Category Archives: Life Extension

Doctor Kevin Cahill is one of the most highly regarded physicians in the US, a man who has treated popes and presidents and a hugely influential figure on humanitarian and refugee issues. In his latest book Labyrinths (Refuge Press New York) about his lifes work, he opens by discussing the powerful impact his Irish background and neighborhood had on his life decisions.

We are all influenced in infancy and childhood by genetics, by the mores and customs of family. In my instance, the story starts a generation before I was born, with all four grandparents emigrating from Ireland in poverty, but with dreams and determination. In those years they held a wake for the immigrant, as they might for the deceased, for when one left it was likely to be forever.

They survived in the new world by a basic system of mutual ethnic support, and by adhering to the universal code of the outsider in society. An old Irish relative, in his policemans uniform, warned me at the age of five, Never write what you can say, and never say it if you can nod your head. That was an immigrants way of avoiding conflict so that his children would have an education and a more secure life in America.

My fathers father came to the United States as a young man from rural County Kerry. He had listed himself on the ships roster as scholar. He came through Ellis Island, was befriended by his cousin, Denis, a policeman, and within a few years joined the NYPD. Gradually, through the mounted horse corps, and the street patrol, he became a Captain; he was NYPDs first Director of the Telegraph Center, proudly supervising a handful of Morse code operators in a single, sparse room. I have a picture of him in that room in my Fifth Avenue desk drawer, never forgetting from whence I sprung.

Read more: How an Irish American doctor changed forever the training of humanitarian workers

Ellis Island. Image: Library of Congress.

His wife died in the childbirth of their third child, Catherine; and he raised his sons, Dan and John, and their daughter with devotion and skill, factors not uncommon in the American Irish immigrant. Since his sons went to a Jesuit scholarship school, it seemed natural to him, though in retrospect it must have been inordinately rare, that he learn Latin and Greek in order to check their homework. He died of diabetes four years before I was born, but his influence remained strong in our family.

My fathers brother, Dan, had just become a practicing lawyer when the Great Depression hit America. My father had, simultaneously, begun medical school and could not afford the tuition (one of the framed items in my office is a 1930 bill from Georgetown Medical School: $350 for the semester with a $10 rental fee for a microscope). Dan gave up his legal career to become a public school teacher in order to secure a regular salary that could pay Dads way through medical school, an act my father never forgot.

My mothers father and mother lived long enough for me to remember them as much as a five-year-old can recall the smells of an old man and woman. They moved into a house on the same block as us in the Bronx in order to be near my fathers medical care. I recall little of this subdued, introspective couple. He was a bookie, a person who set odds and accepted bets on horse races. Years later, I was proud to know he was remembered at the Saratoga Race Track as Honest Mike.

Kevin Cahill and the President of Ireland Michael D Higgins presenting the Distinguished Services Award for the Irish Abroad at Aras An Uachtarain in Dublin this evening. Photo: Sam Boal /RollingNews.ie

My maternal grandmothers sister and brother-in-law both died of the Spanish Flu in 1919 leaving behind nine young children. Honest Mike adopted the family, raising them with his own eight children in a large house in Brooklyn. Those were pre-welfare days, and immigrants protected their own, out of love, loyalty, and necessity. They didnt expect praise, and probably didnt get much. They did whatever was required to keep the family together. All seventeen children graduated from college, no mean feat in any generation.

My earliest memories at about age four, of our home, are of a gentle, colorful, seemingly endless flowing pattern of almost predictable household tasks, affected by the seasons, the sea, and Celtic fairy tales. There were deeply ingrained, but not oppressive, religious traditions in our Irish Catholic home nightly prayers, Saturday confession, Sunday Communion, First Fridays, Ash Wednesdays, with the symbolic markings of burnt palms on the forehead, Lenten sacrifices, Easter, the birth of the Baby Jesus, Sodality, the family rosary disaster all gave a particular rhythm to the calendar year.

The family rosary was promoted by a cape-waving cleric on early TV under the adage the family that prays together stays together. This particular spiritual exercise quickly collapsed in the Cahill home. Trying to keep eight young children on their knees after dinner, repeating prayers and counting beads, was doomed when my fathers pants fell to his ankles as he rose to discipline an inattentive, playful boy.

Laughter and shared joy replaced the mournful, repetitive attempts to reach God in a structured and forced way. That scene became part of family tradition. It reinforced the constant paternal reminder that we should have a healthy skepticism for those with power or position, even for those wearing the cloth, and that we should be suspicious of those who believed there was only one way to achieve success, whatever that was.

He wisely advised us to beware of the people who genuflect too much, noting that the external trappings of religiosity rarely matched the necessary love and compassion promoted by Christ or Mohammed, Buddha or other spiritual leaders.

The subtle, steady, lasting forces of childhood noted above were captured by my father in the poetry of Latin and Greek masters as well as Irish bards, recited repeatedly at our kitchen table. Those early years of childhood and adolescence were a privileged period of protected discovery. We were happy and secure as part of a loving family. Particularly before the identity of each emerges, ones self seemed but an extension of an already existing organism.

Other organisms certainly flourished in our home. The oldest four children were boys, then came four girls. When we were young, we were told we would lose our essential oils if we took more than one hot bath a week. Even then we strongly suspected that the basis for this argument lay in the difficulty (and cost) of getting adequate hot water from the coal-fired heater. To make matters worse, all the boys had to use the same water; it was then changed for the girls. There must have been some deep and hidden Irish Catholic logic at play here.

When I was six, I firmly believed that the Nazis might well land on the beach at our summer home in New Jersey had not my brother John and I watched, carefully, from the upstairs window of a shingled house on a sand dune. We tried to identify the size and shape and sound of American planes so we could detect invaders, and looked for any strange new lights in the sky that might indicate danger. We could then shout to the Coast Guard warden protecting the shoreline on horseback all before falling asleep at 8 p.m.

The interaction of God and State during the war was made very real to me, as a six-year-old who gave up jelly as his penance for Lent. That innocent gesture of sacrifice became inextricably linked, and importantly, allowed me to be involved with the American battle against the evil Japanese and Nazi empires. Having given up jelly I started to substitute butter on my morning bread. But, as my parents quickly noted, I was, in a period of butter rationing, really contributing to the fascist forces in the deadly global struggle, somehow being partially waged at our breakfast table by dietary restrictions. How confusing warfare was; I was soon ordered to resume my morning jelly.

In the Bronx I contributed to winning the war by dutifully collecting tin cans and newspapers that we were told would somehow be transformed into tanks, an evolution I never understood and would repeatedly question. I was also in charge of growing radishes in our backyard Victory Garden. Radishes, I later learned, will grow anywhere and need almost no attention. But being young, and innocent, and very proud of the leafy blossoms above the soil and the bright red, hard bulbs beneath, I was glad to do my small part in the fight for freedom.

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How my Irish heritage shaped my lifes journey and dreams - IrishCentral

The lines are blurring, any which way you look. Thanks to the incredible pace of scientific progress, the very definition of what it means to be 'human' is becoming an increasingly open question.

In a world where living beings like genetically edited babies and human-animal hybrids are made to exist, the questions aren't only ethical, two biomedical experts argue in a new paper - they're legal, too.

The legal definition of what a 'human' being is has to adapt or expand somehow, they say, to recognise and protect whatever level of humanity, altered or otherwise, these lab-made life-forms actually possess.

"Bioscientific advances are nibbling away at classical legal boundaries that form the bedrock of the normative structures on which societies are based," authors Bartha Maria Knoppers and Henry Greely write in their new policy forum paper.

"Determining whether some 'thing' is now some 'one' carries with it profound implications for the rights and obligations the law recognises for 'humans'."

Knoppers and Greely two legal researchers who specialise in issues surrounding bioscience technologies say biotechnology advancements like revived brains being brought back to life from the dead, along with synthetic humans, chimeras, and the seemingly endless possibilities of CRISPR, all challenge existing legal definitions of 'human'.

The pair, who are respectively affiliated with McGill and Stanmore universities, say it's actually pretty hard to legally pin down what a human is, arguing that neither our genetic identity, species identity, nor 'neuro' identity (based on our brain and consciousness) can easily define us in ways that cannot be challenged, especially by new biotechnologies, which increasingly blur the lines even more.

But the solution, they write, it not to go back and seek to legally redefine what it means to be human, as such a course of action could potentially undermine the theoretical foundation of all human rights.

Rather, they suggest, we need to look at the level of substantiality in a being's right to be considered human analogous to the kinds of determinations we make when we recognise humanity in people every day, in more simpler circumstances.

"We care about living organisms that are human in their characteristics, but they do not always need to have exactly human characteristics," the pair writes.

"'Human beings' typically have two arms and two legs, but we recognise as human those without all those limbs, through amputation or congenital condition, as well as people with artificial limbs."

By an extension of that 'substantiality' metaphor, the researchers say we can identify humanity in tissue, where other forms of non-human tissue may be present, and in all other kinds of novel cases.

For that reason, if we retain our old understanding of what it means to be human but marry it to a legal concept of substantiality, we may be able to find a way of recognising humanity, to various levels, on a case by case basis.

It may not be a brilliant solution, the researchers acknowledge but it could give recognition and protection to life-forms in situations where, under traditional law, beings that are in fact 'substantially human' did not previously have any.

"Rules that include the word 'substantially' are never fully satisfying," Knoppers and Greely write.

"Nevertheless, in a Universe where things blend into each other and living organisms are not cleanly divided into Platonic natural kinds, they may be the best filter we can apply: a malleable term for contextual and proportionate evaluation."

The findings are reported in Science.

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It's Time to Expand Our Understanding of What a 'Human' Is, Biomedical Experts Warn - ScienceAlert

Fact.MRs report on Global Plant Hydrocolloids Market

A new report composed by Fact.MR, global plant hydrocolloid market will record a CAGR of 6.1% in terms of volume, between the forecast period 2017 and 2026. Sales of plant hydrocolloid around the world are poised to bring in nearly US$ 8,000 Mn in revenues by 2026-end. Plant hydrocolloid have been substantially utilized in pharmaceutical and food industries as an emulsifying, coating, gelling, stabilizing, and thickening agent. Plant hydrocolloid help in quality enhancements as well as shelf life extension in a wide variety of products. Inclination toward processed and convenience food has surged tremendously around the world over the past few years.

In a recent business intelligence study, Fact.MR presents the nitty-gritty of the global Plant Hydrocolloids market considering 2012-2016 as the historic year and 20172026 as the stipulated timeframe. The business report highlights the drivers, restraints, opportunities and trends affecting market growth. Further, all the market shares associated with the market as well as the segments are expressed in terms of value and volume.

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The Plant Hydrocolloids market study outlines the key regions North America, Latin America, Europe, South Asia, East Asia and Middle East & Africa along with the countries contributing the most in the respective regions. The report presents detailed insights about each market player, including SWOT analysis, main market information, market share, revenue, pricing and gross margin.

Prominent players covered in this research are CP Kelco, Cargill, Inc., Dow, FMC, Ashland Inc., E. I. du Pont de Nemours and Company, Rousselot S.A.S., Symrise AG, Furest Day Lawson Holdings Limited, Kerry Group Plc., Tate & Lyle PLC, Lonza Group Ltd., Dohler GmbH, and Sensient Technologies Corporation.

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Plant Hydrocolloids Market Expected to Grow at a Massive CAGR of over 6.7% by 2026 - News Cast Report

The Court of Appeal (CoA) has upheld a decision extending for ten years, rather than five, the bankruptcy of a property developer over serious failure to co-operate with his bankruptcy trustee.

Mr Justice George Birmingham, president of the CoA, found the extension of Patrick A Dalys bankruptcy was not so severe or disproportionate it should be set aside. He dismissed Mr Dalys appeal over the extension decision.

Mr Daly, formerly of Ballinagore House, Ballinagore, Co Westmeath, was declared bankrupt in 2015 having consented, along with his wife Ann, to a 4.4 million judgment against them in 2012.

He failed to co-operate with the official assignee in bankruptcy, including not filing a statement of affairs or personal information, until High Court proceedings seeking to extend his bankruptcy were brought against him in 2017.

Mr Daly and his wife had been involved in construction and property development over a number of years, operating through a number of companies.

They owned Ballinagore House, a company which owned an adjoining equestrian centre on 50 acres, and a Spanish holiday apartment.

Mr Justice Birmingham said that, by 2012, when they were seriously insolvent, Bank of Ireland, which had already sued them, threatened further proceedings. As a result, they entered into transactions concerning their assets including the sale of their home. While their home property was valued at 550,000, that was reduced to 100,000 because they retained rights of residence.

The house was sold to what the judge said was a friend and business associate of Mr Daly, Devon Anne McNeill, otherwise Devon Anne Ralls, who lived in America. A substantial interest in the equestrian centre was transferred to Mr Dalys brother Brendan through a company, Jalpa Properties. The Spanish apartment was also, in a share transfer deal, given to his brother apparently in payment for debts due to Brendan Daly.

Bank of Ireland, alongside all this, had brought proceedings seeking 4.4 million against Patrick A Daly and judgment was obtained on consent in 2012.

The official assignee alleged against Mr Daly he had failed to co-operate in the realisation of the assets of his estate or had hidden them from creditors.

The High Court ruled in 2018 Mr Daly had failed to do so and extended his bankruptcy by ten years. The High Court found, while Mr Daly had participated in an interview with the official assignee, he was not forthcoming particularly with regard to the involvement of his American associate, Ms McNeill/Ralls, in a Panamanian investment consortium.

In his appeal, Mr Dalys core claim was that the High Court lacked jurisdiction to extend by ten years when the official assignee had initially sought a five-year extension.

Mr Justice Birmingham said the High Court found Mr Dalys approach to his bankruptcy was obstructive. He had made life difficult for the official assignee, for example, in refusing to clarify whether Ms McNeill/Ralls was the same person who was involved in the Panamanian consortium, which Mr Daly was also involved in.

The High Court correctly concluded the non co-operation was at the serious end of the spectrum and a very significant extension was inevitable, he said.

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Appeal court upholds 10-year extension of developers bankruptcy - The Irish Times

Written by Dr Rakesh Sinha | Updated: December 24, 2019 12:29:46 pm In a democratic society, the formulation of a law apart from constitutional compatibility is expected to address two subjective issues. (Illustration: C R Sasikumar)

In a democratic society, the formulation of a law apart from constitutional compatibility is expected to address two subjective issues. The first is its social utility and the second, the moral consciousness of the people. It is in this context that the Citizenship Amendment Act (CAA) should be examined. Its critics assert that it betrays our commitment to secularism, the very foundation of the Constitution. Is this objection valid?

The idea of the CAA was mooted and finally given shape in law to protect people from religious persecution in three neighbouring countries Pakistan, Bangladesh and Afghanistan. All of them are Islamic states and the increasing radicalisation of society in these countries led to brute religious majoritarianism against minorities Hindus, Sikhs, Buddhists, Jains, Parsis and Christians. There has been consensus in India that such victims should be given dignity and protection. In fact, it constitutes a core ingredient of our social philosophy from time immemorial. Even before we framed our secular democratic Constitution, India provided shelter to people facing religious persecution. When Parsis and Jews faced threats to their right to worship and religious identity, they found dignity and space on our soil. According to the 1931 census, there were 1,09,752 Parsis and 24,000 Jews in India. Moreover, both these communities have shown little inclination to return to their respective nations. The CAA is consistent with this secular tradition of India.

The Indian state has never been antithetical to the cause of minorities in our neighbourhood, irrespective of the political party in power. Such victims have been accommodated during the Congress government in the past as well. Even the Left parties supported Indias active intervention to protect refugees from Bangladesh. The 20th party congress of the CPM in 2012 passed a resolution demanding an amendment in the Citizenship Act 2003 to give citizenship to Bengali refugees who were, according to the party, victims of historical circumstances. The unchecked atrocities on minorities in these states by fundamentalists, and the failure of the states to defeat such elements, gave rise to an abnormal situation.

There were over two lakh Hindus and Sikhs in Afghanistan before the 1990s. Their number has dwindled to a few hundred in the last three decades. Further, out of 64 temples and gurudwaras in the country, only three are functional.

The situation in Bangladesh is no less grim. The work of Abul Barkat of Dhaka University and statistics released by the Bangladesh Statistical Bureau revealed a situation beyond our imagination. Barkat, based on decades of research, establishes that 632 Hindus have gone missing everyday in Bangladesh since 1964 (East Pakistan till 1971). Both the sources confirm that no less than 11.1 million Hindus have gone missing in Bangladesh between 1964 and 2013. The Enemy Property Act was renamed as the Vested Property Act after the formation of Bangladesh. It affected more than 1.3 million Hindu households more than two lakh acres of land possessed by the Hindus was forcibly grabbed. The efforts of the state to safeguard Hindus remained abysmally ineffectual. In 2002, Bangladesh enacted the Vested Property (Return) Act and subsequently the Vested Property (Return) Amendment Act, 2011 with the intention to give back possession of their land to Hindus. But this was in vain.

The Jinnah Institute in Pakistan and other sources, including news reports in the international and national media, present a gloomy picture of the condition of Hindus and other religious minorities in that country. Attacks on the dignity of women, forcible conversions, grabbing of land and other properties of the Hindus and Christians have been a part of daily life.

It is thus urgent to address the existential threat to religious minorities in these three countries. And it is with this aim that the Narendra Modi government formulated the CAA. Contending that this humanitarian action is a betrayal of our commitment to secularism is a classic example of the peculiar absurdity of double think. The CAA is, rather, an extension of and commitment to the idea of secularism.

The Act also corrects the historical mistake committed in the Nehru-Liaquat pact. Then Prime Minister Jawaharlal Nehru had not engaged his cabinet colleagues and senior party leaders before signing the pact on February 8, 1950. The secular pretensions of Nehru, emanating from the Western variety of flawed modernity, led him to backtrack from the promises to the Hindus who lived in Pakistan. The Congress leadership had promised during Partition that their life and religion would not be in peril. The pact was a great retreat from that promise. Syama Prasad Mookerjee resigned from the Union cabinet on February 19, 1950, in protest against the Nehru-Liaquat Pact. A few months later, the world witnessed the protest by the Law Minister of Pakistan, J N Mandal, whose close friendship with M A Jinnah was well known. The undiminished atrocities on Hindus, particularly Scheduled Caste women, led him to resign from the government on April 29, 1950 and return to India. He wrote: I cannot bear the load of untruth and pretensions that Hindus live with honour and security of their life, religion and property in Pakistan.

On December 4, 1947, Mahatma Gandhi demanded that the Nehru government bring back Scheduled Castes from Pakistan due to the inhuman treatment meted out to them and their forced conversion. The CAA is a fulfilment of the historical responsibility to those people whom Partition made stateless. Indias secular democracy has historically been invested with moral force and this has been exhibited by the CAA. Earlier, governments used gradualism to provide protection to the Hindus and other minorities of these states. The Modi government has formalised the process to end the uncertainties and odds faced by these stateless and persecuted people.

In a democracy, dissent and doubts are important and logical dialogue is the only way to yield a constructive consensus. But the protests that emerged abruptly against the CAA seem to be explicitly driven by a prejudice against the government that it is pursuing Hindutva majoritarianism to exclude Muslims. This is based on an over-active imagination and conspiracy theories. How does giving humanitarian shelter to the victims affect Indian Muslims or any other citizen of India?

Importantly, Muslims in these countries do not face any crisis in pursuing their right to worship. India cannot meddle in the internal disputes among various sects of Islam, whether Ahmadiya or Shia or Sunni, who have been competing with each other for hegemony and over interpretations of the historical evolution of Islam. Religious persecution and aspiration for hegemony are two different things.

The concept of citizenship is not static or stagnant. It is a dynamic process and is intertwined with the nation state. It progressively expands and sometimes, unwillingly, shrinks according to circumstances.

There are two examples from our own historical experiences. Millions of Indians ceased to be citizens with the formation of Pakistan as fraternity mutated into unfriendliness between communities. The second example is reflected in a correspondence between two great Parsi leaders. Dadabhai Naoroji wrote the following to Dinshaw Wacha on December 20, 1888: We are Indias and India is our mother country and we can only sink and swim as Indians. If we break with it our fate will be that of a peacock feathers.

The CAA fulfils both the constitutional morality and civilisational ethos historically endowed to us. It is time for the Muslims to be part of this Indian tradition rather than being fed the delusion that the Modi government is anti-minority.

This article first appeared in the print edition on December 24, 2019 under the title A deluded dissent. The writer is a Rajya Sabha MP from the BJP

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Its critics want to deny space to the RSS. The Sangh wants to engage with all shades of political opinion and intellectuals and revive the

Dialogue with those he disagreed with, struggle for free India, marked his political life...

Anti-RSSism must not obscure that it is part of an organised smear campaign..

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Citizenship Act is an extension of and commitment to the idea of secularism - The Indian Express

Soy Extract Market: Snapshot

Soy extract is mainly produced from soyabean. High protein and low fat properties of soy makes it a healthy constitute of food. Soy helps in mitigating night sweats and hot flashes for women going through menopause. Moreover, people with lactose intolerance issues may use soymilk as a substitute to buffalo or cow milk.

Soy extracts are used for making many food products. Additionally, manufacturers are further discovering new applications for soy extracts in variety of food products. The increasing number of food products using soy extract is likely to bolster the growth of the globalsoy extract market. It is further found that usage of soy in cosmetics may help in acting as an anti-aging product for the skin. Aging causes skin to lose suppleness, elasticity, and firmness which, in turn triggers the occurrences of wrinkles and fine lines. Proteins and nutrients in soy extract make it a perfect solution for addressing aging skin and it has been used in China for producing anti-aging solutions for centuries now. Furthermore, anti-inflammatory and antioxidant properties of ginger help to reduce free radicals in the body.

Some new studies have stated that the health benefits of soy may be used to prevent or treat age-related diseases, osteoporosis, or even some types of cancers. However, it is very expensive and difficult to obtain the required amount of isoflavones and genistein from soy extracts. Soy extract also find applications in protein supplements attributing to its high protein content and other healthy vitamins. Some studies also claim that daily consumption of soy has increased the life of Asian people. The global soy extract market is poised to grow owing to all these applications and continuous research being conducted for discovering new medical abilities of soy extract.

Soy extract is obtained from soybean which is produced majorly in the United States during the year 2017-2017 according to SOPA. Soy extract is very beneficial for the women suffering from menopause as it helps in relieving the hot flashes and night sweats. Soy extract also helps to provide a relief to women who are expecting hormonal changes and provide nutritional support for healthy bones by inhibition of bone resorption. Soy has shown the super effect in Asian people who consume soy daily in their diet, it has increased the life of Asian people. Soy extract is perfect for people suffering from lactose intolerance as they can now have soymilk in place of traditional cow and buffalo milk.

Soybean production has increased by many folds according to the data provided by SOPA which is a clear indication that the demand for soy extract in the market is huge which a good news for the manufacturer is as strategies can be made to increase the revenues by the end of 2027. This market is expected to grow as more and more products enters the market.

Soy extract Market segmentation

Soy extract market is segmented on the basis of form as Beverages, Capsules, Crme, gel and powder. Soy extract is widely used as the ingredient for many products like it is used in the beverage industry for soy milk and soy drinks which are the nutritious and wonderful product for the people who are lactose intolerant. Soy extract capsules are available in the market which is very useful for women suffering from hot flashes due to menopause and are going through hormonal changes. Soy extract is also used in the cosmetic industry for making crme and gel for anti-ageing skin, to keep healthy and soft. Soy extract powder is used in protein supplements as soy is packed with high protein content and it is perfect protein supplement for vegans.

Soy extract market is segmented on the basis of application as in food market, pharmaceutical market, and cosmetics market. Soy extract has the wide range of application and can be used as the ingredient for the different-different market.

Soy extract regional outlook

Soy extract market is segmented in the key regions like North America, South America, Western Europe, Eastern Europe, Asia-Pacific region, Japan, Middle-east, and Africa. The United States is the leading producer of soybean globally since last 5 years, followed by Brazil, Argentina, Canada, Paraguay, Europe, China, and India.

Soy extract Market Drivers

Soy extract has the wide range of application in the different market, this ingredient is required in ample amount by the manufacturers to produce useful products for the end users. The end user product will shape the market of soy extract and will generate revenue for the manufactures of soy extract. Major driver of soy extract market is wide of products requiring this particular ingredient and the benefits linked with the consumption of soy extract by the end users. Soy contains 40% protein, 22% fat, 25% carbohydrates, and 8% fiber making it is demanded in the food, beverages, healthcare and cosmetic market.

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Soy extract market Restraints

Restraint for soy extract market is the risk factor involved in the consumption of soy extract. Phytates in soy extracts can down regulate the absorption of basic nutrients like zinc, calcium, magnesium and iron. Another concern with soy extract is that consumption of soy extract at the high rate by men can cause feminine characters in men. So if these factors are kept under control then soy extract can be boosted.

Soy extract market key players

The key players of soy extract market identified in this value chain are Natrol LLC, Beiersdorf Australia Limited, Novaforme, Alpro, WhiteWave Services Inc., and Life Extension. These players are making strategies to be on the top of Soy extract market by the end of 2027 and are forecasted to gain great revenues during the term of 2017-2027 keeping the high demand in mind.

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Soy extract Market- Forward-Looking Perspective on Different Factors Driving the Growth of the Industry - News Cast Report

Life insurance companies have been given a two-month extension to withdraw products and riders that are not in tandem with the new product regulations. This is a good news for policyholders as they would have no sudden dearth of products to choose from, while for insurers this means that they have more time to get products out of the market.

The Insurance Regulatory and Development Authority of India (IRDAI) had earlier asked insurers to withdraw products by November 30. But this deadline has now been extended to January 31, 2020.

IRDAI said that they had received representations from Life Insurance Council and various other life insurers, requesting for an extension of the timeline. Insurers had sought an extension citing reasons like the need to ensure system preparedness and necessary training of personnel.

However, the deadline to refile or modify existing products, which was fixed at February 29, 2020, will continue. This applies to products under the linked and non-liked insurance segment.

IRDAI said that the new guidelines with respect to benefit illustrations, periodic statements, agent training for unit-linked insurance plans will be applicable from February 1, 2020 as against the earlier December 1, 2019 deadline.

The regulator had said that the extension does not apply for products already approved under 'File & Use' under the new regulations. IRDAI has advised all life insurers to file these products as early as possible without waiting for the last date available. It also said that the no further requests for extension will be entertained.

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Life insurers get extension till January 2020 to withdraw old products - Moneycontrol.com

A thousand seemingly insignificant things change as an organism ages. Beyond the obvious signs like graying hair and memory problems are myriad shifts both subtler andmore consequential: Metabolic processes run less smoothly; neurons respond less swiftly; the replication of DNA grows faultier.

But while bodies mayseem to just gradually wear out, many researchers believe instead that aging is controlled at the cellular and biochemical level. They find evidence for this in the throngof biological mechanisms that are linked to aging but also conserved across species as distantly related as roundworms and humans. Whole subfields of research have grown up around biologists attempts to understand the relationships among the core genes involved in aging, which seem to connect highly disparate biological functions, like metabolism and perception. If scientists can pinpoint which of the changes in these processes induce aging, rather than result from it, it may be possible to intervene and extend the human life span.

So far, research has suggested that severely limiting calorie intake can have a beneficial effect, as can manipulating certain genes in laboratory animals. But recently in Nature, Bruce Yankner, a professor of genetics and neurology at Harvard Medical School, and his colleagues reported on a previously overlooked controller of life span: the activity level of neurons in the brain. In a series of experiments on roundworms, mice and human brain tissue, they found that a protein called REST, which controls the expression of many genes related to neural firing, also controls life span. They also showed that boosting the levels of the equivalent of REST in worms lengthens their lives by making their neurons fire more quietly and with more control. How exactly overexcitation of neurons might shorten life span remains to be seen, but the effect is real and its discovery suggests new avenues for understanding the aging process.

In the early days of the molecular study of aging, many people were skeptical that it was even worth looking into. Cynthia Kenyon, a pioneering researcher in this area at the University of California, San Francisco, has described attitudes in the late 1980s: The ageing field at the time was considered a backwater by many molecular biologists, and the students were not interested, or were even repelled by the idea. Many of my faculty colleagues felt the same way. One told me that I would fall off the edge of the Earth if I studied ageing.

That was because many scientists thought that aging (more specifically, growing old) must be a fairly boring, passive process at the molecular level nothing more than the natural result of things wearing out. Evolutionary biologists argued that aging could not be regulated by any complex or evolved mechanism because it occurs after the age of reproduction, when natural selection no longer has a chance to act. However, Kenyon and a handful of colleagues thought that if the processes involved in aging were connected to processes that acted earlier in an organisms lifetime, the real story might be more interesting than people realized. Through careful, often poorly funded work on Caenorhabditis elegans, the laboratory roundworm, they laid the groundwork for what is now a bustling field.

A key early finding was that the inactivation of a gene called daf-2 was fundamental to extending the life span of the worms. daf-2 mutants were the most amazing things I had ever seen. They were active and healthy and they lived more than twice as long as normal, Kenyon wrote in a reflection on these experiments. It seemed magical but also a little creepy: they should have been dead, but there they were, moving around.

This gene and a second one called daf-16 are both involved in producing these effects in worms. And as scientists came to understand the genes activities, it became increasingly clear that aging is not separate from the processes that control an organisms development before the age of sexual maturity; it makes use of the same biochemical machinery. These genes are important in early life, helping the worms to resist stressful conditions during their youth. As the worms age, modulation of daf-2 and daf-16 then influences their health and longevity.

These startling results helped draw attention to the field, and over the next two decades many other discoveries illuminated a mysterious network of signal transduction pathways where one protein binds another protein, which activates another, which switches off another and so on that, if disturbed, can fundamentally alter life span. By 1997, researchers had discovered that in worms daf-2 is part of a family of receptors that send signals triggered by insulin, the hormone that controls blood sugar, and the structurally similar hormone IGF-1, insulin-like growth factor 1; daf-16 was farther down that same chain. Tracing the equivalent pathway in mammals, scientists found that it led to a protein called FoxO, which binds to the DNA in the nucleus, turning a shadowy army of genes on and off.

That it all comes down to the regulation of genes is perhaps not surprising, but it suggests that the processes that control aging and life span are vastly complex, acting on many systems at once in ways that may be hard to pick apart. But sometimes, its possible to shine a little light on whats happening, as in the Yankner groups new paper.

Figuring out which genes are turned on and off in aging brains has long been one of Yankners interests. About 15 years ago, in a paper published in Nature, he and his colleagues looked at gene expression data from donated human brains to see how it changes over a lifetime. Some years later, they realized that many of the changes theyd seen were caused by a protein called REST. REST, which turns genes off, was mainly known for its role in the development of the fetal brain: It represses neuronal genes until the young brain is ready for them to be expressed.

But thats not the only time its active. We discovered in 2014 that [the REST gene] is actually reactivated in the aging brain, Yankner said.

To understand how the REST protein does its job, imagine that the network of neurons in the brain is engaged in something like the party game Telephone. Each neuron is covered with proteins and molecular channels that enable it to fire and pass messages. When one neuron fires, it releases a flood of neurotransmitters that excite or inhibit the firing of the next neuron down the line. REST inhibits the production of some of the proteins and channels involved in this process, reining in the excitation.

In their new study, Yankner and his colleagues report that the brains of long-lived humans have unusually low levels of proteins involved in excitation, at least in comparison with the brains of people who died much younger. This finding suggests that the exceptionally old people probably had less neural firing. To investigate this association in more detail, Yankners team turned to C. elegans. They compared neural activity in the splendidly long-lived daf-2 mutants with that of normal worms and saw that firing levels in the daf-2 animals were indeed very different.

They were almost silent. They had very low neural activity compared to normal worms, Yankner said, noting that neural activity usually increases with age in worms. This was very interesting, and sort of parallels the gene expression pattern we saw in the extremely old humans.

When the researchers gave normal roundworms drugs that suppressed excitation, it extended their life spans. Genetic manipulation that suppressed inhibition the process that keeps neurons from firing did the reverse. Several other experiments using different methods confirmed their results. The firing itself was somehow controlling life span and in this case, less firing meant more longevity.

Because REST was plentiful in the brains of long-lived people, the researchers wondered if lab animals without REST would have more neural firing and shorter lives. Sure enough, they found that the brains of elderly mice in which the Rest gene had been knocked out were a mess of overexcited neurons, with a tendency toward bursts of activity resembling seizures. Worms with boosted levels of their version of REST (proteins named SPR-3 and SPR-4) had more controlled neural activity and lived longer. But daf-2 mutant worms deprived of REST were stripped of their longevity.

It suggests that there is a conserved mechanism from worms to [humans], Yankner said. You have this master transcription factor that keeps the brain at what we call a homeostatic or equilibrium level it doesnt let it get too excitable and that prolongs life span. When that gets out of whack, its deleterious physiologically.

Whats more, Yankner and his colleagues found that in worms the life extension effect depended on a very familiar bit of DNA: daf-16. This meant that RESTs trail had led the researchers back to that highly important aging pathway, as well as the insulin/IGF-1 system. That really puts the REST transcription factor somehow squarely into this insulin signaling cascade, said Thomas Flatt, an evolutionary biologist at the University of Fribourg who studies aging and the immune system. REST appears to be yet another way of feeding the basic molecular activities of the body into the metabolic pathway.

Neural activity has been implicated in life span before, notes Joy Alcedo, a molecular geneticist at Wayne State University who studies the connections between sensory neurons, aging and developmental processes. Previous studies have found that manipulating the activity of even single neurons in C. elegans can extend or shorten life span. Its not yet clear why, but one possibility is that the way the worms respond biochemically to their environment may somehow trip a switch in their hormonal signaling that affects how long they live.

The new study, however, suggests something broader: that overactivity in general is unhealthy. Neuronal overactivity may not feel like anything in particular from the viewpoint of the worm, mouse or human, unless it gets bad enough to provoke seizures. But perhaps over time it may damage neurons.

The new work also ties into the idea that aging may fundamentally involve a loss of biological stability, Flatt said. A lot of things in aging and life span somehow have to do with homeostasis. Things are being maintained in a proper balance, if you will. Theres a growing consensus in aging research that what we perceive as the body slowing down may in fact be a failure to preserve various equilibria. Flatt has found that aging flies show higher levels of immune-related molecules, and that this rise contributes to their deaths. Keeping the levels in check, closer to what they might have been when the flies were younger, extends their lives.

The results may help explain the observation that some drugs used for epilepsy extend life span in lab animals, said Nektarios Tavernarakis, a molecular biologist at the University of Crete who wrote a commentary that accompanied Yankners recent paper. If overexcitation shortens life span, then medicines that systematically reduce excitation could have the opposite effect. This new study provides a mechanism, he said.

In 2014, Yankners laboratory also reported that patients with neurodegenerative diseases like Alzheimers have lower levels of REST. The early stages of Alzheimers, Yankner notes, involve an increase in neural firing in the hippocampus, a part of the brain that deals with memory. He and his colleagues wonder whether the lack of REST contributes to the development of these diseases; they are now searching for potential drugs that boost REST levels to test in lab organisms and eventually patients.

In the meantime, however, its not clear that people can do anything to put the new findings about REST to work in extending their longevity. According to Yankner, REST levels in the brain havent been tied to any particular moods or states of intellectual activity. It would be a misconception, he explained by email, to correlate amount of thinking with life span. And while he notes that there is evidence that meditation and yoga can have a variety of beneficial effects for mental and physical health, no studies show that they have any bearing on REST levels.

Why exactly do overexcited neurons lead to death? Thats still a mystery. The answer probably lies somewhere downstream of the DAF-16 protein and FoxO, in the genes they turn on and off. They may be increasing the organisms ability to deal with stress, reworking its energy production to be more efficient, shifting its metabolism into another gear, or performing any number of other changes that together add up a sturdier and longer-lived organism. It is intriguing that something as transient as the activity state of a neural circuit could have such a major physiological influence on something as protean as life span, Yankner said.

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Longevity Linked to Proteins That Calm Overexcited Neurons - Quanta Magazine

JERSEY CITY, N.J.--(BUSINESS WIRE)--New Jersey is home to some of the worlds most accomplished innovators in applied science. Three of them who are pioneering research and solutions in antibacterial therapies, genetics, human life extension, and food production are being honored by Liberty Science Center at its inaugural The Genius of NJ celebration on Monday, December 2.

The celebration starts at 5:30 pm with cocktails and unique technology demonstrations: a full-body 3D scanner from Lenscloud that can scan a person in half a second with 120 cameras and create a realistic 3D avatar; bomb-disposing robots and an autonomous fighting robot from Picatinny Arsenal; and Flyer, a personal aerial vehicle from Kitty Hawk, headquartered in Mountain View, CA.

The New Jersey honorees are Bonnie Bassler, Chair of Molecular Biology at Princeton University, who is developing novel antimicrobial therapies to render pathogenic bacteria harmless; Dr. Robert J. Hariri, Chairman, Founder & CEO of Celularity, Inc. who is pioneering the use of stem cells to cure disease and slow aging; and David Rosenberg, CEO and Co-Founder of AeroFarms, the worlds leader in mass-scale vertical indoor farming.

Our inaugural Genius of NJ Award Winners represent the best this state and the world have to offer in harnessing science for the betterment of humanity, said Liberty Science Center President and CEO Paul Hoffman. Each is using his or her exceptional intellect and creative abilities to disrupt and innovate both in their respective fields and in their commitment to making the world healthier and safer.

Bonnie Bassler is the Squibb Professor of Molecular Biology and Chair of the Department of Molecular Biology at Princeton University, as well as a Howard Hughes Medical Institute Investigator. Professor Bassler deciphered the chemical language bacteria cells use to communicate by studying a harmless marine bacterium called Vibrio fischeri, known to bioluminesce, or make light, like fireflies do. She is a winner of the MacArthur Genius Grant and is now developing therapies that disrupt communication among harmful bacteria and strengthen communication among helpful bacteria. At a time when an increasing number of bacteria are resistant to traditional kinds of antibiotics, Dr. Bassler offers a promising new approach to antimicrobial therapy.

The Chairman, Founder and CEO of Celularity, Inc., in Warren, NJ, and Co-Founder and Vice Chairman of Human Longevity, Inc., Dr. Robert Hariri is the quintessential renaissance man. Hes a neurosurgeon, a medical researcher, and a serial entrepreneur in two technology sectors: aerospace and biomedicine. Dr. Hariri has advised the Vatican on genetics, and in 2018, Pope Francis bestowed on him the Pontifical Key Award for Innovation. Dr. Hariris path to discovering that the placenta, a temporary organ discarded after birth, was a potent source of stem cells began in the 80s when he viewed a first trimester ultrasound of his oldest daughter and wondered why the placenta was so large. Today Dr. Hariri is working to use placental stem cells to cure disease, slow aging, and augment healthy human lifespan.

Prominent entrepreneur David Rosenberg, CEO and Co-Founder of AeroFarms, set out to reinvent one of the most basic aspects of food production, farming. AeroFarms has grown 800 species of plants indoors and can grow them 365 days a year without sun or soil, achieving yields 130 times greater than conventional farming. His system uses 95 percent less water than field farming and no pesticides, herbicides, or fungicides. Rosenbergs adoption of cutting-edge technology has been a cornerstone of AeroFarms, which set up its first indoor vertical farms in abandoned warehouses in Newark. He employs plant biologists, microbiologists, geneticists, systems engineers, and data scientists. AeroFarms innovations in indoor vertical farming have improved not just plant yields but also taste, texture, nutritional density, and shelf life.

Additionally, LSC will honor non-New Jersian Sebastian Thrun, CEO of Kitty Hawk, a company spun off from a Google moonshot effort to free the world from traffic. Kitty Hawk is developing all-electric, vertical take-off flying machines for everyday use. Known as the godfather of self-driving cars, as a Stanford professor in 2005, Thrun led a team that won the $2-million Defense Department Grand Challenge to build an autonomous vehicle which drove itself unassisted on a 132-mile course across the Mojave Desert. His winning entry, Stanley, is now on display at the Smithsonian in Washington, DC. While at Stanford, in 2011 he and colleague Peter Norvig offered their Introduction to Artificial Intelligence course online to anyone, for free. Over 160,000 students in more than 190 countries enrolled! The MOOC (which stands for Massive Open Online Course) was born, and Thrun founded the online education company Udacity, with the goal of democratizing education. Thrun relinquished his tenured Stanford professorship to join Google and founded the companys semi-secret R&D division called Google X (now called simply X) to develop breakthrough technologies, such as self-driving cars, that make the world a radically better place.

Ticket prices for The Genius of NJ start at $750 per guest with options for table sponsorship from $12,500 to $50,000. For more details, please visit The Genius of NJ online. All proceeds from this event will support LSCs mission to inspire the next generation of scientists and engineers.

About Liberty Science Center

Liberty Science Center (LSC.org) is a 300,000-square-foot nonprofit learning center located in Liberty State Park on the Jersey City bank of the Hudson near the Statue of Liberty. Dedicated to inspiring the next generation of scientists and engineers and bringing the power, promise, and pure fun of science and technology to learners of all ages, Liberty Science Center houses the largest planetarium in the Western Hemisphere, 12 museum exhibition halls, a live animal collection with 110 species, giant aquariums, a 3D theater, live simulcast surgeries, a tornado-force wind simulator, K-12 classrooms and labs, and teacher-development programs. More than 250,000 students visit the Science Center each year, and tens of thousands more participate in the Centers off-site and online programs. Welcoming more than 750,000 visitors annually, LSC is the largest interactive science center in the NYC-NJ metropolitan area.

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Liberty Science Center's Inaugural Genius of New Jersey to Honor Innovators Who Make the State a World Leader in Cutting-Edge Applied Science -...

Increasingly, the unprecedented levels of food waste in the developed world, at a time when close to one billion of the worlds population faces starvation, is seen as an international scandal.

At the same time, people are becoming more aware of the enduring damage inflicted upon the planet by the disposal of 20th century packaging materials.

Tackling these problems at source will require massive changes, all under circular economy principles.

However, such actions are hugely disruptive to well-established industries and often come at significant extra cost - ultimately to the consumer.

One measure which can be taken quickly - and often at comparatively low cost - is to extend the shelf life of food and drink.

When it comes to shelf life extension, one area currently under investigation is the use of packaging materials which have been enhanced to reduce microbiological growth. Also known as active packaging, the packaging material is treated directly, and/or the food products are coated with antimicrobial agents.

These antimicrobial agents can be essential oils such as oregano, clove or orange, or organic acids such as acetic acid or natural polymers, for example chitosan, which are derived from shellfish and insects.

Initial research conducted on active packaging and its ability to control microbiological growth has been promising, with a variety of materials assessed. However, further analytical work is required to understand the full scope of antimicrobial efficacy against a variety of microorganisms, as well as how temperature abuse might affect the proposed packaging and coatings. Additionally, the packaging materials themselves must be thoroughly assessed to understand potential chemical and physical hazards.

As it shifts from traditional plastic packaging to novel active packaging and coatings, the food industry should therefore work closely with scientific safety analysis (as well as with sensory panel testing) to understand the potential hazards.

Otherwise, the benefits of longer shelf life could come at the cost of serious unintended consequences for human health.

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Antimicrobial packaging can extend shelf life and prevent food waste - but more analysis is needed - The Grocer