Category Archives: DNA

Dr. Stephen Schoenberger of La Jolla Institute for Immunology to present data validating a novel, synthetic biology-based neoantigen platform and ability to identify immunogenic cancer mutations and TCRs

San Diego, CA, Nov. 01, 2021 (GLOBE NEWSWIRE) -- Codex DNA, Inc. (Nasdaq: DNAY), a pioneer in automated benchtop synthetic biology systems, today announced that one of its customers will be presenting data at the upcoming PEGS Europe Protein and Antibody Engineering Summit. During the conference, Codex DNA will be showcasing its award-winning BioXp system and a complete line of synthetic biology products at booth #506.

Biologics-based discovery of novel therapeutics is one of the most important areas of research for improving medical advances through the engineering of antibodies or other proteins for cancer treatment, infectious diseases, and inflammatory or autoimmune disorders. However, the process for developing effective monoclonal antibodies, antibody-drug conjugates, single-domain antibody variants, chimeric antigen receptor T cells (CAR Ts), and T cell receptors (TCRs) can be challenging. This is further compounded by the long lead times associated with sourcing synthetic DNA products that are necessary for screening, identification, and optimization of these novel protein or antibody candidates. The Codex DNA BioXp system is the only push-button, fully automated platform for on-demand synthesis of custom DNA libraries, gene fragments, clones, and mRNA. The system enables researchers to eliminate several manual processes from the traditional workflow and accelerate the identification and generation of validated lead candidates.

WHO: Stephen Schoenberger, Ph.D.Professor, Laboratory of Cellular Immunology, La Jolla Institute for Immunology

Dr. Schoenberger is a translational immunologist who guides an integrated research consortium involving research scientists, physicians, and bioinformaticians working to identify neoantigens through a novel functional strategy based on validation rather than prediction. He is a recipient of Scholar Awards from both The American Cancer Society and The Leukemia and Lymphoma Society. Dr. Schoenberger received his PhD in microbiology and molecular genetics from the University of California, Los Angeles, and completed postdoctoral training in immunohematology and tumor immunology at the University of Leiden in The Netherlands.

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WHAT: Leveraging the Power of Synthetic Biology in NeoAg Identification

Dr. Schoenberger will present his novel neoantigen identification approach that is being used to identify immunogenic cancer mutations and the TCRs that recognize them. The IPV (Identify-Prioritize-Validate) platform combines HLA-agnostic bioinformatic filtering of matched tumor/normal sequence data with functional analysis of autologous lymphocytes to enable functional validation of neoantigens (NeoAg) and specific TCRs with significantly higher efficiency than previous, purely predictive approaches using routinely available clinical samples.

WHEN: Wednesday, November 3, 2021, at 9:30 am CEST

WHERE: Hotel Arts Barcelona Ritz Carlton, Barcelona, Spain

Scientists involved in biologics discovery and antibody and protein engineering often need to custom-build libraries or synthesize numerous clones to screen new variants, but traditional methods are costly and have extremely long lead times, said Todd R. Nelson, PhD, CEO of Codex DNA. With the ability to generate up to 32 libraries, gene fragments, or clones in less than 24 hours, our benchtop BioXp system streamlines the antibody production process, allowing researchers to significantly increase the quantity and quality of suitable candidates to advance into downstream applications in their own laboratory.

Both Dr. Schoenberger and Dr. Nelson are available for media interviews during the conference. Please contact EMAIL if you are interested in scheduling a private briefing.

About Codex DNA

Codex DNA is empowering scientists with the ability to create novel, synthetic biology-enabled solutions for many of humanitys greatest challenges. As inventors of the industry-standard Gibson Assembly method and the first commercial automated benchtop DNA and mRNA synthesis system, Codex DNA is enabling rapid, accurate, and reproducible writing of DNA and mRNA for numerous downstream markets. The companys award-winning BioXp system consolidates, automates, and optimizes the entire synthesis, cloning, and amplification workflow. As a result, it delivers a virtually error-free synthesis of DNA/RNA at scale within days and hours instead of weeks or months. Scientists around the world are using the technology in their own laboratories to accelerate the design-build-test paradigm for a novel, high-value products for precision medicine, biologics drug discovery, vaccine and therapeutic development, genome editing, and cell and gene therapy. Codex DNA is a public company based in San Diego. For more information, visit codexdna.com.

Codex DNA, the Codex DNA logo, Gibson Assembly, and BioXp are trademarks of Codex DNA Inc.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Such forward-looking statements are based on Codex DNAs beliefs and assumptions and on information currently available to it on the date of this press release. Forward-looking statements may involve known and unknown risks, uncertainties and other factors that may cause Codex DNAs actual results, performance, or achievements to be materially different from those expressed or implied by the forward-looking statements. These risks are described more fully in Codex DNAs filings with the Securities and Exchange Commission (SEC) and other documents that Codex DNA subsequently files with the SEC from time to time. Except to the extent required by law, Codex DNA undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

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MEDIA ALERT: Codex DNA Customer to Highlight Advantages of Automated BioXp System in Precision Cancer Immunotherapy Applications at 13th Annual PEGS...

CHICAGO (CBS) Its been four years since Shantieya Smiths body was found in a West Side garage. The case is still unsolved and the mother of the murdered Chicago woman is looking for answers.

CBS 2 Suzanne Le Mignot investigates.

The mother says she called the Chicago police detective on the case at least five times in the past two years. She says shes gotten the same response when she was able to talk to the detective, were still waiting, for the DNA results.

Latonya Moore expresses her frustration, in her quest for justice.

Its the same thing, the DNA is not back and I was like, how, its been four years and the DNA is not back, Moore said.

On May 26th in 2018, Moores daughter, Shantieya Smith, was reported missing. Almost two weeks later, She was found in a garage underneath a car in North Lawndale.

The Medical Examiner ruled Smiths death a homicide. She had blunt trauma to her head and neck. Moore spoke to us back in 2019.

In 2019, police had told us, DNA results were not back yet. Now, three and a half years after her daughters murder, the Lawndale alley and garage where she was found, look the same. Moore says, the status of finding her daughters killer, appears to be the same too.

Its just like Ive been getting run around. At first, there was supposed to be a handprint on the garage. Never found out about that, so I dont know whats really going on with the case, Moore said.

Moore says shes not only waiting for handprint results, but primarily the DNA. Police had named a person of interest in her daughters case. A man she was last seen with, before she disappeared.

DNA dont take that long, especially for fingerprints, to come back. Fingerprints, did you find any DNA on her dress, did you find anything. Its like, no answers, she said.

Moore says that DNA would let her know, if the person of interest is the one responsible for her daughters death, or if the killer, is still at large.

We as parents, all we want to do is make sure the murderer is not on the street and make sure theyre tried for the crime that they did, Moore said.

So where is the DNA sample? The Illinois State police crime lab says the sample was given to the Chicago police. A spokesperson says the case is still open.

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After 3 Years, A Mother Is looking For Answers For The Murder Of her Daughter Found In A West Side Garage - CBS Chicago

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The results to by-elections of different states came on Tuesday. Some results have showed the BJP. The BJP lost its seats to Congress in Himachal Pradesh. However, the BJP won two seats in MP. DNA discusses the result of this by-election.

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DNA: Result of by-elections of different states announced - DNA India

Typical diets and excessive exercise not giving you the results you want? With a simple cheek swab,TheVitagene DNA Ancestry Test Kit & Health Plan Voucherwill teach you about your ancestry and educate you on how to achieve your bodys healthiest state.

The Vitagene test kit will analyze your genetic make-up, dissect your DNA and provide you with advanced health plans based on your information summary. The reports will help you learn how genetics play a significant role in your diet and assist you in tailoring supplements and workouts to best suit your bodys needs. Youll be guided on how to shift your lifestyle, fitness goals, and food choices based on the DNA reports. Receivecustomized meal plans, specific macronutrient percentages, lactose and gluten sensitivity info, metabolic breakdowns, and more.This unique test kit will change the way you see yourself and how you live your life.

The kit includes 2 vials, 2 cheek swabs, an instruction manual, and a return shipment box. All you have to do is quickly swab your cheek, mail the vials, and youll receive your results from the lab within 4-6 weeks. Once you get your personal genetic reports, you can officially begin transforming your dietary intake based on your DNA. You will begin to understand your global ancestry with an interactive ethnic map & regional percentages. The rest of your health habits will finally make sense and youll be able to adapt them accordingly. The detailed reports will allow you to makeinformed food choicesand learn what types of workouts are best for your body.

This DNA kit has 5 stars on Trustpilot and over 200 reviews. It is quickly becoming a consumer favorite for its simplicity and accuracy.Vitagene is also compatible with other home testing kits and accepts raw DNA files from AncestryDNA, 23andMe, and MyHeritage.

Get theVitagene DNA Ancestry Test Kit & Health Plan Voucherfor$74.99originally $99. Find out who you really are and become the best version of yourself!

Prices subject to change.

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This DNA Kit Will Help You Discover Your Ancestry And Design A Personalized Health Plan - Black Enterprise

NAGS HEAD, N.C. -- Three decades after infant remains were found in a North Carolina beach town, police say they have arrested and charged a couple based on new DNA evidence.

Scott Gordon Poole, 54, and his wife Robin Lynn Byrum, 51, were arrested last week and charged with concealing the birth of a child, a Class I felony, the Nags Head Police Department said in a news release.

The case dates back to April 4, 1991, when police officers found the infant remains in the trash at a location in Nags Head. At the time, authorities were not able to identify the baby's gender because decomposition had already begun, police said.

Investigators connected the couple to the infant after they sent one of its rib bones to a Texas lab for forensic analysis in 2019 and human DNA was recovered, officials said. That evidence was then used to create genealogical profile, leading investigators to Poole and Byrum.

"The tragedy of this child's death and the manner in which his body was disposed of is compounded by the fact that, until now, no one has been found responsible for this incredibly heartbreaking act," Nags Head Police Chief Phil Webster said.

The couple is being held at the Dare County Detention Center in Manteo, police said. Their bond was set at $250,000 each.

The-CNN-Wire & 2021 Cable News Network, Inc., a WarnerMedia Company. All rights reserved.

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Cold case solved: DNA evidence leads to arrests of Scott Gordon Poole, wife 30 years after infant body found in Nags Head - WTVD-TV

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Just as the Navajo researcher Rene Begay started to fall in love with the field of genetics, she learned that the Navajo Nation had banned all genetic testing on tribal land. Now she is struggling to figure out what the future of genetics might look like, and whether the Navajo and other Indigenous communities should be a part of it.

Further reading: Race, Genetics, and Scientific Freedom, Return the National Parks to the Tribes, The Search for Americas Atlantis, Elizabeth Warrens DNA Is Not Her Identity

A transcript of this episode will soon be made available. Please check back.

Be part of The Experiment. Use the hashtag #TheExperimentPodcast, or write to us at theexperiment@theatlantic.com.

This episode was produced by Peter Bresnan and Julia Longoria, with help from Tracie Hunte and Alina Kulman. Editing by Jenny Lawton and Emily Botein. Fact-check by Michelle Ciarrocca. Sound design by David Herman, with additional engineering by Joe Plourde. Transcription by Caleb Codding. Special thanks to Pauly Denetclaw.

Music by Keyboard (Ojima, Staying In, and Being There), Naran Ratan (Jam for Bwengo), Parish Council (Its Purple, Not Blue, Durdle Door, and Scented Letters), R McCarthy (Contemplation at Lon Lon), and Column ( Scan), provided by Tasty Morsels. Additional audio from the National Institutes of Healths All of Us Research Program.

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What Does It Mean to Give Away Our DNA? - The Atlantic

Joel Gottfrieds relatives never know what to get him for his birthday.

That changed a few years ago, when Gottfried began researching his family tree. He started with his fathers parents Jews who fled hardship and persecution in Europe and managed to document, in minute detail, their arrival at Ellis Island. He loved it.

So when Gottfrieds 69th birthday rolled around in March 2018, his sister Debbie Heller at last had the perfect gift for her big brother. She ordered both of them an at-home genetic test, 23AndMe, so they could explore their genetic history together. It would be fun.

When they viewed the results six weeks later, their jaws dropped:

What they had believed all their lives that they shared the same biological parents was not true. The results instead showed that they were only half-siblings. While they shared the same mother, they had different fathers.

So whos your daddy? Gottfried asked his sister, stunned.

To which she instantly replied: Whos your daddy?

The two people who perhaps couldve provided answers for them their parents, George and Tina Gottfried had died years before. Other older relatives who mightve had information were long gone, too.

I was shocked to such a degree that it didnt seem real, said Gottfried, who lives in Wyndmoor. Im a data guy. And here I am looking at data that is very clear no ambiguity. We were not [full] brother and sister.

At first, both Gottfried and Heller presumed the other sibling was born of the mystery father. But soon, Gottfried admits, he began to believe that the mystery father was probably his.

For one thing, in the siblings entire extended family, no one is close to six feet tall. Yet Gottfried is 6-foot-2 (his dad nicknamed him Stretch).

And growing up, Gottfried was an academic whiz kid who excelled at science and math and for whom school came easily. No one else in his family, he said, had his degree of academic prowess or technical bent (hes an MIT- and Penn-educated software developer).

So he began doggedly pursuing a scientific trail of DNA connections, which he has now chronicled in a self-published book called Whos My Daddy? (available on Kindle and in print-on-demand through Amazon).

Spoiler alert: Gottfried is indeed the offspring of the mystery father. But what makes Whos My Daddy? a more compelling read beyond the now-ubiquitous tales of DNA family reveals is the question it raises regarding long-ago infertility treatments and the age-old yearning of young couples to become parents.

Gottfried and Heller began the inquiry into their half-sibling status by asking a first cousin, Roy the son of their fathers brother to undergo a genetic test, which he agreed to do. The results showed that Roy was related to Heller but not Gottfried. Which confirmed for Gottfried that his biological father was not the big-hearted, hard-working, and boisterous Bronx salesman who had loved and raised him.

Eager for more data to analyze, Gottfried submitted his DNA to three more testing companies. Subsequent results genetically linked him to others, to differing degrees, some of whom Gottfried tracked down. Some of them were helpful; others were not. Gottfried just kept plugging.

Along the way, he got wind of an intriguing episode of This American Life on PBS, which told the story of a Jewish man, also raised by parents from the lower middle class Bronx, who learned late in life that his father wasnt his biological father.

Listening to it, my jaw just about hit the floor, said Gottfried, who was struck by the storys similarity to his own.

The man had used DNA testing to uncover his genetic history. While his biological dad turned out to be his uncle, he mentioned that hed once had suspicions about his mothers obstetrician/gynecologist a big-deal specialist whom his Bronx mom traveled all the way into Manhattan to see.

Then I realized: Wait a minute. Thats the same story as my mom, said Gottfried, who knew that his mother, after marrying his father, had for five years been unable to conceive. She finally conceived Gottfried after consulting a Park Avenue doctor (whose name Gottfried eventually learned).

And suddenly, Gottfried had not just a growing pile of data to analyze, but a hunch to explore: Did the doctor somehow figure into Gottfrieds origins?

Piece by piece, he said, he discovered what seemed like a possible link between people who seemed to be related to him and people who were somewhere in the branches of the doctors family tree.

Finally, two people provided the breaks his investigation needed.

The first was a man named David Levine, whom tests indicated was Gottfrieds second cousin. When they connected, Levine had interesting information: The doctor whod treated Gottfrieds mother was Levines fathers first cousin.

The second was a woman from California named Maimoona Ahmed who agreed to take a DNA test to help Gottfried uncover his own identity. She turned out to be Gottfrieds biological first cousin. Her father and the doctor had been brothers.

And at long last, Gottfried said, he knew who had fathered him.

Exactly how that came to be, Gottfried does not know. He cannot imagine, he says that, it was infidelity on his mothers part. The doctor had been an early fertility practitioner, and his mother turned to him after five years of being unable to conceive.

Once he made his discovery, Gottfried sought to learn what he could about the doctor, a respected physician with a prestigious clientele whom Ahmed, his niece, remembers with great affection and esteem.

The whole family always put him on a pedestal. We adored him, said Ahmed, 77, of the doctor, who died in 2001. He was so handsome, so charming.

The doctors family came to the United States from Russia; Gottfrieds fathers family emigrated from Hungary. The doctor had been part of a field unit of physicians sent to help prisoners being liberated from Nazi concentration camps after World War II. Gottfried has a copy of a very moving letter that the doctor wrote home about what he saw.

Gottfried said he was able to identify and then contact the doctors now-adult children; he says they did not respond to his request to connect. But Gottfried has gotten to know four of his newly discovered second cousins and two first cousins, especially Ahmed, with whom he spent a day while in California a couple years ago.

It was like a whole lifetime to catch up on, he said.

Ahmed, meanwhile, was glad to help her newfound cousin.

Im not the sleuth he is, she said, but I love to put people together. I love family stories. My kids know all know about Joel. Were all excited.

Gottfrieds journey has only tightened his bond with his sister, Debbie Heller, who stayed by his side through every twist of his investigation.

Weve always been close, but this drew us even closer, he said. She was so supportive in helping me through this.

And in his heart, George Gottfried the dad who raised him to respect the working man, who passed on his zany sense of humor, who made him feel protected and loved is still very much his father.

His sperm was not used to create me, but he was my father in every sense of the word, Gottfried said.

Hes glad for the revelations of the past few years, he said. Theyve made him more introspective, more appreciative of his unique life.

Because you know what? As bizarre as this was, I do cherish who I am, and Im happy with who I am, he said. I have my mother. I have my father who raised me. I have the father whose sperm started me off. It all came together, and I am happy with who I am. And I wanted to tell the story.

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A home DNA test revealed that the man who raised him wasnt his biological father. What he learned next shocked him and made him grateful. - The...

If youve ever wanted to know more about your history and where you came from but dont know where exactly to start, an ancestry test kit is a good place to begin. But theres a lot more you can learn about yourself than just your ancestries.

In fact, there are some kits that can even dig into your health and tell you what foods are best for you. The Vitagene DNA Ancestry Test Kit is one of those premium kits and right now its on sale for $74.99.

With a simple cheek swab, Vitagene can provide you with actionable health plans based on your DNA, lifestyle, and goals. You can learn things like how your genetics influence your diet, understand which supplements and workouts are best for you, and discover how your genes inform your global ancestry.

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To submit your sample all you have to do is complete a simple cheek swab, place the swab in the provided vials and send your sample via the return shipment box. Dont worry, it comes with an easy-to-read instruction manual that will give you step-by-step instructions.

Once your sample is received and analyzed, youll receive a customized report on not only your genetics but also how your genetics influence your diet. Youll be given detailed information including meal plans with tailored macronutrient percentages, gluten sensitivity info, best supplements and medication for your health conditions, and even the best workouts suited for your DNA.

Youll also receive an interactive ethnic map so that you can understand your global ancestry better.

Given a 5-star approval rating on Trustpilot, The Vitagene DNA Ancestry Test Kit is an important part of your future that you need today. For a limited time you can get this test kit for $74.99. Thats 24% off the regular price of $99 but only for a limited time.

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Reach your health goals and discover your ancestry with this DNA test kit - WJXT News4JAX

BioTech Breakthroughs Annual Awards Program Recognizes Innovation in the Global Life Sciences and Biotechnology Industry

NEW YORK, October 28, 2021--(BUSINESS WIRE)--Lucid Diagnostics Inc. (Nasdaq: LUCD) ("Lucid") a commercial-stage, cancer prevention medical diagnostics company, and subsidiary of PAVmed Inc. (Nasdaq: PAVM, PAVMZ) ("PAVmed"), today announced its EsoGuard Esophageal DNA Test has been selected as winner of the "Diagnostics Innovation of the Year" award in the inaugural awards program conducted by BioTech Breakthrough, a leading independent market intelligence organization that evaluates and recognizes standout life sciences and biotechnology companies, products and services around the globe.

"We are honored to have Lucids EsoGuard recognized as BioTech Breakthroughs inaugural Diagnostics Innovation of the Year," said Lishan Aklog M.D., Lucids Chairman and Chief Executive Officer. "This award adds to a growing list of accolades and recognition for Lucids products, including a prestigious 2020 Edison Best New Product Award, a National Cancer Institute highlight as one of the years significant advances in cancer prevention in its 2020 report to Congress, and FDA Breakthrough Device Designation indicating the potential to offer more effective diagnosis or treatment of life-threatening diseases."

"We believe EsoGuard, the first and only commercially available diagnostic test capable of serving as a widespread screening tool to prevent esophageal cancer deaths through early detection of precancer, could have as great an impact as widespread screening has had in preventing breast, colon, and cervical cancer deaths," Dr. Aklog added.

The mission of the annual BioTech Breakthrough Awards program is to conduct the industrys most comprehensive analysis and evaluation of the top technology companies, solutions, and products in the life sciences and biotechnology industry today. This years program attracted more than 1,200 nominations from over 12 different countries throughout the world.

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"Lucid Diagnostics is empowering clinicians to save lives by accurately detecting esophageal precancer in an office setting at a stage when it can be effectively managed or treated to prevent progression to highly lethal esophageal cancer," said Bryan Vaughn, Managing Director of BioTech Breakthrough Awards. "Congratulations on being our choice for the Diagnostics Innovation of the Year award."

Gastroesophageal reflux disease (GERD), also known as chronic heartburn, is ubiquitous and can lead to a highly lethal form of esophageal cancer (EAC). Over 80% of EAC patients die within five years of diagnosis, making it the second most lethal cancer in the U.S. The U.S. incidence of EAC has increased 500% over the past four decades, while the incidences of other common cancers have declined or remained flat. In nearly all cases, EAC silently progresses until it manifests itself with new symptoms of advanced disease.

All EAC is believed to arise from esophageal precancer which occurs in up to 5% to 15% of at-risk GERD patients. Early esophageal precancer can be monitored until it progresses to late esophageal precancer which can be cured with endoscopic esophageal ablation, reliably halting progression to cancer. Screening is already recommended by clinical practice guidelines in many millions of GERD patients with multiple risk factors, including age over 50 years, male gender, White race, obesity, smoking history, and a family history of esophageal precancer or cancer. Unfortunately, less than 10% of those recommended for screening undergo traditional invasive endoscopic screening. The profound tragedy of an EAC diagnosis is that likely death could have been prevented if the at-risk GERD patient had been screened and then undergone surveillance and curative treatment. The only missing element for a viable esophageal cancer prevention program has been the lack of a widespread screening tool that can detect esophageal precancer. Lucid believes EsoGuard is that missing element.

EsoGuard is a bisulfite-converted next-generation sequencing (NGS) DNA assay performed on surface esophageal cells collected with EsoCheck. It quantifies methylation at 31 sites on two genes, Vimentin (VIM) and Cyclin A1 (CCNA1). The assay was evaluated in a 408-patient multicenter case-control study published in Science Translational Medicine and showed greater than 90% sensitivity and specificity at detecting esophageal precancer and cancer. EsoGuard is commercially available in the U.S. as a Laboratory Developed Test (LDT) performed at a CLIA/CAP-certified laboratory. At-risk GERD patients can undergo the EsoCheck procedure for EsoGuard testing at gastroenterology physician offices or at a growing network of Lucid Test Centers.

About Lucid Diagnostics

Lucid Diagnostics Inc. (Nasdaq: LUCD) is a commercial-stage, cancer prevention medical diagnostics company, and subsidiary of PAVmed Inc. (Nasdaq: PAVM). Lucid is focused on the millions of patients with gastroesophageal disease (GERD), also known as chronic heartburn, who are at risk of developing esophageal precancer and cancer. Lucids EsoGuard Esophageal DNA Test, performed on samples collected in a brief noninvasive office procedure with its EsoCheck Esophageal Cell Collection Device, is the first and only commercially available diagnostic test capable of serving as a widespread screening tool to prevent cancer and cancer deaths through early detection of esophageal precancer in at-risk GERD patients. EsoGuard is commercialized in the U.S. as a Laboratory Developed Test (LDT). EsoCheck is commercialized in the U.S. as a 510(k)-cleared esophageal cell collection device. EsoGuard, used with EsoCheck, was granted FDA Breakthrough Device designation and is the subject of two large, actively enrolling, international multicenter clinical trials to support FDA PMA approval. Lucid is building a network of Lucid Test Centers where at-risk GERD patients can undergo the EsoCheck procedure for EsoGuard testing.

Forward-Looking Statements

This press release includes forward-looking statements. Forward-looking statements are any statements that are not historical facts. Such forward-looking statements, which are based upon the current beliefs and expectations of Lucids management, are subject to risks and uncertainties, which could cause actual results to differ from the forward-looking statements. Risks and uncertainties that may cause such differences include, among other things, volatility in the price of Lucids common stock; general economic and market conditions; the uncertainties inherent in research and development, including the cost and time required advance Lucids products to regulatory submission; whether regulatory authorities will be satisfied with the design of and results from Lucids clinical and preclinical studies; whether and when Lucids products are cleared by regulatory authorities; market acceptance of Lucids products once cleared and commercialized; Lucids ability to raise additional funding as needed; and other competitive developments. In addition, Lucid has been monitoring the COVID-19 pandemic and the pandemics impact on Lucids businesses. Lucid expects the significance of the COVID-19 pandemic, including the extent of its effect on its financial and operational results, to be dictated by, among other things, the success of efforts to contain the pandemic and the impact of such efforts on Lucids businesses. All of these factors are difficult or impossible to predict accurately and many of them are beyond Lucids control. In addition, new risks and uncertainties may arise from time to time and are difficult to predict. For a further list and description of these and other important risks and uncertainties that may affect Lucids future operations, see Lucids registration statement on Form S-1 filed with the Securities and Exchange Commission. Lucid disclaims any intention or obligation to publicly update or revise any forward-looking statement to reflect any change in its expectations or in events, conditions, or circumstances on which those expectations may be based, or that may affect the likelihood that actual results will differ from those contained in the forward-looking statements.

View source version on businesswire.com: https://www.businesswire.com/news/home/20211028005523/en/

Contacts

Investors Lisa DeScenzaLaVoieHealthScience(617) 351-0243ldescenza@lavoiehealthscience.com

Media Kristi BrunoLaVoieHealthScience(617) 865-3940PAVmed@lavoiehealthscience.com

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Lucid Diagnostics EsoGuard Esophageal DNA Test Wins "Diagnostics Innovation of the Year" Award - Yahoo Finance

Well turns out, their father is my father," Nancy Crane said. He knew that he had me, but I didnt know I had him.

HOUSTON It's an extraordinary story of a family reunion like no other. Six Houston siblings got the surprise of a lifetime when they got their DNA results back.

It started with a 23andMe DNA kit that me and my husband decided to order and do," Andrea Carnero said.

When Carnero got the results, she noticed she had a cousin she had never met.

Putting the pieces together

Carnero's aunt, Monica Limon, had a piece of paper from 23 years ago.

I was writing down everything that he was telling me about this woman," Limon said.

They were notes from her father about a woman with which he had an affair while stationed in the Army. He knew that woman had a daughter that he never met.

But for 30 years I was never able to find anything," Limon said.

Finally meeting

On Wednesday, Nancy Crane met her five sisters for the first time in person.

Well turns out, their father is my father," Nancy Crane said. He knew that he had me, but I didnt know I had him.

Crane grew up with her own mother and father, and only four months ago, she found out the truth.

Theyve taken me in like I was there my whole life. Its just unbelievable," Crane said.

More siblings

The story doesnt stop here. Theres one more piece to complete this puzzle, and this shocked these siblings most of all.

I swear I just lost it. I was, like, 'what?' Virginia Castillo said.

Their father had a second affair, and in that, Joseph was born.

They said, 'hey, not only do we have a sister, we have a brother,'" Castillo said.

Nancy and Joseph have lived 30 minutes apart in New Jersey not knowing each other their entire lives.

I couldve walked this earth and never knew about them and my loss," Crane said.

They'll all meet Joseph soon, but before Crane leaves town, there was one final introduction that needed to be made. She needed to meet the father she never met.

Hes not here to greet her. And thats what he wanted on his last days of life. He would say 'find her find her, I dont want to leave without finding her,'" Castillo said. I think that she will know my dad through us.

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'Turns out, their father is my father' | DNA results lead Houston family to long-lost siblings - KHOU.com