Category Archives: Psychedelics

Psilocybin was shunned by mainstream society in the 1960s as "Substance 1" dangerous and of no medical use. And for decades, evidence suggesting that psilocybin could be therapeutic lay buried in books. But over the past decade, a resurgence in psychedelic research has yielded new insights, with some labs running human trials.

David Nutt calls it the "brave new world of psychedelic psychiatry." Nutt is a neuro-psycho-pharmacologist and professor at Imperial College London. He suggests psychiatry is slowly emerging from a 30-year dark age, during which anti-depressants were the only accepted medicinal treatment for mental health conditions.

Apart from being costly, Nutt says anti-depressants help only a small percentage of the people who take them. Side effects can include a blunting of the emotions.

"I like to think of it as a force field," says Nutt. "They protect you. They cocoon you from the stresses of life, which are many and repeated, and they allow your brain to heal."

But the effects only last as long as you take anti-depressants. When you come off them, you can experience severe withdrawal symptoms. And perhaps more importantly, anti-depressants do not deal with the root cause of depression or anxiety, says Nutt.

Meanwhile, psilocybin appears to offer a different and longer-lasting alternative.

Nutt and his team of researchers have been concluding a second human trial of psilocybin to treat depression.

Read more:Coronavirus and mental health: 'We are not made for social isolation'

Neuropsychopharmacologist David Nutt warns of severe withdrawal symptoms of anti-depressants.

Controlling the trip

Volunteers with moderate to severe depression are given a 25 milligram (0.000881849 ounce) pill of psilocybin. That's a macrodose which causes a powerful, deep "trip" for about four hours.

But it's not like hippies tripping in a field. The tests are done in a controlled environment, with two therapists assigned to each volunteer.

"Depressed people having a trip aren't having fun," says Nutt. "They are often going back to the most horrible experiences of their lives and reliving things which they've often forgotten but which are causing the depression."

The therapists prepare the volunteers for what they might experience. They hold the volunteers' hands during the test to provide a sense of security. And after the trip, the therapists help the volunteers make sense of the experience through psychotherapy.

"This is not something you just go and do outdoors by yourself," says Nutt. "This is serious medicine. This is powerful medicine."A glimpse of the first clinical trial at Imperial College London can be found in this youtube video:

Rapid and lasting effects

In one trial, 20 patients who had not responded to treatment for depression, were given two doses of psilocybin one week apart. Nutt's team found rapid and long-lasting improvements in the patients' health. None of the patients required traditional anti-depressants for the first five weeks after the tests. Six months later, they had follow-up tests that showed many of their symptoms had stayed away.

But there was no control groupno way to compare the results directly. A team under Robin Carhart-Harris at the Centre for Psychedelics Research in London is now running similar tests with such controls in place.

Patient testimonies, available online, report huge improvements in health. One patient, called Andy, says that all standard treatments had failed him. No therapy had helped him find an underlying cause for his depression. But he says psilocybin gave him a missing piece of the jigsaw puzzle. It was "the one that changed things."

Read more:Happiness, where are you?

Andy participated in the first ever clinical trial of psilocybin to treat depression

Science and society

It's been difficult for some health professionals and scientists to accept any therapeutic benefits of psilocybin despite the evidence.

For decades, doctors have told people how dangerous these drugs areand those dangers or risks are real when psychedelics are taken in uncontrolled, so-called "recreational," settings.

In controlled settings, however, psychedelics could offer patients, suffering from depression or addiction, treatments that work better for them than traditional anti-depressants, or plain will power.

"They should at least have the opportunity of treatments which might work for them," says Nutt. "To deny them that on the basis of some kind of moral philosophy against drugs is, I think, unethical."

Stephen Ross, a psychiatrist based in New York, has had to confront that belief himself. In his entire medical training at the University of California, Los Angeles, there was no mention of psychedelics.

Psilocybin in the active ingredient found inside magic mushrooms

Psychedelics buried deep in literature

Then in 2006, Ross heard about a conference, marking the 100th birthday of Albert Hofmann, a Swiss scientist who discovered lysergic acid diethylamide and synthesized psilocybin.

Ross was puzzled. "Why would anybody be celebrating the discovery of LSD? All I had heard about LSD from my training was that it was a bad, dangerous drug."

So, he started looking into the medical history and found a huge body of research hidden in plain sight. The 1950s, 60s and 70s were a rich time for psychedelic research. Among the reports Ross found, there was a strong focus on using LSD to treat alcoholism. As an addiction psychiatrist, Ross' curiosity was piqued.

But with LSD shunned as a Substance 1 drug, it was a struggle to get funding for research.

To increase his chances at success, Ross turned to psilocybin, a psychedelic that like LSD had been branded a Substance 1 drug, but it was one with "less cultural baggage." And he turned to a condition with less social stigma than depression or addiction: cancer.

Read more:Never tried LSD - the drug my father discovered

Stephen Ross is conducting clinical trials of psilocybin on terminal cancer patients.

Psilocybin and cancer

"Cancer is a very scary thing in any culture. Cancer patients start to have this existential distress, where they feel hopeless, that life is meaningless, pointless," says Ross, now associate professor at New York University's School of Medicine. "And there's no treatment for that kind of existential distress."

In 2016, Ross completed the first human trial with psilocybin to reduce depression and anxiety in 29 patients with terminal cancer.

He says that psilocybin helps people reconceptualize cancer as "a part of their life," rather than it being their whole life.

"A lot of patients come out of the experience and say that they connected to this profound sense of love or universal love or God's love, or that the feeling of love was profoundly healing to them," says Ross.

Read more:Differences in personality: What psychiatrists can learn from mice to treat depression

The spheres show connectivity inside a human brain.

Under the influence of a psychedelic drug like psilocybin, more and more neurons interact with each other. These neurons may not have been interacting before because the mind was in a rut or fixed pattern of thinking. Psychedelics add flexibility. A placebo is shown to compare how evident the effect is.

Careful, it's a new revolution

Psychedelics could also be used to treat other conditions, including anorexia, obsessive compulsive disorder, post-traumatic stress disorder and personality disorders.

But Ross says we still need to be careful with psychedelics. He says there may be a bias among researchersafter years of struggling to get psychedelic studies funded, combined with the excitement of new resultsto believe that psilocybin will cure everything.

Their work is finding a new audience and perhaps a new form of acceptance, with popular science books out on the shelves. But researchers say there is a lot more work to be done before psychedelics can be used in medicinal treatment.

"I'm not saying that psychedelics should be used clinically yet at all. We need more research," says Ross. And even then, psychedelic treatments may not be for everyone. Researchers warn against using psychedelic treatments with patients suffering a psychosis, or young people whose brains are still developing.

Link to the documentary:A New Understanding: The Science of Psilocybin

Read more:Instant gratification and the pursuit of perfection: Why our brains love Instagram

When done in moderation, endurance sports like jogging and cycling are ideal for fighting stress and its negative consequences. They help to decrease stress hormones while strengthening the heart and improving circulation. The endorphins released make you feel happier and more energetic. However competitive sports often do the contrary, as they create a new source of stress.

Relaxation therapies like Progressive Muscle Relaxation and Autogenic Training have scientifically-proven benefits. And many people swear by yoga and meditation. They all reduce muscle tension and agitation, making people more stress-resistant, relaxed and happy. These relaxation techniques can also provide emergency relief in acute stress situations.

Silence is an effective medicine in relieving stress. It calms frazzled nerves and helps the mind unwind. If there's a quiet room in your home, consciously spend 15 or 20 minutes there each day. Even bustling big cities have peaceful places of refuge -- like museums, libraries and churches. You just have to look for them!

Dutch researchers have discovered that green is a calming color that makes us happy. And it's been proven that people who have a garden or live by a park have better mental health and fewer circulatory problems than other city dwellers. So make sure to get out into nature, take a deep breath, and listen to the leaves rustling and the birds singing!

Regularly make time in your schedule for stress busters like jogging, Autogenic Training or a trip to the park. City dwellers in particular tend to fill up their free time with appointments and dinner engagements. So if you're feeling stressed, reduce your social engagements in favour of relaxation time.

Body and spirit both need time to regenerate. Spending the whole day sitting behind a desk can cause tense muscles and back pain, and cause the levels of stress hormones in your bloodstream to soar. Going for a brisk walk in the fresh air and stretching your muscles can help. And you'll return to your desk feeling calm and composed.

Most people get too little sleep. The amount you need varies from person to person, but make sure you give your body enough time to recharge! Sleep is also a natural stress reducer. When possible, sleep in a well-ventilated room that's free from disturbances -- including snoring bed partners!

See original here:

Psychedelic mushrooms for depression: 'This is the one that changed things' - DW (English)

While trying to understand what makes the psychedelic drug LSD work, Dr. Mattias Liechti, head of the Liechti Laboratory at the University of Basel Hospital, stumbled onto something unexpected. During his research, he found a substance that seemed to abort the hallucinogenic effects of LSD within 20 to 30 minutes.

MindMed, a pharmaceutical company focused on developing psychedelic drugs into medicines, has filed for a patent on the research in collaboration with the laboratory. The company plans to develop it into a drug that might help reduce the length of time people experience hallucinations on an LSD trip.

Mitigating LSDs effects is a real focus for MindMed as it continues to study ways in which the drug can be used as a treatment for mental health issues such as anxiety and attention deficit disorder. While it has shown promise in research, not everyone is comfortable with the reality-altering side effects of the drug. The main issue with using LSD to treat medical conditions is that its effects are prominent and they last a long time, anywhere from 12 to 18 hours.

If you can neutralize LSD, you potentially can help in emergency situations, says Scott Freeman, chief medical officer at MindMed. Our concern is: Can we make a better therapeutic experience?

Freeman says his company is exploring ways in which this LSD neutralizer might be used. It could become a drug that someone takes to end a trip in progress. Alternatively, MindMed may explore how the substance might be time-released within another drug. In many ways, the latter scenario would be preferable, because it allows the company to ensure the recipient is getting the best effects from the drug while mitigating potentially negative experiences. Such a drug could also deter abuse.

LSD is actually an amazing drug, says Freeman. The real issue with it is the abuse potential.

Freeman notes that LSD is one of the safest drugs out there from a physiological perspective. However, if you take a psychedelic dose, people have died through suicide, jumping in front of cars, jumping off bridges, he says. So there is a death toll from LSD, but its a psychiatric death toll, not physiological.

LSD was discovered in Switzerland, and the country has remained open to research related to the substance even after other countries have made the drug illegal. Dr. Liechtis work is focused on understanding the mechanisms of MDMA and LSD and the use of both substances in psychotherapy.

Early research shows that LSD may help alleviate symptoms of depression and anxiety, though more research still needs to be done. MindMed is hoping to contribute to that field as it works to bring psychedelics and versions of psychedelics with fewer side effects to market. Already, the company is planning to start safety trials on a variant of ibogaine, a psychedelic drug that has shown potential against addiction, in the second half of 2020.

Read the original:

MindMed wants to develop a drug to help end a bad LSD trip - Fast Company

If you have watched Adventure Time and Rick and Morty, youre pretty much prepared for The Midnight Gospel. The Netflix animated series by Adventure Time creators, comedian Duncan Trussell and animator Pendleton Ward is a sort of creative test for the limits of podcast-style narrations. But more importantly, it's a technicolour dream for stoners. The show revolves around spacecaster Clancey, who owns a malfunctioning multiverse simulator. With this device, he travels through several universes including versions of Earth to record material for his space-wide podcast (more like spacecast) in hopes of gaining subscribers. The Midnight Gospel holds with it the promise of trippy visuals to match with seemingly spontaneous conversations that go nowhere but wind up on innately profound subjects. Even non-stoners want that! When the trailer dropped it was met with expectations of a visual high.

The Midnight Gospel Trailer: A Trippy Escape For Adventure Time Fans

Did I mention that the multiverse simulator has a portal through which Clancy traverses across universes? He begins his travels by putting his head through a device which happens to look like a giant vagina, no big deal moving on. Cryptic as the trailer is, The Midnight Gospel is basically a mash-up of Duncan and Pendleton doing what they do best - Duncan, known for The Duncan Trussell Family Hour goes back to podcast conversations and Ward, to his inventive animation. The whole thing looks like improvised chats that are shot into space creating enough run-time for the most bizarre plots. Every episode begins with Clancy picking a universe and planet to land on, zeroing in on an interview subject and being launched into space. As the episodes play out the conversations with his subjects get progressively profound, weird but profound. It's practically a series of frank, real talks set on the backdrop of psychedelic visuals.

If you think the trailer was a bit much on the spectacles you aren't prepared for how many landscapes, characters, colours and details the show can pack in a single frame of 20+ minutes of binge-able episodes. It's almost exhausting how much your eyes are exposed to. But all that distraction is evenly matched with engaging dialogue. This works like a perfect blend of action-heavy scenes set on good music except the action scenes are the animation scenes and the music is the conversation. Clancy takes relatable questions to a cosmic level exploration of life, the universe and everything. And that's a trip you will want to take.

Disclaimer: This article contains partial spoilers of The Midnight Gospel. If you havent watched the first episode of the show, this is your chance to leave. Spoilers drop in 3... 2 1

More than anything, this show is about questions, questions that you and I have all the time, things you would discuss at a chill house party session while waiting for a high to hit or in complete sobriety. The first episode sees Clancy launched onto an Earth embroiled in a hilarious zombie apocalypse. Here, he talks to the President of the United States who is between shooting zombies and protecting the White House. Clancy tags along with a series of questions like - Should marijuana be legalised? What if a high-induced hallucination takes you lower? Are psychedelics even useful? What are the ambiguous feelings you have while meditating and what happens when you and follow them? All of this unsurmountable discussion takes place with a running narrative of zombies painting the town blood red. Thats not even it, there are moments that look totally random but create a plot full of survival and escape tropes. These are pretty serious themes for otherwise light conversations. The real high hits when the technicolour visions on-screen get down to play a representation of a high adding music to the mix (of course, psychedelic music plays a big role in the show). It will change your perception and leave you wondering long after the end credits which by the way are a spin on dialogue highlights of the episode.

In every episode, Clancy meets a new person or creature and they begin to look increasingly like a manifestation of his own inner thoughts and struggles. The further you move into run-time the more personal the conversations get. Every once in a while, the spacecaster will throw in his own experiences, some of which are really disturbing if you take the distractions of the colourful episodes away. The context of the narrations is a lot less trivial than the scenes make them out to be. This is where the show is at its most impactful height. In these moments you will find the serious parts of the language of the show right before it goes back to mindless details of mind-melting scenes.

Youll find that The Midnight Gospel comes with its own set of limitations. Viewers could find the overarching story monotonous pretty early into the 8-episode binge. You could also tire of the barrage of visuals. Or you could choose to get lost into them, somewhere in the multiverse, coming to terms with your own existentialism. Either way, this is a fun option for weird yet profound shows to escape into.

The Midnight Gospel is now available on Netflix.

Cover artwork: Bhavya Poonia/Mashable India

Go here to see the original:

Netflixs The Midnight Gospel Is a Profoundly Weird Psychedelic Trip You Want To Take - Mashable India

Hallucinogens have been used in religious ceremonies, mind control experiments, therapy

ANNIKA ZEIGLER

Use of hallucinogens can cause hallucinations within 20 to 90 minutes after ingestion. The trips can last from six to 12 hours.

For centuries, hallucinogens, also known as psychedelics, have been used by people in many cultures for religious rituals and recreation as well as by artists to spark creativity.

Kenneth Faunce, a WSU history clinical assistant professor who teaches classes on drugs and its history, said hallucinogens are a class of drugs that can cause hallucinations or sensations and images that seem real although they are not.

Experiences while under the influence of hallucinogens are commonly referred to as trips, he said. Trips can begin within 20 to 90 minutes of ingesting a hallucinogen and last for about six to 12 hours.

Faunce said the most remarkable potential benefit of hallucinogens is an ego death. This is an experience where people lose their sense of self-identity and, as a result, can relieve themselves of concerns like fear of death, addiction and anxiety.

In the past a lot of psychedelics was used in religious ceremonies, he said. It was considered opening your mind up for enlightenment and opening your mind up to visions from the spirits or the gods.

He said although hallucinogens remain illegal, they are being used in guided ceremonies, also called sessions, and are happening across the country.

The Native American church is allowed to use psychedelics because its considered part of a religious practice but only if you are a true member, said Faunce.

Government agencies like the CIA used synthetic hallucinogens to experiment with it for mind control, he said. The agencies thought if they dosed people with LSD, it would make them more pliable to answer questions or follow commands.

Faunce said Project MK-Ultra was a top-secret CIA project in which the agency conducted hundreds of experiments to assess the potential use of LSD and other drugs for mind control, information gathering and psychological torture.

People who have mental or emotional issues might try hallucinogens to alter their state of mind, Faunce said. Research has been conducted on hallucinogens to see whether they can be used as a form of therapy for some individuals.

Matthew, whose name has been changed for his protection, said he has used shrooms, which are also known as magic mushrooms or psychedelic mushrooms.

You have a three-hour long moment of profound clarity, where everything you dont know about yourself, and that you dont know about the world around you suddenly become perfectly clear, Matthew said.

Faunce said a bad hallucinogenic experience can result in a lost sense of reality and even long-term psychological trauma in very rare situations. This can happen in people using other drugs or with a history of mental health issues.

He said the stigmatization of psychedelics has lessened over time, but it still very much persists.

I think the science and the eroding of the cultural stigma of psychedelics goes hand in hand, Faunce said.

Read the rest here:

Professor describes uses and history of hallucinogens - The Daily Evergreen

Media Central Corp (CSE: FLYY) CEO Brian Kalish joined Steve Darling from Proactive Vancouver to discuss the company making a major move to cover two very big sectors, eGames and Psychedelics.

Kalish discusses just how big these two topics are and how they plan on providing coverage for them. Kalish also told Proactive about the big increase in readership for their publications during the worldwide pandemic.

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events

The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of Media Central Corporation named herein, including the promotion by the Company of Media Central Corporation in any Content on the Site, the...

Read the original:

Media Central moves to provide coverage on emerging Psychedelics and eGames sectors - Proactive Investors USA & Canada

After just a 15-minute experience with Soundself, people were reporting a unitive experience of consciousness with the same regularity that youd get with a psilocybin trip.

Thats Robin Arnott, the creator of a new video game named Soundself: A Technodelic.Calling it a video game might be a little derivative, actually, Arnott would prefer you call it a transformative gaming experience a suitable enough title for an idea that came to him one year at Burning Man.

History has seen its fair share of trippy video game moments, accidental or otherwise. Descending into the Lovecraftian horror of latter-halfBloodborne, accidentally inhaling half a hemp field in Far Cry 3, or experiencing game-coded psychosis inHellblade: Senuas Sacrificeare all moments made to disorientate or flat-out freak out the player, but whatSoundselfdoes is a little different.

After checking that your microphone works, the game starts you at the base of tree, looking upward to a night sky. Youre then invited to begin breathing, concentrating on the stillness of your body and the gaps between your breaths. To rise up the tree, you must sing out in long, constant tones; ohhmmm. And when you reach its canopy, the world explodes into a neon-coloured, swirling landscape of fractals, spirals, and sound.

Every noise you make, picked up via your microphone, is fed back to you with differing levels of distortion. Where other games for example voice-controlled Kinect commands in Mass Effect 3or movement recognition inJust Dance have tried to embrace the whole body as a sort of controller, none have really made the integration seamless. Thats whatSoundselfattempts, as Arnott tells us.

you look at most games you play and youre using your fingers. Youre either using a keyboard and mouse or a joystick or something, which means that the game is only really interfacing with your sense of agency, with that which youre trying to do. But its not listening to your heart, its not listening to your breath, its not getting to know you intimately, its getting to know you on a very mental level.

As a result, most games wind up being pretty disembodying. Youre not playing it with your whole body, youre not wholly in it, youre projecting an identity into it and youre experiencing a kind of disembodied fantasy.

How do I, instead of having a persons attention going outward, how do I draw their attention back inward? How do I give them something to do, but while Im doing that, nourish something deep within them? And we can use game design principles to give people really powerful transformative experiences, but theyre not I think when we see the purpose of our gaming as an escape, that really limits how much of ourselves we can bring into the experience.

The game draws its design principles from meditation and ceremony and quite obviously, psychedelic experiences. Soundselfis more like a guided meditation than any conventional video game, although the only actual guidancecomes at the start and end of each session.

Soundselfscreator is an experimental game designer who has been a longstanding speaker for mindfulness in games. In Arnotts words, his whole career has been looking at meditation and ceremony and mysticism through the lens of video games.

Which isnt an especially difficult connection to make; both gaming and meditation rely on a voluntary disconnection from the outside world and the immersion in an inner world, whether thats within yourself or written into a CD. To Arnott, the two practices are closer than most people realise.

A meditation is a game; if youre doing a breath meditation, youre playing a game. The game is Im going to bring my attention back to my breath when I notice my attention deviating. And when you play that game, it has the psychological effect just like if you play God of War or something like that itll have the psychological effect of increasing your cortisol levels and getting you amped up and excited.

Youll have these bouts of tension, release, tension, release, which can be pretty emotionally satisfying, sure, but theres certain predictable effects from playing a game like that. When you play a game of meditation, it has a certain predictable effect, which is that its going to disengage your mental narrative, its going to help you witness yourself, and its going to drop you into a state of stillness.

The idea for Soundself came to Arnott while he was mid-LSD trip at Burning Man; the annual Black Rock City festival known for its wild ideas and wilder inhabitants. Like most realisations that burn into ones mind during a psychedelic experience, it took some time to blossom thereafter:

I had my first oneness experience at Burning Man and it just it didnt leave me untouched, it didnt leave me the same. And a few months later, when I was remembering that experience, I had the insight that video games are very powerful, theyre very trance-inducing, they bring us to places especially with the advent of virtual reality they can teleport us, they can evoke incredible emotion in us.

And I had this insight that a video game could do for a person what meditation does, and do for a person what psychedelics do without needing to take the risk of taking psychedelics or without having to practice the discipline of meditation because a game could provide the interactive context that could lull your mind into a trance state.

For a video game to do what psychedelics can accomplish is a bold goal. Substances such as psilocybin, LSD, or DMT are repeatedly cited as being responsible for some of the most emotionally significant and spiritual experiences of users lives. To climb that mountain in 15 minutes, at face value, seems impossible.

When I playedSoundself, I chose a 20-minute session. The gameplay footage above doesnt quite do the immersive nature of the experience justice you do lose yourself within the halls of sound and colour; a hyper-digitised feedback loop that that invites you in and doesnt let go.

The experience was deeply relaxing and Ill definitely be back for another session, but it didnt boast the same arresting power as certain chemicals have for me in the past. That said, I was a sample size of one, and research conducted by the games creator has shown that yes, this game can take you to the same places psilocybin can.

I just had to do the research and so we started working with Dr. Jeff Tarrant, whos a real expert on EEG and meditation and he knows the signatures of those transcendent states like anyone. It was just a small study and what we found were really remarkable brainwave patterns, we found a big increase in high gamma which is one of the signatures of a psychedelic experience.

But also from the subjective questionnaires we found that people report unitive states of consciousness with and this is after just a 15-minute experience with Soundself people were reporting a unitive experience of consciousness with the same regularity that youd get with a psilocybin trip.

Whether or not youve experienced psychedelic substances, Soundselfis a game aimed at you. Its an excellent introduction to meditation for those whove long wanted to dip into that world, and its delivery in the video game format means itll likely inform a new audience to the benefits of these practices.

And hey, it might take you into an altered state that was previously only accessible through meditation training or eating up some magic mushrooms. The only way to find out is to turn on, tune in, drop out toSoundself: A Technodelic yourself.

Soundself: A Technodelicout now on PC, MAC and PC VR via Steam.

The rest is here:

This video game does the same things to your brain as magic mushrooms - Happy Mag

Infinite colors. Spaces wider than the mind can comprehend. This is where White Nights dwells. Eschewing the black metal which obviously inspires the project, the mystery person behind White Nights embraces the kaleidoscope, resulting in a psychedelic, droning, metallic experience. Listen to an exclusive stream of Into the Lap of the Ancient Mother below.

At times both harsh and soothing, this debut EP draws from a variety of influences, be it the droning, motorik nature of kraut rock, the darkness of deathrock, or the pummeling nature of black metal, yet it is neither. This is a truly creative, bizarre release which transcends genre. Read a brief interview with the mystery person behind White Nights below.

White Nights has elements from a variety of sources, the most of which is black metal. However, black metal can be strict about defining itself. Do you consider White Nights to be black metal? If not, what do you classify it as?

I would say the influence is obvious and inescapable considering our love of the satanic arts, but we are not a black metal band by any stretch of the imagination. In fact our full-length, if it ever comes out, has even less of that influence running through it overall. We try to not define or classify what we do. We feel that its best to leave that to people who actually care about such nonsense.

The album itself and the visual elements which accompany it are psychedelic in nature a kaleidoscope of colors and mushrooms adorn the presented artwork. Is this album meant to be accompanied with psychedelics?

Psychedelics are illegal not because a loving government is concerned that you may jump out of a third story window. Psychedelics are illegal because they dissolve opinion structures and culturally laid down models of behaviour and information processing. They open you up to the possibility that everything you know is wrong. Terence McKenna

The European pagan elements (Irminsul, for instance) clash with the more new-agey/Eastern psychedelia which paints the albums color palette. What spiritually inspired the creation of Into the Lap of the Ancient Mother?

The Yuga Cycle doctrine tells us that we are now living in the Kali Yuga; the age of darkness, when moral virtue and mental capabilities reach their lowest point in the cycle. The Indian epic The Mahabharata describes the Kali Yuga as the period when the World Soul is Black in hue; only one quarter of virtue remains, which slowly dwindles to zero at the end of the Kali Yuga. Men turn to wickedness; disease, lethargy, anger, natural calamities, anguish and fear of scarcity dominate. Penance, sacrifices and religious observances fall into disuse. All creatures degenerate. Change passes over all things, without exception. Bibhu Dev Misra

Brothers will fight and kill each other, sisters children will defile kinship. It is harsh in the world, whoredom rifean axe age, a sword ageshields are rivena wind age, a wolf agebefore the world goes headlong. No man will have mercy on another. Vlusp

The vocals which accompany the music are half-dictated and half-sung, which creates a harsh dichotomy when compared to the black metal roots to which the album clings. What led to the use of this vocal style?

The music is not black metal, so it made sense to also make the vocals, art, etc. of a similar nature. As I stated above, if we ever release our full-length, everything will continue to be a reflection of itself as it unfolds. Less of some, more of others or possibly nothing at all!

Into the Lap of the Ancient Mother releases April 24th viaIron Bonehead Productions.

Support Invisible Oranges on Patreon and check out our merch.

Read more here:

Inborn Psychedelia on White Nights' Into the Lap of the Ancient Mother - Invisible Oranges

Welcome to theCannabis Countdown. In this weeks rendition, well recap and countdown the top 10 Marijuana and Psychedelic Stock News stories for the week of March 30th April 5th, 2020.

Without further ado,lets get started.

*Yahoo Finance readers, please click here to view full article.

10. COVID-19 Forces Analysts to Reassess, 8 Pot Stocks with Recent Ratings and Price Target Updates

The COVID-19 Pandemic Has Changed the Game for Nearly Every Cannabis Company

In response to theCoronavirus, many analysts have updated their research on individualPot Stocksto factor in the virus impact. Heres a recap of the recent analyst activity including updated ratings and price targets.

READ FULL ANALYSTS UPDATES ARTICLE

9. Aurora Cannabis is a Piece of Crap, This Fund Manager Says

There Are Many Bargains Out There Right Now But Aurora Isnt One of Them, Says Brian Acker of Acker Finlay

Acker appeared (from home) on BNN Bloombergs Market Call program recently and fielded a call on onetime market darlingAurora Cannabis(NYSE: ACB). His answer to whether or not the beaten-down stock was a buy was a resounding no.

READ FULL AURORA CANNABIS ARTICLE

8. MindMed Acquires Exclusive License to Eight Clinical Trials of LSD

MindMed Partners with World-Leading Psychedelic Research Laboratory at University Hospital Basel

The multi-year deal givesMindMed (OTC: MMEDF)access to largest collection of clinical trials & knowhow for LSD psychedelic research including a Phase 2 clinical trial ofLSDfor the treatment of anxiety.

READ FULL MINDMED ARTICLE

7. NYSE Aims to Boot CannTrust After Concluding Cannabis Producer No Longer Suitable for Listing

NYSE Said it Reached its Decision After the CannTrust Obtained a Creditor Protection Order from the Ontario Superior Court of Justice

TheNew York Stock Exchanges (NYSE)regulatory enforcement arm has initiated the delisting process forCannTrust Holdings (NYSE: CTST)after concluding the Canadianlicensed producer (LP)is no longer suitable for listing.

READ FULL CANNTRUST ARTICLE

6. Pot Stocks Plunge After Another Round of Disappointing Earnings

Hexo Drops Over 20% After Large Write-Downs, Medipharm Notes Oversupply of Bulk Cannabis Hurt Prices

HEXO Corp. (NYSE: HEXO)ledCannabis Stocksdown this week after the company reportedEarningsthat were hit by huge write-downs.MediPharm Labs (OTCQX: MEDIF) fell as well after the company reported net income of $1.9 million versus a net loss of $3.5 million a year ago.Cronos Group (NASDAQ: CRON)also reported earnings this week.

READ FULL CANNABIS EARNINGS ARTICLE

5. Cronos Group Will Emerge from this Crisis, Raymond James Says

Raymond James analyst Rahul Sarugaser Reviewed Q4 Earnings from Canadian LP Cronos Group

In the analysts update to clients onCronos Group (NASDAQ: CRON), Sarugaser said the ho-hum earnings coupled with a hitch in the companys U.S. business are enough to trigger a target reduction, but that the stock is still looking attractive at these prices.

READ FULL CRONOS GROUP ARTICLE

4. Champignon Brands Bolsters Special Advisory Committee + SHRM Technical Breakout Chart Update

Champignon Brands Appoints Jay Kheita to the Companys Special Advisory Committee

Champignon Brands (OTC: SHRMF)announced that it appointed another essential member to its Special Advisory Committee. Mr. Kheita is a founder of AltMed Capital Corp, a leading CanadianPsychedelicmedicine clinic operator. Sincelast weeks technical breakout alert, shares ofSHRMhave surged as much as 77%.

READ FULL CHAMPIGNON BRANDS ARTICLE

3. Hollister Biosciences Closes Transformational Venom Extracts Acquisition, Psychedelics Deal Up Next

The Highly Accretive Acquisition Strengthens Hollisters Brand Portfolio While Expanding its Footprint Across Multiple States

Venom Extracts brings with it 2019 EBITDA of $2.5 million on revenue of $16.4 million, puttingHollister Biosciences(OTC: HSTRF)on the fast track to becoming a cannabis industry leader in 2020. In addition to becoming a leader in the cannabis sector, Hollister is diversifying into the highly promising world ofPsychedelics.

Story continues

READ FULL HOLLISTER ARTICLE

2. FDA Grants GW Pharma Priority Review for Cannabidiol Drug in Seizure Condition

This Status is Usually Granted to Therapeutics That Have the Potential to Treat an Illness That Doesnt Have an Existing Therapy

A drug fromGW Pharmaceuticals (NASDAQ: GWPH)targeting a cause of genetic epilepsy has received Priority Review status from the U.S. Food and Drug Administration.

READ FULL GW PHARMA ARTICLE

1. These 2 Companies Could Be Turning LSD, Magic Mushrooms, Ketamine and MDMA into the Next Blockbuster Drugs

Investors Who Missed the Last Bull Market in Weed Stocks or Got in Too Late Should Start Researching the Shroom Boom Immediately

Early cannabis investors and business minds are positioning themselves in the world of Psychedelic Medicine as the flow of smart money hits the market.Canopy Growth (NYSE: CGC)founderBruce Lintonand Billionaire Mr. WonderfulKevin OLearyfrom Shark Tank, are going all-in on what they think is a much bigger opportunity than the cannabis boom.

READ FULL SHROOM BOOM ARTICLE

Image byStephen VanHovefromPixabay

See more from Benzinga

2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Read the original here:

Cannabis Countdown: Top 10 Marijuana And Psychedelic Stock News Stories Of The Week - Yahoo Finance

New research shows that the active ingredient in hallucinogenic mushrooms, called psilocybin, could affect the brain long after it has left the users system.

To date, most studies of this type focused on the acute effects of psilocybin or how the brain functioned while under the influence of the drug. In this study, published in the journal Scientific Reports, researchers instead looked at the enduring effects of the drug.

According to Fredrick S. Barrett, an assistant professor at Johns Hopkins University School of Medicine, and one of the authors of the study:

Nearly all psychedelic imaging studies have been conducted during acute effects of psychedelic drugs. While acute effects of psychedelics on the brain are of course incredibly interesting, the enduring effects of psychedelic drugs on brain function have great untapped value in helping us to understand more about the brain, affect, and the treatment of psychiatric disorders

In the latest study, 12 volunteers received a single high dose of psilocybin, each undergoing tests the day before, one week later, and one month after administration. Volunteers were tasked with completing three different assessments meant to quantify their processing of emotional information (through facial cues, mostly) while researchers monitored and recorded brain activity using an MRI.

Its a small sample, and relied on a lot of self-reporting, but respondents claimed emotional distress was reduced in the week following psilocybin administration. It returned to baseline levels one month later.

Barrett and his team also observed a decrease in amygdala response to emotional information for one week after administration, though this to returned to baseline in the next test, one month later.

A single high dose of psilocybin, administered to properly screened individuals in a carefully controlled setting can have lasting positive effects on emotional functioning in healthy individuals, Barrett told PsyPost. These effects were reflected in transient changes in the function of brain regions that support emotional processing.

Psychedelics like psilocybin and DMT have long been a captivating subject for researchers. Earlier studies have shown promise in using psychedelic drugs to treat everything from posttraumatic stress disorder (PTSD) to depression andanxiety.

Whether Barretts study brings us a step closer to a natural solution to common mental health maladies remains to be seen, but if hes looking for subjects for a larger study I may know some people.

Read next: Facebook launches Tuned, a scrapbook messaging app just for couples (with iPhones)

Read our daily coverage on how the tech industry is responding to the coronavirus and subscribe to our weekly newsletter Coronavirus in Context.

For tips and tricks on working remotely, check out our Growth Quarters articles here or follow us on Twitter.

Read the original here:

Psychedelic mushrooms could affect the brain long after its active ingredient leaves the system - The Next Web

Psychedelic drugs could be commonly used to treat mental health patients in as little as half a decade, according to a leading expert in the field.

David Nutt, professor and neuropharmacologist at Imperial College London and former U.K. government drug adviser, told Newsweek he believes we are "less than five years" away from such drugs being given to patients.

Nutt made the forecast after co-authoring a commentary in the journal Cell, which explores the resurgence of research investigating the potential benefits of using drugs such as LSD and magic mushrooms in controlled medical settings to treat mental disorders like depression, anxiety and PTSD.

During the 1950s and 1960s, LSD was researched widely and considered a potential breakthrough drug by psychiatrists, according to the team, but work ground to a halt after such substances were taken recreationally and subsequently banned.

In the article, Nutt and colleagues argue that the war on drugs, which ended such research, was "one of the worst examples of censorship of human research in the history of science."

"In the past decade, research on these compounds has been re-established by a few groups around the world, culminating in new centers for psychedelic research at Imperial College London and Johns Hopkins University," they said.

For instance, after "battling" with regulators to use the schedule 1 drug psilocybin, the active ingredient in magic mushrooms, researchers found "remarkable" effects on patients who were given it alongside psychological support. Two experiences with the drug appeared to ease symptoms of depression in some people for weeks, and even years "positioning it as one of the most powerful therapeutics for treatment-resistant depression," the team wrote.

Nutt and colleagues will soon finish a trial comparing psilocybin with the antidepressant drug escitalopram on patients with depression.

The writers said psychedelics may have a profound effect on participants in such trials, as patients suffering from conditions like anxiety and depression often dwell too much on negative thoughts, such as their own failings, and the combination of these drugs and therapy sessions seem to break these cycles.

"Standard antidepressants protect against the stressors that lead to and perpetuate depression, but don't directly access and remedy underlying biopsychosocial causes," the team wrote.

"In contrast, psychedelic therapy harnesses a therapeutic window opened up by the brain via the effects of the drugs to facilitate insight and emotional release and, with psychotherapeutic support, a subsequent healthy revision of outlook and life-style."

However, more work is needed, they said, to explain the mechanism behind the effects of these drugs.

The writers also cast doubt on microdosing, where drugs are taken at small enough doses not to change a person's state in any conceivable way but which some claim can balance a person's mood. A study last year concluded there is no evidence to show the practice works. Nutt and colleagues questioned how, for instance, microdosing psilocybin three times a week could elicit the same effect as a "macrodose" used in trials where participants have experiences that are "variously called breakthrough, peak, or mystical."

Nutt and his co-authors also argued that regulators should consider rescheduling psychedelics drugs, particularly psilocybin, in order to make it easier for them to be studied by researchers.

"The resurrection of research into the neuroscience and therapeutic application of psychedelics represents one of the most important initiatives in psychiatry and brain science in recent decades," they wrote.

The team concluded: "What is now needed is a combined, multi-level, multidisciplinary program of research into the mechanisms underpinning" recent finding on psychedelics."

Ravi Das of the UCL Clinical Psychopharmacology Unit, who did not work on the commentary, told Newsweek: "I am in complete agreement with Professor Nutt that we need more robust research into whether these drugs are effective and particularly into how they produce beneficial changes."

Das said he agreed that it could be beneficial to reschedule certain psychedelics so they are easier to research and gather "proper empirical data" on.

"The way drugs are currently classified legally has little relation to their underlying pharmacology, toxicity, or potential for harm or benefit," said Das. "The psychedelic drugs Nutt reviews are far less toxic than alcohol and tobacco, for example, with much greater potential for benefit."

Asked how many years he predicts will pass before psychedelics are commonly used to treat patients, Das said: "Owing to the stagnation in psychiatry that Nutt and colleagues note in their review, research scientists and psychiatrists tend to get excited about new 'step-change' developments in treatment approaches."

Das said there was a tendency, particularly in private clinics in the U.S. to offer treatments too prematurely, before mechanisms are properly understood.

Read more

"I have no doubt that we will see private clinics offering such treatments in the next few years, albeit without a solid empirical grounding. Nutt and colleagues highlight the need for mechanistic research into these drugs and I think this is critical to ensuring they are used most effectively and safely in disorders where they are likely to have most benefit," said Das.

The take-home message for the general public is clear, according to Das and Nutt.

Nutt told Newsweek it is unsafe for the general public to experiment with psychedelic drugs at home, as the powerful therapies require trained medical supervision. Drugs like LSD, for instance, can trigger mental health problems, according to health officials.

Das said many people use psychedelics recreationally and do not experience the lasting, or "life-changing" insights some study participants report.

"There is therefore no guarantee that experimenting at home will have effects remotely like those seen in carefully controlled studies," he said. "Given that the leading researchers in the field still don't really understand how psychedelics work to improve mental health, those choosing to experiment at home would be truly 'flying blind'. As with all potential psychiatric treatments, potential psychedelic therapies should be overseen by a qualified healthcare professional."

Das concluded: "I do think there is real promise in psychedelic therapies and agree with Nutt et al's recommendations on almost all fronts.

"I would like to stress, however, that we're really still at the very early stages of this research and understanding how these drugs work. Whether they truly represent the 'revolution' in psychiatry some tout them to be still needs to be shown by research."

See the original post here:

We Could Be Taking Psychedelics to Help Treat Mental Illness in Just Five Years - Newsweek