma - Summer Calling (Ft. Taylor Fowlis) (Tantrum Desire...

By: chatek310

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Test: Glide Gear DNA-5050 - Video

IOS Plague Inc DNA Hack No Survey
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By: The Crit Reaper

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Italy to DNA Test Your Dog #39;s Poo! - NEWSFLASH
The city of Naples, Italy, is going CSI to DNA test dog poo in the street to see who doesn #39;t pick up after their pooch! FUNKY TIME SHIRTS!! http://samtimenew...

By: samtimenews

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Italy to DNA Test Your Dog's Poo! - NEWSFLASH - Video

http://WWW.TERAMOWEB.IT - Modus fm Roseto - Basket Recanati: 81-61 - DNA Silver 02.03.2014
Il Roseto di coach Trullo supera con una certa tranquillit l #39;ostacolo Recanati di coach Sacco ma non pu restare troppo tranquilla, soprattutto dopo il riti...

By: teramo teramoweb

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http://WWW.TERAMOWEB.IT - Modus fm Roseto - Basket Recanati: 81-61 - DNA Silver 02.03.2014 - Video

dna capsules medical powerpoint presentation slides f
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dna capsules medical powerpoint presentation slides c
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