Category Archives: DNA

The Beauty of Diagrams 5 - DNA (2010)

By: Cyril Merde

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The Beauty of Diagrams 5 - DNA (2010) - Video

TRP DNA Model Tour

By: T.R. Pollicita

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TRP DNA Model Tour - Video

[First Impressions] Vapor Shark DNA 20
I just received the Vapor Shark DNA 20 from a buddy earlier this evening and have been vaping the heck off it. ** Trying out a new feature on Youtube called "Live Events" so again, this video...

By: wernshen

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[First Impressions] Vapor Shark DNA 20 - Video

PUBLIC RELEASE DATE:

30-Apr-2014

Contact: Deborah Williams-Hedges debwms@caltech.edu 626-395-3227 Landes Bioscience

A gene known to repair DNA damage in healthy cells may also provide new insights about treating a genetic disorder of the bone marrow, Caltech researchers say.

This finding was published in the May 15 print edition of the journal Cell Cycle.

In the study led by Judith Campbell, professor of chemistry and biology at Caltech, the researchers investigated the relationship between two genesFANCD2 and DNA2both known to play roles in fixing broken or damaged strands of DNA within a cell, called DNA repair. A defective version of the FANCD2 gene can result in the genetic disease Fanconi anemia (FA), which is characterized by failure of the bone marrow (an inability to replenish the body's supply of blood cells) and a predisposition to certain developmental disorders and cancers. Although DNA2 has not been associated with an FA family as yet, genetic studies implicate DNA2 in the FA DNA repair pathway.

To determine the relationship between the genes, the researchers applied formaldehyde and other DNA-damaging substances to three types of cells: those lacking FANCD2, those lacking DNA2, and cells lacking both FANCD2 and DNA2. The groups of cells in which only one of the two genes had been deleted quickly succumbed to the formaldehyde-induced DNA damage; however, the cells lacking both FANCD2 and DNA2 were able to repair the DNA damage and survive.

"A key implication of this finding is the potential to manipulate DNA2 to improve the survival of FANCD2-deficient cells, and hopefully, by extension, the survival of FA patients," says Kenneth Karanja, a former postdoctoral scholar in Campbell's laboratory and first author on the study. Currently, the only treatment for FA is a bone marrow transplant, but even after the transplant the disease remains lethal.

"DNA2 is a well-studied gene, and this recent discovery could potentially become the basis for ameliorating the symptoms of this incurable disorder," Campbell says. Furthermore, she says, the protein DNA2 encodes is a nucleasewhich is a specific type of enzyme that has become a promising drug target.

"Since much is known about the mechanism of action of DNA2, it is an attractive target for future drug treatmentslike small-molecule inhibitors that could reduce an FA patient's cancer predispositionas well as a possible gene therapy for aiding a patient's blood cell development," she says.

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DNA repair gene provides new ideas for disease treatment

The DNA Conspiracy, The Sacred Spiral and You.
The DNA Conspiracy, The Sacred Spiral and You. A great lecture on the DNA and what it is TRULY made of and its REAL function. The DNA is still a hotly debated topic. The very pattern of our...

By: Steve Moore

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The DNA Conspiracy, The Sacred Spiral and You. - Video

Ancestry DNA Results (Ancestry.com)
Okay, here are my results. I #39;m somewhat surprised by some of the stuff I found out. Either way, I #39;m beyond satisfied and I think I will do this again for another person in my family.

By: Matt Seaton

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Ancestry DNA Results (Ancestry.com) - Video

MAURY: Kim #39;s 13th, 14th And 15th DNA Test
wow.

By: Raymond Orosco

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MAURY: Kim's 13th, 14th And 15th DNA Test - Video

Dr. Dennis McCormac - Varieties of DNA
Dr. Dennis McCormac answers the question, "How many varieties of DNA exist in the world?" submitted by students at West Kildonan Collegiate in Winnipeg, Mani...

By: LetsTalkScience

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How to gain S-Off on the HTC One M8 (works /w M7,Butterfly,Droid DNA other HTC Qualcomm devices)
This is my video tutorial on how to gain S-Off on a HTC One M8 (or any other HTC Qualcomm device including the HTC One M7, Butterfly Droid DNA...) Pre-Requisites: Root Access If you want...

By: C4ETech

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How to gain S-Off on the HTC One M8 (works /w M7,Butterfly,Droid DNA & other HTC Qualcomm devices) - Video

Citizenship and Immigration Services I AABB DNA Testing I 877-680-5800
http://www.aabbimmigrationdnacenter.com Citizenship and Immigration services requires many families to provide DNA testing in order to definitively prove their relationship with an alleged...

By: DNA Paternity Testing Specialists

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Citizenship and Immigration Services I AABB DNA Testing I 877-680-5800 - Video