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Category Archives: Technology

Hisense Drives Technology Industry to a New High, Jointly Releases Latest Industry Key Figures with GfK and Ipsos – PR Newswire

Posted: March 29, 2022 at 12:31 pm

Hisense Sales and Brand Awareness is Leading in Global Market

According to GfK, in 2021, 16% of consumers upgraded their home appliances, which led global home appliances sales to increase by 13% and TVs sales up 6%, reaching record high growth rates. Meanwhile, Hisense's market growth outside PRC exceeds 30%, with 8% market share in the TV industry. Moreover, Norbert Herzog, Global Strategic Insights Head of GfK SE, believes premiumization has become a market consumption trend.

In recent years, Hisense has continued to focus on premium industries and globalization strategies, successfully provided qualified products and excellent services to global consumers,led Hisense to achieve greater success in sales and brand awareness.

According to Ipsos research data for 2019-2021, Hisense brand equityhas grown 54% in three years, and Hisense's brand awareness in 2B businesses such as intelligentcity, transportation, and healthcare ranked among the top in the industry. This means that Hisense's global brand awareness has gained tremendous growth while effectively leading to increased sales. In 2021, Hisense TV sales in the United States, Mexico, and major Western European markets such as the UK, France, and Germany grew by more than 30% YoY, and Hisense Laser TV sales in overseas markets outside of PRC grew by 279% YoY.

Globalization and Develop Premium Technology to Achieve Brand Success

Hisense VP of International Marketing Jerry Liu said: "Hisense's dedication towards technology has never changed over the years; we are constantly insisting on R&D to create premium products for global consumers." Through continuous efforts in branding and premium products, Hisense expects its flagship product ULED TV will achieve premium sales growth of more than 40% YoY; Laser TV will grow doubled.

In terms of business layout, Hisense will establish nearly 100 premium flagship stores globally; more R&D centers will be built in the United States and Japan, increasing investment in overall development to achieve better production, distribution and sales layout

In the future, Hisense will continuously pursue R&D in technology to deliver a premium product and high-end lifestyle to consumers, and become a trustworthy technology brand worldwide.

SOURCE Hisense

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Hisense Drives Technology Industry to a New High, Jointly Releases Latest Industry Key Figures with GfK and Ipsos - PR Newswire

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Nkarta Appoints Manufacturing Technology Executive, Angela Thedinga, to Board of Directors – Yahoo Finance

Posted: at 12:31 pm

Nkarta, Inc.

Appointment brings extensive operational expertise in supply chain and novel commercial-scale manufacturing systems

SOUTH SAN FRANCISCO, Calif., March 29, 2022 (GLOBE NEWSWIRE) -- Nkarta, Inc. (Nasdaq: NKTX), a clinical-stage biopharmaceutical company developing engineered natural killer (NK) cell therapies to treat cancer, announced today the appointment of Angela M. Thedinga, MBA, MPH, to its Board of Directors.

The speed of manufacturing innovation in cell and gene therapies in recent years has accelerated significantly. Angela is one of a handful of people who have been at the center of this activity, said Paul J. Hastings, President and CEO of Nkarta. Her expertise and insight in technical operations, supply chain and commercial manufacturing will be instructive for Nkartas operational strategy and the planned expansion of our in-house cell therapy manufacturing capabilities. We welcome her to our Board and look forward to her contributions.

Angela Thedinga most recently served as Chief Technology Officer of Adverum Biotechnologies, where she led the process development, manufacturing and supply chain functions that supported the development of ocular gene therapies. Before joining Adverum in 2019, she held executive roles in manufacturing and supply chain management and strategy at AveXis, now Novartis Gene Therapies, to deliver the first approved gene therapy for Spinal Muscular Atrophy. Her earlier industry experience includes manufacturing strategy roles in bioprocess engineering at Abbott Laboratories and vaccine development at Novartis Vaccines and Diagnostics. She earned an MBA and MS in Chemical Engineering from the Massachusetts Institute of Technology (MIT), an MPH at the University of North Carolina, Chapel Hill, and a BS in Chemical Engineering from University of Wisconsin. She is a founding member of Chief, an organization focused on connecting and supporting women executive leaders.

Ive lived through the challenges of technology transfer, supply chain and commercial-scale up of disruptive in vivo, gene-engineered products, said Angela Thedinga. I am excited to contribute my experience and perspective to the development and delivery of off-the-shelf natural killer cell therapies. The manufacturing capabilities of Nkarta are robust and impressive, and I look forward to joining the Board and the Nkarta team as we develop next generation cell therapies for cancer patients.

Story continues

About Nkarta Nkarta is a clinical-stage biotechnology company advancing the development of allogeneic, off-the-shelf natural killer (NK) cell immunotherapies for cancer patients. By combining its cell expansion and cryopreservation platform with proprietary cell engineering technologies and CRISPR-based genome engineering capabilities, Nkarta is building a pipeline of future cell therapies engineered for deep anti-tumor activity and intended for broad access in the outpatient treatment setting. For more information, please visit the companys website at http://www.nkartatx.com.

Cautionary Note on Forward-Looking StatementsStatements contained in this press release regarding matters that are not historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as "anticipates," "believes," "expects," "intends," plans, potential, "projects, would, and "future" or similar expressions are intended to identify forward-looking statements. Examples of these forward-looking statements include statements concerning Nkartas expectations regarding any or all of the following: Ms. Thedingas future contributions to Nkarta and the benefits of her appointment to Nkartas Board; Nkartas ability to build and advance a pipeline of NK cell therapies; expansion of Nkartas in-house manufacturing capabilities; and the anti-tumor activity and accessibility of Nkartas product candidates. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, among others: Nkartas limited operating history and historical losses; Nkartas lack of any products approved for sale and its ability to achieve profitability; Nkartas ability to raise additional funding to complete the development and any commercialization of its product candidates; Nkartas dependence on the success of its co-lead product candidates, NKX101 and NKX019; that Nkarta may be delayed in initiating, enrolling or completing any clinical trials; competition from third parties that are developing products for similar uses; Nkartas ability to obtain, maintain and protect its intellectual property; Nkartas dependence on third parties in connection with manufacturing, clinical trials, and pre-clinical studies; the complexity of the manufacturing process for CAR NK cell therapies; and risks relating to the impact on Nkartas business of the COVID-19 pandemic or similar public health crises.

These and other risks are described more fully in Nkartas filings with the Securities and Exchange Commission (SEC), including the Risk Factors section of Nkartas Annual Report on Form 10-K for the year ended December 31, 2021, filed with the SEC on March 17, 2022, and Nkartas other documents subsequently filed with or furnished to the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, Nkarta undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

Contacts:

Greg MannNkarta, Inc. gmann@nkartatx.com

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What If The Top Technologies In Manufacturing Worked Together? – Forbes

Posted: at 12:31 pm

A plethora of technologies shape manufacturing and continue to do so. Think CNC machining, robotics, 3D-printing, robotics, software, Internet of Things (IoT), digital twins, AI/AR, and photonics, just to name some important ones. What each can do is amazing. But, these technologies have different origins, physical shape, and scopein terms of hardware, biology, materials, or software.

GANZHOU, CHINA - OCTOBER 21: A robotic arm moves wood bricks at an intelligent furniture factory ... [+] using 5G and artificial intelligence (AI) technologies on October 21, 2020 in Ganzhou, Jiangxi Province of China. (Photo by Liu Zhankun/China News Service via Getty Images)

Think of it not just as a material difference but as a challenge of language. Each belongs to separate categories, but not everyone speaks all of them. Even biological or software machines dont always communicate amongst each other. For machines on a shop floor, this can become a problem.

Several manufacturing technologies came out of university labs, such as MIT, Stanford, University of Cambridge, or Carnegie Mellon, all places that claim to know communication. While others were developed by industry R&D such as in Bell Labs, understandably more applied to a specific purpose. Tech with a surprisingly wide scope for applied energy emerged from military labs like Los Alamos, or non-profit labs such as CERN, even academies like the Chinese Academy of Sciences. Some emerged as collaborative efforts across sectors, such as the German Fraunhofer society. Nowadays most technologies are a mix of the above, relying on a cyber-physical ensemble of materials to work. The technologies developed ages ago are still found on shop floors. However, contrary to the empty talk of the staged evolution from 1.0 to 4.0 generations, they can co-exist. Is it a problem if some of them were designed to work with others and some were designed to work on their own?

Technologists complicate things. We aren't trying to show off but we speak our own specialist language. Do you speak tech? You might speak a little, enough to get by, perhaps, but theres many tech languages. The obvious one from office work is programming. C++, Python, or Fortran, each take eons to learn, and if better ones emerge, they may go extinct. In manufacturing, speaking tech might mean to be a wizard at operating industrial machines, or mastering industrial control systems. Perhaps you are a diehard CNC machining operator, or you love operating robots? Thats all good. Because you are then in high demand. But it would be good for society should everyone learn to operate robots, 3D printers, computers, or digital twins. How do we do that without coding?

Lets do a thought experiment. Imagine manufacturing started out as LEGO. I mean interchangeable plastic bricks, or indeed any modular parts that you can build things with. Construct towers, towns, or taxis. LEGO may look simple but building with them requires motor skills, spatial awareness, reasoning, the ability to engage in imaginative play, and various other skills. LEGO has been a part of the courses at the MIT Media Lab for years. Theres a LEGO Robotics course on MIT open Courseware developed all the way back in 2007. Mindstorms, a robotic invention system that revolutionized LEGO construction kits, grew out of LEGOs 20-year collaboration with the Media Lab. I belong to the proud category of AFOLS, adult fans of LEGO (see LEGO exclusive: AFOLs taught us to take adults seriously). When my kids stop playing with LEGO, Im the one who has to be brought down for dinner. Importantly, once you have built something, the fun is not over. You can continue to play with what you built, adapt it, or even tear it down and start over. Starting over is crucial. Theres nothing LEGO aficionados hate more than glued together pieces.

A McLaren 720S made entirely out of Lego bricks is shown to Britain's Prince William, Duke of ... [+] Cambridge (L) by Mike Flewitt, CEO of McLaren Automative, in Woking, west of London on September 12, 2017, during his visit to McLaren Automotive Production Centre. - During the visit the Duke toured the technology centre and production centre where he got to see McLaren cars throughout the years as well as walk the factory floor to view the building of their commercial cars and speak to employees. (Photo by CHRIS J RATCLIFFE / POOL / AFP) (Photo credit should read CHRIS J RATCLIFFE/AFP via Getty Images)

Now imagine that you built a factory simply with LEGO pieces. What does that mean? For one, it means that you can reconfigure your factory piece by piece. It also means that even though a complex factory requires specifications and plans, everyone can take some part in building it. Dont like the way the CNC machines work? Build a different one, smaller, bigger. Put it somewhere else if you dont like where you put it.

For clarity, Im not suggesting actually building a factory in LEGO. It is the principle behind it, the creative thrust, that I respect. Im saying this in the same way that I feel government services would be different if they were run by Disney. Imagine a magic wristband giving you full access to everything the government has to offer but with smiling faces everywhere. Now, the metaphor isnt literal and I dont really want Disney to run the government.

Manufacturing is not like LEGO or Disney. We are not in kindergarten any more (I never wentwhich some say explains a lot of my playfulness) but the reality is, technologies arent interchangeable or interoperablewe would say in tech speak. These days, its popular to think in terms of first principles;. We have Elon Musk to thank for that (see Why Innovators Like Elon Musk and Jeff Bezos Embrace This Ancient Problem-Solving Technique). A first principle is one that cannot be deduced from any other assumption. Philosophers love first principled thinking. Descartes, for example, said his starting point was that his own mind exists (cogito ergo sum). Now in modern times, scientists are famous for thinking in first principles. Except, do they actually?

Enough with my analogies. We have become used to thinking by analogy instead of first principles. Its a shorthand. However, when building machines, analogy is a dead end because it leads to mediocrity. Instead of rebuilding factories from scratch, manufacturers often resort to retrofitting so-called brownfields as opposed to building greenfields which are more expensive. Industrial tech is one big mesh of new and old machinery and software that barely patches together. Large manufacturers, or their tech suppliers, prefer to integrate startup technologies by M&A instead of inventing something themselves (based on open components) or partnering with startups. The standing on the shoulders of giants strategy, or picking winners works quite well to achieve things quickly. However, we paint ourselves into a corner if we incur technological debt.

Conrad Leiva, director of Ecosystem and Workforce Development at CESMII, the US smart manufacturing institute writes 7 first principles that add up to smart manufacturing. Leiva cites security, real-time insights, proactive dashboards, openness, resilience, scalability, and sustainability. The problem is, these are concepts everyone can agree with, but unless we standardize terminology, commit manufacturers to actions, and regulate interactions, togetherness will not magically happen.

Instead, we should start from scratch; app-based approaches start from a new premise. As a first-principle explains: whoever is trying to solve a problem should have the means to do so. To accomplish that, instead of LEGO bricks, we have apps. What is an app but a simple algorithm which turns industrial workflows into a process that can achieve a business goal. Apps are implemented in computer code, but to work like LEGO bricks, this code is not a necessary requirement for the user to understand. Apps can come pre-configured, but should be easily configurable. They are a powerful version of a spreadsheet with a drag-and-drop interface. If you can operate a cellphone, you can use an app, and if you can play computer games, you can become an app developer. Good manufacturing apps connect to machines to accomplish real-world jobs on the shop floor or in the supply chain: ordering things, instructing work, monitoring quality, and shipping products. Apps do this by augmenting workers, not by replacing them.

Cely-en-Biere (north-central France) on 2014/09/20. Naimeric Villafruela, head of the FabLab Moebius ... [+] association, organizes courses on 3D printing for the general public in the town hall of Cely-en-Biere. Presentation and making of small plastic items (Photo by: Andia/Universal Images Group via Getty Images)

What could we achieve if the top technologies in manufacturing worked together? With so-called software-driven manufacturing built on an interchangeable (interoperable) platform, we could build microfactories in minutes, that could make advanced products in your home, in your maker space at school, or in the community or workplace. Wait? This already exists. The analog is the FabLab network, spinning out of Professor Neil Gershenfelds work at MIT. Except FabLabs are only for the thousands of volunteer enthusiasts.

Im talking about changing the entire logic of manufacturing, switching to a modular platform run by drag-and-drop. As web-tech slowly penetrates manufacturing, we are about to find out what that could be. Though, it might take a while because its not in everybodys interest. So what if we mandated that any technology on the shop floor must communicate with others. The same way it would be unacceptable to be silent if taking part in a group of humans who are trying to learn together. At the very least, any government sponsored technology should have an interoperable interface. If you spend public money, make manufacturing that all workers can use. Dont glue together LEGO.

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What If The Top Technologies In Manufacturing Worked Together? - Forbes

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Scientists advance cloud-seeding capabilities with nanotechnology – MIT Technology Review

Posted: at 12:31 pm

Dr. Zou leads a groundbreaking research project using nanotechnology to develop cloud-seeding materials. Cloud seeding is a form of weather modification that mimics what naturally occurs in clouds but enhances the process by adding particles that can stimulate and accelerate the condensation process. However, Dr. Zou explains, The cloud-seeding materials used today have been around for many decades. The information and techniques are out of date and their effectiveness is not well understood.

Cloud seeding has strict requirements. To be successful, scientists need the right air temperature, the right humidity, a surface that attracts water and keeps it, and then the correct size material to allow condensation to form on the particle.

Through the advancement in nanotechnology and nanoscience, nowadays we are working to design and engineer cloud-seeding materials with optimal properties to ensure water vapor condensation will occur effectively and maximize the rainfall achieved, explains Dr. Zou.

Laurel Ruma: From MIT Technology Review, I'm Laurel Ruma, and this is Business Lab. The show that helps business leaders make sense of new technologies coming out of the lab and into the market place.

Our topic today is cloud seeding to increase rainfall. Although cloud seeding has been around since the 1940s, climate change and population growth are driving scientists to take a closer look at the technology, which could offer a viable cost-effective supplement to existing water supplies, particularly in arid and semi-arid regions, like the United Arab Emirates.

To help advance the science, in 2015 the UAE government launched a new initiative, the UAE Research Program for Rain Enhancement Science. The aim is to get other innovative projects from scientists in the field of rain enhancement from all over the world, with the winning ideas obtaining a grant of $5 million to work and improve on concepts for a period of three years. Two words for you: nanoengineered materials.

My guest today is Dr. Linda Zou, who is a professor of civil and environmental engineering at Khalifa University of Science and Technology. Dr. Zou leads a groundbreaking research project using nanotechnology to develop cloud seeding materials.

She was awarded a grant by the UAE Research Program on rain enhancement science from 2016 to 2019. Dr. Zou's research interests include applying nanotechnology and membrane science to the development of low energy and high efficiency novel desalination and water purification solutions. This podcast is produced in partnership with the UAE Pavilion Expo 2020 Dubai. Welcome, Dr. Zou.

Dr. Zou: Thank you, Laurel.

Laurel: You were one of the first scientists in the world to explore the use of nanotechnology in cloud seeding. Why are you interested in this type of research?

Dr. Zou: The cloud seeding materials used today have been around for many decades. The information and techniques are out of date and their effectiveness is not well understood. Through the advancement in nanotechnology and nanoscience, nowadays we are working to design and engineer cloud seeding materials with optimal properties to ensure water vapor condensation will occur effectively and maximize the rainfall achieved.

Laurel: Cloud seeding is a form of weather modification that mimics what naturally occurs in clouds but enhances the process by adding particles that can stimulate and accelerate the condensation process. Could you explain in more detail how cloud seeding works?

Dr. Zou: In the natural water cycle on the earth, the sun irradiates on the surface of our planet and the water on the surface is evaporated by the heat as the vapors. The tiny vapors rise into the atmosphere without condensation nuclei, which are small particles. They remain as vapors in the air and move higher and further.

The natural occurring condensation nuclei are such as dust particles, volcano flash, or pollens. Unfortunately, such material is unpredictable, where and how much available. On the other hand, cloud seeding practice is to release artificial seeding materials as nuclei to initiate the water vapor in the cloud to condense into droplets and promote the formation of large droplets until they grow big enough to fall as rain.

The key factors of a successful cloud seeding operation include, first, identifying the suitable cloud for seeding. Second, having the efficient seeding material for water droplet formation.

Laurel: To successfully cloud seed, you need a number of things: the right air temperature, the right humidity, a surface that attracts water and keeps it, and then the correct size material to allow condensation to form on the particle. Is that correct?

Dr. Zou: Yes. Yes.

Laurel: Although cloud seeding has been around for decades, how does today's technology move it toward a greater success rate?

Dr. Zou: As we know, the global water shortage has continuously intensified by rapid population growth and economic development around the world. Conventional water resources such as rivers, lakes, and groundwater have become very limited, which is driving scientists and engineers to look for alternative water resources.

Atmospheric water is one such alternative resource. At the moment, all possible solutions that could resolve the water shortage issue should be examined carefully.

Nanotechnology can engineer material and design the material with well controlled size, shapes, and properties. So it has a huge possibility to improve its efficiency.

Laurel: Your research focuses on the cloud seeding material itself, specifically the nanomaterials as you mentioned, which is a more effective tool in generating rain from existing clouds. What are conventional cloud seeding materials, and then how does nanotechnology come into play?

Dr. Zou: The conventional cloud seeding materials include mostly hydroscopic salt mixture, which can change from salt crystals into water droplets at the right condition. The delivery of this salt is to vaporize them by ignition by a flare device. This salt vapor then will recondense as very small particles. Because the process is random and uncertain, the form and size of the particle cannot be controlled and most are probably too small to be effective cloud seeding materials.

The conventional cloud seeding material can only be activated at a very high relative humidity in atmosphere in the cloud, such as greater than 75% relative humidity. In my project, we have changed the surface of the material to make it more reactive so it can work at a lower and wider relative humidity to make it more likely to happen.

To achieve this, we use the nanotechnology to deposit titanium dioxide nanoparticles as a shell layer and sodium chloride crystal core. This nanoengineered shell core structured material can be activated at much broader relative humidity conditions such as about 65%. Because the coated nanolayers are more hydrophilic and porous, the water can be absorbed easily and increase the local relative humidity of the crystals and increase the probability of forming water droplets. So it is a synergistic effect.

Laurel: You've also developed another kind of technology, ice nucleating particles. How do those compare to cloud seeding materials?

Dr. Zou: Yes. As you know, cold clouds with sub-zero temperatures are also present in the atmosphere. They are made of many super cooled water vapors, so although they are below zero, they remain as vapor. Once such cloud encounters the ice nucleation particles, they rapidly form a large number of ice crystals and bypass the liquid water phase. So they form super cool vapor and crystallize into ice particles.

Ice nucleation is important. It will initiate from the thin water layer formed on the surface of the ice nuclease, and the ice will grow rapidly at the expense of the water vapor in the cloud. We designed and fabricated a porous nanocomposite of 3D reduced graphite oxide and silica dioxide nanoparticles. This material can initiate ice nucleation followed by rapid growth starting from a temperature of minus 80 degrees. This temperature is much higher than most other known ice nucleate material. Often they require minus 25 degrees or even lower.

Laurel: This is very critical because the cloud seeding materials go very high up into the atmosphere where it is very cold, correct?

Dr. Zou: Yes. The higher you move up to the atmosphere, quickly moving into subzero and very cold.

Laurel: In the past, one of the challenges scientists encountered when researching cloud seeding was the lack of a simulation environment. You took this on as part of your research. What did you develop and how will it facilitate future research?

Dr. Zou: It is a challenge area and I have collaborated with the Cloud Microphysics Modeling International team. The innovation of my project is the characteristics data we obtained from the experiment. This data describing my new seeding materials property and their interactions in atmosphere. So we can use them as input to develop one-dimensional and three-dimensional modeling of precipitation enhancement caused by cloud seeding, and the results prove quite successful.

Laurel: Could you describe that weather chamber that you used in your experiments? What are the challenges with then deploying the material out in the real world?

Dr. Zou: The cloud chamber is a three-dimensional experimental environment. They vary in size. Theres a small one, a medium one, and a large one. The small one could be 20 meters and the large one could be like a building. I used an eight cubic meter chamber with controlled humidity and temperature. A device at the top of the chamber releases the seeding materials.

Immediately after the seeding is released, the electronic equipment, which are electronic optical cameras, will quickly take many, many photos to record the image while the seeding material's falling. Then we can later analyze at what stage the droplets formed and at what number and size of the droplets. We can do a spectrum analysis and to find out their vapor condensation, the droplet formation, and the size and the number of the droplets. Using this information is very good to compare the performance of different materials, and we did that extensively.

Laurel: Then in the real world where we don't have this controlled chamber, it's not quite as easy necessarily to measure that kind of success.

Dr. Zou: Yes, you are right. In the open environment, it's more challenging.

Laurel: Your research signifies a milestone toward achieving greater water security in the world. What kind of effect can cloud seeding potentially have on a country, like the UAE, which typically only records four inches of rain in a year?

Dr. Zou: Yeah. UAE is in the arid climate zone, and the government has already taken the initiative of this UAE research program for re-enhancement science. We call them UAEREP [United Arab Emirates Research Program for Rain Enhancement Science]. My research work has been supported in their first cycle and received excellent worldwide exposure.

Today, together with the National Center of Meteorology of the UAE, we can see the application of these new seeding materials in real operations very quickly across UAE to increase the rainfall.

Laurel: Back to your technology, you filed a patent on the cloud seeding material itself. What are you working on now, and what are you thinking about next?

Dr. Zou: Yeah. One patent is filed on the titanium dioxide, sodium chloride material for warm cloud seeding, and another patent is filed for porous graphite oxide, silica dioxide, nano compensated for cold cloud seeding.

At the moment, I'm working collaboratively on a project to evaluate the effects of these materials in the open air. A team of pilots is conducting an investigation by releasing the seeding materials and in real time capturing and analyzing them. It's very promising to know more about the effects of this seeding material.

On the other hand, I am also dedicated to the scale up of the production, reduce the cost, and the application of the materials. We are looking forward to moving the seeding materials from laboratory to the commercial venture for not only cloud seeding applications, but wider applications, such as different weather modification efforts, including agriculture or crop protection, hail, or storm suppression, and the artificial snow making at the ski resort. Yes, such type of applications.

Laurel: Certainly, a number of possible commercial ventures. You are also pursuing funding initiatives at this point too, for your research. Is that correct?

Dr. Zou: We want to move the materials, as I mentioned, from laboratory already and scale up, so it has a chance of reaching the market and to reach many different parts of the world as well, because there are so many countries worldwide that practice weather modification.

Laurel: Dr. Zou, thank you so much for being with us here on the Business Lab. This has been an absolute, fantastic conversation.

Dr. Zou: Thank you for having me.

Laurel: That was Dr. Linda Zou, a professor of civil and environmental engineering at Khalifa University of Science and Technology, who I spoke with from Cambridge, Massachusetts, the home of MIT and MIT Technology Review, overlooking the Charles River.

That's it for this episode of Business Lab. I'm your host, Laurel Ruma. I'm the Director of Insights, the custom publishing division of MIT Technology Review. We were founded in 1899 at the Massachusetts Institute of Technology, and you can find us in print on the web and at events each year around the world. For more information about us and the show, please check out our website at technologyreview.com.

This show is available wherever you get your podcasts. If you enjoyed this episode, we hope you'll take a moment to rate and review us. Business Lab is a production of MIT Technology Review. This episode was produced by Collective Next. Thanks for listening.

This podcast episode was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Reviews editorial staff.

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Proman partners with CropX to invest in cutting-edge technology to make farming more sustainable – PR Newswire

Posted: at 12:31 pm

WOLLERAU, Switzerland, March 29, 2022 /PRNewswire/ --Proman, an integrated energy company and one of the world's top ten nitrogen fertilizer producers, today announced a new strategic partnership with CropX, a global pioneer in digital farm management systems.

CropX technology provides farmers and industry experts with the data and information they need to increase farming sustainability through conserving resources across the value chain and increasing crop yields, resulting in a more sustainable food production environment.

Over seventy-five percent of Proman's nitrogen-based product is sold as fertilizer, supporting farmers around the world to achieve healthy plant growth and high crop yields at a time when the global population is growing by some 80 million per annum. Data-driven precision farming delivers more efficient farming and resource conservation, resulting in both economic and environmental benefits. This investment underlines Proman's commitment to actively supporting innovative technology solutions which can improve agricultural sustainability at a time when it is crucial for global food security and nutrition.

David Cassidy, Chief Executive of Proman said, "We look forward to contributing our expertise as a fertilizer producer to this initiative and supporting CropX's vision to utilise technology to boost farmer productivity and incomes, improve food security, and strengthen the resilience of the global food production systems. With food security becoming an increasingly pressing global issue, we believe that Digital Agro technologies have the potential to significantly increase agricultural productivity and support more sustainable agriculture around the world."

Tomer Tzach, Chief Executive of CropX said, "We are extremely fortunate to partner with such an incredible global leader in nitrogen fertilizer! Using technology to precisely manage fertilizer application is the next frontier, and companies such as Proman and CropX will lead the way. We are excited that Proman sees the great value in our fertilizer management capabilities, which are an important part of the growing suite of decision tools that CropX offers to help farmers grow more with less."

NOTES TO EDITORS

About Proman

Proman is an integrated energy company and global leader in natural gas derived products and services. Headquartered in Switzerland, with assets in the United States, Trinidad and Tobago and Oman, and ongoing expansion into Mexico, Proman is the world's second largest methanol producer and is one of the top ten global nitrogen-fertilizer companies.

Proman is committed to developing sustainable methanol and ammonia as cleaner alternatives to fossil fuels, offering a pathway to drastically cutting emissions in power generation, overland transportation, shipping and industry.

Learn more about our full value chain integration here: https://www.proman.org

About CropX

Since 2015, CropX has been helping farmers everywhere grow more with less - less water, less fertilizer, less chemicals, less labour, less energy, and less stress. Its technologies and cloud-based platform offer advanced farm intelligence to farmers in over 40 countries, across all the arable continents, on over 75 crop types. With experienced teams of agronomists, data scientists, and engineers, CropX is committed to improving and simplifying digital tools for profitable and sustainable farm management. Learn more athttps://www.cropx.com.

Logo - https://mma.prnewswire.com/media/1775856/CropX_Logo.jpgLogo - https://mma.prnewswire.com/media/1775857/Proman_Logo.jpg

SOURCE Proman AG; CropX

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FreeWheel Launches New Audience-Based TV Buying Technology to Enable Unified Planning Across Premium Linear and Connected TV – WV News

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Country

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IrelandUruguay, Eastern Republic ofUzbekistanVanuatuVenezuela, Bolivarian Republic ofViet Nam, Socialist Republic ofWallis and Futuna IslandsWestern SaharaYemenZambia, Republic ofZimbabwe

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FreeWheel Launches New Audience-Based TV Buying Technology to Enable Unified Planning Across Premium Linear and Connected TV - WV News

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Gb Sciences’ Nanoparticle Encapsulation Technology Improves the Efficacy of Terpenes for Use in Our Chronic Pain Formulations as Demonstrated in New…

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LAS VEGAS, March 29, 2022 (GLOBE NEWSWIRE) -- Gb Sciences, Inc. (OTCQB:GBLX), a leading cannabis- and plant-inspired, biopharmaceutical research and development company, announces that their sponsored study investigating the effect of nanoparticle encapsulation of three cannabis-based terpenes on their potential efficacy in pain management waspublished in theInternational Journal of Pharmaceuticson March 25. For the Gb Sciences-sponsored study, researchers at the University of Seville in Spain have developed time-released, oral nanoparticles to deliver Gb Sciences' patent-protected chronic pain formulations, which are based on synergistic mixtures of terpenes. Terpenes are normally highly volatile, highly lipophilic molecules that are difficult to formulate into stable drug products, so Gb Sciences and their colleagues believe that nanocarriers can improve their stability, solubility, and bioavailability.

"This research represents an important advance in the creation of novel terpene-containing pharmaceutical products for chronic pain, which have the potential to deliver relief over time in a safer and more efficient manner through our time-released delivery technology," said Dr. Andrea Small-Howard, President and Chief Science Officer of Gb Sciences, who co-authored the paper with researchers from the University of Seville in Spain and Chaminade University in Hawai'i. "There was a considerable technological challenge to developing a suitable drug delivery system for terpenes.This study demonstrates how nanomedicines offer an elegant solution for administering these efficacious molecules and opens up new opportunities for their use in chronic pain medicines."

In the U.S. alone, chronic pain represents an estimated health burden of between $560 and $650 billion dollars, and an estimated 20.4% of U.S. adults suffer from chronic pain that significantly decreases their quality of life. Despite the widespread rates of addiction and death, opioids remain the standard of care treatment for most people with chronic pain. Concerns over those issueshave made novel chronic pain treatments such as Gb Sciences' therapies an important and promising field of research and development.

The Gb Sciences-sponsored study tested the effect of poly(lactide-co-glycolide) nanoparticles containing the three terpenes versus the effect of free terpenes in a cell model with TRPV1 receptors, which are known pain receptors. The study found that the encapsulated terpene nanoparticles produced significantly higher calcium responses alone or in combinations versus the free terpenes alone or in combinations. The elevated calcium responses through the TRPV1 channels indicate greater activation of these pain receptors, which can have an analgesic effect via desensitization of these important pain receptors.

In addition to its potential therapy for chronic pain, Gb Sciences has four other advanced preclinical-stage programs, including a Parkinson's disease treatment being prepared to enter a first-in-human clinical trial.

To learn more about Gb Sciences, visitwww.gbsciences.com.

About Gb Sciences and GbS Global Biopharma

Gb Sciences, Inc. is a plant-inspired, biopharmaceutical research and development company creating patented, disease-targeted formulations of cannabis- and other plant-inspired therapeutic mixtures for the prescription drug market through its Canadian subsidiary, GbS Global Biopharma, Inc. The "plant-inspired" active ingredients in its therapeutic mixtures are synthetic homologues identical to the original plant compounds but produced under current Good Manufacturing Practices. Gb Sciences' intellectual property portfolio contains six issued U.S. and three issued foreign patents, as well as 18 U.S. and 49 foreign patent-pending applications. In its drug development pipeline, Gb Sciences has five preclinical phase product development programs. Gb Sciences' lead program for Parkinson's disease is being prepared for a first-in-human clinical trial. Gb Sciences' formulations for chronic pain, anxiety, and depression are currently in preclinical animal studies with researchers at the National Research Council Canada. The company also recently received positive preclinical proof-of-concept data supporting its complex mixtures for the treatment of Cytokine Release Syndrome related to COVID-19, and its lead candidates will be optimized based on late-stage preclinical studies at Michigan State University. Gb Sciences' productive research and development network includes distinguished universities, hospitals, and Contract Research Organizations. To learn more, visitwww.gbsciences.com.

Forward-Looking Statements

This press release may contain statements relating to future results or events, which are forward-looking statements. Words such as "expects," "intends," "plans," "may," "could," "should," "anticipates," "likely," "believes" and words of similar import may identify forward-looking statements. These statements are not historical facts, but instead represent only the Company's belief regarding future events, many of which, by their nature, are inherently uncertain and outside of the Company's control. It is possible that the Company's actual results and financial condition may differ, possibly materially, from the anticipated results and financial condition indicated in these forward-looking statements. Further, information concerning the Company and its business, including factors that potentially could materially affect the Company's business and financial and other results, are contained in the Company's filings with the Securities and Exchange Commission, available at http://www.sec.gov. All forward-looking statements included in this press release are made only as of the date of this press release, and we do not undertake any obligation to publicly update or correct any forward-looking statements to reflect events or circumstances that subsequently occur or of which we hereafter become aware.

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Mike Albanesemike.albanese@newswire.com

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Gb Sciences' Nanoparticle Encapsulation Technology Improves the Efficacy of Terpenes for Use in Our Chronic Pain Formulations as Demonstrated in New...

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Fintech Roundup: Will financial technology startups dodge the venture slowdown? – TechCrunch

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Welcome to my weekly fintech-focused column. Ill be publishing this every Sunday, so in between posts, be sure to listen to the Equity podcastand hearAlex Wilhelm,Natasha Mascarenhas and me riff on all things startups! And if you want to have this hit your inbox directly once it officially turns into a newsletter on May 1, sign up here.

On March 25, PitchBook released its 2021 Annual Fintech Report, which found that the fintech industry raised $121.6 billion last year up 153% year-over-year in terms of global VC deal value. Alex and I will be doing a deep dive on that report next week, but its a nice lead-in to what Im examining today.

There has been much talk as of late of a slowdown in venture funding. But if this past weeks mega-rounds in fintech are any indication, the sector is proving it has the potential to be quite the outlier at least for now.

In what was not a surprise but is still noteworthy, corporate spend and expense management startup Ramp confirmed that it raised $200 million in equity, secured $550 million in debt and doubled its valuation to $8.1 billion. Not bad for a company that only publicly launched just over two years ago.

I also exclusively covered Jeeves $180 million Series C, which quadrupled that companys valuation to $2.1 billionin half a years time. Ive been writing about Jeeves since it came out of stealth last June with $31 million in equity and its been wild watching it grow. It also operates in the corporate spend and expense management space, with more of a global footprint and infrastructure component. In fact, it describes itself as thefirst cross country, cross currency expense management platform. Jeeves has a presence in, and is seeking to expand in, Latin America, Canada and Europe. Its also eyeing Southeast Asia and potentially Saudi Arabia and Africa.

Another thing that both Ramp and Jeeves have in common besides skyrocketing valuations is that both companies are experiencing hyper-growth. Unfortunately, as with most private companies, neither startup will share hard revenue figures. But they do at least provide some metrics. Ramp says its revenue grew early 10x in 2021 compared to 2020 while its cardholder base grew 7x and its user base grew 15x. CEO Eric Glyman also tells us that Ramp is powering over $5 billion in annualized payments volume. Considering it makes money off of each transaction, its safe to say that Ramp is well, ramping up into impressive revenue territory. Meanwhile, Jeeves says it has seen its revenue grow by 900% since its September raise and even more impressively, that in the first two months of 2022, it brought in more revenue than all of 2021. Meanwhile, the startup has doubled its client base to more than 3,000 companies and reached about $1.3 billion in annualized gross transaction volume (GTV).

Is this market big enough for so many global players? That remains to be seen. But it will be fun watching how the race in the space plays out. As Alex, my friend and Equity podcast co-host, pointed out this week it seems these companies cant stop adding features and new products fast enough. For example, Brex announced last week that it provided $10 million in growth capital via venture debt to Zesty.ai, a leading provider of predictive data analytics in the climate risk space. Brex launched a venture debt program last August as part of its effort to be many financial-related things to startups and maturing companies alike. (It had also filed for a bank charter last year but ended up withdrawing its application). Meanwhile, newer players are also entering the scene. I recently wrote about a new company called Glean AI, started by former OnDeck and Better.com CFO Howard Katzenberg, which aims to help businesses save money by using machine learning to analyze things like deal terms, line-item data, redundant offerings and negotiation opportunities. Startups like these are keeping the incumbents (relatively speaking) on their toes.

Its safe to say that as long as these startups keep adding on to what they can offer to other companies, the rapid pace of funding to support those initiatives will likely also continue but theres a caveat IF theyre showing fast growth as described above.

Its too early to tell truly if fintech is truly an outlier when it comes to a pullback in global venture funding, or if were just seeing deals that were initiated late last year starting to close. The second quarter will give us more insight as to whether fintech is in fact experiencing, or dodging, a slowdown.

On that note, our amazing fintech/crypto reporter Anita Ramaswamy talked to Lightspeed Venture Partners Justin Overdorff on the topic and at least in his view, fintech is not immune to the global slowdown. For context, Overdorff joined Lightspeed in 2021 to help lead the teams fintech practice. He told Anita:

Image Credits: Self-proclaimed fintech junkie Justin Overdorff / Lightspeed Venture Partners website

Were seeing pretty big market changes. Maybe valuations arent coming down yet, but what is changing is that we are certainly seeing round sizes are shrinking. And the number of term sheets that are being offered are shrinking. So when you see, you know, a deal, and a [founder] who normally was going to go out for a $20 million Series A, theyre being told by the market to raise 12 to 15 million, because thats where the appetite is. And instead of eight term sheets, youre going to get two. And thats been happening pretty clearly.Now, with that said, I think that theres still a lot of appetite [for fintech] across the board.

On the venture side, Overdorff told Anita that from what hes hearing, VCs are trying to make their funds last longer and as a result, theres an unknown of where it goes.

So if Overdorffs observations are any indications, both startup founders and investors alike are working harder to make their dollars last longer.

In other notable news, Robinhood this week announced it was launching a new debit card that allows for spare-change investing. As my very talented colleague Sarah Perez and I discussed, the move was significant in that it shows that Robinhood is taking concrete steps to expand beyond trading and into more consumer finance areas. Sarahs exact words were: It puts it in more direct competition with other fintechs such as Chime and even P2P payment companies such as CashApp and PayPal/Venmo, which tie online customer accounts to physical payments cards. The roundup feature can also help to increase customers investments passively like Acorns [with its savings app] and like Venmo is doing with crypto.

Another example of fintechs trying to do all the things.

Meanwhile, as our friends at Protocol reported, Apple is reportedly buying U.K. open-banking startup Credit Kudos for around $150 million. This follows its early February introduction of a new Tap to Pay feature for iPhone that turns the device into a contactless payment terminal. The tech behemoth is clearly encroaching into fintech territory.

As usual, there was no shortage of fundings around the world, although I do have to admit, this list feels shorter than in weeks past. Heres a sample of just a few:

Mastercard announced the launch of a new suite of open banking-driven smart payment decisioning tools aimed at eliminating friction and improving success rates in the payments ecosystem. The credit card giant called the move one of the first significant technology developments to come out of its acquisition of Finicity.

This article by our own Alex Wilhelm ties into the is fintech an outlier narrative from above: Forges public debut will pose fresh test to SPAC-led exits. Forge operates a market for private shares equity in unicorn startups, basically. It went public via a SPAC this week and, gasp, actually had an impressive debut.

Ola said on March 24 that it has reached an agreement to acquire Avail Finance, a financial services startup that serves the blue-collar workforce, as the ride-hailing giant looks to expand its financial services offerings. Manish Singh gives us all the details in this piece.

Sightline, which just a few months ago became Nevadas first unicorn, announced last week that J.P. Morgan Payments will become the primary processor for its Play+ transactions spanning online casino, mobile sports betting, cashless payments at casinos and more. The company told me: The gaming industry has a notoriously clunky payments ecosystem bogged down by regulations and casinos reliance on cash. But recently there have been huge technological advancements, like Sightline helping launch the worlds first casino with a fully cashless infrastructure.

Stori reports that it expects to reach 1 million active customers this month. Says CEO and co-founder Bin Chen: We are super excited about reaching this milestone, particularly because most of our customers were rejected by traditional banks in the past. With a Stori card, they are building credit history and gaining financial upward mobility. I wrote about the startups $32.5 million Series B in February of 2021.

BMO Financial Group and 1871 last week issued a national call for applications for their leading fintech industry program for women-led startups, WMNfintech. Applications for the 2022 program will be accepted through April 22, 2022.

In this Q&A with FinLedger, Morty co-founderNora Apsel discusses the online mortgage marketplaces journey, overarching goals and plans moving forward. I talked with Nora myself earlier this year and the former engineer is very impressive. Her company raised a $25 million Series B in July 2021 at a $150 million valuation. In February, she told me that the startups revenue has grown nearly 14x since 2019 and doubled in the last year alone.

Image Credits: Nora Apsel / Morty

Speaking of women in fintech, Mila Ferrell, a founding member of Zooms product team, last week joined Cervin, becoming the first female partner at the early-stage venture capital firm. In her new role, according to the firm, Ferrell will define the future of work and shape fintech infrastructure in the next decade and beyond.

Image Credits: Mila Ferrell / Cervin

Tishman Speyer, one of the worlds largest real estate developers, announced it secured $100 million in commitments, anchored by the National Pension Service of Korea and Investment Management Corporation of Ontario, for its first proptech venture capital fund. The venture says it seeks to raise up to $150 million in total equity to fund investments in technology-driven opportunities related to all sectors of real estate.

Well, thats it for this week! My newsletter was set to launch today but for logistical reasons, that date has officially been moved to May 1. Thanks for hanging in there and reading this column in the meantime. Have a great Sunday, and week ahead!

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Fintech Roundup: Will financial technology startups dodge the venture slowdown? - TechCrunch

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Reversing hearing loss with regenerative therapy | MIT News | Massachusetts Institute of Technology – MIT News

Posted: at 12:31 pm

Most of us know someone affected by hearing loss, but we may not fully appreciate the hardships that lack of hearing can bring. Hearing loss can lead to isolation, frustration, and a debilitating ringing in the ears known as tinnitus. It is also closely correlated with dementia.

The biotechnology company Frequency Therapeutics is seeking to reverse hearing loss not with hearing aids or implants, but with a new kind of regenerative therapy. The company uses small molecules to program progenitor cells, a descendant of stem cells in the inner ear, to create the tiny hair cells that allow us to hear.

Hair cells die off when exposed to loud noises or drugs including certain chemotherapies and antibiotics. Frequencys drug candidate is designed to be injected into the ear to regenerate these cells within the cochlea. In clinical trials, the company has already improved peoples hearing as measured by tests of speech perception the ability to understand speech and recognize words.

Speech perception is the No. 1 goal for improving hearing and the No. 1 need we hear from patients, says Frequency co-founder and Chief Scientific Officer Chris Loose PhD 07.

In Frequencys first clinical study, the company saw statistically significant improvements in speech perception in some participants after a single injection, with some responses lasting nearly two years.

The company has dosed more than 200 patients to date and has seen clinically meaningful improvements in speech perception in three separate clinical studies. Another study failed to show improvements in hearing compared to the placebo group, but the company attributes that result to flaws in the design of the trial.

Now Frequency is recruiting for a 124-person trial from which preliminary results should be available early next year.

The companys founders, including Loose, MIT Institute Professor Robert Langer, CEO David Lucchino MBA 06, Senior Vice President Will McLean PhD 14, and Harvard-MIT Health Sciences and Technology affiliate faculty member Jeff Karp, are already gratified to have been able to help people improve their hearing through the trials. They also believe theyre making important contributions toward solving a problem that impacts more than 40 million people in the U.S. and hundreds of millions more around the world.

Hearing is such an important sense; it connects people to their community and cultivates a sense of identity, says Karp, who is also a professor of anesthesia at Brigham and Womens Hospital. I think the potential to restore hearing will have enormous impact on society.

From the lab to patients

In 2005, Lucchino was an MBA student in the MIT Sloan School of Management and Loose was a PhD candidate in chemical engineering at MIT. Langer introduced the two aspiring entrepreneurs, and they started working on what would become Semprus BioSciences, a medical device company that won the MIT $100K Entrepreneurship Competition and later sold at a deal valued at up to $80 million.

MIT has such a wonderful environment of people interested in new ventures that come from different backgrounds, so were able to assemble teams of people with diverse skills quickly, Loose says.

Eight years after playing matchmaker for Lucchino and Loose, Langer began working with Karp to study the lining of the human gut, which regenerates itself almost every day.

With MIT postdoc Xiaolei Yin, who is now a scientific advisor to Frequency, the researchers discovered that the same molecules that control the guts stem cells are also used by a close descendant of stem cells called progenitor cells. Like stem cells, progenitor cells can turn into more specialized cells in the body.

Every time we make an advance, we take a step back and ask how this could be even bigger, Karp says. Its easy to be incremental, but how do we take what we learned and make a massive difference?

Progenitor cells reside in the inner ear and generate hair cells when humans are in utero, but they become dormant before birth and never again turn into more specialized cells such as the hair cells of the cochlea. Humans are born with about 15,000 hair cells in each cochlea. Such cells die over time and never regenerate.

In 2012, the research team was able to use small molecules to turn progenitor cells into thousands of hair cells in the lab. Karp says no one had ever produced such a large number of hair cells before. He still remembers looking at the results while visiting his family, including his father, who wears a hearing aid.

I looked at them and said, I think we have a breakthrough, Karp says. Thats the first and only time Ive used that phrase.

The advance was enough for Langer to play matchmaker again and bring Loose and Lucchino into the fold to start Frequency Therapeutics.

The founders believe their approach injecting small molecules into the inner ear to turn progenitor cells into more specialized cells offers advantages over gene therapies, which may rely on extracting a patients cells, programming them in a lab, and then delivering them to the right area.

Tissues throughout your body contain progenitor cells, so we see a huge range of applications, Loose says. We believe this is the future of regenerative medicine.

Advancing regenerative medicine

Frequencys founders have been thrilled to watch their lab work mature into an impactful drug candidate in clinical trials.

Some of these people [in the trials] couldnt hear for 30 years, and for the first time they said they could go into a crowded restaurant and hear what their children were saying, Langer says. Its so meaningful to them. Obviously more needs to be done, but just the fact that you can help a small group of people is really impressive to me.

Karp believes Frequencys work will advance researchers ability to manipulate progenitor cells and lead to new treatments down the line.

I wouldn't be surprised if in 10 or 15 years, because of the resources being put into this space and the incredible science being done, we can get to the point where [reversing hearing loss] would be similar to Lasik surgery, where you're in and out in an hour or two and you can completely restore your vision, Karp says. I think we'll see the same thing for hearing loss.

The company is also developing a drug for multiple sclerosis (MS), a disease in which the immune system attacks the myelin in the brain and central nervous system. Progenitor cells already turn into the myelin-producing cells in the brain, but not fast enough to keep up with losses sustained by MS patients. Most MS therapies focus on suppressing the immune system rather than generating myelin.

Early versions of that drug candidate have shown dramatic increases in myelin in mouse studies. The company expects to file an investigational new drug application for MS with the FDA next year.

When we were conceiving of this project, we meant for it to be a platform that could be broadly applicable to multiple tissues. Now were moving into the remyelination work, and to me its the tip of the iceberg in terms of what can be done by taking small molecules and controlling local biology, Karp says.

For now, Karp is already thrilled with Frequencys progress, which hit home the last time he was in Frequencys office and met a speaker who shared her experience with hearing loss.

You always hope your work will have an impact, but it can take a long time for that to happen, Karp says. Its been an incredible experience working with the team to bring this forward. There are already people in the trials whose hearing has been dramatically improved and their lives have been changed. That impacts interactions with family and friends. Its wonderful to be a part of.

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One Network Enterprises Named Leader in Nucleus Research’s Supply Chain Planning Technology Value Matrix 2022 for the 3rd consecutive year – PR…

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Nucleus Research recognizes One Network as a Leader in its Supply Chain Planning Technology Value Matrix 2022.

With supply and labor shortages, geopolitical disruptions and demand fluctuations still challenging global supply chains, the Nucleus Research report once again positions One Network Enterprises as a technology leader. The report credits One Network's enhancements to its NEO platform and AI predictive capabilities with implementation of new supply chain planning (SCP) and execution functions called "NEO Intelligent Agents". The new features improve the automation and prescriptive capabilities of fulfillment (global demand-supply matching), transportation and last-mile delivery. ONE's ongoing improvements to global inbound and last mile capabilities, allow products and materials to be tracked with automated serial numbers to establish accountability at every stage of their journey (and precisely targeted for recall if necessary).

"One Network Enterprises is once again a leader in our 2022 Supply Chain Planning Technology Value Matrix, helping organizations prepare for unforeseen supply chain disruptions, drive efficiencies and impart greater resilience. The investments and developments One Network continues to make to their NEO platform, ML decision-making and multi-tier supplier networks are enabling organizations globally to adapt and stay competitive and profitable in spite of market disruptions," said Isaac Gould, lead analyst of this report at Nucleus Research. "Given their investment and R&D in their unique network-based intelligent agent technology, we expect them to continue leading in supply chain planning technology."

"We are proud to once again be recognized by Nucleus Research as a leader in the 2022 Supply Chain Planning Technology report," said Mark Brady, CEO of One Network Enterprises. "As Nucleus Research has highlighted, the ongoing improvements we are making to supply chain planning functionality is having a major impact on the resiliency of global supply chains. In today's volatile business environment, quickly resolving supply chain disruptions is of critical importance. Our enhanced NEO intelligent agents better predict and resolve issues, to further improve supply chain resilience with autonomous decision-making and control."

About One Network Enterprises One Network is the leader in supply chain control towers and provider of the Digital Supply Chain Network. It is the only solution that gives supply chain managers and executives end-to-end visibility and control with one data model and one truth, from raw material to last mile delivery. Powered by NEO, One Network's machine learning and intelligent agent technology, it enables seamless planning and execution, across inbound supply, outbound order fulfillment, and logistics, matching demand with available supply in real-time. Lead your industry by providing the highest service levels and product quality at the lowest possible cost. Visit: http://www.onenetwork.com.

Contact: Michelle Gaubert One Network Enterprises+1 510 316 0590[emailprotected]

SOURCE One Network Enterprises

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