Category Archives: DNA

HAMILTON, Ont. -- Police say DNA testing has helped them crack a cold case involving a Hamilton man who disappeared 30 years ago.

David Nixon was 24 years old when he was reported missing in 1984 but police say it wasn't until last month that remains found in Lake Ontario around that time were identified as his.

Nixon was last seen by a family member on July 6, 1984 (at the corner of King Street West and James Street North) in Hamilton.

The investigation into his disappearance extended to police agencies across Canada and the United States, and was publicized in area media as well.

An unidentified male body was found in Lake Ontario in Toronto's east end in August 1984 but police say information provided about the remains did not match Nixon's description and the remains were buried in an unmarked grave in Toronto.

Hamilton police say they found out last month that the body had been confirmed as being Nixon's after DNA testing that involved comparing evidence from the cold case with DNA samples from Nixon's parents.

Coroner's officials say staff at the Centre of Forensic Sciences who analyzed the DNA found the likelihood that the remains were those of a child of the Nixons was 77 billion times greater than that of a random person.

Police say they are continuing to investigate the circumstances of Nixon's death and the discovery of his remains.

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DNA helps Hamilton police crack 30-year cold case

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DNA leads to arrest of man accused of raping 101-year-old woman
MILWAUKEE For the second time in state history, the DNA of a relative has led to the arrest of a suspect wanted for sexual assault.

By: todaystmj4

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DNA leads to arrest of man accused of raping 101-year-old woman - Video

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Although every person's DNA remains the same throughout their lives, scientists know that it functions differently at different ages.

As people age, drastic changes occur in their DNA methylation patterns, which are thought to act as a "second code" on top of the DNA that can lock genes in the on or off position. However, what the consequences of these changes are remains a mystery.

To begin deciphering this process, scientists at Wake Forest Baptist Medical Center studied methylation patterns in the blood cells of 1,264 persons ages 55 to 94 who participated in the Multi-Ethnic Study of Atherosclerosis (MESA).

In a study published in the current issue of Nature Communications, the researchers found age-related differences in DNA methylation in 8 percent of the 450,000 sites tested across the genome. Most of these changes did not seem to affect which cellular genes were turned on or off.

However, the Wake Forest Baptist team did find a small subset of age-linked DNA methylation changes -- 1,794 of the 450,000 sites tested -- that were associated with altered gene expression. Out of this subset, 42 sites were associated with pulse pressure, a measure of vascular health that is known to change with age.

"Our work suggests that most of the age-associated changes in DNA methylation do not have an obvious effect on cellular function, in this case altering gene expression, and some of them may just amount to noise," said Yongmei Liu, M.D., Ph.D., associate professor of public health sciences at Wake Forest Baptist and corresponding author of the study.

"The methylation sites that are linked to altered gene expression are good candidates as potential drivers of the negative effects of aging, especially the small subset linked to pulse pressure. Our findings provide new insights into the aging process."

Future studies will try to test the relationship between these methylation sites and specific health outcomes, Liu said. Eventually, the scientists hope to be able to target and reverse specific sites that are involved with age-related diseases.

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The above story is based on materials provided by Wake Forest Baptist Medical Center. Note: Materials may be edited for content and length.

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DNA methylation: The role it plays in aging cells