Category Archives: DNA

When Randy Newman sang his tongue-in-cheek tune about short people, he called attention to their little hands, little eyes and their little baby legs. Nowhere does his1978 hit mention that short people also have an increased risk of coronary artery disease.

But scientists have established this link in several large studies, and a new one shows that its not just a coincidence. Some of the genetic variants that cause people to have short stature also tend to boost their levels of bad cholesterol and triglycerides two risk factors for coronary artery disease.

After examining the DNA of 65,066 people with coronary artery diseasealong with that of 128,383 controls, researchers calculated that the risk for the condition rose by 13.5% for each 2.5-inch drop in height below the average. They also found thatLDL cholesterol andtriglycerides explain about one-third of this unfortunate relationship.

Theresults were published this week by the New England Journal of Medicine.

Coronary artery diseaseis a condition in which cholesterol and other substances in the blood form plaques that build up inside the vessels that supply the heart. This narrows the vessels and, over time, can weaken the heart muscle by depriving it of oxygen and nutrients. It also makes people vulnerable to a heart attack because its easier for an errant clot to cut off the blood supply altogether.

Coronary artery diseaseis the most common cause of death for men and women in the United States, according to the National Heart Lung and Blood Institute.

Some people had speculated that the link between shortness and coronaryartery diseasewas a matter of geometry. Tall people have bigger coronary arteries, and short people have smaller ones. Therefore, it stands to reason that any given amount of plaque has the potential to do more damage to someone with petite arteries than it does to someone with wider ones.

But the research team found a problem with this theory. Women have smaller-caliber arteries than men, they noted. That should mean that short women have the greatest risk of coronary artery disease. Instead, the researchers discovered that the genetic link between height and the diseasewas weaker in women than in men.

The researchers began their analysis by focusing on 180 places in the human genome that were shown to be associated with height in a 2010 study known as the Genetic Investigation of Anthropometric Traits, or GIANT. None of these 180 genetic variants had any previously known connection to the risk of coronary artery disease.

The researchers estimated how much a change in each of these height-related variants changed the odds of the diseaseamong thousands of people who had already participated in genome-wide association studies and clinical trials related to coronary artery disease. Most of the variants had little to no effect on their own. But once all of them were added together, the net effect was that the risk of coronary artery diseaserose as height fell.

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DNA analysis validates link between short stature and heart risk

A BILL seeking for the establishment of a forensic deoxyribonucleic acid (DNA) databank has been filed in the House of Representatives.

Las Pias City Representative Mark Villar said the recent advances in the forensic DNA testing are now paving the way for reforming the manner by which cases are resolved in courts of law through the way suspected offenders are apprehended during criminal investigation.

"This technology can be used to identify potential suspects whose DNA may match evidence left at a crime scenes, exonerate persons wrongly accused of crimes, and to identify victims of crime," Villar said.

At present, the DNA technology is being used to identify victims of calamities, establish paternity and other filial relationships, he said.

Villar's House Bill 5372 provides that any information from the DNA databank shall be admissible as conclusive proof of the DNA identification in any proceedings in any court.

DNA is the chain of molecules found in every nucleated cell of the body. The totality of an individual's DNA is unique for the individual, except identical twins.

DNA profile means genetic information derived from DNA testing of a biological sample obtained from a person, which biological sample is clearly identifiable as originating from that person.

Under the bill, the DNA databank shall maintain the DNA profiles for the purpose of human identification in relation to forensic investigation, and may be used in assisting the recovery or identification of human remains from a disaster or for humanitarian purposes; and the identification of living or deceased persons.

An intimate sample of a person reasonably suspected or having committed an offense or a detainee may be taken for forensic DNA analysis only if an authorized officer authorizes it to be taken by a government medical officer, only if there is an appropriate consent in the prescribed form given by the person concerned, or from the Regional Trial Court judge who has jurisdiction over the case.

Taking of non-intimate sample of a person reasonably suspected or having committed an offense or a detainee may be taken only if an authorized officer authorizes it on the grounds for suspecting that the person has committed an offense; and believing that the sample will tend to confirm or disprove the commission of the offense by that person; or an arrest has been effected on or a detention has been made against under the law.

Continued here:
Bill seeks creation of DNA databank

HUNTINGTON STATION, N.Y. (CBSNewYork) The Town of Huntington on Long Island is using science to fight crime.

As CBS2s Tracee Carrasco reported, a company will use DNA from plants to track down jewelry and other valuables stolen in home burglaries.

Im excited that Huntington will be one of the first in the nation to trial this technology, said Suffolk County Legislator Dr. William Spencer (D-Huntington).

The Town of Huntington is providing 500 residents with a vial containing a plant-based product that can be used to leave an invisible print on valuables. The product includes DNA extracted from an assortment of common plants in homes and yards.

If those items are stolen and recovered or pawned, an ultraviolet light can be used to reveal the mark which would then be traced to the owners so the items can be returned, WCBS 880s Sophia Hall reports.

The program that makes it all possible is called DNANET. In Huntington Station on Friday, state lawmakers and police joined the head of the local startup tech company that created the DNA Net kit.

Application is easy, said Jim Hayward of Applied DNA Sciences. Just swab the DNA onto an item, creating a marking just smaller than a dime.

Hayward demonstrated how easy it is for police officers to shine the UV light onto valuables afterward. The plant DNA shines brightly, and can even be sent by a computer to a lab to match it to stolen items listed on the companys database.

An infinitesimal amount of each unique mark can identify an item belonging to your or to your family, Hayward said.

The plant-based substance can be used on anything valuable.

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Long Island Town Giving Residents DNA Tool To Fight Crime

DNA: AAP completes 49 days in Delhi, no Lokpal Bill yet
AAP #39;s government completes 49 days in Delhi but there is no sign of Lokpal Bill yet.

By: Zee News

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DNA: AAP completes 49 days in Delhi, no Lokpal Bill yet - Video

Advanced Warfare: SN6 DNA Bomb on Recovery! (DNA Saturday)
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AW: ASM1 DNA | Flugzeugabsturz - Meine Meinung
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AW: ASM1 DNA | Flugzeugabsturz - Meine Meinung - Video

AW: | AMR9 DNA on Comeback | Rizzik ber Peter Fox !
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AW: | AMR9 DNA on Comeback | Rizzik ber Peter Fox ! - Video

Zem ze dna svta erp sly
cover - szidi tobias, Horek Michal.

By: David Machek

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Zem ze dna svta erp sly - Video

40 B.A.R.R.S. ON CHAYNA ASHLEY: I #39;M TOP 2, SHE #39;S NOT DNA "HE #39;S NOT ANYBODY TO BE AFRAID OF"
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40 B.A.R.R.S. ON CHAYNA ASHLEY: I'M TOP 2, SHE'S NOT & DNA "HE'S NOT ANYBODY TO BE AFRAID OF" - Video

DNA: Farmers #39; suicide rate soars after unseasonal rain destroys crops
Farmer suicides in distress is not a new issue in India. However, suicide rates among Indian farmers are soaring after unseasonal rain destroyed thousands of hectares of crops before harvest.

By: Zee News

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DNA: Farmers' suicide rate soars after unseasonal rain destroys crops - Video