Category Archives: Technology

University of Central Florida researchers have developed a device for artificial intelligence that mimics the retina of the eye.

The development could lead to advanced AI that can instantly recognize what it sees, like automatic descriptions of pictures taken by a camera or phone. The technology also has applications in self-driving vehicles and robotics.

The device, which is detailed in a new study in the journal ACS Nano, also outperforms the eye in the number of wavelengths it can see, from ultraviolet to visible light and on to the infrared spectrum.

Its uniqueness also comes from its ability to integrate three different operations into one. Current intelligent imaging technology, like whats used in self-driving vehicles, requires separate sensing, memorization and processing of data.

By combining the three steps, the UCF-designed device is many times faster than current technology, the researchers say. The technology is also very small, with hundreds of the devices fitting on a one-inch-wide chip.

It will change the way artificial intelligence is realized today, says study principal investigator Tania Roy, an assistant professor in UCFs Department of Materials Science and Engineering and NanoScience Technology Center. Today, everything is discrete components and running on conventional hardware. And here, we have the capacity to do in-sensor computing using a single device on one small platform.

The technology expands upon previous work by the research team that created brain-like devices that can enable AI to work in remote regions and space.

We had devices, which behaved like the synapses of the human brain, but still, we were not feeding them the image directly, Roy says. Now, by adding image sensing ability to them, we have synapse-like devices that act like smart pixels in a camera by sensing, processing and recognizing images simultaneously.

For self-driving vehicles, the versality of the device will allow for safer driving in a range of conditions, including at night, says Molla Manjurul Islam 17MS, the studys lead author and a doctoral student in UCFs Department of Physics.

If you are in your autonomous vehicle at night and the imaging system of the car operates only at a particular wavelength, say the visible wavelength, it will not see what is in front of it, Islam says. But in our case, with our device, it can actually see in the entire condition.

There is no reported device like this, which can operate simultaneously in ultraviolet range and visible wavelength as well as infrared wavelength, so this is the most unique selling point for this device, he says.

Key to the technology is the engineering of nanoscale surfaces made of molybdenum disulfide and platinum ditelluride to allow for multi-wavelength sensing and memory. This work was performed in close collaboration with YeonWoong Jung, an assistant professor with joint appointments in UCFs NanoScience Technology Center and Department of Materials Science and Engineering, part of UCFs College of Engineering and Computer Science.

The researchers tested the devices accuracy by having it sense and recognize a mixed wavelength image an ultraviolet number 3 and an infrared part that is the mirror image of the digit that were placed together to form an 8. They demonstrated that the technology could discern the patterns and identify it both as a 3 in ultraviolet and an 8 in infrared.

We got 70 to 80% accuracy, which means they have very good chances that they can be realized in hardware, says study co-author Adithi Krishnaprasad 18MS, adoctoral studentin UCFsDepartment of Electrical and Computer Engineering.

The researchers say the technology could become available for use in the next five to 10 years.

Study co-authors also included Durjoy Dev 21, a graduate of UCFs doctoral program in electrical engineering; Ricardo Martinez-Martinez 19MS, a student in UCFs doctoral program in optics and photonics; Victor Okonkwo, a UCF undergraduate student studying biomedical sciences and mechanical engineering; Benjamin Wu with Stony Brook University; Sang Sub Han, a postdoctoral associate in the Jung Research Group at UCF; Tae-Sung Bae and Hee-Suk Chung with the Korea Basic Science Institute; and Jimmy Touma, a research scientist at the U.S. Air Force Research Laboratory.

The work was funded by the U.S. Air Force Research Laboratory through the Air Force Office of Scientific Research, and the U.S. National Science Foundation through its CAREER program.

Roy joined UCF in 2016 and is a part of the NanoScience Technology Center with a joint appointment in the Department of Materials Science and Engineering, theDepartment of Electrical and Computer Engineeringand theDepartment of Physics. Her National Science Foundation CAREER awardfocuses on the development of devices for artificial intelligence applications. Roy was a postdoctoral scholar at the University of California, Berkeley prior to joining UCF. She received her doctorate in electrical engineering from Vanderbilt University.

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UCF Researchers Develop Technology for AI that Mimics the Human Eye - UCF

INTRODUCTION

Applying digital technologies in dental practices today can be confusing, especially for removable prosthodontics. Until recently, complete denture technologies and procedures had remained practically unchanged for the better part of a century. The invention of the intraoral scanner, printable biocompatible resins, and the desktop 3D printer has essentially revolutionized complete denture techniques for the modern dentist. However, acquiring these technologies alone does not necessarily lead to better outcomes. Digital hardware and software must be utilized with sound principles practically and efficiently to benefit dentists in clinical practice meaningfully.

The topic of digital dentures is popular today and encompasses many techniques and workflows that must be understood and combined for successful outcomes. Arguably, the limitations of digital techniques are as important to consider as the possibilities. Today, dentists have more choices available to them for digital denture fabrication than ever before. This case report will follow a specific treatment pathway of a patient receiving complete denture therapy where both digital and analog processes were utilized.

CASE REPORT

A 65-year-old female presented with her chief concern being an ill-fitting and worn upper complete denture (Figure 1). The existing prosthesis was more than 15 years old and no longer stable or retentive. The patient reported she became edentulous in her early thirties, and the current prosthesis was her third complete denture.

Figure 1. Preoperative presentation.

She also reported her previous long-time dentist recently attempted to replace the denture unsuccessfully. The fit, retention, stability, and tooth arrangement were not to the patients satisfaction, and she sought to have it remade by a different clinician.

After a review of the medical and dental history, the patient was evaluated clinically and radiographically with a panoramic radiograph. A soft-tissue exam was completed with no significant findings. The patient was fully edentulous in the maxilla and partially edentulous in the mandible. The remaining lower anterior teeth were worn, and there was significant resorption in the posterior mandible as well as the maxilla. The palatal arch form was somewhat flat, and the residual ridge was thin and knife-edged anteriorly. The patient reported having a mandibular removable partial denture that was never comfortable and that she was unable to wear it. She reported being able to function adequately with her remaining dentition. The upper denture was found to be worn with an uneven occlusal plane and curve of Spee. The denture tooth arrangement had a midline discrepancy of approximately 8 mm toward the patients right side.

The patient was referred for a surgical consultation to assess the remaining bone volume and evaluate for possible implant support. There was minimal bone remaining, and implant therapy would require significant augmentation procedures the patient was not interested in pursuing. All findings and options were presented and discussed with the patient, including no treatment, as well as risks and benefits. The treatment plan was finalized to replace the complete upper denture and have no treatment in the mandibular arch at the current time.

The patient expressed a desire to have the new denture resemble her existing denture as closely as possible with respect to tooth size, contour, arrangement, and display. It was mutually agreed upon that the midline would be corrected by shifting it to the patients left and bisecting the philtrum of her upper lip. She requested the shade to be similar to but slightly brighter than her existing denture.

The reference denture technique was utilized to accomplish treatment using the patients existing denture and to combine analog and digital workflows. The first step in clinical treatment consisted of making full-face digital portraits with the patient wearing the existing denture in both smiling and retracted poses. These 2 portraits were aligned over each other in digital smile design software (TRIOS Smile Design [3Shape]) that allows the tooth positions to be designed and visualized and toggled accurately between the views.

The proportions and positions of the proposed denture teeth can be customized as the clinician deems appropriate for the particular situation at a level not possible with premanufactured denture teeth. Special care was taken to ensure the patients head did not move significantly between the photographs. If the patients head moves between the poses, its not possible to accurately toggle between the views when designing the tooth positions.

The existing denture was cleaned, and approximately 1 to 2 mm of intaglio acrylic was removed to create space for polyvinyl siloxane. The denture (not coated with adhesive) was loaded with VPS impression material and placed into the mouth in the usual fashion, making sure to record and maintain proper peripheral border molding. The impression was made in 2 phases, with the second phase recording the posterior border palatal seal (Figure 2).

Figure 2. Reference denture impression.

Upon removal of the denture after proper manufacturer setting time, the impression was evaluated and inspected for any significant voids, pulls, or artifacts. The prosthesis was then digitized using a handheld intraoral scanner (TRIOS 4 [3Shape]), beginning on the intaglio surface, then continuing to the peripheral border and, finally, to the labial and occlusal aspects of the denture teeth. The denture was then placed back into the mouth to record the bite relationships. The opposing arch dentition was also recorded with the intraoral scanner in the usual fashion. The denture and all necessary information to design a new denture were now digitized and ready to be utilized (Figure 3).

Figure 3. Data was captured and aligned digitally.

The digital files were exported from the scanning software and imported into the laboratory computer-aided design (CAD) software denture module (Dental System [3Shape]). The denture was virtually designed, and careful attention was paid to the pretreatment goal of maintaining the overall tooth setup and correcting the midline discrepancy (Figure 4).

Figure 4. Virtual denture setup and design.

The digital full-face portraits were aligned with the intraoral scan using common landmark points to allow visualization of the denture in relation to the patients smile (Figure 5). The desired midline correction could also be visualized within the reference of the patients smile to further refine the digital tooth setup (Figure 6).

Figure 5. Digitized impression scan aligned to the facial portrait.

Figure 6. Digital design of the denture setup with a facial reference.

This denture was designed to be milled from a monolithic acrylic puck containing both the gingival base and tooth layer (Ivotion Denture System [Ivoclar Vivadent]). When the design was completed, it was exported from the CAD design software in an STL file format (Figure 7).

Figure 7. Prototype STL file.

This file was imported into the onsite desktop 3D printing computer-aided manufacturing (CAM) software (Form 3B [Formlabs]) and printed as a denture prototype using biocompatible denture tooth resin (Denture Tooth Resin [Formlabs]). The prototype was tried in the patient and evaluated for aesthetics, occlusion, and phonetics (Figure 8).

Figure 8. Prototype try-in.

Photographs were retaken and analyzed by both the doctor and patient. Following the evaluation, the file was sent to a digital denture laboratory (The Denture Center, Windsor, Ont, Canada) for manufacturing and delivered to the patient in normal fashion. Final photographs were obtained at the one-week postoperative visit (Figure 9).

Figure 9. Final prosthesis.

DISCUSSION

Rates of edentulism in the United States have been on a steady decline since the middle of the 20th century.1 In the 1950s, up to 19% of the general population was edentulous. By 2012, that figure declined to about 5%. This decline constituted a 78% relative decline. Dental schools followed this trend and generally allocated less time and emphasis to teaching complete dentures than in previous periods. In recent years, as dental schools began adopting digital techniques, some institutions even considered the notion of eliminating analog denture content from their curriculums. The topic of how to handle complete denture education in the modern era can be somewhat controversial and variable, depending on the institution.

Since the 20th century, dentistry itself as a profession has undergone marked changes with the development of new technologies, techniques, equipment, and services. Aesthetic, implant, and prosthodontics have developed and enjoyed robust innovations in materials, techniques, and armamentaria. However, proficiency in complete denture techniques still helps one master many of the critical skills required to assess aesthetics, smile design, occlusion, phonetics, and more. The development of digital denture techniques in recent years can complement and enhance the basic skills and concepts learned with analog processes.

Digital denture techniques have developed and grown over the last 2 decades.2 However, there can be confusion about just what a digital denture is. The term digital denture can be divided between digital information capture and digital manufacturing. There are many decisions that are necessary for each unique clinical situation on how best to use or not use digital technology. The advent of advanced intraoral scanners has allowed dentists to capture edentulous data digitally for the first time. The advancement of milling and printing technologies over the past 20 or so years has allowed the dental technician freedom to manufacture dentures using various techniques, workflows, and materials.

The clinical case presented above utilized multiple techniques and technologies to produce the outcome. The impression was made analog and then immediately digitized. The digital file was used to perform a virtual denture setup and then additively manufactured into a denture prototype rather than a traditional wax setup. Denture prototypes differ from wax try-ins in that a prototype will have a fit identical to the final prosthesis because it is produced from the master impression itself rather than a baseplate hand-formed over the master cast. This allows the clinician an opportunity to evaluate and assess retention and stability prior to finalizing the prosthesis. A significant advantage of this technique is the try-in step with the printed prototype. If retention and stability are not ideal, the prototype can itself be used as a custom impression tray to obtain an updated impression before the final prosthesis is manufactured. With analog-style techniques, cases with a lack of adequate retention and stability were often only discovered at the final prosthesis delivery appointment. This could be potentially upsetting to both doctor and patient when the intention is to finalize treatment during the appointment.

Today, some dentists are adding digital design and manufacturing equipment to their private offices to produce dentures and other final restorations on-site rather than outsource them.3 While certainly possible, producing final restorations on-site may not align with all clinicians looking to leverage technology without also adding cost, complexity, and responsibility. Dentists producing prostheses on-site are essentially starting in-house laboratories in their clinics. Taking control and responsibility for final prostheses ideally requires a trained team, laboratory equipment, and various denture materials.4 If a practice is not performing large numbers of cases, the return on investment may not deliver as intended.

However, utilizing the workflow outlined in this case report allows the clinician to leverage digital technology while still outsourcing final manufacturing. By combining an intraoral scanner, CAD design software, and a desktop 3D printer, the modern clinician can control the data capture, virtual design, and manufacturing of the denture prototype with relatively minimal capital investment. The responsibility and investments required to produce the final restoration can still be outsourced.

The development of digital denture design software allows any clinician to accomplish denture tooth setups accurately and efficiently without the learning curve of traditional manual waxing. These software products have essentially leveled the playing field with respect to the design process such that any clinician can easily learn and apply the workflows. Whereas final outcomes with analog workflows are highly dependent on the technicians specific experience and hand skills, digital design allows even a novice operator to produce denture setups comparable to those from expert technicians.

Today, many clinicians are interested in using intraoral scanners to record edentulous tissues and eliminating physical impression procedures from complete denture workflows. The proof of concept has been well-documented by groups in the United States and internationally.5 While it is most certainly possible to record edentulous tissues with todays generation of intraoral scanners, it often remains one of the more technique-sensitive and situation-specific procedures in digital dentistry with some inherent limitations. Variables including limited oral access, strong muscle tone, lack of keratinized tissue, hypermobile tissues, and poor patient cooperation must be considered before scanning tissues directly. Understanding the limitations of digital technology is as essential as understanding its capabilities. In the authors experience, immediately digitizing an impression offers a consistent method of capturing the necessary information without the variables mentioned above. Combining analog impression techniques with sound prosthodontic principles and digital design/manufacturing processes may offer the best of all worlds in treating complete denture patients today. The patient presented here was immediately satisfied with her new prosthesis, and it required minimal post-op adjustments. Implementing digital workflows in complete denture patients can empower the clinician to provide a more predictable and efficient rendering of complete denture services.

CONCLUSION

Digital techniques in dentistry and removable prosthodontics are rapidly changing the capabilities and workflows available to the contemporary dental clinician. Leveraging digital technologies with sound prosthodontic principles and time-tested analog techniques results in a hybridization of techniques to improve patient outcomes and treatment efficiency.

Dentists taking responsibility for data capture, design, and prototyping while outsourcing final manufacturing offer a pragmatic and practical utilization of digital technologies for complete denture prosthodontics.

REFERENCES

1. Slade GD, Akinkugbe AA, Sanders AE. Projections of U.S. edentulism prevalence following 5 decades of decline. J Dent Res. 2014;93(10):95965. doi:10.1177/0022034514546165

2. Bonnet G, Batisse C, Bessadet M, et al. A new digital denture procedure: a first practitioners appraisal. BMC Oral Health. 2017;17(1):155. doi:10.1186/s12903-017-0440-z

3. Dusmukhamedov S, Lee C-N, Jeong S-M, et al. Digital denture fabrication: a technical note. Appl Sci. 2021;11(17):8093. doi.org/10.3390/app11178093

4. Andreescu CF, Ghergic DL, Botoaca D, et al. Evaluation of different materials used for fabrication of complete digital denture. Materiale Plastice. 2018;55(1):1248.

5. Lo Russo L, Caradonna G, Salamini A, et al. Intraoral scans of edentulous arches for denture design in a single procedure. J Prosthet Dent. 2020;123(2):2159. doi:10.1016/j.prosdent.2019.03.022

ABOUT THE AUTHOR

Dr. Rajan brings more than 18 years of experience to a full-time general practice in Mendham, NJ, focused on restorative, implant, and aesthetic dentistry. Dr. Rajan has been involved with digital techniques in dentistry since 2007. His focus is on optimizing intraoral scanning and digital workflows in restorative practices.

He has lectured extensively nationally and internationally as a key opinion leader for 3Shape, Straumann, and Henry Schein as well as for the Seattle Study Club. Dr. Rajan has obtained Fellowship in the AGD and trained at both Spear Education and the Pankey Institute. He is actively involved in dental education as the assistant director of digital dentistry at the Touro College of Dental Medicine and a founding member at CADpro Academy, a center for education in digital dentistry.

He can be reached at naren@cadproacademy.com.

Disclosure: Dr. Rajan has been a key opinion leader for 3Shape.

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Dentures and the Practical Application of Digital Technology - Dentistry Today

DUBLIN--(BUSINESS WIRE)--The "Antisense & RNAi Therapeutics Global Market Report 2022: By Technology, By Route, By Indication" report has been added to ResearchAndMarkets.com's offering.

The global antisense & RNAI therapeutics market is expected to grow from $1.32 billion in 2021 to $1.42 billion in 2022 at a compound annual growth rate (CAGR) of 8%. The market is expected to reach $2.14 billion in 2026 at a CAGR of 10.8%.

Major players in the antisense & RNAi therapeutics market are Alnylam Pharmaceuticals, Benitec Biopharma Ltd., Gene Signal, GlaxoSmithKline Plc, Ionis Pharmaceuticals, Marina Biosciences, Quark Pharmaceuticals, Sanofi S.A, Acuitas Therapeutics and Antisense Therapeutics Ltd.

The antisense & RNAi therapeutics market consists of sales of antisense & RNAi therapeutics products and related services by entities (organizations, sole traders and partnerships) that develop antisense & RNAi therapeutics to treat various diseases. RNA interference (RNAi)-based and RNA-based antisense oligonucleotide therapies are advanced methods used for the treatment of various respiratory diseases including chronic obstructive pulmonary disease (COPD) and asthma. In addition to this, antisense & RNAi therapeutics finds its application in curing cancer, infectious diseases, cardiovascular diseases, and genetic disorders.

The main technologies of antisense & RNAi therapeutics are RNA interference, antisense RNA. RNA interference is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids and regulates protein-coding gene expression.

The various route of administration include pulmonary delivery, intravenous injections, intra-dermal injections, intraperitoneal injections, topical delivery, other delivery methods that are used for the indication of oncology, cardiovascular diseases (CVDs), respiratory disorders, neurological disorders, infectious diseases, other.

The rising prevalence of coronary artery diseases, neurodegenerative disorders, and infectious diseases is projected to contribute to the demand for the antisense & RNAi therapeutics market. Gene suppression approaches including RNA interference and antisense oligonucleotides are used for the treatment of various neurodegenerative conditions by repairing mutant genes.

According to the National Institute of Environmental Health Sciences, Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases affecting millions of people globally. In the USA, around 930,000 people had Parkinson's disease by the end of 2020. Hence, the growing prevalence of several neurodegenerative diseases and infectious diseases is expected to drive the growth of the antisense & RNAi therapeutics market.

The high cost of RNA interference-based drugs is expected to act as a major restraint for the growth of the antisense & RNAi therapeutics market in the future. For instance, according to Future Medicine, the price of Onpattro is approximately $450,000 per year. Onpattro (patisaran) is the RNA interference-based drug used for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults.

Stringent regulations, long product approval process, high development cost, and a comparably small number of patients are few factors leading to the high cost of RNA interference drugs, which is expected to hinder the antisense & RNAi therapeutics' market growth in upcoming years.

Major companies operating in the antisense & RNAi therapeutics market are undertaking strategic initiatives such as collaborations and partnerships for product innovation to sustain in the increasingly competitive market, companies are developing innovative products as well as sharing skills and expertise with other companies.

While companies have long collaborated with each other as well as with academic and research institutions in this market by way of partnerships, and in or out-licensing deals, this trend has been increasing over recent years.

Companies Featured

Key Topics Covered:

1. Executive Summary

2. Antisense & RNAi Therapeutics Market Characteristics

3. Antisense & RNAi Therapeutics Market Trends And Strategies

4. Impact Of COVID-19 On Antisense & RNAi Therapeutics

5. Antisense & RNAi Therapeutics Market Size And Growth

5.1. Global Antisense & RNAi Therapeutics Historic Market, 2016-2021, $ Billion

5.1.1. Drivers Of The Market

5.1.2. Restraints On The Market

5.2. Global Antisense & RNAi Therapeutics Forecast Market, 2021-2026F, 2031F, $ Billion

5.2.1. Drivers Of The Market

5.2.2. Restraints On the Market

6. Antisense & RNAi Therapeutics Market Segmentation

6.1. Global Antisense & RNAi Therapeutics Market, Segmentation By Technology, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

6.2. Global Antisense & RNAi Therapeutics Market, Segmentation By Route of Administration, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

6.3. Global Antisense & RNAi Therapeutics Market, Segmentation By Indication, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

7. Antisense & RNAi Therapeutics Market Regional And Country Analysis

7.1. Global Antisense & RNAi Therapeutics Market, Split By Region, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

7.2. Global Antisense & RNAi Therapeutics Market, Split By Country, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

8. Asia-Pacific Antisense & RNAi Therapeutics Market

8.1. Asia-Pacific Antisense & RNAi Therapeutics Market Overview

8.2. Asia-Pacific Antisense & RNAi Therapeutics Market, Segmentation By Technology, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

8.3. Asia-Pacific Antisense & RNAi Therapeutics Market, Segmentation By Route of Administration, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

9. China Antisense & RNAi Therapeutics Market

10. India Antisense & RNAi Therapeutics Market

11. Japan Antisense & RNAi Therapeutics Market

12. Australia Antisense & RNAi Therapeutics Market

13. Indonesia Antisense & RNAi Therapeutics Market

14. South Korea Antisense & RNAi Therapeutics Market

15. Western Europe Antisense & RNAi Therapeutics Market

16. UK Antisense & RNAi Therapeutics Market

17. Germany Antisense & RNAi Therapeutics Market

18. France Antisense & RNAi Therapeutics Market

19. Eastern Europe Antisense & RNAi Therapeutics Market

20. Russia Antisense & RNAi Therapeutics Market

21. North America Antisense & RNAi Therapeutics Market

22. USA Antisense & RNAi Therapeutics Market

23. South America Antisense & RNAi Therapeutics Market

24. Brazil Antisense & RNAi Therapeutics Market

25. Middle East Antisense & RNAi Therapeutics Market

26. Africa Antisense & RNAi Therapeutics Market

27. Antisense & RNAi Therapeutics Market Competitive Landscape And Company Profiles

27.1. Antisense & RNAi Therapeutics Market Competitive Landscape

27.2. Antisense & RNAi Therapeutics Market Company Profiles

28. Antisense & RNAi Therapeutics Pipeline Analysis

29. Key Mergers And Acquisitions In The Antisense & RNAi Therapeutics Market

30. Antisense & RNAi Therapeutics Market Future Outlook and Potential Analysis

For more information about this report visit https://www.researchandmarkets.com/r/q4hkt1

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Global Antisense & RNAi Therapeutics Market Research Report 2022: Technology, Route, Indication Analysis & Forecasts, 2016-2021, 2021-2026F,...

By Anser Hassan

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CASTRO VALLEY, California (KGO) It has been 28 years since Jenny Lin was murdered in her home in Castro Valley. The family continues the search for the killer.

A vigil and march was held Friday night in Castro Valley in her honor.

We think about her and we ask ourselves, Is this what Jenny would want us to do? And thats what keeps us going, explains Mei-Lian Lin, Jennys mother.

In 1994, then 14-year-old Jenny Lin was murdered in their house in Castro Valley. Jennys father found her dead body in the bathroom. But no one has found the killer.

We are still pretty frustrated that after all these years, the case is still not solved. However, we are encouraged, says John Lin, Jennys father.

Encouraged because new technology may have led to a breakthrough in the case, says Alameda County Sheriff Greg Ahern.

Sheriff Ahern says all the evidence has been reexamined with new DNA technology, which allows them to extract new cells, and has given them new leads.

We have a couple of possibilities that we are holding close to our vest. We want to make sure we dont disclose too much to a potential suspect, says Sheriff Ahern.

Ahern says Sebastian Shaw was once considered the prime suspect, but was later ruled out. Shaw died last year in prison while severing three life sentences for murder.

Jennys parents they couldnt do this without community support.

Mei-Lian says it has been hard as a mother over all these years, but adds this is a parents commitment to justice and to their daughter.

It is very hard, but we have learned how to manage it, says Mei-Lian. We know its sad. But we also know that we need to find justice for Jenny.

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New technology may lead to breakthrough in 1994 murder of teen, sheriff says - KTVZ

INDEPENDENCE, Mo. Intellectual Property Developers LLC in Independence, Mo., is introducing zinc oxide thin-film transistors technology for radiation-hardened applications in space.

Called the ZnO Radiation-Hardened Thin-Film Transistors, the patented rad-hard space electronics technology was developed together with Auburn University in Auburn, Ala.

A thin-film transistor is made up of an annealed layer comprising crystalline zinc oxide, with a passivation layer adjacent to the thin-film transistor. The passivation layer has a thickness and material composition such that when a dose of radiation from a radiation source irradiates the thin-film transistor, a portion of the dose that includes an approximate maximum concentration of the dose is located within the annealed layer.

Related: Radiation-hardened MOSFET qualified for commercial and military satellites and space power solutions

The annealed layer has a thickness and threshold displacement energies after it has been annealed such that a difference between a transfer characteristic value of the thin-film transistor before and after the dose is less than a first threshold; and a difference between a transistor output characteristic value of the thin-film before and after the dose is less than a second threshold. The thresholds are based on a desired performance of the thin-film transistor.

The ZnO technology is radiation-hardened upon irradiation of gamma-ray radiation, and is intended for radiation hard electronics application in space, nuclear power facilities, high-altitude aviation, and other radiation environments.

ZnO technology offers reduced volume, mass, and power consumption that can operate in extreme temperature ranges.

Related: Radiation-hardened space electronics enter the multi-core era

ZnO technology compares favorably to silicon carbide (SiC), gallium nitride. ZnO technology is relatively inexpensive to synthesize device quality materials compared to GaN or SiC, Intellectual Property Developers officials say.

The company has completed a two-year research project, which shows that ZnO transistors are working well under exposure in difficult radiation situations. A patent for ZnO technology has been approved by the U.S. Patent and Trademark Office in Alexandria, Va.

For more information contact Vincent Salva, president of Intellectual Property Developers LLC, by email at vpsuss@aol.com, or by phone at 816-254-6670.

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Zinc oxide thin-film transistors technology introduced for radiation-hardened applications in space - Military & Aerospace Electronics

The COVID-19 pandemic forced a shift to remote learning overnight for most higher-education students, starting in the spring of 2020. To complement video lectures and engage students in the virtual classroom, educators adopted technologies that enabled more interactivity and hybrid models of online and in-person activities. These tools changed learning, teaching, and assessment in ways that may persist after the pandemic. Investors have taken note. Edtech start-ups raised record amounts of venture capital in 2020 and 2021, and market valuations for bigger players soared.

A study conducted by McKinsey in 2021 found that to engage most effectively with students, higher-education institutions can focus on eight dimensionsof the learning experience. In this article, we describe the findings of a study of the learning technologies that can enable aspects of several of those eight dimensions (see sidebar Eight dimensions of the online learning experience).

In November 2021, McKinsey surveyed 600 faculty members and 800 students from public and private nonprofit colleges and universities in the United States, including minority-serving institutions, about the use and impact of eight different classroom learning technologies (Exhibit 1). (For more on the learning technologies analyzed in this research, see sidebar Descriptions of the eight learning technologies.) To supplement the survey, we interviewed industry experts and higher-education professionals who make decisions about classroom technology use. We discovered which learning tools and approaches have seen the highest uptake, how students and educators view them, the barriers to higher adoption, how institutions have successfully adopted innovative technologies, and the notable impacts on learning (for details about our methodology, see sidebar About the research).

Exhibit 1

Survey respondents reported a 19 percent average increase in overall use of these learning technologies since the start of the COVID-19 pandemic. Technologies that enable connectivity and community building, such as social mediainspired discussion platforms and virtual study groups, saw the biggest uptick in use49 percentfollowed by group work tools, which grew by 29 percent (Exhibit 2). These technologies likely fill the void left by the lack of in-person experiences more effectively than individual-focused learning tools such as augmented reality and virtual reality (AR/VR). Classroom interaction technologies such as real-time chatting, polling, and breakout room discussions were the most widely used tools before the pandemic and remain so; 67 percent of survey respondents said they currently use these tools in the classroom.

Exhibit 2

The shift to more interactive and diverse learning models will likely continue. One industry expert told us, The pandemic pushed the need for a new learning experience online. It recentered institutions to think about how theyll teach moving forward and has brought synchronous and hybrid learning into focus. Consequently, many US colleges and universities are actively investing to scale up their online and hybrid program offerings.

Some technologies lag behind in adoption. Tools enabling student progress monitoring, AR/VR, machine learningpowered teaching assistants (TAs), AI adaptive course delivery, and classroom exercises are currently used by less than half of survey respondents. Anecdotal evidence suggests that technologies such as AR/VR require a substantial investment in equipment and may be difficult to use at scale in classes with high enrollment. Our survey also revealed utilization disparities based on size. Small public institutions use machine learningpowered TAs, AR/VR, and technologies for monitoring student progress at double or more the rates of medium and large public institutions, perhaps because smaller, specialized schools can make more targeted and cost-effective investments. We also found that medium and large public institutions made greater use of connectivity and community-building tools than small public institutions (57 to 59 percent compared with 45 percent, respectively). Although the uptake of AI-powered tools was slower, higher-education experts we interviewed predict their use will increase; they allow faculty to tailor courses to each students progress, reduce their workload, and improve student engagement at scale (see sidebar Differences in adoption by type of institution observed in the research).

While many colleges and universities are interested in using more technologies to support student learning, the top three barriers indicated are lack of awareness, inadequate deployment capabilities, and cost (Exhibit 3).

Exhibit 3

More than 60 percent of students said that all the classroom learning technologies theyve used since COVID-19 began had improved their learning and grades (Exhibit 4). However, two technologies earned higher marks than the rest for boosting academic performance: 80 percent of students cited classroom exercises, and 71 percent cited machine learningpowered teaching assistants.

Exhibit 4

Although AR/VR is not yet widely used, 37 percent of students said they are most excited about its potential in the classroom. While 88 percent of students believe AR/VR will make learning more entertaining, just 5 percent said they think it will improve their ability to learn or master content (Exhibit 5). Industry experts confirmed that while there is significant enthusiasm for AR/VR, its ability to improve learning outcomes is uncertain. Some data look promising. For example, in a recent pilot study, students who used a VR tool to complete coursework for an introductory biology class improved their subject mastery by an average of two letter grades.

Exhibit 5

Faculty gave learning tools even higher marks than students did, for ease of use, engagement, access to course resources, and instructor connectivity. They also expressed greater excitement than students did for the future use of technologies. For example, while more than 30 percent of students expressed excitement for AR/VR and classroom interactions, more than 60 percent of faculty were excited about those, as well as machine learningpowered teaching assistants and AI adaptive technology.

Eighty-one percent or more of faculty said they feel the eight learning technology tools are a good investment of time and effort relative to the value they provide (Exhibit 6). Expert interviews suggest that employing learning technologies can be a strain on faculty members, but those we surveyed said this strain is worthwhile.

Exhibit 6

While faculty surveyed were enthusiastic about new technologies, experts we interviewed stressed some underlying challenges. For example, digital-literacy gaps have been more pronounced since the pandemic because it forced the near-universal adoption of some technology solutions, deepening a divide that was unnoticed when adoption was sporadic. More tech-savvy instructors are comfortable with interaction-engagement-focused solutions, while staff who are less familiar with these tools prefer content display and delivery-focused technologies.

According to experts we interviewed, learning new tools and features can bring on general fatigue. An associate vice president of e-learning at one university told us that faculty there found designing and executing a pilot study of VR for a computer science class difficult. Its a completely new way of instruction. . . . I imagine that the faculty using it now will not use it again in the spring. Technical support and training help. A chief academic officer of e-learning who oversaw the introduction of virtual simulations for nursing and radiography students said that faculty holdouts were permitted to opt out but not to delay the program. We structured it in a were doing this together way. People who didnt want to do it left, but we got a lot of support from vendors and training, which made it easy to implement simulations.

Despite the growing pains of digitizing the classroom learning experience, faculty and students believe there is a lot more they can gain. Faculty members are optimistic about the benefits, and students expect learning to stay entertaining and efficient. While adoption levels saw double-digit growth during the pandemic, many classrooms have yet to experience all the technologies. For institutions considering the investment, or those that have already started, there are several takeaways to keep in mind.

In an earlier article, we looked at the broader changes in higher education that have been prompted by the pandemic. But perhaps none has advanced as quickly as the adoption of digital learning tools. Faculty and students see substantial benefits, and adoption rates are a long way from saturation, so we can expect uptake to continue. Institutions that want to know how they stand in learning tech adoption can measure their rates and benchmark them against the averages in this article and use those comparisons to help them decide where they want to catch up or get ahead.

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Technology is shaping learning in higher education - McKinsey

Accountancy and business advisory firm BDO has appointed Ian McBane as its new national head of Technology and Media, effective 4 July 2022.

McBane is currently the lead Business Services and Outsourcing partner in London, and has been an active member of BDOs Technology and Media Leadership Team since joining the firm in 2019.

He has experience dealing with high growth scale-ups, mid-market private equity (PE) backed businesses and international tech companies, and he also works with a number of US-owned tech clients and listed group affiliates.

In his new role, McBane takes over from Tony Spillett who has led the Technology and Media sector group since 2016, during which time the firms turnover has more than doubled to over 100m a year in the sector.

McBane said: With innovation and disruption in its DNA, the Technology and Media sector is such an exciting place in which to operate, which is why I cant wait to take on this role.

BDO has been building its brand and growing its presence significantly in the market over the last few years. Im looking forward to building on that momentum and strengthening our client offering by drawing on skills and expertise from right across our UK and global network.

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BDO names new head of Technology and Media - Accountancy Today

Respected Chinese university and SFBU to collaborate on education, academic research, language training, academic conferences, and scientific research

FREMONT, Calif., June 20, 2022 /PRNewswire/ -- A memorandum of understanding has been signed between Nanchang Institute of Technology (NIT) and San Francisco Bay University (SFBU) to promote cooperation in the areas of education, academic research, personnel training, and other fields.

Both universities agreed to establish a cooperative relationship and work together to provide better educational opportunities for students. This agreement is an exciting development for both schools and will help promote international academic exchange between China and the United States.

Areas of cooperation include:

SFBU Executive Vice President Paul Choi said regarding the agreement, "Nanchang Institute of Technology is a respected university and we're pleased that they feel the same about SFBU. We look forward to a long and successful relationship with NIT, sharing scientific learning materials, expertise, and academic knowledge."

Please contact [emailprotected]for additional information.

SFBU is a premier WASC/WSCUC-accredited, nonprofit university located in the San Francisco Bay Area/Silicon Valley. SFBU offers degree programs in computer science, engineering, technology, and management. Learn more at http://www.SFBU.edu.

SOURCE San Francisco Bay University

Originally posted here:

Nanchang Institute of Technology and San Francisco Bay University Sign Cooperation Agreement - PR Newswire

ReportLinker

Therapeutic Respiratory Devices Market Research Report by Product Type (Capnographs, Gas Analyzers, and Humidifiers), Technology, Application, End-Use, Region (Americas, Asia-Pacific, and Europe, Middle East & Africa) - Global Forecast to 2027 - Cumulative Impact of COVID-19

New York, June 20, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Therapeutic Respiratory Devices Market Research Report by Product Type, Technology, Application, End-Use, Region - Global Forecast to 2027 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p06287091/?utm_source=GNW

The Global Therapeutic Respiratory Devices Market size was estimated at USD 13.98 billion in 2021 and expected to reach USD 16.07 billion in 2022, and is projected to grow at a CAGR 15.22% to reach USD 32.72 billion by 2027.

Market Statistics:The report provides market sizing and forecast across five major currencies - USD, EUR, JPY, GBP, AUD, CAD, and CHF. It helps organization leaders make better decisions when currency exchange data is readily available. In this report, the years 2019 and 2020 are considered historical years, 2021 as the base year, 2022 as the estimated year, and years from 2023 to 2027 are considered the forecast period.

Market Segmentation & Coverage:This research report categorizes the Therapeutic Respiratory Devices to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Product Type, the market was studied across Capnographs, Gas Analyzers, Humidifiers, Nebulizers, Oxygen Concentrators, Positive Airway Pressure Devices, and Ventilators. The Humidifiers is further studied across Built-In Humidifiers, Heated Humidifiers, Integrated Humidifiers, Passover Humidifiers, and Stand-Alone Humidifiers. The Nebulizers is further studied across Compressor-Based Nebulizers, Piston-Based Hand-Held Nebulizers, and Ultrasonic Nebulizers. The Oxygen Concentrators is further studied across Fixed Oxygen Concentrators and Portable Oxygen Concentrators. The Positive Airway Pressure Devices is further studied across Auto-Titrating Positive Airway Pressure Devices, Bi-Level Positive Airway Pressure Devices, and Continuous Positive Airway Pressure Devices. The Ventilators is further studied across Adult Ventilators and Neonatal Ventilators.

Based on Technology, the market was studied across Electrostatic filtration, HEPA filter technology, Hollow fiber filtration, and Microsphere Separation.

Based on Application, the market was studied across Asthma, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Obstructive Sleep Apnea, and Respiratory Distress Syndrome.

Based on End-Use, the market was studied across Emergency Centers, Homecare Settings, and Hospital.

Based on Region, the market was studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas is further studied across Argentina, Brazil, Canada, Mexico, and United States. The United States is further studied across California, Florida, Illinois, New York, Ohio, Pennsylvania, and Texas. The Asia-Pacific is further studied across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Taiwan, and Thailand. The Europe, Middle East & Africa is further studied across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, and the long-term effects are projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlying COVID-19 issues and potential paths forward. The report delivers insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecasts, considering the COVID-19 impact on the market.

Cumulative Impact of 2022 Russia Ukraine Conflict:We continuously monitor and update reports on political and economic uncertainty due to the Russian invasion of Ukraine. Negative impacts are significantly foreseen globally, especially across Eastern Europe, European Union, Eastern & Central Asia, and the United States. This contention has severely affected lives and livelihoods and represents far-reaching disruptions in trade dynamics. The potential effects of ongoing war and uncertainty in Eastern Europe are expected to have an adverse impact on the world economy, with especially long-term harsh effects on Russia.This report uncovers the impact of demand & supply, pricing variants, strategic uptake of vendors, and recommendations for Therapeutic Respiratory Devices market considering the current update on the conflict and its global response.

Competitive Strategic Window:The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies to help the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. It describes the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth during a forecast period.

FPNV Positioning Matrix:The FPNV Positioning Matrix evaluates and categorizes the vendors in the Therapeutic Respiratory Devices Market based on Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Market Share Analysis:The Market Share Analysis offers the analysis of vendors considering their contribution to the overall market. It provides the idea of its revenue generation into the overall market compared to other vendors in the space. It provides insights into how vendors are performing in terms of revenue generation and customer base compared to others. Knowing market share offers an idea of the size and competitiveness of the vendors for the base year. It reveals the market characteristics in terms of accumulation, fragmentation, dominance, and amalgamation traits.

Competitive Scenario:The Competitive Scenario provides an outlook analysis of the various business growth strategies adopted by the vendors. The news covered in this section deliver valuable thoughts at the different stage while keeping up-to-date with the business and engage stakeholders in the economic debate. The competitive scenario represents press releases or news of the companies categorized into Merger & Acquisition, Agreement, Collaboration, & Partnership, New Product Launch & Enhancement, Investment & Funding, and Award, Recognition, & Expansion. All the news collected help vendor to understand the gaps in the marketplace and competitors strength and weakness thereby, providing insights to enhance product and service.

Company Usability Profiles:The report profoundly explores the recent significant developments by the leading vendors and innovation profiles in the Global Therapeutic Respiratory Devices Market, including Becton, Dickinson and Company, BMC Medical Co., Ltd., CAIRE Inc., Chart Industries, Inc., Compumedics Limited., Drgerwerk AG & Co. KGaA, Fisher & Paykel Healthcare Limited, GE Healthcare, Hamilton Medical AG, ICU Medical, Inc., Inogen, Inc., Invacare Corporation, Koninklijke Philips N.V., Medtronic PLC, Nidek Medical Products, Inc, Nihon Kohden Corporation, Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Siemens Healthcare, Teleflex Incorporated, and Vyaire Medical, Inc..

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyze penetration across mature segments of the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, certification, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and breakthrough product developments

The report answers questions such as:1. What is the market size and forecast of the Global Therapeutic Respiratory Devices Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Therapeutic Respiratory Devices Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Therapeutic Respiratory Devices Market?4. What is the competitive strategic window for opportunities in the Global Therapeutic Respiratory Devices Market?5. What are the technology trends and regulatory frameworks in the Global Therapeutic Respiratory Devices Market?6. What is the market share of the leading vendors in the Global Therapeutic Respiratory Devices Market?7. What modes and strategic moves are considered suitable for entering the Global Therapeutic Respiratory Devices Market?Read the full report: https://www.reportlinker.com/p06287091/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Therapeutic Respiratory Devices Market Research Report by Product Type, Technology, Application, End-Use, Region - Global Forecast to 2027 -...

DUBLIN--(BUSINESS WIRE)--The "Energy-Based Therapeutics Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2022-2027" report has been added to ResearchAndMarkets.com's offering.

The global energy-based therapeutics market reached a value of US$ 6.6 Billion in 2021. Looking forward, the publisher expects the market to reach US$ 9.71 Billion by 2027, exhibiting a CAGR of 6.4% during 2022-2027.

Companies Mentioned

Keeping in mind the uncertainties of COVID-19, they are continuously tracking and evaluating the direct as well as the indirect influence of the pandemic on different end use sectors. These insights are included in the report as a major market contributor

Energy-based therapeutics are employed for the modification or destruction of tissues with the help of technologies such as microwave, thermal, hydro-mechanical, radiofrequency, cryotherapy, and ultrasound. These therapeutics are divided on the basis of clinical applications into general, ophthalmic and aesthetic surgeries.

General surgeries include lithotripsy, gynecology, ENT microsurgery and surgery for cardiovascular diseases. Ophthalmic surgeries are often done for diseases like glaucoma and cataract. Aesthetic surgeries can be both invasive and non-invasive in nature and aid in reducing scars, acne, sun damage, pigmentation, redness and vascular lesions

Breakthroughs in the field of aesthetic medicine have led to an increase in the adoption of energy-based aesthetic surgeries, especially for anti-aging treatments. Along with this, there has been a shift from invasive to non-invasive aesthetic procedures on a global level, owing to the affordability and efficacy of these therapies.

Similarly, the increasing popularity of minimally invasive surgeries for the treatment of diseases like cardiac arrhythmias and cancer tumors, along with the benefits associated with these procedures like reduced complications, are creating a positive outlook for the global energy-based therapeutics market.

Apart from this, the rising trend of physician-owned ambulatory surgical centers, also known as ASCs, is another key factor which is driving the market growth. Since most energy-based therapeutic procedures do not require hospital stays, surgeons across the world have started performing these therapies in their own clinics.

Key Questions Answered in This Report:

Key Topics Covered:

1 Preface

2 Scope and Methodology

3 Executive Summary

4 Introduction

4.1 Overview

4.2 Key Industry Trends

5 Global Energy-Based Therapeutics Market

5.1 Market Overview

5.2 Market Performance

5.3 Impact of COVID-19

5.4 Market Breakup by Technology Type

5.5 Market Breakup by Clinical Application

5.6 Market Breakup by End-User

5.7 Market Breakup by Region

5.8 Market Forecast

6 Market Breakup by Technology Type

7 Market Breakup by Clinical Application

8 Market Breakup by End-User

9 Market Breakup by Region

10 Global Energy-Based Therapeutics Industry: SWOT Analysis

11 Global Energy-Based Therapeutics Industry: Value Chain Analysis

12 Global Energy-Based Therapeutics Industry: Porters Five Forces Analysis

13 Global Energy-Based Therapeutics Industry: Price Analysis

14 Competitive Landscape

14.1 Market Structure

14.2 Key Players

14.3 Profiles of Key Players

For more information about this report visit https://www.researchandmarkets.com/r/k83kji

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Insights on the Energy-Based Therapeutics Global Market to 2027 - by Technology Type, Clinical Application, End-user and Region -...