Category Archives: DNA

DUBLIN--(BUSINESS WIRE)--The "Global In Situ Hybridization Market Size, Share & Trends Analysis Report by Technology (FISH, CISH), Probe Type (DNA, RNA), Product, Application, End-user (CROs), Region, and Segment Forecasts, 2021-2028" report has been added to ResearchAndMarkets.com's offering.

The global in situ hybridization market size is expected to reach USD 2.6 billion by 2028, according to the report. The market is expected to expand at a CAGR of 8.9% from 2021 to 2028.

The growing popularity of in-vitro diagnostics over conventional disease diagnostic methods has majorly driven the ISH market over the past years.

The market is gaining momentum in breast cancer with the FISH test. For instance, Roche offers a comprehensive ISH workflow solution with automated assay and digital pathology for breast cancer. Thus, increasing the scope of application is expected to drive the market to a major extend. In addition, technological advancements in instruments have fueled the market growth.

The COVID-19 is found to have a mixed impact on the market space. Social distancing mandates and lockdown policies have negatively affected the market to a considerable extent. However, the pandemic has opened new opportunities for operating entities by allowing them to deploy ISH methods in the R&D of COVID-19 related programs.

The leading institutions and market competitors are now focusing on designing fluorescence in situ hybridization probes to visualize COVID-19 RNA in the infected cells. FISH has proven to offer relevant information on the virus at a cost-effective method.

Market Report Highlights

Key Topics Covered:

Chapter 1. Methodology and Scope

Chapter 2. Executive Summary

Chapter 3. Market Variables, Trends & Scope

3.1 Market Segmentation

3.2 Parent Market Lineage

3.3 Ancillary Market Lineage

3.4 Market Dynamics

3.4.1. Market Drivers Analysis

3.4.1.1 Rising Prevalence Of Target Disorders

3.4.1.2 Technological Advancement

3.4.1.3 Increase In R&D Investments In In-Vitro Diagnostics

3.4.2 Market Restraint Analysis

3.4.2.1 High Cost Of ISH

3.4.2.2 Presence Of Ambiguous Regulatory Framework

3.4.3 Market Opportunity Analysis

3.4.4 Market Challenge Analysis

3.5 SWOT Analysis; by Factor (Political & Legal, Economic and Technological)

3.6 Porter's Five Forces Analysis

3.7 Major Deals and Strategic Alliances Analysis

3.7.1. Mergers and Acquisitions

3.7.2 Technological Collaborations

3.7.3 Licensing and Partnerships

3.8 COVID-19 Impact Analysis

3.8.1 Challenge Analysis

3.8.2 Opportunity Analysis

3.8.3 Key Developments and Activities

Chapter 4. Competitive Analysis

Chapter 5. In Situ Hybridization Market: Technology Type Business Analysis

Chapter 6. In Situ Hybridization Market: Probe Business Analysis

Chapter 7. In Situ Hybridization Market: Product Business Analysis

Chapter 8. In Situ Hybridization Market: Application Business Analysis

Chapter 9. In Situ Hybridization Market: End User Business Analysis

Chapter 10. In Situ Hybridization Market: Regional Business Analysis

Chapter 11. Company Profiles

For more information about this report visit https://www.researchandmarkets.com/r/dxsw9l

About ResearchAndMarkets.com

ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

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Global In Situ Hybridization Market Segment Forecasts 2021-2028: DNA Probes Segment Forecast to Maintain Dominance Due to Increasing DNA-based Studies...

SUNBURY The state attorney general has again opposed a Northumberland County mans effort to obtain court approval for DNA testing of evidence he claims will clear him of a 1986 murder.

Deputy Attorney General Christopher J. Schmidt has asked the state Supreme Court not to accept the appeal of Scott R. Schaeffer who claims he was wrongly convicted of the murder of Rickey Wolfe.

Schaeffer, of the Sunbury area, is appealing a Superior Court ruling in October that denied as untimely a request for DNA testing.

The ruling affirmed the decision by specially assigned Lycoming County Senior Judge Dudley N. Anderson who in addition found that Schaeffer failed to make a prima facie showing the requested DNA testing would establish actual innocence.

Schaeffer wants the Supreme Court to interpret what the legislature intended when in 2018 it amended the Post-Conviction Relief Act to include those who have completed their sentences like him.

The amendment, while it permits DNA testing when there is reasonable possibility it would produce exculpatory evidence, did not change the time period in which to seek it.

It makes no sense for the legislature without overriding the timeliness requirement to allow those who have completed their sentences to seek DNA testing, Schaeffers attorney Joel Wiest argues.

Otherwise, requests like his clients would be denied as untimely, he wrote in asking the Supreme Court to accept the appeal.

Schmidt contends the high court should not accept the appeal because Schaeffer argued in lower courts his petition was timely not that the amendment altered that requirement.

Schmidt further contends the Superior Courts memorandum does not present rare, special or important reasons for granting a review.

Superior Court properly concluded Schaeffers first request for DNA testing, which he made almost 30 years after he was charged, was untimely, he said.

The opinion did not address whether Anderson erred in concluding there was no reasonable probability DNA testing would lead to evidence of actual innocence.

If the Supreme Court would be inclined to review that issue it would have to remand it to Superior Court, Schmidt claims.

The body of Wolfe, 30, of Mifflinburg, was found Dec. 12, 1986, face down in a pool of blood near his car at a state Fish Commission boat ramp along the Susquehanna River north of Montandon.

Schaeffer was one of five men charged (two were acquitted) with beating Wolfe while he was blindfolded, on his knees and with his hands secured behind him.

The prosecutions theory was Wolfe was kidnapped and beaten to death because he owed a drug debt.

Schaeffers 1991 conviction on first-degree murder and other charges and that of William Lloyd Hendricks III were vacated after co-defendant Robert Eugene Hummel said he had testified falsely under pressure from state police.

Schaeffer and Hendricks in 2004 pleaded no contest to conspiracy to commit third-degree murder and conspiracy to commit kidnapping. They were re-sentenced to 10 to 20 years in prison followed by 10 years probation. Although Schaeffer had served the minimum, he remained in jail two more years for a total of 17 before paroled.

Schmidt maintains DNA testing was available in 2004 but Schaeffer waited until 2018 to seek it.

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Pa. mom gets state prison term for driving two children while high on PCP

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Pa. AG continues to oppose DNA testing that man claims will clear him of 1986 murder - PennLive

The Simpsonville woman accused of homicide by child abuse in the death of a 3-year-old girl has been ordered to submit to a DNA test, according to online court records.

No trial date has been set yet for Ariel Robinson, who's been charged with homicide by child abuse in the death ofVictoria Rose Smith, who was not yet formallyadopted and was under care of the state Department of Social Services at the time of her death,according to the Thirteenth Circuit Solicitor's Office.

A trial is expected to come by summer, according to the Solicitor's Office.

Jerry Robinson, Ariel Robinson's husband, has also been charged with homicide by child abuse in the case. His trial is also yet to be scheduled.

'System failed': 'System failed' 3-year-old Simpsonville girl who died in abuse case, family member says

At a bond hearing for Ariel Robinson in February,Assistant SolicitorChristy Sustakovitch said attorney Lucas Marchant contacted prosecutors a few days after Victoria's death in January to sayhis client, Jerry Robinson,wanted to make a statement to investigators.

Jerry Robinson told investigators that his wife sometimes beat Victoria with things such as a belt anda paddle, and he said he was outside of his house when he heard his wife hitting the little girl with a belt on the day she died,according toSustakovitch.

The order for Ariel Robinson's DNA collection was issued on Nov. 29, according to court records.

Calls to her attorney, William Bouton, were not returned.

More: Husband says Simpsonville woman hit 3-year-old with belt before the girl's death

She's been held without bond at the Greenville County Detention Center, according to online records.

Robinson was a contestant of the Food Network's 20th seasonof "Worst Cooks in America", according to Discovery Network representative Irika Slavin.

Jerry Robinsonwas granted a $150,000 surety bond, clearing the way for his beingunder house arrest with GPS monitoring pending his trial. He's to reside with his parents and have no contact with anyone under the age of 18, according toJudge Letitia Verdin.

Care has been arranged for four other children who lived with the Robinsons, including two boys biologically related to Victoria, according to the Simpsonville Police Department and the Solicitor's Office.

Victoriadiedfrom multiple blunt-force injuriesafter being found unresponsive at the Robinson's houseon Sellwood Circle in the Westwood subdivision ofSimpsonville on the afternoon of Jan. 14, according to the Greenville County Coroner's Office.

Her adoption had been scheduled to be formalized five days after her death, according to the Solicitor's Office.

Related: Simpsonville man charged with homicide by child abuse has been granted bond

Tamia Boyd is a Michigan native who covers breaking news in Greenville. Email her at tboyd@gannett.com, and follow her on Twitter @tamiamb.

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Simpsonville woman accused of homicide by child abuse has been ordered to submit DNA - Greenville News

Kids playing in a small wooded area behind the Club House Diner on Street Road in Bensalem Township found something theyre likely to never forget on September 18, 1995.

The kids uncovered the skeletal remains of a

woman. The woman was unclothed and her remains wrapped in a plastic tarp. An autopsy revealed the womans remains had been there for two to three years and she died by an unspecified means of homicide.

Despite an ongoing investigation and tips over the years, Bensalem Township authorities werent able to identify her. In fact, they had ruled out numerous possible women who they suspected the body might have belonged to.

Over 50 missing women were excluded as being Jane Doe, police said in a statement.

In May 2004, Bensalem Township police exhumed the womans remains and sent samples to the University of North Texas Center for Human Identification where a DNA profile was extracted and uploaded into the national CODIS system. It was all part of an attempt to identify her, and names were crossed out, but no positive identification was uncovered.

That changed recently.

Bensalem Township police said Monday they are confident the body belonged to Merrybeth Hodgkinson, who was 31 years old and lived in Warminster. She also was known to have lived on Rhawn Street in Philadelphia, the George Washington Motor Lodge, and the Oakford Inn.

Police said Hodgkinson disappeared in September 1992 after visiting with family. She was working at the time as an exotic dancer in Lower Bucks County.

BODE Technology, a DNA analysis firm area police have worked with for years, developed a DNA profile for the unknown womans remains in November 2021. Working with BODE and Jennifer Moore, of Innovative Forensic Investigations, police were able to link the body to Hodgkinson through GEDmatch and FamilyTreeDNA.com, companies that allow users to find relatives through DNA samples.

Police said they also tested the DNA of Hodgkinsons siblings as part of their investigation.

Hodgkinsons remains rest in Telford and her grave lists her as a Jane Doe.

No arrests have been made in connection with Hodgkinsons death.

Several items of interest were located near Hodgkinsons body in 1995. Police said theyre not sure if the items were connected, but they suspect some or all may have belonged to her.

A blue quilted sleeveless vest, a pink t-shirt with KPMG Peat Marwick, and a white T-shirt with Property of Alcatraz Penitentiary Swim Team, San Francisco printed on it were located. A brown beaded seat cushion (possibly used in an vehicle) and two crucifixes, one gold and one silver, were also found near the remains.

Police asked anyone who knew Hodgkinson or who may have information on the death to contact Bensalem Township Detective Chris McMullin at 215-633-3726 or Bucks County Detective Greg Beidler at 215-348-6344.

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NEARBY: DNA Used To ID Woman Years After Death, Detectives Seek Tips - LevittownNow.com

Hugo Lloris has claimed that Antonio Conte has a winning culture in his DNA and believes the Italian can help Tottenham make the next step in their quest to achieve silverware.

Tottenham hired Conte last month following the dismissal of Nuno Espirito Santo and things appear to be going well in the early stages of his tenure.

Much was made of Spurs appointment given that the 52-year-old has enjoyed such a decorated managerial career so far, winning league titles at Juventus, Chelsea and most recently Inter Milan.

Lloris understands the fine details needed for a side to claim titles himself, having captained France to the World Cup in 2018 and the 2021 Nations League.

The long-time Spurs goalkeeper praised Contes impressive career achievements so far and backed him to bring the quality the club needs to succeed in the future.

Lloris told the clubs website: Football is all about details. And when you come close to the final step, details are so important. We know that we have the manager who can help the team improve in those details.

Antonio Contes CV talks by itself. Hes bringing his energy, his football approach but also, mainly, his mentality. He has the winning culture in his DNA.

He played all his career for Juve, was at Juve as a manager and has won everywhere hes been. So, its important to use his experience, but also for the players to take responsibility, and to become better as a team.

Spurs Web Opinion

Conte appears to be having a bid influence on a number of Spurs players already which should bode well heading into the second half of the season.

As long as the players continue to have faith and listen to his methods, there shouldnt be a limit as to what the club can achieve.

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Winning culture in his DNA Hugo Lloris on what Conte can bring to Spurs - The Spurs Web

The Australian Federal Police (AFP) recently announced plans to use DNA samples collected at crime scenes to make predictions about potential suspects.

This technology, called forensic DNA phenotyping, can reveal a surprising and growing amount of highly personal information from the traces of DNA that we all leave behind, everywhere we go including information about our gender, ancestry, and appearance.

Queensland police have already used versions of this approach to identify a suspect and identify remains. Forensic services in Queensland and New South Wales have also investigated the use of predictive DNA.

This technology can reveal much more about a suspect than previous DNA forensics methods. But how does it work? What are the ethical issues? And what approaches are other countries around the world taking?

The AFP plans to implement forensic DNA phenotyping based on an underlying technology called massively parallel sequencing.

Our genetic information is encoded in our DNA as long strings of four different base molecules, and sequencing is the process of reading the sequence of these bases.

Older DNA sequencing machines could only read one bit of DNA at a time, but current massively parallel machines can read more than six trillion DNA bases in a single run. This creates new possibilities for DNA analysis.

DNA forensics used to rely on a system that matched samples to ones in a criminal DNA database, and did not reveal much beyond identity. However, predictive DNA forensics can reveal things like physical appearance, gender, and ancestry regardless of whether people are in a database or not.

This makes it useful in missing persons cases and the investigation of unidentified remains. This method can also be used in criminal cases, mostly to exclude persons of interest.

The AFP plans to predict gender, biogeographical ancestry, eye color, and, in coming months, hair color. Over the next decade, they aim to include traits such as age, body mass index, and height, and even finer predictions for facial metrics such as distance between the eyes, eye, nose and ear shape, lip fullness, and cheek structure.

DNA can reveal highly sensitive information about us. Beyond ancestry and externally visible characteristics, we can predict many other things including aspects of both physical and mental health.

It will be important to set clear boundaries around what can and cant be predicted in these tests and when and how they will be used. Despite some progress toward a privacy impact assessment, Australian forensic legislation does not currently provide any form of comprehensive regulation of forensic DNA phenotyping.

The highly sensitive nature of DNA data and the difficulty in ever making it anonymous creates significant privacy concerns.

According to a 2020 government survey about public attitudes to privacy, most Australians are uncomfortable with the idea of their DNA data being collected.

Using DNA for forensics may also reduce public trust in the use of genomics for medical and other purposes.

The AFPs planned tests include biogeographical ancestry prediction. Even when not explicitly tested, DNA data is tightly linked to our ancestry.

One of the biggest risks with any DNA data is exacerbating or creating racial biases. This is especially the case in law enforcement, where specific groups of people may be targeted or stigmatized based on pre-existing biases.

In Australia, Indigenous legal experts report that not enough is being done to fully eradicate racism and unconscious bias within the police. Concerns have been raised about other types of potential institutional racial profiling. A recent analysis by the ANU also indicated that 3 in 4 people held an implicit negative or unconscious bias against Indigenous Australians.

Careful consideration, consultation, and clear regulatory safeguards need to be in place to ensure these methods are only used to exclude persons of interest rather than include or target specific groups.

DNA data also has inherent risks around misinterpretation. People put a lot of trust in DNA evidence, even though it often gives probabilistic findings which can be difficult to interpret.

Predictive DNA forensics is a relatively new field, and countries across Europe have taken different approaches regarding how and when it should be used. A 2019 study across 24 European countries found ten had allowed the use of this technology for practical purposes, seven had not allowed it, and seven more had not yet made a clear determination on its use.

Germany allows the prediction of externally visible characteristics (including skin color), but has decided biogeographical ancestry is simply too risky to be used.

The one exception to this is the state of Bavaria, where ancestry can be used to avert imminent danger, but not to investigate crimes that have already occurred.

A UK advisory panel made four recommendations last year. These include the need to clearly explain how the data is used, presenting ancestral and phenotypic data as probabilities so uncertainty can be evaluated, and clearly explaining how judgments would be made about when to use the technology and who would make the decision.

The VISAGE consortium of academics, police, and justice institutions, from eight European countries, also produced a report of recommendations and concerns in 2020.

They urge careful consideration of the circumstances where DNA phenotyping should be used, and the definition of a serious crime. They also highlight the importance of a governing body with responsibility for deciding when and how the technology should be used.

The AFP press release mentions it is mindful of maintaining public trust, and has implemented privacy processes. Transparency and proportionate use will be crucial to keep the public on board as this technology is rolled out.

This is a rapidly evolving field and Australia needs to develop a clear and coherent policy that can keep up with the pace of technological developments - and considers community concerns.

Caitlin Curtis, Research fellow, The University of Queensland and James Hereward, Research fellow, The University of Queensland

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Should the Police Have the Power to Link DNA With Appearance and Ancestry? - Interesting Engineering

Ginkgo Bioworks Holdings, (DNA) disclosed a change of 6.58% and its listed share value at $11.17 in the recent trade transaction. This company belong to USA Country and part of Healthcare sector. DNA exchanged 59206633 shares on hands in most recent trading session and observed an average volume with 8406.33K shares. The stock acknowledged active focus on shares in the current trading session. It has a market capitalization of $16309.99M. Using market capitalization to display company size because this is basic factor of different characteristics to develop the investors interests including risk.

TECHNICAL INTERPRETATION:

A Simple moving average is one of the most flexible as well as most-commonly used technical analysis indicators. It is highly popular among traders, mostly because of its simplicity. It works best in a trending environment. Simple Moving Average calculated as an average of the last N-periods (20-Day, 50-Day, 200-Day).The share price is positive from its 20 days moving average with 1.53% and trading from 50 days moving average with -9.08%. The stock price is performing along rising drift from its 200 days moving average with 3.26%.Any type of moving average can be used to generate buy or sell signals and this process is very simple. The charting software plots the moving average as a line directly into the price chart.

Currently Relative Strength Index (RSI-14) reading of stock is 49.55. RSI reading varies between 0 and 100. Speed and change of stock price movement is measured by the RSI momentum oscillator. J. Welles Wilder developed Relative Strength Index (RSI) that is used most commonly as momentum indicator. Commonly when RSI goes below 30 then stock is overload and stock is overbought when it goes above 70. 30 to 70 are considered a normal reading of a stock. General trend, finding deviations and failure swings can be detected by using RSI.

VOLATILITY ANALYSIS:

Volatility remained at 13.69% over last week and shows 11.21% volatility in last month. VOLATILITY is also measured by ATR an exponential moving average (14-days) of the True Ranges. ATR value stands at 1.19.

PROFITABILITY SNAP:

PERFORMANCE REVIEW:

DNA revealed weekly performance of 10.92%. The stock moved to 12.71% in last six months and it maintained for the month at -17.81%. The stock noted year to date performance at 10.38% and changed about 0.54% over the last three months. The stocks price situated at -29.59% from 52 week high and stock price seen at 41.21% when looking at 52 week low price.

ANALYSTS OPENION:

Looking ahead of 52-week period, the stock will achieve $14.83 price. This mean target price is expected by analysts.

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You Need to See this stock? Ginkgo Bioworks Holdings, (DNA) - The Union Journal

Country

United States of AmericaUS Virgin IslandsUnited States Minor Outlying IslandsCanadaMexico, United Mexican StatesBahamas, Commonwealth of theCuba, Republic ofDominican RepublicHaiti, Republic ofJamaicaAfghanistanAlbania, People's Socialist Republic ofAlgeria, People's Democratic Republic ofAmerican SamoaAndorra, Principality ofAngola, Republic ofAnguillaAntarctica (the territory South of 60 deg S)Antigua and BarbudaArgentina, Argentine RepublicArmeniaArubaAustralia, Commonwealth ofAustria, Republic ofAzerbaijan, Republic ofBahrain, Kingdom ofBangladesh, People's Republic ofBarbadosBelarusBelgium, Kingdom ofBelizeBenin, People's Republic ofBermudaBhutan, Kingdom ofBolivia, Republic ofBosnia and HerzegovinaBotswana, Republic ofBouvet Island (Bouvetoya)Brazil, Federative Republic ofBritish Indian Ocean Territory (Chagos Archipelago)British Virgin IslandsBrunei DarussalamBulgaria, People's Republic ofBurkina FasoBurundi, Republic ofCambodia, Kingdom ofCameroon, United Republic ofCape Verde, Republic ofCayman IslandsCentral African RepublicChad, Republic ofChile, Republic ofChina, People's Republic ofChristmas IslandCocos (Keeling) IslandsColombia, Republic ofComoros, Union of theCongo, Democratic Republic ofCongo, People's Republic ofCook IslandsCosta Rica, Republic ofCote D'Ivoire, Ivory Coast, Republic of theCyprus, Republic ofCzech RepublicDenmark, Kingdom ofDjibouti, Republic ofDominica, Commonwealth ofEcuador, Republic ofEgypt, Arab Republic ofEl Salvador, Republic ofEquatorial Guinea, Republic ofEritreaEstoniaEthiopiaFaeroe IslandsFalkland Islands (Malvinas)Fiji, Republic of the Fiji IslandsFinland, Republic ofFrance, French RepublicFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabon, Gabonese RepublicGambia, Republic of theGeorgiaGermanyGhana, Republic ofGibraltarGreece, Hellenic RepublicGreenlandGrenadaGuadaloupeGuamGuatemala, Republic ofGuinea, RevolutionaryPeople's Rep'c ofGuinea-Bissau, Republic ofGuyana, Republic ofHeard and McDonald IslandsHoly See (Vatican City State)Honduras, Republic ofHong Kong, Special Administrative Region of ChinaHrvatska (Croatia)Hungary, Hungarian People's RepublicIceland, Republic ofIndia, Republic ofIndonesia, Republic ofIran, Islamic Republic ofIraq, Republic ofIrelandIsrael, State ofItaly, Italian RepublicJapanJordan, Hashemite Kingdom ofKazakhstan, Republic ofKenya, Republic ofKiribati, Republic ofKorea, Democratic People's Republic ofKorea, Republic ofKuwait, State ofKyrgyz RepublicLao People's Democratic RepublicLatviaLebanon, Lebanese RepublicLesotho, Kingdom ofLiberia, Republic ofLibyan Arab JamahiriyaLiechtenstein, Principality ofLithuaniaLuxembourg, Grand Duchy ofMacao, Special Administrative Region of ChinaMacedonia, the former Yugoslav Republic ofMadagascar, Republic ofMalawi, Republic ofMalaysiaMaldives, Republic ofMali, Republic ofMalta, Republic ofMarshall IslandsMartiniqueMauritania, Islamic Republic ofMauritiusMayotteMicronesia, Federated States ofMoldova, Republic ofMonaco, Principality ofMongolia, Mongolian People's RepublicMontserratMorocco, Kingdom ofMozambique, People's Republic ofMyanmarNamibiaNauru, Republic ofNepal, Kingdom ofNetherlands AntillesNetherlands, Kingdom of theNew CaledoniaNew ZealandNicaragua, Republic ofNiger, Republic of theNigeria, Federal Republic ofNiue, Republic ofNorfolk IslandNorthern Mariana IslandsNorway, Kingdom ofOman, Sultanate ofPakistan, Islamic Republic ofPalauPalestinian Territory, OccupiedPanama, Republic ofPapua New GuineaParaguay, Republic ofPeru, Republic ofPhilippines, Republic of thePitcairn IslandPoland, Polish People's RepublicPortugal, Portuguese RepublicPuerto RicoQatar, State ofReunionRomania, Socialist Republic ofRussian FederationRwanda, Rwandese RepublicSamoa, Independent State ofSan Marino, Republic ofSao Tome and Principe, Democratic Republic ofSaudi Arabia, Kingdom ofSenegal, Republic ofSerbia and MontenegroSeychelles, Republic ofSierra Leone, Republic ofSingapore, Republic ofSlovakia (Slovak Republic)SloveniaSolomon IslandsSomalia, Somali RepublicSouth Africa, Republic ofSouth Georgia and the South Sandwich IslandsSpain, Spanish StateSri Lanka, Democratic Socialist Republic ofSt. HelenaSt. Kitts and NevisSt. LuciaSt. Pierre and MiquelonSt. Vincent and the GrenadinesSudan, Democratic Republic of theSuriname, Republic ofSvalbard & Jan Mayen IslandsSwaziland, Kingdom ofSweden, Kingdom ofSwitzerland, Swiss ConfederationSyrian Arab RepublicTaiwan, Province of ChinaTajikistanTanzania, United Republic ofThailand, Kingdom ofTimor-Leste, Democratic Republic ofTogo, Togolese RepublicTokelau (Tokelau Islands)Tonga, Kingdom ofTrinidad and Tobago, Republic ofTunisia, Republic ofTurkey, Republic ofTurkmenistanTurks and Caicos IslandsTuvaluUganda, Republic ofUkraineUnited Arab EmiratesUnited Kingdom of Great Britain & N. IrelandUruguay, Eastern Republic ofUzbekistanVanuatuVenezuela, Bolivarian Republic ofViet Nam, Socialist Republic ofWallis and Futuna IslandsWestern SaharaYemenZambia, Republic ofZimbabwe

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Snapchat chatter, DNA led to arrest in shooting death of Hitchcock teen - Galveston County Daily News

SANDI Sandrik, 51, a nurse, lives in Phoenix, Arizona, with husband Ken, 55, a warehouse driver.

She describes the remarkable story of how she found out her colleague was her brother.

5

5

Looking around the table, I smiled at my colleague Allen, who I was hosting for dinner. What was incredible was I had just learnt he was also my brother.

I had no idea that I was adopted until I was 11, when a friend blurted it out.

When I asked my parents, they admitted that my biological mum, named Anna, was a distant relative of the man I knew as my father.

Although some people in our town were already aware, it was a complete shock to me.

I loved my parents so much, I couldnt bring myself to ask more questions in case it hurt them, but I never stopped wondering, and as a teenager, I developed a fear of rejection.

In 1985, aged 15, I met Ken, and we married two years later when I was pregnant with our eldest child Ryan, now 33.

Life was good, and we went on to have our daughter, Hali, 30, and another son, Eric, 29, and I trained to be a nurse.

Sadly, my mum died in September 2013, followed by my dad in August 2016.

I was swimming in grief the night Dad died, when my phone lit up with a text from my biological mother Anna, whod got my number through family.

Shed promised my parents not to contact me while they were alive, but said shed always wanted me in her life.

She explained how shed become pregnant at 20 while dating a man called Gary, but that she was still in love with her ex.

Adoption within the family seemed the best thing to do, so she handed me over to Mum and Dad and lost touch with Gary.

I found out I also had a half-sister, Sophie*, now 52, and after messaging and talking on the phone for many months, in February 2017, I met both Anna and Sophie, and I felt a connection straight away.

We have a great relationship now, but it was a lot to take in, so for a long time I didnt even think about trying to find my biological father, too.

But then my kids paid for me to have a DNA test in November 2017.

The manufacturer connects you with other genetic relatives, and I realised this could be a way to track down my dad.

Six months later, I connected with a cousin, who shared Garys Facebook profile with me.

I didnt see anything of myself in him, and it took me two months to send him a message to introduce myself.

As time went on and I didnt get a reply, I tried not to think about him.

Then in summer 2019, a new nurse called Allen started at my work.

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5

He was kind, thoughtful and like me calm under pressure, and I liked him immediately.

He kept saying he was sure that he knew me from somewhere, but I just shrugged it off.

Meanwhile, Id occasionally check Garys Facebook profile, still hopeful that hed reply, but he never did.

It was in December 2020, while looking through Garys friends list, that I spotted Allen.

When I saw him at work next, I asked how he knew my biological father Gary.

Oh my god, he replied. Hes my dad, too.

Bursting into tears, he pulled me into a hug, saying he was overjoyed.

Back home, I told Ken. Like me, he was in disbelief.

Allen and I exchanged numbers, and over the next few days I learned he was five years older than me and was three when Gary divorced his mum.

Allen wasnt close to Gary, but he was in his life. As we shared our stories, I felt our connection grow.

When we had a family meal in January 2021, I invited Allen and his wife Stacie to join us, and it was lovely.

Later that week, Allen spoke to Gary, who initially denied everything.

I can understand his reaction it was a shock for us all but he agreed to meet me at a lunch Allen organised.

I was nervous, but it was really nice to be together. Gary and I are now slowly getting to know each other, though weve not discussed much of the past yet.

My relationship with Allen has gone from strength to strength. Hes now close to my husband and kids, and we speak constantly.

My advice to anyone thinking of doing a DNA test is to be careful as there are many peoples feelings involved.

But for me, discovering Allen was the most wonderful surprise of all.

*name has been changed

5

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A DNA test revealed my colleague was my brother he kept saying he knew me from somewhere but I shrugged i... - The Sun

If you're not sure where to start when looking for the next multi-bagger, there are a few key trends you should keep an eye out for. Amongst other things, we'll want to see two things; firstly, a growing return on capital employed (ROCE) and secondly, an expansion in the company's amount of capital employed. Ultimately, this demonstrates that it's a business that is reinvesting profits at increasing rates of return. So when we looked at the ROCE trend of Skyline Champion (NYSE:SKY) we really liked what we saw.

For those that aren't sure what ROCE is, it measures the amount of pre-tax profits a company can generate from the capital employed in its business. To calculate this metric for Skyline Champion, this is the formula:

Return on Capital Employed = Earnings Before Interest and Tax (EBIT) (Total Assets - Current Liabilities)

0.28 = US$200m (US$1.0b - US$289m) (Based on the trailing twelve months to October 2021).

Thus, Skyline Champion has an ROCE of 28%. In absolute terms that's a great return and it's even better than the Consumer Durables industry average of 15%.

See our latest analysis for Skyline Champion

Above you can see how the current ROCE for Skyline Champion compares to its prior returns on capital, but there's only so much you can tell from the past. If you'd like, you can check out the forecasts from the analysts covering Skyline Champion here for free.

Investors would be pleased with what's happening at Skyline Champion. The numbers show that in the last five years, the returns generated on capital employed have grown considerably to 28%. Basically the business is earning more per dollar of capital invested and in addition to that, 309% more capital is being employed now too. The increasing returns on a growing amount of capital is common amongst multi-baggers and that's why we're impressed.

In another part of our analysis, we noticed that the company's ratio of current liabilities to total assets decreased to 29%, which broadly means the business is relying less on its suppliers or short-term creditors to fund its operations. So shareholders would be pleased that the growth in returns has mostly come from underlying business performance.

To sum it up, Skyline Champion has proven it can reinvest in the business and generate higher returns on that capital employed, which is terrific. Since the stock has returned a staggering 434% to shareholders over the last three years, it looks like investors are recognizing these changes. With that being said, we still think the promising fundamentals mean the company deserves some further due diligence.

If you'd like to know about the risks facing Skyline Champion, we've discovered 1 warning sign that you should be aware of.

High returns are a key ingredient to strong performance, so check out our free list ofstocks earning high returns on equity with solid balance sheets.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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We Think Skyline Champion (NYSE:SKY) Might Have The DNA Of A Multi-Bagger - Simply Wall St