Category Archives: DNA

RD BY - "Development and Precision" Live dropped dna bomb
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Trip to DNA in Infected#1
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681 DNA
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By: xNoVaFr Nova

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681 DNA - Video

In a study to be presented on Feb. 5 in an oral plenary session at 8 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in San Diego, researchers will report that cell free DNA analysis is less effective than sequential screening as primary testing for fetal chromosomal abnormalities.

The study, titled Cell free DNA Analysis vs. Sequential Screening as Primary Testing Considering Chromosomal Abnormalities, compared sequential screening to cell free DNA for detection of all fetal chromosomal abnormalities in a general prenatal cohort.

The study discusses some of the complexities of cell free DNA screening when implemented in large populations. Although cell free DNA can very precisely detect Down syndrome and a few other serious chromosome abnormalities (as well as fetal sex), there are two limitations that are important. One is that cell free DNA screens for a very limited panel of abnormalities, as compared to current screening, which is able to determine that there is an increase in risk in the presence of a very broad array of fetal abnormalities, including many different chromosome problems in addition to the common conditions.

Secondly, sequencing of fetal DNA is complex, and requires that a minimum amount of fetal DNA be present in the mother's blood. In those patients with low fetal DNA or failed sequencing interpretation, the risk of aneuploidy (chromosome abnormality) is higher, so some cases of aneuploidy will remain undetected. In this study, the investigators considered these two characteristics in analyzing cell free DNA testing in comparison to the current screen as implemented in the California Prenatal Screening Program.

In a cohort of 450,000 women, the California PNS detected 82 percent of chromosome abnormalities at a 4.9 percent screen positive rate. It was calculated that cell free DNA would have detected approximately 68 percent at a one percent screen positive rate. If all the patients with failed cell free DNA tests were flagged as "high risk," the detection rate would increase to 78 percent but the false positive rate would be 5.5 percent.

"Overall, when considering all chromosome abnormalities and including those cases with no test result, sequential screening has better test performance than cell free DNA," stated Mary Norton, M.D. with the University of California, San Francisco, Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences. Norton will present the study.

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The above story is based on materials provided by Society for Maternal-Fetal Medicine. Note: Materials may be edited for content and length.

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Sequential screening provides better test performance than cell free DNA

Scientists have identified a biological clock that provides vital clues about how long a person is likely to live.

Researchers studied chemical changes to DNA that take place over a lifetime, and can help them predict an individual's age. By comparing individuals' actual ages with their predicted biological clock age, scientists saw a pattern emerging.

People whose biological age was greater than their true age were more likely to die sooner than those whose biological and actual ages were the same.

Four independent studies tracked the lives of almost 5,000 older people for up to 14 years. Each person's biological age was measured from a blood sample at the outset, and participants were followed up throughout the study.

Researchers found that the link between having a faster-running biological clock and early death held true even after accounting for other factors such as smoking, diabetes and cardiovascular disease.

Scientists from the University of Edinburgh, in collaboration with researchers in Australia and the US, measured each person's biological age by studying a chemical modification to DNA, known as methylation.

The modification does not alter the DNA sequence, but plays an important role in biological processes and can influence how genes are turned off and on. Methylation changes can affect many genes and occur throughout a person's life.

Dr Riccardo Marioni, of the University of Edinburgh's Centre for Cognitive Ageing and Cognitive Epidemiology, said: "The same results in four studies indicated a link between the biological clock and deaths from all causes. At present, it is not clear what lifestyle or genetic factors influence a person's biological age. We have several follow-up projects planned to investigate this in detail."

The study's principal investigator, Professor Ian Deary, also from the University of Edinburgh's Centre for Cognitive Ageing and Cognitive Epidemiology, said: "This new research increases our understanding of longevity and healthy aging. It is exciting as it has identified a novel indicator of aging, which improves the prediction of lifespan over and above the contribution of factors such as smoking, diabetes, and cardiovascular disease."

The study is published in the journal Genome Biology.

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DNA clock helps to get measure of people's lifespans

The National Anti-corruption Directorate (DNA) on Monday asked the Parliament to allow it to prosecute ex-Tourism and Regional Development Minister Elena Udrea and ex-Economy Minister Ion Ariton, in the Gala Bute case where searches were conducted in Bucharest and four counties in the morning, about transactions between state institutions and private companies participating in the organisation of Gala Bute, a sportive event organised by the company of the former President of the Romanian Boxing Federation, Rudel Obreja, and which benefited from an important financial support from the state.

Head of the National Anticorruption Directorate (DNA) Laura Codruta Kovesi sent Romanias Prosecutor-general the papers needed for the notification of the Chamber of Deputies in connection with the request for the start of the prosecution of deputy Elena Udrea, who, at the time when the suspected crimes were perpetrated, was filling the position of Minister of Regional Development and Tourism.

According to a DNA release sent on Monday to Agerpres, the request for the start of prosecution proceedings zeroes in on the crimes of abuse of power and drawing of undue benefits for self or others, the attempt to use fake documents, the submission of inaccurate, incomplete or false statements for unduly accessing funding from the EU budget and graft.

The deeds under the spotlight are connected to the supposedly illegal award and use, between 2010 2012, of funds under the management of the Ministry of Regional Development and Tourism.

On June 24, 2011, the Ministry of Regional Development and Tourism awarded a contract worth 10,175,168.44 lei under which company SC Europlus Computers SRL [owned by then head of the Romanian Boxing Federation Rudel Obreja] was to provide services for Romanias promotion in the events that were to accompany the International Professional Boxing Gala organised by the Romanian Boxing Federation. The contract was awarded without negotiation and without the publication of an advertisement, and the amount was to be repaid from European funds. Under this contract, on February 1, 2012, the Ministry of Regional Development and Tourism paid 8,116,800 lei for the promotion services. The public funds were used in a manner that is prohibited by law, specifically for the financing of a sports event organized by a trading company and the amount transferred under the contract represents in its entirety a loss to the Ministrys assets, the release reads.

DNA shows that the real purpose of the contracts conclusion was that of ensuring the necessary funds for the organization of the said boxing gala and the procurement of advertising services was actually just a formal smokescreen, because Ministry did not really need such services and the sole purpose of such actions was to give all these moves the appearance of legality. The anti-corruption body holds that Elena Udrea was actually after electoral benefits, seeking to link her name to that of high-profile boxer Lucian Bute, who was to be the top attraction of the gala. The contract was pushed through under the umbrella of the project Promoting Romanias tourism brand that was supposed to get funding from the European Regional Development Fund.

Yet, the prosecutors note that the contract was allegedly awarded in breach of legal public procurement procedures and the services acquired are not included in the categories of expenditures that are eligible for European funding programs. These circumstances entailed the refusal of the managing authority of European funds to settle the amount, so that, because of the public servants faulty on-the-job acting, the said amounts were fully covered from the state budget. The criminal investigations conducted so far revealed that then Minister of Regional Development and Tourism Elena Udrea had the most important contribution to the perpetration of these deeds and the final outcome.

The cited source underscores that Elena Udrea decided to have the gala organised following informal talks with Rudel Obreja, that she pressed for the passage of the regulatory acts that defined the legal framework for the financing of the event, repeatedly asked the public servants reporting to her to meet Rudel Obreja to identify solutions for the contracts conclusion and directly participated in the establishment of the budget the Ministry of Regional Development and Tourism was to assign outside the regulated public procurement procedure.

The existing evidence also shows that Elena Udrea used her influence as a Minister and Deputy Chairperson of the party at rule on a bank decision-maker and the Ministrys Secretary-general to elicit the fast-track grant, to S.C. Europlus Computers S.R.L, of a bank loan under more favorable than usual terms, reports Agerpres.

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DNA: Ex-Economy Minister Ion Ariton put pressure on state-owned companies to sponsor Bute Boxing Gala

DNA au hall blues club plussin le 30 janvier 2015 -1
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By: littlecouinie

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DNA au hall blues club plussin le 30 janvier 2015 -1 - Video

DNA Bomb #4 - FRRRRRRRRRRRZZZZZZTTT
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By: Gayzor

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DNA Bomb #4 - FRRRRRRRRRRRZZZZZZTTT - Video

Aw: Freeestyle I 1vs1 Turnier mit Abo #39;s? I Double DNA Bomb
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By: OnPoinT

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Aw: Freeestyle I 1vs1 Turnier mit Abo's? I Double DNA Bomb - Video

AW | LA CONCHITA DE TES MORTS ! TONIO L #39;ILLUMINATI !(DNA SNIPER ?)
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By: Tonioo25

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AW | LA CONCHITA DE TES MORTS ! TONIO L'ILLUMINATI !(DNA SNIPER ?) - Video