Category Archives: Nootropics

Kin is part of a flourishing functional beverage category, often branded with gradient, pastel colors, 1970s nostalgia logos and no alcohol. Poppi, Ruby, Superfrau, Dune Glow Remedy, Droplet, Brighter, Evexia Kafe, Sunwink and De Soi, co-founded by Katy Perry, assert that their seltzers, juices and tonics can heal you from the inside out with prebiotics, mushrooms, apple cider vinegar, collagen, ginger, antioxidants, amino acids, nootropics and adaptogens, which is not an accepted scientific term, despite rampant use in the wellness and beverage industries. Some of these ingredients are longtime home remedies and supplements recommended by doctors; others, like adaptogens, are more dubious in their claims and may amount to little more than marketing.

In any case, the drinks are selling. What can they actually do for you?

Purported benefits include a balanced gut, a relaxed mind and brighter skin similar to the promises supplements and topical skin-care products have always made. The caveat: these drinks are not regulated by the F.D.A. and none of the effects have been backed up by regulatory or trade commissions.

When I go to Sephora, its all of these products offering me moisture and anti-aging benefits, and its the same things you see going down these beverage aisles, said Andrea Hernndez, a food and beverage forecaster and the founder of Snaxshot, a newsletter about trendy seltzers, canned wines, dips, cereals and more. These drinks are literally labeling beauty as a function.

And people will pay up for anything perceived as a shortcut to beauty or better health.

Sales of functional beverages increased by almost 16 percent between November 2020 and November 2021, according to Spins, a data firm. Its one of the fastest growing, nonalcoholic drink categories in the United States. Brands like Poppi and Ruby are sold at mainstream supermarkets like Whole Foods; Erewhon, the California market chain, is an investor in Barcode.

In early January, Ms. Perry introduced De Soi, her sparkling aperitif made with mind mellowing adaptogens. Barcode, originally developed for N.B.A. players by Mubarak Malik, fancies itself a better-for-you Gatorade with adaptogens; and Ghia, aperitifs and spritzes with nervines (herbs that purport to boost energy and alleviate stress), became an influencer favorite on Instagram. Droplet sells a three-can sampler of its sparkling adaptogen drinks, Pretty Balanced, Pretty Happy and Pretty Bright, for $20.

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Beverages With Benefits: Do They Really Work? OR Are Beauty Drinks Too Good to Be True? - The New York Times

Opinions expressed by Entrepreneur contributors are their own.

The coronavirus has fundamentally altered and elevated the health and wellness space in the last two years in ways that will continue to impact brands in 2022.

Faced with existential uncertainty and chronic stress, many people chose to focus on stabilizing their own health and wellness, taking active measures in order to reduce stress, improve sleep, and maintain both physical and mental health.

The demand for supplements skyrocketed, which makes sense. When reality feels out of control, consumers reach for products that help with mood, prevent illness and strengthen our systems for the challenges of uncertaintyand that demand is only predicted to grow.

Another by-product of the pandemic: Cannabis proved itself to be recession-proof, and millions of Americans found cannabinoids to be a key source of plant-derived stress relief. Mushrooms are having a moment as well (both psychedelic and otherwise), and their popularity further underscores the revived Western interest in ancient herbal medicine traditions and rising consumer appetite for plant-based alternatives to pharmaceutical drugs. Millennials and Gen Z are leading the charge in their openness to natural remedies and integrative healththeyre all about the ounce of prevention.

All of these developments are good news for consumers, brands, and investors in the supplement space as well as those in cannabis, hemp, and fungi. Here are the trends I see dominating markets in 2022.

Related:Here Are Some Smart Cannabis Predictions for 2022

Supplements that enhance cognitive performance are in higher demand than everafter all, who doesn't want a better brain? But increasingly, consumers are taking the long view, investing in supplements like pharmaceutical grade Omega-3s, CBD, herbs, and mushrooms with neuroprotective properties. Preserving brain function is top of mind for many older Americans; Gen Xers and millennials also want nootropics, but for different reasons. They seek natural brain boosters that will help them focus and increase their productivity without the unpleasant side effects of caffeine, sugar, or prescription medications.

Stress and upheaval of the pandemic have led people to place a higher priority on calm, clear thinking. The pandemic fundamentallyaltered our approach to mental healthmost of us found life tougher to navigate, and many people needed more support to cope with issues like fatigue and brain fog. No wonder nootropics that have been shown to reduce the impact of stress spiked in popularity.

The year 2022 may very well be fungis biggest year yet. Books like Michael Pollans How To Change Your Mind, the documentary Fantastic Fungi, and regular headlines on the genuinely thrilling new research emerging from the Johns Hopkins Psychedelic Research Unit have brought psychedelic exploration and therapeutics into the mainstream. Psychedelics are looking like the next big investor movementindeed, the psychedelic market is projected to reach $10.75 billion by 2027. At Fortune, investor Sean McClintock linked the rush to invest to the pandemic: In the context of a post-COVID world, psychedelic health care will become an essential tool in the treatment of worsening mental health issues.

Science is also revealing that even non-magic mushrooms have some pretty astounding qualities: from lion's mane and its impact on brain health, cordycepss immune system effects, and chagas anti-inflammatory properties, its no wonder a population newly interested in preventative health is seeking them out.

This seeming pipe dream of national cannabis legalization could actually become a reality in 2022. The first-ever Republican-proposed federal bill to legalize marijuana was introduced this past November; nearly half of the Republican voters support decriminalization at the federal level. A whopping 91% of Americans support legalization in some form. The DEA has signaled that Delta 8 (a controversial cannabinoid similar to THC thats usually derived from hemp) is not federally prohibited, which puts even more pressure on the federal government to act on legalization. A recent report from the Economic Policy Institute states frankly that Federal legalization of the cannabis industry appears likely to happen within the next few years. We may actually reach the tipping point for legalizing cannabis nationwide in the coming yearwhich would unleash a flood of change. New tax revenue alone is estimated at $128.8 billion, and legalization could result in 1.6 million new jobs. Research on cannabis therapeutics will explode. The economic impact will create disruption the likes of which Silicon Valley technologists could only dream of. Im keeping a close eye on this spaceanyone adjacent to health and wellness should do the same.

If weve learned anything in the pandemic, it's the need for resilience and the ability to adapt in the face of disruption and change. But consumers growing interest in natural and preventative health measures is, in my view, a positive development. Seeing health as a long-term commitment that involves daily choices, proactivity and self-care wont just drive marketsit will result in better health outcomes for everyone.

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3 Key Supplement and Wellness Trends to Watch in 2022 - Green Entrepreneur

Global Global Smart Drugs Market from 2021 to 2027 research provided by MarketsandResearch.biz provides an overview of the industry, including important insights, applications, and the industrial chain structure. It emphasises historical, present, and projected market size in terms of volume and value by focusing on the global and regional markets and providing an in-depth analysis of the markets overall growth prospects. It also includes a competitive analysis for the years 2021-2027.

It also includes information on the global market, such as the competitive landscape, development status, industry segments, and sub-segments that impact the current and future markets growth scenarios. The Smart Drugs study provides important market share and size analyses of the leading competitors based on revenue projections. Market dynamics and current market trends, as well as obstacles and Porters Five Forces, are all covered.

DOWNLOAD FREE SAMPLE REPORT: https://www.marketsandresearch.biz/sample-request/183360

Different sorts of industries have different global Smart Drugs segmentations. The research focuses on well-known suppliers in the Smart Drugs categories by applications, revenue, and market share by types in the global market.

Market Segmentation by Type:

Attention and Focus, Memory Enhancement, Mood and Depression, Sleep and Anxiety, Others

Market Segmentation by application:

Offline, Online

We have provided extensive competition analysis of the major competitors in order to give consumers with a full perspective of the industry:

Nootrobox, Cephalon, Purelife Bioscience, Peak Nootropics, Nootrico, SupNootropic Biological Technology, AlternaScript, Accelerated Intelligence, Onnit Labs, Powder City, Ceretropic, Nootropic Source, Clarity Nootropics

The leading players in the market are concentrating their efforts on expansion, mergers and acquisitions, and new product development. In Smart Drugs sales, product differentiation is also important.

ACCESS FULL REPORT: https://www.marketsandresearch.biz/report/183360/global-smart-drugs-market-2021-by-manufacturers-regions-type-and-application-forecast-to-2026

The report looks at the following regions:

North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia, Italy, and Rest of Europe), Asia-Pacific (China, Japan, Korea, India, Southeast Asia, and Australia), South America (Brazil, Argentina, Colombia, and Rest of South America), Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa, and Rest of Middle East & Africa)

The research study examines the Smart Drugs on a global and regional basis, including its size, share, trends, and growth.

Customization of the Report:

This report can be customized to meet the clients requirements. Please connect with our sales team (sales@marketsandresearch.biz), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

Contact UsMark StoneHead of Business DevelopmentPhone: +1-201-465-4211Email: sales@marketsandresearch.bizWeb: http://www.marketsandresearch.biz

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Global Smart Drugs Market 2021 Valuable Growth Prospects and Upcoming Trends till 2027 Discovery Sports Media - Discovery Sports Media

If you find it more challenging to concentrate than usual, some simple exercises and foods can help regain your focus.

Researchers have estimated that the average person will have over 6,000 thoughts per day. We must filter out most of this data to get anything done. If you have a task you need to complete, you must focus on that task and ignore any of these incoming thoughts.

Many people are having a challenging time focusing during the ongoing pandemic. However, according to Dr. Amishi Jha, a cognitive and behavioral neuroscience professor at the University of Miami, we can learn to focus better by training our brain as a muscle. Specifically with 3 to 12-minute bursts of daily exercises.

Dr. Jha highlights that stress is one of the biggest obstacles to focusing. In a high-alert state, we often start pondering and get stuck in loops of doom or imagined scenarios. In addition, this mode affects our working memory: the amount of information that our minds can hold and use for a task. Working memory is like a mental whiteboard with disappearing ink, explained Dr. Jha.

Once that whiteboard is filled with thoughts, feelings, and images relating to the root of our stress, theres no room for new data. We might start zoning out, blanking, or snapping at our loved ones, then feel guilty, which doesnt make focusing any easier it just makes it more challenging. Another issue is that we now have far more sources of distraction, like new apps, smartphones, and video games.

Short bursts of daily mindfulness training can help us notice the traffic of thoughts and urges that continuously distract us. One of these exercises involves sitting upright, closing your eyes, and focusing on where your breathing feels most prominent, typically in the chest or diaphragm. Direct your focus there like a beam of light and recognize when thoughts or sensations pull it away: a memory arising; a reminder that you need to reply to an email; an itch. Do this for 3 to 12 minutes every day, for one week.

While training your brain with simple daily exercises is very effective, some foods and beverages can also rejuvenate and boost the brain.

A pair of researchers discovered that a bioflavonoid called quercetin, found in pickled capers, can modulate proteins needed for bodily functions, including the heartbeat, brain, muscular contraction, thyroid, pancreas, and gastrointestinal tract.

Humans have used capers as traditional medicine for hundreds if not thousands of years. Scientists are studying them for their anti-cancer, anti-helminthic, anti-diabetic, and anti-inflammatory properties. Capers are the highest known natural source of quercetin, with a maximum concentration of 520 mg/100 g for canned capers and 323 mg/100 g quercetin for raw capers.

In a study published on July 8, 2020, in the journal Communications Biology, researchers from the Irvine School of Medicine at the University of California found that quercetin regulates potassium ion channels in the KCNQ gene family.

Potassium ion channels are incredibly influential in human health, and their malfunction is linked to many human diseases, such as epilepsy, cardiac arrhythmia, and diabetes.

The study revealed that quercetin regulates the KCNQ channels by modulating how they perceive electrical activity in the cell, suggesting an unexpected mechanism for capers therapeutic properties. Other quercetin-rich foods and quercetin-based nutritional supplements may also hold this mechanism.

An international group of scientists was inspired by the idea that mammals brain structure and function are likely shaped by evolving with exposure to particular diets. So, they conducted a study that focused on whether bioactive factors (natural compounds) found in apples directly affect hippocampal neurogenesis (the production of new brain cells) in the adult mouse.

The team led by Tara Louise Walker from the University of Queensland and Gerd Kempermann from the German Center for Neurodegenerative Diseases found that high concentrations of phytonutrients from apples could help boost brain function (learning and memory) by stimulating neurogenesis.

Phytonutrients are chemical substances in plants known to affect the body, including the brain, positively. Examples of phytonutrients include epigallocatechin-3-gallate (EGCG) in green tea and resveratrol in red grapes skin, which is linked to a reduced risk of age-related conditions such as cancer, diabetes, and heart disease.

The researchers found that its the quercetin (a flavonol in apple peel) and 3,5-dihydroxybenzoic acid found in apple flesh that does the work. The team used lab-grown stem cells from adult mouse brains. They added the phytonutrients commonly found in apples to the cell cultures. The brain cells were protected from death and generated more neurons when exposed to quercetin or dihydroxy benzoic acid (DHBA).

Further experiments with mice showed that stem cells multiplied and produced more neurons in distinct brain structures associated with memory and learning when the animals were given high doses of quercetin or DHBA. The effects were comparable to those experienced after physical exercise, an established stimulus for neurogenesis.

This studys takeaway is that natural compounds in the fruit, especially quercetin and DHBA, could promote better brain function when given high concentrations. However, further analysis is needed to prove if phytonutrients can enhance learning and cognitive function.

A 2019 study led by researchers from the National University of Singapore (NUS), in collaboration with researchers from the University of Essex and University of Cambridge, found that regular tea drinkers have better-organized brain regions than non-tea drinkers. Having the cells in your brain more organized is associated with healthy cognitive function. The team made this discovery by examining neuroimaging data of 36 older adults.

Kin is an alternative non-alcoholic euphoric beverage brand that makes drinks designed for social drinkers. Euphoric beverages are engineered with natural chemicals to give you various euphoric sensations and increase your conscious connection with others. So, with Kin, you can maintain the treasured rituals of alcohol, minus its downsides.

Combined, adaptogens, nootropics, and Botanics grant you various pleasant sensations, allowing you to indulge in lush, more rewarding socializing. You get a boost to your mood and feel good the next day! You wont get drunk, but you will feel warm, focused, and have a better sense of connection with others.

Each individual will experience the effects differently because the herbs react to your body chemistry, creating a plethora of possible feelings from person to person. Some report a relaxing, calm sensation, while others euphoric joy. And the cognitive brain boost can make the drink a valuable aid in your daily routine.

There are three Kin euphoric choices Kin Spritz, High Rhode, and Dream Light each with unique benefits and flavors. Kin High Rhode is an herbaceous euphoric thats designed as a mixer with mood-heightening effects that can boost your brainpower.

Integrating a combination of these daily brain exercises and brain-boosting foods may be a game-changer for your productivity.

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How To Clear Your Frazzled Brain and Regain Your Focus - Intelligent Living

SALT LAKE CITY, Jan. 20, 2022 (GLOBE NEWSWIRE) -- LifeVantage Corporation (Nasdaq:LFVN) announced today that it will release financial results for its second quarter ended December 31, 2021, after the stock market closes on Tuesday, February 1, 2022. The Company will hold a conference call for investors at 2:30 p.m. Mountain Time (4:30 p.m. Eastern Time) that same day.

Investors interested in participating in the live call can dial (877) 705-6003 from the U.S. or international callers can dial (201) 493-6725. A telephone replay will be available approximately two hours after the call concludes and will be available through Tuesday, February 8, 2022, by dialing (844) 512-2921 from the U.S. and entering confirmation code 13726365, or (412) 317-6671 from international locations, and entering the confirmation code.

There will also be a simultaneous, live webcast available on the Investor Relations section of the Company's web site at https://lifevantage.gcs-web.com/events-and-presentations or directly here. The webcast will be archived for approximately 30 days.

About LifeVantage Corporation

LifeVantage Corporation (Nasdaq: LFVN) is a pioneer in nutrigenomics, the study of how nutrition and naturally occurring compounds affect human genes to support good health. The Company engages in the identification, research, development, formulation and sale of advanced nutrigenomic activators, dietary supplements, nootropics, pre- and pro-biotics, weight management, skin and hair care, bath & body, and targeted relief products. The Company’s line of scientifically-validated dietary supplements includes its flagship Protandim® family of products, LifeVantage® Omega+, ProBio, and Daily Wellness dietary supplements, TrueScience® is the Company's line of skin, hair, bath & body, and targeted relief products. The Company also markets and sells Petandim®, its companion pet supplement formulated to combat oxidative stress in dogs, Axio® its nootropic energy drink mixes, and PhysIQ, its smart weight management system. LifeVantage was founded in 2003 and is headquartered in Lehi, Utah. For more information, visit http://www.lifevantage.com.

Investor Relations Contact: Reed Anderson, ICR (646) 277-1260 reed.anderson@icrinc.com

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LifeVantage to Announce Second Quarter Fiscal Year 2022 Results on February 1, 2022 - Stockhouse

Supplements are not a replacement for food. Theyre an addition to your diet. Supplements can be used in many ways, whether its to provide certain nutrients that you may lack or just as a quick and easy way to get some extra calories if youre too busy or lazy to cook. Some people might also use supplements for weight loss purposes, but this is usually temporary because the body will eventually get used to them and stop responding so well. Ultimately, supplements should be taken with knowledge of their main benefits and how they work best.

Supplements are used to enhance ones diet by adding nutrients that may not be obtained through everyday food consumption. Supplements can also be used as a form of medication for those who cannot eat certain types of foods, such as people with allergies or celiac disease. They can also be taken to increase the effects of medications, improve athletic performance, and cognitive function. Most commonly people start using the best nootropics to help their cognitive functions when studying during college, and other supplements later in life. The smart drugs come in many different forms, but most commonly these include stimulants such as caffeine and Adderall that help improve focus and attention when studying or completing work.

Not everyone needs to take supplements. Some might think they need them when in fact their diet is providing them with the necessary nutrients or caloric intake that they need. People who work out regularly and exercise intensely will most likely go through an increased demand for energy and protein, which means theyre more likely to benefit from taking supplements. Other people might have a caloric deficit because of the amount of physical activity they do in a day, so they can take in more calories from supplements.

People who suffer from medical conditions may also take certain types of supplements to help manage their symptoms or prevent them from getting worse. Those with celiac disease or gluten intolerance will have to avoid gluten in their diet because it will cause a severe negative reaction. To ensure they dont accidentally consume something with gluten, some people might take supplements that contain all the necessary vitamins and minerals that their body needs.

There are several different types of supplements available for consumers, but they can be broken down into three main categories: vitamins, minerals, and macronutrients.

The first step to taking supplements is research. You need to know what youre putting into your body, so start by researching the different types of supplements available and their main benefits. Its also important to consult with a doctor before starting any supplement regimen since not everyone needs them and they may interact with other medications or medical conditions.

The next step is figuring out how much supplementation youll need to meet your goals this will depend on several factors including age, weight, fitness level, health problems, diet habits, etc. There are many calculators online for this purpose just be sure to fill in all fields accurately because some calculations use averages which may not work well for you. Finally, make sure that when youre purchasing the supplements you get a high-quality product that contains what it says it does. You would be surprised at how many products on the market dont live up to their manufacturers claims, so dealing with a reputable company is important when taking any type of supplement.

See the article here:

The Different Types Of Supplements And Their Main Benefits - Toys Matrix

TMZ may collect a share of sales or other compensation from links on this page.

Feeling run down lately? Could your brain use a boost? Are your thoughts not as clear as they used to be? You're not alone. But luckily, there's an energy drink that can help.

Qualia Nootropic Energy isn't like most energy drinks. Its the result of years of scientific research into the way the human brain functions ... and how to enhance those functions safely and effectively.

Qualia Nootropic Energy is made up of 12 precisely measured ingredients like EnXtra Alpinia galanga Root Extract, Cereboost ... and more. What this means for you is enhanced cognitive function, mood, and support for overall brain health.

You've probably heard of nootropics before -- they're chemical compounds consumed by the brain in order to perform all its different functions. In essence ... they're fuel for your noodle.

Qualia Nootropic Energy is made for optimizing brain health and also helps support muscle performance during exercise. Enhanced stress response, recall, and energy -- these are just some of the results you can get with Qualia Nootropic Energy. Try it today!

Prices subject to change.

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This Energy Drink Uses Nootropics To Give Your Brain The Boost It Needs - TMZ

Save up to 30% on supplements from Amazon today.

It's around this time of year that we start to flag and fade a bit: The vitamin D isn't quite as plentiful, we could all do with a bit of sun, and the cold temperatures are starting to sink into our bones. Luckily, you can save up to 30% off supplements from Amazon today for a little pick-me-up.

There's a ton of different vitamins on sale, including nootropics from Himalaya Organics ($13.43, was $14.45), which are supposed to help relieve mental fatigue and get your cognitive wheels turning a bit more easily.

Himalaya Organic Bacopa Monnieri / Brahmi, Nootropic Brain Supplement Booster, 750 mg, 60 Caplets

Himalaya

amazon.com

$13.43

There's also additions foryour smoothies or morning wellness routine, including combo Vitamin D3 and K2 drops ($15.27, was $19.99) and organic beet root powder ($9.59, was $12.89 who doesn't love staining things with fresh beet juice first thing in the morning?). And, if your weekend nights go a little too late, there's also antioxidant capsules for "a better tomorrow" (hey, 4.5 stars doesn't sound like a bad bet to us, especially at $14.39 instead of $18.32).

MAX Absorption, Vitamin D3 + K2 (MK-7) Liquid Drops with MCT Oil, Peppermint Flavor

SBR Nutrition

amazon.com

$19.99

Organic Beet Root Powder (1 lb) by Naturevibe Botanicals, Raw & Non-GMO

Naturevibe Botanicals

amazon.com

$9.59

PartySmart Provides Antioxidants 250 mg, 10 Capsules

Himalaya

amazon.com

$17.81

Shop the full sale over at Amazon before it ends today.

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Keep yourself healthy this winter with up to 30% off supplements from Amazon - SFGate

Methylene Blue boosts mitochondrial energy, is anti-aging, and improves mood and memory

Methylene Blue (methylthioninium chloride) is a synthetic compound used as a nootropic to increase memory, mood and longevity.

Soon after Methylene Blue was synthesized as a textile dye in the late 1800s, it became the first synthetic drug to be used in humans. It was used for the treatment of malaria.

In the early 20th century, psychiatrists were using Methylene Blue in the experimental treatment of schizophrenia.[i]

Methylene Blue is currently being studied as potential therapy for mild cognitive impairment, Alzheimers and Parkinsons disease, and other neurodegenerative disorders. All sharing a common problem with mitochondrial function.

Your brains neurons rely almost entirely on mitochondria-derived energy. Failure of mitochondrial function can affect the rest of your body. But its particularly detrimental to your brain.

This is where Methylene Blue steps in as possibly one of the most important anti-aging and neurological disease preventing nootropics we have available today.

As a nootropic, Methylene Blue quickly crosses the blood-brain barrier. It improves mitochondrial efficiency and respiration, acts as an antioxidant, and increases brain cell lifespan. Resulting in improved memory and mood.

Here well dive into over 140 years of research on how Methylene Blue helps your brain.

Methylene Blue helps:

Methylene Blue (methylthioninium chloride) was first synthesized in 1876 by German chemist Heinrich Caro at BASF as an aniline-based dye for cotton staining.

In 1891, German physician and Noble Prize recipient Paul Ehrlich pioneered the use of Methylene Blue for the treatment of malaria.[ii]

Ehrlich discovered that when MB was injected into animals in the lab, it would quickly concentrate in the brain. And had an uncanny ability to selectively target diseased tissues in the body.

It was Ehrlich who coined the term Magic Bullet for this unique action displayed by Methylene Blue. A term still in use today.

Methylene Blue has since been used to treat dementia, in cancer chemotherapy, malaria, methemoglobinemia, urinary tract infections, cyanide and carbon monoxide poisoning.[iii]

As a nootropic, Methylene Blue is used to enhance mitochondrial function, increase cerebral blood flow, and acts as an antidepressant.

Methylene Blue boosts brain health and function in several ways. But two in particular stand out.

Studies show dramatic increases of cellular oxygen consumption and glucose uptake when using Methylene Blue. MB increases CMRO2 (cerebral metabolic rate) through increased activity in the mitochondrial electron transport chain.

Methylene Blue functions as an alternative electron carrier in the electron transport chain in mitochondria. It accepts electrons from NADH and transfers them to cytochrome c.[iv]

Cytochrome complex (cytochrome c) is a component of the electron transport chain in mitochondria. Playing a role in apoptosis and as an antioxidant.

Methylene Blue also stimulates glucose metabolism. Taken together, increases in CMRO2 and glucose uptake means that MB elevates oxygen consumption which helps glucose increase ATP production.

Increases in ATP production provides more cellular energy for better overall brain function including cognition, mood and memory.

Methylene Blue binds to superoxide and reduces it to water. It stops the oxidative cascade at its very beginning. Before it gets a chance to do damage.[v]

So think of Methylene Blue as having a unique dual property. First, it increases cellular energy production which normally leads to oxidative stress. And second, it eliminates this oxidative stress. Making it a metabolic enhancer and an antioxidant.

Researchers tested Methylene Blue in animal models of neurological disease. First, researchers used rotenone (a potent pesticide) which causes severe dopamine depletion in the part of the brain associated with Parkinsons.

Methylene Blue rescued brain cell mitochondria from the damaging effects of this toxin. By donating electrons in the electron transport chain broken by rotenone. Essentially bypassing the broken transport chain with donated electrons as an alternative electron carrier.

Methylene Blue also countered cerebral ischemia reperfusion damage. The tissue damage caused when blood supply returns to tissue after a lack of oxygen from a stroke. And can occur with Traumatic Brain Injury. MB accomplished this by rerouting mitochondrial electron transfer.

And Methylene Blue dramatically countered the behavioral, neurochemical, and neuropathological impairment found in Parkinsons disease.[vi]

As we live life, our brain chemistry and metabolism changes.

Mitochondrial energy levels decline

Attention, memory and mental agility decline

Tau proteins and amyloid plaques clog the brain

Free radicals damage brain cell mitochondria

Cerebral blood flow declines

All of these changes can happen at any age. And are a product of the food we eat, what we drink, lifestyle habits, the air we breathe and more.

So Methylene Blue can help for age-related cognitive decline, as well as a student looking to do better in school. By boosting brain cell mitochondria energy production levels. And improving cerebral blood flow.

Low dose Methylene Blue supplementation provides memory enhancing effects in animals and humans. It works as an antidepressant, is anti-aging, helps dementia, Huntingtons and Alzheimers.

Methylene Blue increases low blood pressure, improves cognition in healthy people, boosts mitochondrial function, is anti-microbial, can help eliminate fear and even slow skin aging.

Research shows that Methylene Blue is anacetylcholinesterase inhibitor with a preference for muscarinic acetylcholine receptors. Meaning MB prevents the breakdown of acetylcholine and making more available in your brain.[vii]

Methylene Blue is a monoamine oxidase inhibitor (MAOI). It inhibits MAO-A more than MAO-B, but inhibits both at large doses.[viii]

One study in 1987 showed that 15 mg per day of Methylene Blue was a potent antidepressant in those with severe depression.[ix]

Another study with 31 Bipolar Disorder patients compared 300 mg per day of Methylene Blue with 15 mg per day. The patients were also on lithium treatment. The study showed that the 300 mg dose of Methylene Blue was a useful addition to lithium in the long-term treatment of manic-depressive psychosis. And patients were significantly less depressed.[x]

Alzheimers disease and other forms of dementia are associated with a buildup of the protein Tau. Clinical trials show that Methylene Blue inhibits Tau formation. And is under consideration as a treatment for Alzheimers.[xi]

Methylene Blue has an inhibitory action on the cGMP pathway, and affects other molecular events closely related to the progression of Alzheimers.

Methylene Blue boosts neuron resistance to the formation of amyloid plaques and neurofibrillary tangles. And helps repair impairments in mitochondrial function and cellular metabolism.

Research also shows that cholinergic, serotonergic and glutamatergic systems all play important roles in the development of Alzheimers and other cognitive disorders. Methylene Blue provides beneficial effects in mediating these pathways.[xii]

This is particularly significant because most existing treatments for Alzheimers can only prevent the disease before it is diagnosed. But Methylene Blue shows promise in delaying the effects of Alzheimers and dementia after it is diagnosed.

Research shows that Methylene Blue is an effective anti-aging nootropic. MB increases mitochondrial complex IV by 30%, enhances cellular oxygen consumption by 37-70%, increases heme synthesis, and reverses premature senescence caused by H2O2 or cadmium.

Methylene Blue is considered a redox agent. Meaning it cycles between oxidized and reduced forms. This cycling by MB helps block oxidant production in brain cell mitochondria.[xiii]

Mitochondrial complex IV is the last enzyme in the respiratory electron transport chain in mitochondria. The last step in synthesizing ATP. Your cellular source of energy.

Iron (heme) is an essential element and participates in oxygen transport, DNA synthesis and electron transport. Heme synthesis begins in mitochondria. Every cell requires heme to function properly.[xiv]

Senescence or biological aging is the gradual deterioration of cellular function. And is caused by telomere shortening that triggers DNA damage in response to reactive oxygen species, hydrogen peroxide (H2O2), cadmium and other toxins. Methylene Blue helps prevent premature senescence or premature cell death.

Animal studies have shown that a single low dose of Methylene Blue enhances long-term contextual memory. This type of memory is the conscious recall of the source and circumstances of a specific memory.

Other studies show that Methylene Blue in low doses taken after the event helps memory retention of the event. A study done with rats revealed why this works.

In this study, rats received 1 mg/kg of MB post-training for 3 days. The researchers then measured cytochrome c oxidation in participants brains. The idea was to determine if an increase in metabolic energy was behind the memory enhancing qualities of MB.

The study found that in the Methylene Blue treated group, brain cytochrome oxidase activity was 70% higher than in the placebo-treated group.

The findings suggest that repeated post-training supplementation of Methylene Blue improves memory consolidation. And this memory boost is due to the increased metabolic capacity in brain regions that require more energy during discrimination learning.[xv]

Methylene Blue as a nootropic will likely feel different than any other supplement youve ever tried.

When reading or studying, once youre done, you should feel like you fully understand the subject material. And youll be able to use what you learned in the future.

Methylene Blue seems to facilitate a full understanding of something on the first try.

Many neurohackers report the biggest nootropic effect they experience with Methylene Blue is after the fact learning. You take in the information. And its like your brain sorts through the material. Then stores it in a form you can easily access later.

Methylene Blue has this uncanny ability to rewire your brain to forget about any negative associations you have of a situation. And only retains the positive aspects of that memory.

Some report that Methylene Blue makes you feel young again. It eliminates social anxiety. Youll feel focused and more confident.

Workouts seem easier because you have more energy. Your mitochondria are energized. And you may find that recovery from workouts is easier.

Methylene Blue helps eliminate stress. So you have more energy in any situation with a relaxed state of mind.

And one recurring theme from many is improved sleep while using Methylene Blue.

Research into Methylene Blue for its therapeutic value goes back to the late 1800s. But its only in the last couple of decades that scientists have been able to decode exactly how Methylene Blue works in the brain. All the way down to the molecular level in mitochondria.

A study in 2017 found that Alzheimers Disease could be caused by more than the accumulation of amyloid beta in the brain. The scientists looked into the two main components that produce energy in cells.

The researchers found that as the brain ages, mitochondrial metabolism deteriorates. Resulting in a reduction in the molecules needed for energy production. And possibly the main culprit behind many neurological diseases including Alzheimers and Parkinsons.[xvi]

A study conducted at Childrens Hospital Oakland Research Institute may have found the solution to this mitochondrial energy problem in brain cells.

The researchers found that Methylene Blue can prevent or slow the decline of mitochondrial function.

One of the key aspects of Alzheimers is mitochondrial dysfunction. Specifically complex IV dysfunction. And this is where Methylene Blue steps in.

The study found that Methylene Blue enhances complex IV in mitochondria. It increases oxygen consumption. And it reverses premature cell death.

The researchers concluded that Methylene Blue may be useful to delay mitochondrial dysfunction with aging and the decrease in complex IV in Alzheimers disease.[xvii]

26 healthy volunteers aged 22 62 participated in a double-blind, randomized, placebo-controlled clinical trial. Purpose of the study was to measure the effects of Methylene Blue on working memory and sustained attention.

Study results showed that a single low-dose of Methylene Blue resulted in an increase in short-term memory ability. In an area of the brain associated with the senses and visual processing.

Timothy Duong, Ph.D., the study author concluded Methylene Blue showed promise in healthy aging, cognitive impairment, dementia and other conditions that might benefit from drug-induced memory enhancement.[xviii]

Another study published in the American Journal of Psychiatry tested fear extinction (elimination of fear) and contextual memory. Both are forms of long-term memory.

In this study, participants received either Methylene Blue or a placebo after being placed in a small dark chamber for a couple of minutes to address their fear.

One month later, participants that had used Methylene Blue had less retained fear than those given a placebo. The study authors concluded, Methylene Blue enhances memory and the retention of fear extinction.[xix]

Increasing evidence shows that Bipolar Disorder may be a progressive condition. Dealing with bipolar symptoms long-term can result in deterioration of the cortex and less gray matter.

A study at Dalhousie University in Halifax compared the effectiveness of lamotrigine (Lamictal) along with daily supplementation of either 195 mg or 15 mg of Methylene Blue in patients with Bipolar Disorder.

Patients took a dose (Lamictal and either 195 mg or 15 mg of Methylene Blue) for three months. Then switched to the other dose for 3 months. The team found that bipolar participants had reduced depression and anxiety when taking the higher dose of Methylene Blue compared to when they were on the lower dose.

Several Bipolar Disorder patients in the study chose to continue using Methylene Blue after the study concluded.[xx]

Recommended safe doses based on clinical studies with animals and humans ranges from 0.5 4 mg/kg. So a 90 kg (200 lb.) body weight translates to 45 360 mg of Methylene Blue.

45 mg of Methylene Blue is a safe starting dose. But 360 mg of MB is much too high in my opinion even if youre 200 lbs.

The bottom line is there is no true recommended dose for Methylene Blue. My recommendation is start with the lowest dose of 0.5 mg/kg and see how you react.

Methylene Blue is water-soluble so you dont need to take it with a meal, or healthy fat like some nootropics.

Methylene Blue has a half-life of about 5 hours. So you can dose twice a day.

Methylene Blue is famous for turning urine blue. But for most neurohackers, your urine will only stain blue at doses roughly exceeding 500 mcg. Some recommend preventing blue urine by mixing Methylene Blue with ascorbic acid for 3 hours before taking it.

Methylene Blue is also available as a doctor-administered injection for therapeutic use. Typically used to treat diseases like malaria or with anti-cancer therapy.

Methylene Blue shows a hormetic dose-response, with opposite effects at low and high doses.

In other words, lower doses of Methylene Blue work well as a nootropic. But high doses do not because MB can potentially steal electrons away from the electron transport chain. Disrupting the redox balance and acting as a pro-oxidant (instead of an antioxidant).[xxi]

Adverse effects of Methylene Blue also come from chemical impurity. Even pharmaceutical (USP) grade Methylene Blue can contain impurities like arsenic, aluminum, cadmium, mercury and lead.

At low doses, these contaminants are not that big of a problem. But higher doses will result in the accumulation of these toxins in your cells.

Side effects with Methylene Blue are rare when doses are under 2 mg/kg. But can include stomach pain, chest pain, dizziness, headache, sweating, confusion, high blood pressure, shortness of breath, accelerated heartbeat, tremor, skin turning blue, urine turning blue or green, reduction of red blood cells, or jaundice (only reported in infants).

Monoamine Oxidase (MAOI) inhibition becomes a big problem at around 2 mg/kg of Methylene Blue. So if you are using antidepressants or antianxiety medications that affect dopamine or serotonin, you should NOT use Methylene Blue. Because using Methylene Blue with one of these medications could cause a hypertensive crisis or Serotonin Syndrome.

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Methylene Blue Nootropics Expert

Alzheimers disease is a mental health issue that sets in mid 60s which leads to deterioration the memory and thinking skills. It accounts for 60 to 70% of dementia cases. Having to deal with difficulties relating to thinking, reasoning, remembering, and behaviour, life turns harder with time after the onset of Alzheimers disease.Also Read - Alzheimers Disease And Dementia: Causes, Symptoms, Diagnostic Tests And Treatment

Although there is no treatment for Alzheimers disease, medications help manage symptoms and cope with the disease. With nootropics being widely used in treating patients suffering from Alzheimers disease, the question is could consuming food that are natural nootropics help managing symptoms of Alzheimers disease. Nootropics are substances that have stimulant effects and help boosting brains performance which enhances memory. Also Read - World Alzheimer's Day 2021: From Weight Loss to Anger Issues - Major Symptoms You Should Know About

Certain types of mushrooms are natural nootropics that boost the brains functions when consumed. Lions Mane mushroom, Chaga mushroom and Cordyceps are popular super mushrooms that are widely used among health enthusiasts for strengthening the immune system and improving gut balance. Their nootropic benefits make them apt to be used to help managing symptoms of Alzheimers disease. Also Read - Alzheimers Likely Causes Identified Says Australian Researchers

The simplest way is to replace your regular coffee with mushroom coffee.

(Authored article by Rajat Bahl, Director at The Forest Superfood)

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Can Mushrooms Help in Managing Alzheimer's Disease? Here's What we Know - India.com