Category Archives: DNA

DNA: Keith Murray vs. Fredro Is Expanding the Culture
http://www.vladtv.com - DNA shared his thoughts on the upcoming September 28th MC War battle between Fredro Starr vs. Keith Murray, in this clip from his exclusive interview with VladTV Battle...

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DNA: Keith Murray vs. Fredro Is Expanding the Culture - Video

Watch: DNA special edition from US with Sudhir Chaudhary
Watch DNA special edition from US with Sudhir Chaudhary only on Zee News.

By: Zee News

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Watch: DNA special edition from US with Sudhir Chaudhary - Video

DNA: PM Modi to keep Navratri fast during US visit
DNA: PM Narendra Modi will keep Navratri fast during his visit to the US. Modi keeps fast for all the nine days with only drinking water with a strict adherence to yoga, meditation and puja...

By: Zee News

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DNA: PM Modi to keep Navratri fast during US visit - Video

DNA: All about ISRO #39;s Mars Orbiter Mission
DNA brings you everything you need to know about Mars Orbiter Mission (MOM) and what makes it so special.

By: Zee News

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DNA: All about ISRO's Mars Orbiter Mission - Video

Fishbowl Teleseminar: Maximum likelihood sequence detection: from DNA sequencing to nano- imaging
Abstract: The basic problem of inferring useful information from noisy data streams appears in several domains such as communications, speech processing, radar signal processing etc. The implement...

By: CESG TAMU

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Fishbowl Teleseminar: Maximum likelihood sequence detection: from DNA sequencing to nano- imaging - Video

Darkorbit - Time to Say Goodbye PhantasieLoos DE2 i All DNA Member
LESEN BITTE Ich Mchte mich hier mit bei Allen Freunden und DNA Suchtis Die immer mit mir am suchten waren und immer mit mir im Ts gehockt habe, Danke Darfr :* Besonder #39;s ...

By: P[TV]

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Darkorbit - Time to Say Goodbye PhantasieLoos DE2 i All DNA Member - Video

Jai Brooks | DNA
Just made a really quick Jai video since i havent posted anything on here for ages 🙂 Twitter: @33sluke.

By: janoskian fan

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Jai Brooks | DNA - Video

ES Guelma 14/15 | Rendez-Vouz : DNA Est J03 ESG vs Hamra ( 720p )
DNA Est 3e Journe : ES Guelma vs Hamra Annaba - a 16h - Stade Ali Abda Guelma. Esperanza Official FB Page : http://urlz.fr/Ey2.

By: ES Guelma

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ES Guelma 14/15 | Rendez-Vouz : DNA Est J03 ESG vs Hamra ( 720p ) - Video

dna solo a
come si fa come si fa a credere a un calcio pulito.

By: maria tiziano

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dna solo a - Video

Most organisms, including humans, have parasitic DNA fragments called "jumping genes" that insert themselves into DNA molecules, disrupting genetic instructions in the process. And that phenomenon can result in age-related diseases such as cancer. But researchers at the University of Rochester now report that the "jumping genes" in mice become active as the mice age when a multi-function protein stops keeping them in check in order to take on another role.

In a study published today in Nature Communications, Professor of Biology Vera Gorbunova and Assistant Professor of Biology Andrei Seluanov explain that a protein called Sirt6 is needed to keep the jumping genes -- technically known as retrotransposons -- inactive. That's an entirely different function from the ones scientists had long associated with Sirt6, such as the repairing of broken DNA molecules and regulating metabolism.

"About half of the human genome is made up of retrotransposons," said Gorbunova. "By better understanding why these genomic parasites become active, we hope to better understand and perhaps delay the aging process in humans."

For the most part, retrotransposons remain silent and inactive in organisms' genomes. But once they do become active, these DNA fragments can duplicate themselves and "jump" to new areas of the genome, disrupting the function of another gene by landing in an important part of the gene and changing its DNA sequence information.

But what happens to the Sirt6 proteins that kept the jumping genes inactive in younger cells? The answer lies in the role that Sirt6 plays in repairing DNA damage. Cells accumulate a lot of DNA damage over time that needs to be constantly repaired. As cells get older, Sirt6 becomes busier in taking care of the DNA damage. Gorbunova and Seluanov hypothesized that Sirt6 becomes so preoccupied in repairing DNA damage in older cells that it is no longer available to keep the jumping genes inactive.

To test the theory, the team artificially caused DNA damage in young cells using gamma radiation or the chemical hydrogen peroxide. Once the damage took place, Sirt6 was immediately recruited to the damaged sites of the DNA to do its repair work. Gorbunova and Seluanov found that the stressed cells -- the ones with increased DNA damage -- had a higher rate of "jumping gene" activity, when compared to the other cells. Then, when the amount of Sirt6 was artificially increased in the stressed cells, the retrotransposons did not become as readily active, keeping the genome safe.

"This suggests that supplying more Sirt6 protein might protect older cells from aging," said Gorbunova. "The idea would be to increase the Sirt6 pool so that enough proteins are available for both DNA repair and for keeping the retrotransposons inactive."

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The above story is based on materials provided by University of Rochester. Note: Materials may be edited for content and length.

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Multi-function protein is key to stopping genomic parasites from 'jumping'