Category Archives: DNA

Neanderthal skulls. Image by leted via Flickr

Scientists have increasingly realized that DNA is only part of what makes us us perhaps equally important is how our genes activity is modified by a process called epigenetics. Recently this cutting-edge field has turned its attention to some very old DNA: Researchers today announced they have reconstructed methylation maps for our extinct relatives. The findings might explain certain differences in appearances between Neanderthals, Denisovans, and us, as well as the prevalence of disease.

Epigenetics is a branch of science that explores how the expression of our DNA can be influenced by external factors without the DNA itself changing. Research in the field has focused on DNA methylation. This is when a chemical compound called a methyl group attaches to DNA. This can regulate an individuals genetic expression and even be passed down through generations. DNA methylation has been linked to disease and also to an individuals appearance and behavior. This is the first time, however, that an archaic pattern of methylation has been reconstructed for early humans.

Researchers set out to reconstruct the DNA methylation activity of Neanderthals and Denisovans, two species of archaic human that split from modern humans more than half a million years ago. The researchers could not use methyl measurement techniques that are currently standard procedure in labs because the methods require DNA to be destroyed, an impractical approach when dealing with rare archaic DNA samples.

Instead, the team turned to cytosines, one of the four nucleobases that are the building blocks of DNA. Over time, cytosines naturally decay into other nucleobases: unmethylated cytosines become uracils, while methylated cytosines decay to thymines. Because DNA methylation occurs primarily in cytosines, measuring their rate of decay in the archaic DNA allowed researchers to build a detailed picture of how archaic human DNA had methylated and how it compares with that of modern humans.

The team identified about 2,000 regions in modern and archaic human genomes that had significantly different degrees of methylation. One of those regions, the HoxD cluster, is important in the development of body structure. Researchers theorize that the HoxD cluster, which was highly methylated in archaic humans, may be responsible for some of their differences in physical appearance from modern humans, including shorter, more robust limbs. The researchers published their findings today in Science.

Researchers also discovered that highly methylated regions distinct to modern humans were nearly twice as likely to be related to disease, and that more than a third of the disease-related genes were linked to psychiatric or neurological disorders. The team emphasized that additional research was needed, but suggested their findings could indicate that such diseases had only recently emerged in humans.

Read more from the original source:
Epigenetics Helps Explain Early Humans' Appearances

PUBLIC RELEASE DATE:

18-Apr-2014

Contact: Greger Larson greger.larson@durham.ac.uk 44-796-390-5362 National Evolutionary Synthesis Center (NESCent)

Durham, NC Ancient DNA adds a twist to the story of how barnyard chickens came to be, finds a study to be published April 21 in the journal Proceedings of the National Academy of Sciences.

Analyzing DNA from the bones of chickens that lived 200-2300 years ago in Europe, researchers report that just a few hundred years ago domestic chickens may have looked far different from the chickens we know today.

The results suggest that some of the traits we associate with modern domestic chickens -- such as their yellowish skin -- only became widespread in the last 500 years, much more recently than previously thought.

"It's a blink of an eye from an evolutionary perspective," said co-author Greger Larson at Durham University in the United Kingdom.

The study is part of a larger field of research that aims to understand when, where and how humans turned wild plants and animals into the crops, pets and livestock we know today.

Generally, any mutations that are widespread in domestic plants and animals but absent from their wild relatives are assumed to have played a key role in the process, spreading as people and their livestock moved across the globe. But a growing number of ancient DNA studies tell a different tale.

Chickens are descended from a wild bird called the Red Junglefowl that humans started raising roughly 4,000-5,000 years ago in South Asia. To pinpoint the genetic changes that transformed this shy, wild bird into the chickens we know today, researchers analyzed DNA from the skeletal remains of 81 chickens retrieved from a dozen archeological sites across Europe dating from 200 to 2,300 years old.

See the rest here:
Ancient DNA offers clues to how barnyard chickens came to be

Nucleic Acids 13: Even More About 3D Structure of DNA

By: T Holbrook

Read the original post:
Nucleic Acids 13: Even More About 3D Structure of DNA - Video

DESTRUCTION (Interview) with Marcel "Schmier" Schirmer 04/01/14 @ DNA Lounge CAPITALCHAOSTV.COM
http://www.facebook.com/CapitalChaos https://plus.google.com/u/0/b/1180158... http://www.capitalchaostv.com/ Destruction interview with Marcel "Schmier" Schi...

By: Capital Chaos TV

The rest is here:
DESTRUCTION (Interview) with Marcel "Schmier" Schirmer 04/01/14 @ DNA Lounge CAPITALCHAOSTV.COM - Video

DnA #39;s Evolution (live 4/11/14) - Part 1
DnA #39;s Evolution at the Harmonix PAX East Extravaganza - Laugh Boston - 4/11/14 Part 1: Psycho Killer - The Heist - Go to Ground Part 2 is here: https://www.y...

By: Adam Cardoza

Excerpt from:
DnA's Evolution (live 4/11/14) - Part 1 - Video

Nucleic Acids 20: DNA to RNA to Proteins

By: T Holbrook

Go here to see the original:
Nucleic Acids 20: DNA to RNA to Proteins - Video

How Is Your Emotional DNA Impacting Your Relationship?
To get Relationship Advice from the Ma #39;ats and a FREE GUIDE Inside The Head Heart of The Opposite Sex...CLICK BELOW: http://relationshipadvicewithayizeaiya...

By: Relationship Advice with Ayize and Aiyana Maat

Go here to read the rest:
How Is Your Emotional DNA Impacting Your Relationship? - Video

Hydrogen bonding in DNA
For more information, log on to- http://shomusbiology.weebly.com/ This lecture explains the importance of hydrogen bonding in the stability of DNA structure ...

By: Suman Bhattacharjee

See more here:
Hydrogen bonding in DNA - Video

Building on the DNA of Discovery: Vision Concept #39;s exterior
Taking familiar touches from Discovery #39;s DNA such as the body colour C-pillar, stepped waistline and alpine lights, Discovery Vision Concept is holds both a ...

By: LandRoverUK

Visit link:
Building on the DNA of Discovery: Vision Concept's exterior - Video

16) Dr.Abbas 16 [DNA : RNA synthesis in prokaryotes, eukaryotes Synthesis of mRNA]
RNA synthesis in prokaryotes - RNA synthesis in eukaryotes - Synthesis of mRNA ** . : https://www.mediafire.com/#2x2fxuzcj5a22.

By: Forsan El Kasr

See original here:
16) Dr.Abbas 16 [DNA : RNA synthesis in prokaryotes, eukaryotes & Synthesis of mRNA] - Video