Category Archives: DNA

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John Brickman Wall, 49, enters 3rd District Court in Salt Lake City on Oct. 3, 2013.

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SALT LAKE CITY Lawyers for a Salt Lake City pediatrician accused of killing his ex-wife asked a judge Monday to toss DNA evidence gathered from skin cells found underneath her fingernails and on a pillowcase.

An attorney for John Brickman Wall, 50, said investigators found about three skin cells not enough to draw any conclusions. A prosecutor conceded the evidence doesn't point directly to Wall, but said it does eliminate nine other possible suspects.

The DNA on the pillowcase could have come from any one of the couple's four children, according to Elizabeth Johnson, an expert testifying for the defense during a hearing Monday who said her calculations show it didn't come from Wall. Prosecutors disputed that.

The DNA is a key piece of evidence in the case, which was filed more than a year after the death of 49-year-old Uta Von Schwedler, a biologist at the University of Utah.

"This case is a huge circumstantial case," said defense attorney G. Fred Metos. "It's not the only piece of evidence they're going to rely on, but it's certainly very important."

A medical examiner couldn't say if Von Schwedler's death was a homicide or a suicide. She was found drowned in an overflowing bathtub in 2011, having overdosed on Xanax, a drug she didn't have a prescription for.

Von Schwedler was in a bitter custody battle with her ex-husband over their four children. There was evidence of a struggle in her room, and she had cuts on her body, authorities said.

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Doctor wants DNA evidence left out of murder case

In a darkened lab in the north of England, a research associate is intensely focused on the microscope in front of her. She carefully maneuvers a long glass tube that she uses to manipulate early human embryos.

"It's like microsurgery," says Laura Irving of Newcastle University.

Irving is part of a team of scientists trying to replace defective DNA with healthy DNA. They hope this procedure could one day help women who are carrying genetic disorders have healthy children.

"We are talking about conditions for which there is currently no cure," says Dr. Doug Turnbull, a professor of neurology at Newcastle University who is leading the research. These mitochondrial diseases are caused by hereditary defects in human cells.

"Mitochondria are like little power stations present in all our cells," Turnbull says. These power stations provide the energy that cells need. If the mitochondrial DNA is defective, the cells don't work right. The cells in effect run out of energy.

"I see the anguish of the families in every clinic that I do," says Turnbull. The severity of the disease can vary, with some families seeing their babies die in the first few hours of life. For others it can be a slow, progressive illness often leading to an early death.

Mitochondria have their own DNA, separate from the DNA that helps control the color of our eyes and hair, the shape of our noses, and how tall or smart we are. The mitochondrial DNA is passed down from mothers to their children.

Replacing defective mitochondrial DNA with healthy DNA might prevent these diseases from occurring. And that's exactly what Turnbull and his team want to do: DNA transplants.

Newcastle University scientists perform DNA transplants on very early embryos. The scientists hold the embryo very still with the tip of a pipette, left. They pull out the nuclear DNA of a mother and father hoping to have a healthy baby. It's then inserted into the embryo of a donor with healthy mitochondrial DNA. That embryo has had the rest of its DNA removed.

But the idea of scientists manipulating a human being's DNA in this way is very controversial. It would be the first time genetic changes have been made in human DNA that would be passed on, down the generations, through the germline. Any baby born this way would have genes from three different people.

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Combining The DNA Of Three People Raises Ethical Questions

"So Close" Road To - DNA BOMB Infected #2 - (Call of Duty: Advanced Warfare Gameplay)
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ADVANCED WARFARE: DNA BOMB (PC)
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AW: "DNA BOMB" on Solar w/HBRa3 (42 Killstreak!) - Call of Duty: Advanced Warfare
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