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Category Archives: Life Extension

The Rockies Went Backwards by Doing Nothing – FanGraphs

Posted: August 4, 2021 at 2:25 pm

At 4 PM EST last Friday, the trade deadline closing bell rang, and when it did, those of us on the outside looking in were glued to Twitter to learn about the trades that had been completed right before the countdown clock hit zero. It usually takes a little while to learn about all the transactions that get completed in those final minutes. Plenty of players found new homes, but the surprise of the afternoon was that when the dust settled, Trevor Story was still a member of the Colorado Rockies.

The Rockies are 21 games out of first place in their division. Per our Playoff Odds (and good sense), their chances of reaching the postseason this year are a big fat zero, and have been for some time. They also play in the toughest division in baseball, with the Dodgers and Padres looking like teams that will sit at the top of the National League West standings for years to come. The Rockies need to make drastic changes in order to take on those two powerhouses (and the Giants arent exactly slouches), and those changes should have begun on Friday. Instead, they sat on their hands, losing a golden opportunity to kick-start a return to competitiveness for a franchise that has reached the playoffs just five times in 28 seasons and has still never won a division title.

Colorado did make one trade during deadline week, sending reliever Mychal Givens and his expiring contract to the Reds for a pair of fringe pitching prospects. But thats not starting a re-build or, if that term strikes you as too strong, re-tooling the roster so much as it is taking care of some necessary chores. And while Givens departed, there were other players rumored to be on the move who ended up staying put. Holding on to Jon Gray is a curious decision. The team hasnt earned the benefit of anybodys doubt, but lets give it to them in the case of Gray, who has publicly stated his desire to stay in Colorado. Player comfort leads to better player performance, and if they can sign him to an extension, this makes sense. The jury can still be out on that one. But Daniel Bard still being the teams closer on August 1 is significantly more difficult to explain. Again, there is surely some loyalty here, and the Rockies deserve some credit for getting Bard back on the mound and finding a decent late-inning option in the process, but as a free agent following the 2022 season (a season in which Colorado will almost certainly not contend), the club just squandered Bards peak trade value, and yet another chance to boost a farm system that is among the worst in baseball.

Rockies leadership tries to say the right things (well ignore the clubs strange insistence that this is a very talented team that has simply underperformed), like that they are excited about the young core in their starting rotation, and that they want to spend this winter trying to improve the offense. You know, the offense that could use a guy like Nolan Arenado, who was jettisoned in a move that seemed to be at least somewhat driven by a clash with management just two years after signing a Rockie-for-life extension. Or the offense that would benefit from a contact-driven machine like DJ LeMahieu. At least there, owner Dick Monfort admitted the team erred by allowing LeMahieu to sign elsewhere when he inked a two-year deal with the Yankees prior to the 2019 season that was below industry expectations. But trying to say the right thing hasnt translated to good process or results, and now we can add Trevor Story to the list of playoff-caliber players looking forward to getting out of Denver.

Maybe they really do believe that the compensatory draft pick theyll receive when Story departs in free agency after being tagged with a qualifying offer is better than the deadline offers they had in hand. Storys 2021 performance certainly led to a depressed market for the shortstop. But its nearly impossible to believe that no team was willing to offer a prospect, or a package of prospects, with greater value than a pick in the 30s. Not to mention that that player (or players) would immediately become a Rockie and hopefully begin his path to the big leagues, while the player Colorado gets with a 2022 compensation pick wont even begin his pro career until a year from now, thus further delaying any hope for a return to competitiveness.

Despite their struggles as a franchise, the Rockies have never had a full front office turnover. The people in charge can be traced, family-tree style, to the teams origins. In terms of their strategy, behavior and responsiveness, other clubs have found them somewhere between confusing and frustrating to work with for years. There is nothing wrong with zigging when other teams zag, but at times the Rockies operate with seemingly no understanding of the Major League Baseball rule set, or what must be done within it to build a good roster.

And to be clear, I feel bad for Bill Schmidt, the teams vice president of scouting who currently serves as the interim general manager. With front office personnel departing the organization left and right over the last 12 months, he was put in an exceptionally difficult spot. Hes a well-respected talent evaluator and a well-liked person who was placed in an absolutely untenable situation; its like being made captain of the Titanic, but only after it hits the iceberg. I cant help but think that his activity (or more accurately, unforgivable inactivity) during deadline week rests on the shoulders of Monfort, who at times seems to care more about optics than winning. Those optics took a severe hit when a visibly upset Story expressed his frustration and confusion with the situation, talked about the toll it has taken on his on-field performance, and pulled himself from Fridays lineup.

Bud Black spoke after the deadline about how the team needed to score more runs. Hes certainly not wrong, as the Rockies entered the week 10th in the National League in on-base percentage and ninth in slugging despite playing half of their games at Coors Field. No position player has accumulated as much as 2 WAR on the season; their best qualified hitter has been Brendan Rodgers, who has a wRC+ of 103. The third overall pick in the 2015 draft, at age 24 Rodgers feels like hes begun to turn a corner. His wild approach is now merely aggressive, and the power potential is starting to show up in games. Hes beginning to look very much like a building block kind of player and he doesnt reach free agency until after the 2025 season. But based on what weve seen from the Rockies over the past five years, and their inability to project anything close to a competent organization, chances are much better than hell just become the next disillusioned, talented infielder looking for a way out of the Mile High City.

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The Rockies Went Backwards by Doing Nothing - FanGraphs

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Lumen Technologies and Texas Rangers extend partnership through end of 2021 season – MLB.com

Posted: at 2:25 pm

Arlington, Texas Lumen Technologies, one of the worlds leading network providers, and the Texas Rangers Baseball Club today announced their partnership extension through the 2021 season.

Lumen Technologies currently acts as the Texas Rangers exclusive technology provider for infrastructure and telecommunications at Globe Life Field. Lumen works to deliver scalable, high-bandwidth connectivity for critical data and apps via a flexible, on-demand networking architecture that intelligently adjusts to real-time capacity needs.

Lumen has been a tremendous partner in helping us deploy a technology infrastructure at Globe Life Field that will serve us well in enabling the rapid evolution of technology for years to come, said Mike Bullock, Texas Rangers VP of Information Technology.

As a brand-new facility with the latest innovations in technology, Globe Life Field is among the most technologically advanced stadiums today. The ballpark regularly connects nearly 14,000 devices, a number that increases to over 40,000 devices on game days.

Lumen Technologies solutions at Globe Life Field include,

The Rangers first approached Lumen in 2017 to provide a variety of services and cloud technologies as part of the Globe Life Field construction project.

Lumen is guided by our belief that humanity is at its best when technology advances the way we live and work. With approximately 450,000 route fiber miles and serving customers in more than 60 countries, we deliver the fastest, most secure platform for applications and data to help businesses, government and communities deliver amazing experiences.

Learn more about the Lumen network, edge cloud, security, communication and collaboration solutions and our purpose to further human progress through technology at news.lumen.com/home, LinkedIn: /lumentechnologies, Twitter: @lumentechco, Facebook: /lumentechnologies, Instagram: @lumentechnologies and YouTube: /lumentechnologies. Lumen and Lumen Technologies are registered trademarks in the United States.

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Lumen Technologies and Texas Rangers extend partnership through end of 2021 season - MLB.com

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garden patio breathes life into 19th-century house renovation by meirav galan in tel aviv – Designboom

Posted: at 2:25 pm

within the historic neve tzedek neighborhood of tel aviv, israel, meirav galan architects (MGA) has refurbished a 19th-century residence to accommodate a large family of six. the renovation includes the meticulous restoration of the aged structure, as well as its extension, resulting in a spacious redesigned townhouse with a newly added garden patio.

all images courtesy of gidon levin, unless stated otherwise

the house was one of the first structures built in the picturesque neighborhood at the end of the 19th century and was originally formed as a one-story residence with a flat roof. during the 1930s, the dwelling was extended and architecturally redesigned, adding a second floor with a tiled roof, a gallery balcony, and exterior stairs. however, with the passage of time, the building suffered from neglect.

on my first visit to the house, underneath all the neglect, I could sense the european charm combined with the local mediterranean scent, describes architect meirav galan. I discovered impressive high ceilings, classic european wooden doors and windows, iron detailed balustrades, and a beautiful mediterranean balcony with a parisian touch. I imagined myself reviving the story and interweaving with my clients dreams

the architectural design of the townhouse, spanning over a long rectangle lot, included preservation as required by the municipality law, partial destruction, and new additions that extended the built area from 250 to 580 sqm. the existing two floors were preserved as well as the faades original openings and unique balcony. the large tower that had held a staircase connecting the two levels was demolished and replaced by a new extension, built and redesigned as if it had always been there. meanwhile, the tiled roof was replaced by a rooftop balcony with a sea view and plunge pool.

the front yard that had originally been two meters higher than the street was terraced, creating a new level with a welcoming exterior entrance and a service area on the street level as well as a new lowered yard that brings in natural light and air to the basement. a new staircase was designed and built to lead towards the preserved entrance level.

meanwhile, the southern wing was rebuilt and extended to include two new floors lower than the old wing floors due to preservation heights limitations, and a tiled roof attic with a balcony. the faade, though new, was designed with details similar to the original northern elevation. a garden patio was designed as the heart of the house between the old wing and the new one, providing extra natural light and functioning as an intimate private outdoor space in the middle of a very dense urban fabric. while the street facades preserve the aesthetic character of the original house and of the neighborhood, the patios steel framed windows facades were designed as a contrast entity, emphasizing the new architectural design.

image courtesy of roee dori

project info:

name: neve tzedek patio housearchitects: meirav galan architects (MGA)project management and supervision: bar engineering eran eldor and tomer ben tovimstructural engineering: buky snir interior design: dana oberson garden design: haim kohen lighting design: tzach cohenphotoshoot styling: roni tishler location: tel aviv, israelgross built area: 580 sqmlot area: 246 sqmphotography: gidon levin (after photos), roee dori (before photos)

designboom has received this project from our DIY submissions feature, where we welcome our readers to submit their own work for publication. see more project submissions from our readers here.

edited by: myrto katsikopoulou | designboom

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garden patio breathes life into 19th-century house renovation by meirav galan in tel aviv - Designboom

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Ceremony to honor Bob Sliger’s life to be held Aug. 13 – Advocateanddemocrat

Posted: at 2:25 pm

The Monroe County Cattlemens Association is set to dedicate a memorial plaque to Bob Sliger on Aug. 13.

The public is invited to the event which will take place at the East Tennessee Livestock Center in Sweetwater starting at 5 p.m.

Sliger, the former longtime UT extension agent in Monroe County, passed away on March 21.

According to Monroe County Cattlemans Association (MCCA) President Dr. Hugh McCampbell, MCCA will hang a plaque that is dedicated to Sliger in the lobby of the stockyard.

The plaque will list several of his accomplishments and contributions to the livestock industry in Monroe County, McCampbell said. Sliger was the agent for about 39 years and had made all kinds of innovations.

Among his accolades, Sliger was named the national outstanding young agent of the year by the National Association of County Agents in 1973 and in 2006 he was honored as the Monroe County Outstanding Citizen of the Year by the Monroe County Chamber of Commerce and The Monroe County Advocate & Democrat.

According to a news release from the MCCA, Sligers innovative programs are still in use today helping producers realize more profit in the livestock industry.

He started boosting steer sales and he was a real component of the graded feeder calf sales which require vaccination programs and things like that which increase the value of Tennessee cattle, McCampbell stated. He was really a proponent of cost effective management practices. He started the bull leasing program here at one of the banks in Sweetwater so people could lease a bull for a season and it would cost them a whole lot less than buying a bull.

He noted the leased bulls were of high quality for those who utilized the service.

They buy them at sales that had records on what the bulls performance would be, McCampbell said. He did a lot of that kind of stuff and he was a wonderful person to work with. He was always positive about things, very receptive to ideas and really worked to get things accomplished that would benefit producers.

A special guest will be at the event, as well. Sligers daughter, Cecile Wimberley, will be on hand along with a few other speakers.

After the speeches we will have cake, coffee and water for people to partake in the lobby of the stockyard, McCampbell expressed. Bob passed away in March and we want to honor him while his passing is still fresh on our producers mind so that we could all take the time to honor him. He was always the kind of southern gentleman who you would want to introduce to your mom or your wife and that says a lot about a man.

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Ceremony to honor Bob Sliger's life to be held Aug. 13 - Advocateanddemocrat

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Global Withania Somnifera Extract Market Where is Industry’s Growth Heading by 2027? |Life Extension, Taos Herb Company, General Nutrition Centers …

Posted: at 2:25 pm

Amid the pandemic the healthcare sector suffered a lot. The global Withania Somnifera Extract market value witnesses a sudden change in its value. In year 2020, it was USD XX but in 2021 it is expected to reach USD XX at a CAGR of XX%.

Download Free Sample PDF including COVID19 Impact Analysis, full TOC, Tables and Figures@ https://www.infinitybusinessinsights.com/request_sample.php?id=608007

The healthcare sector is growing at a rapid speed, the reason behind this growth is the increasing importance of health checkups and diagnosis of the patients. The sector has grown in recent years, but that growth has brought with it some issues. Along with the old strategy, a few resources, and insufficient employees to service the expanding clients, the absence of infrastructure to accommodate the demand produced many challenges.

Infrastructure problems are not confined to a single region, country, or economy; they are causing havoc in every corner of the globe. The data demonstrates how infrastructural issues and other issues in the sector are harming the Withania Somnifera Extract sector and the health of the people.

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Middle East and Africa

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Contact Us:Amit JainSales Co-OrdinatorInternational: +1 518 300 3575Email: inquiry@infinitybusinessinsights.comWebsite: https://www.infinitybusinessinsights.comFacebook: https://facebook.com/Infinity-Business-Insights-352172809160429LinkedIn: https://www.linkedin.com/company/infinity-business-insights/Twitter: https://twitter.com/IBInsightsLLP

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Global Withania Somnifera Extract Market Where is Industry's Growth Heading by 2027? |Life Extension, Taos Herb Company, General Nutrition Centers ...

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SBM Offshore signed the Letter of Intent for FPSO Alexandre de Gusmo lease and operate contracts – GlobeNewswire

Posted: at 2:25 pm

August 3, 2021

SBM Offshore is pleased to announce that it has signed with Petrleo Brasileiro S.A. (Petrobras) the Letter of Intent for a 22.5 years lease and operate contracts of FPSO Alexandre de Gusmo. The unit will be deployed at the Mero field in the Santos Basin offshore Brazil, approximately 160 kilometers from Arraial do Cabo, Rio de Janeiro state, in Brazil.

The Libra block, where the Mero field is located, is under a Production Sharing Agreement to a Consortium comprised of Petrobras with 40 percent, Shell Brasil with 20 percent, Total Energies with 20 percent, CNODC and CNOOC with 10 percent each and the state-owned company Pr-Sal Petrleo SA as manager of the Production Sharing Contract.

SBM Offshore will design and construct the FPSO Alexandre de Gusmo using its industry leading Fast4Ward program as it incorporates the Companys new build Multi-Purpose Floater (MPF) hull combined with several standardized topsides modules. SBM Offshores fifth MPF hull has been allocated to this project. Completion of the FPSO is expected in 2024.

The FPSO will be designed to produce 180,000 barrels of oil per day and treat 12 million standard cubic meters of gas per day. Furthermore, the unit will have a water injection capacity of 250,000 barrels per day and a minimum storage capacity of 1.4 million barrels of crude oil. The unit will be spread moored in approximately 1,900 meters water depth.

Bruno Chabas, CEO of SBM Offshore, commented:

The signing of this Letter of Intent is the second major project award this year by our key client Petrobras. Our industry leading Fast4Ward program continues to address clients needs to develop large-scale and complex FPSOs providing cost efficient and low GHG intensity solutions.

Corporate Profile

The Companys main activities are the design, supply, installation, operation and the life extension of floating production solutions for the offshore energy industry over the full lifecycle. The Company is market leading in leased floating production systems, with multiple units currently in operation.

As of December 31, 2020, the Company employs approximately 4,570 people worldwide spread over offices in our key markets, operational shore bases and the offshore fleet of vessels.

SBM Offshore N.V. is a listed holding company headquartered in Amsterdam, the Netherlands. It holds direct and indirect interests in other companies.

Where references are made to SBM Offshore N.V. and /or its subsidiaries in general, or where no useful purpose is served by identifying the particular company or companies SBM Offshore or the Company are sometimes used for convenience.

For further information, please visit our website at http://www.sbmoffshore.com.

The Management BoardAmsterdam, the Netherlands, August 3, 2021

For further information, please contact:

Investor RelationsBert-Jaap DijkstraGroup Treasurer and IR

Media RelationsVincent KempkesGroup Communications Director

Disclaimer

This press release contains inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation. Some of the statements contained in this release that are not historical facts are statements of future expectations and other forward-looking statements based on managements current views and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance, or events to differ materially from those in such statements. Such forward-looking statements are subject to various risks and uncertainties, which may cause actual results and performance of the Companys business to differ materially and adversely from the forward-looking statements. Certain such forward-looking statements can be identified by the use of forward-looking terminology such as believes, may, will, should, would be, expects or anticipates or similar expressions, or the negative thereof, or other variations thereof, or comparable terminology, or by discussions of strategy, plans, or intentions. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described in this release as anticipated, believed, or expected. SBM Offshore NV does not intend, and does not assume any obligation, to update any industry information or forward-looking statements set forth in this release to reflect subsequent events or circumstances. Nothing in this press release shall be deemed an offer to sell, or a solicitation of an offer to buy, any securities.

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SBM Offshore signed the Letter of Intent for FPSO Alexandre de Gusmo lease and operate contracts - GlobeNewswire

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Pune civic body extends life insurance cover of employees till the end of pandemic – The Indian Express

Posted: at 2:25 pm

With the possibility of a third wave of Covid-19 looming large, the Pune Municipal Corporation (PMC) decided to extend the tenure of its life insurance cover of Rs 50 lakh for civic healthcare workers dying due to Covid till the end of the pandemic.

PMC had launched the Covid Suraksha Kavach insurance scheme for its staff and assured Rs 50 lakh financial assistance or Rs 25 lakh financial assistance and a job to one of the family members of the deceased staff. This was in addition to the insurance cover of Rs 50 lakh assured by the Union government for Covid warriors. Over 50 civic staff have died of Covid-19 so far.

The Union government had declared a life insurance cover of Rs 50 lakh for healthcare workers dying of Covid during the pandemic. The PMC on the same lines had launched its scheme on June 4, 2020. The civic administrations proposal to extend it till the pandemic is over has been approved, said chairperson of the standing committee Hemant Rasane.

Stay updated with the latest Pune news. Follow Express Pune on Twitter here and on Facebook here. You can also join our Express Pune Telegram channel here.

The PMC in June last year had declared the insurance cover for healthcare and frontline workers till July 30, 2020 as the Union government scheme was declared till June 30, 2020.

The Union government under its National Health Mission had launched the Pradhan Mantri Garib Kalyan Package: Insurance Scheme for Health Workers Fighting Covid19 in which a Rs 50 lakh insurance cover was provided to healthcare workers treating or serving Covid patients.

The state government conveyed on April 28 this year that the Union government has extended its scheme by 180 days from March 2021 while the state government has declared it till June 30, 2021.

Taking into consideration that the Union government has decided to extend the life insurance scheme, PMC felt it to be needful to extend its own scheme. The PMC insurance cover scheme had to be either extended till the date of extension of the Union government scheme or the declaration of the end of pandemic by the government, said municipal commissioner Vikram Kumar.

The PMC has been under criticism for delaying the sanctioning of the life cover amount to the family members of deceased civic staff. The civic body, after a gap of one year, handed over a cheque of Rs 25 lakh as financial assistance to the family members of the civic staff who died of Covid-19.

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The decisions that led to Indias worst offshore disaster – Scroll.in

Posted: at 2:25 pm

Rahman Shaikh never really cared about birthdays.

On May 15, he turned 51 without any fanfare, and went about his usual work as the chief engineer on board Papaa-305, an accommodation barge anchored at the Oil and Natural Gas Corporations Heera Oil Field, around 70 km off the Mumbai coast. When his colleagues wished him for his birthday, he thanked them politely, and did the same with his family during his regular afternoon phone call with them.

The Wi-Fi on the barge allowed Shaikh to have frequent Whatsapp calls with his brother, sister-in-law and their two sons, with whom he lives for four or five months a year, when he is not at sea. Just the previous day, they had all exchanged greetings for Ramzan Eid.

On the morning of May 16, Shaikh had a casual phone conversation with his brother, but did not talk about Cyclone Tauktae, the storm that was scheduled to pass northwards along the coast of Maharashtra later that night. Cyclones are quite common when you are out at sea, so we are used to it, said Shaikh, a stout man who speaks in short, quick sentences.

Shaikhs father had spent all of his working life as a cook on international ships; his brother too had worked on ships and barges, as an engineer, before setting up a shipping company eight years ago. Shaikh started his own career in 1990 in a marine parts manufacturing workshop in Mumbai, but took up an opportunity to be an offshore diesel mechanic on a ship in 2005. It took him 15 years to rise up the ranks and become a chief engineer, and he has seen dozens of cyclones at sea over the years. They are usually manageable, but with this one, we did not imagine how bad the storm was going to be, he said.

Rajesh Prasad, a technical worker onboard Papaa-305, first heard about Cyclone Tauktae on May 15, when a supervisor informed him and his colleagues that the storm was not going to impact them, since they were not in its path. Our supervisor had heard this from the captain, but we were worried because the sea had started becoming a little rough, he said.

Prasad, whose actual name has been withheld on request, is in his twenties. He was the first member of his family to take up a job at sea. In the three years that he had spent working on maintenance projects on the ONGCs oil fields, he had been trained in swimming, safety and emergency rescue while at sea. But the training was basic, and Prasad had never actually been in a potentially dangerous situation.

As the weather worsened on May 16, Prasad found himself grappling with anger, frustration and growing fear. It was very scary when the cyclone started, but I did not have the authority to do anything, he said.

His supervisors assurance that they would be safe proved to be horribly wrong.

That night, as Tauktae barrelled up the coast in all its fury, it lashed the barge, causing it to loll violently in the sea. Papaa-305 was an 8,900-tonne, 96-metre long barge stacked vertically, it would be about 24 floors high. As its eight anchors snapped one by one, it was left adrift in the sea. At 9.45 the next morning, the barge collided with an oil drilling platform nearby, and gradually began to capsize. Sheikh, Prasad and the other 259 men on board were forced to jump into the sea, where waves nearly 10 metres high tossed them around like rag dolls.

As they struggled to remain afloat in their life jackets, Shaikh and other men tried holding hands and staying in groups of 10 or 12 people.

At 10 am on May 18, after a 36-hour nightmare, Shaikh was hauled to safety during extensive search-and-rescue operations carried out by the Indian Navy. He had severely injured his right knee and was wheelchair-bound for weeks after his rescue. But somehow, he had managed to cling to life.

Prasad, too, was rescued by the INS Kolkata, a Navy ship. I was not injured, but I was freezing and vomiting blood, he said. They took me to the ships hospital and later gave me a phone so I could let my family know I was safe.

Shaikh and Prasad were among the 186 men from Papaa-305 who survived; 75 died.

I dont usually like to celebrate my birthday. But that day it felt like I was born again, said Shaikh. He spoke to Scroll.in in mid-June, seated on a sofa in his small, modest apartment in Mumbra, a densely-populated town in Thane district, north of Mumbai.

I was very lucky, he said. But many of my friends were not.

Papaa-305 was not the only vessel caught in the midst of Tauktae on May 16 and 17. It was one among 99 different supply ships, drill ships, barges and tugboats deployed to work at the ONGCs offshore oil and gas fields in the Arabian Sea.

Most of the 99 vessels had moved to safe locations after the India Meteorological Department first issued warnings about an approaching storm on May 13. But six vessels did not, of which two capsized during the storm. One was Papaa-305. The other was tugboat MV Varapradha, which lost 11 out of the 13 men on board.

In all, 86 people died and 86 families were left bereaved in what has become the deadliest accident in the history of the ONGC, a public sector unit under the union Ministry of Petroleum and Natural Gas, and Indias largest producer of crude oil and gas.

In statements by the Navy and the ONGC, the dead were described as BNVs Brave Natures Victims. But conversations with survivors and crucial email correspondence reveal that the tragedy was entirely man-made and entirely preventable.

Two days after his rescue, while Rahman Shaikh was still recovering from his knee surgery at a south Mumbai hospital, he registered a complaint with the citys Yellow Gate police station blaming Papaa-305s captain, barge master Rakesh Ballav, for knowingly putting the lives of the 261 people on board in harms way. In the first information report filed on the basis of this complaint, the police has made out a case of culpable homicide, naming Ballav and other related people as the main accused.

Ballav is among the 86 people who died at sea on May 17. Scroll.in was unable to trace his family members. Ballavs side of the story will never be known, but in the blame game that ensued after the tragedy, he was accused of negligence not just by Shaikh but also by the two major agencies involved in the incident, which have not accepted responsibility themselves: the ONGC and Afcons Infrastructure, the company contracted to carry out maintenance work on ONGC platforms.

The ONGC runs three major offshore oil fields discovered in the Arabian Sea in the 1960s and 1970s: Mumbai High, located around 170 km off Mumbais coast, Bassein and Satellite Fields, around 80 km to the north-west of the city, and Neelam and Heera Fields, around 45 km to the south-west of the city.

Together, these expansive operations contain 12 fixed platforms for exploring and extracting oil and gas, eight moveable oil rigs owned by the ONGC, and 28 rigs hired on contract from other companies. Over 4,000 people work on these offshore assets, of which around a third are employees of the ONGC. Most of the work particularly the mammoth task of maintaining the infrastructure of the platforms and rigs is typically outsourced on a contract-basis to an assortment of private companies. These include infrastructure developers, ship owners, ship managers, manpower suppliers and agencies that recruit licensed seafarers.

A consortium led by Afcons had been contracted to carry out maintenance work on these oilfields. A company within the Shapoorji Pallonji conglomerate, Afcons brought in a total revenue of over Rs 10,130 crore in 2019-20. Afcons, in turn, had contracted technical workers like welders, riggers, scaffolders, electricians and engineers from different manpower supply agencies.

The main benefit of his job as a technical worker, according to Prasad, was knowing that he would not have to spend most of his salary on accommodation or food. But this benefit came at a steep price. We have to work 15 to 16 hours a day, seven days a week. And we dont get any days off when we are at sea, said Prasad. None of these things are written in our contract, but they have been followed for years.

Apart from contracting the workforce, Afcons also chartered, or hired, a variety of vessels from ship-owning companies to ferry and house workers and materials. Papaa-305 was an accommodation barge a large, flat-bottomed floating vessel with living amenities for workers and no engine or propulsion of its own. Such barges are towed and anchored with the help of tugboats Afcons had assigned one to each barge.

Papaa-305 was paired with tugboat Nove, both owned by Durmast Enterprises, a company registered in the island nation of Seychelles and a subsidiary of Mumbai-based firm Ocean Diving Centre. While the technical workers on the barge had been recruited from a Mumbai-based manpower agency named Mathew Associates, the seafaring crew of the two vessels, including captain Ballav and chief engineer Shaikh, were hired for the ONGC project through Papaa Shipping Pvt Ltd, another Mumbai-based subsidiary of Ocean Diving Centre.

Durmast, Papaa Shipping, Ocean Diving they are all different companies on paper but they are run by the same people, said Shaikh, who has worked with the companies for the past 15 years. For different offshore projects my contracts have listed different companies within the group as my employers, but I have always dealt with the same staff, the same HR [human resources] and accounts team.

According to a lawyer who specialises in shipping and maritime matters, this kind of convoluted business structure is common in much of the worlds shipping industry.

These include insurance claims by workers and seafarers who may get injured while on a vessel, or by the families of those who die.

Shaikhs contract for the ONGC project named Papaa Shipping Pvt Ltd as the employer, but the agreement was drafted under the letterhead of Udya Shipping Services, a crew management company. The agreement was signed with an illegible signature, accompanied by a seal of Udya Shipping and the words on behalf of the Employer as agents only. Such arrangements are common in the shipping industry, said Shaikh, because every shipping company may not have the Recruitment and Placement Services License that is mandatory under Indian law for firms recruiting seafarers.

The ONGCs model of contracting companies that subcontract others is not unique. Such outsourcing has become the norm in Indias public sector companies. A 2014 study by the Indian Staffing Federation found that as much as 43% of the government sector employed contract labour to get its work done. When things go wrong, complex chains of contractual agreements allow various stakeholders to shrug off responsibility for the lives and safety of workers and pin the blame on others.

This is exactly what played out in the days after the 86 men died at sea while working, on contract, in oil fields owned by a government-run company.

In an interview with television channel Times Now soon after the incident, an ONGC spokesperson claimed that following cyclone alerts and ensuring safety was the responsibility of vessel captains and the consortium of companies contracted to carry out maintenance work at the oil fields.

In statements to the media soon after the cyclone deaths, Afcons claimed that the captain of Papaa-305 and its owner Durmast Enterprises were in charge of making decisions about the barges safety. Durmast has made no public statements about the incident so far, but in an interview with The Sunday Guardian, officials from Udya Shipping claimed it would be incorrect to blame Ballav, who had 14 years of experience, for the tragedy.

On July 2, as part of its investigation into Shaikhs FIR, the Mumbai Police arrested three onshore employees of Papaa Shipping Pvt Ltd. According to the police, the three senior staffers had ignored weather warnings about the cyclone and went along with the captains decision to keep the barge anchored near the oil drilling platform at Heera Field rather than move to safety.

The deaths of 11 crew members on tugboat Varapradha are also under criminal investigation by the Mumbai Police. Varapradha, owned by Mumbai-based company Glory Ship Management, was assigned to handle accommodation barge Gal Constructor, owned by Kolkata-based Tirupati Vessel Pvt Ltd.

On June 24, the police filed an FIR against Glory Ship Management and its managing director Rajesh Shahi, booking them for culpable homicide based on a complaint by Francis Simon, the acting chief engineer of Varapradha and one of its two survivors. Simons allegation is that the tugboat sank because it was an old vessel in a poor condition, and that the owners deployed it even though it was not seaworthy.

Running parallel to the police investigations is an inquiry by a high-level committee instituted by the Ministry of Petroleum and Natural Gas on May 19. The three-member committee, comprising senior bureaucrats from the ministries of shipping, petroleum and defence, is yet to complete its probe to determine who should be held accountable for the May 17 incident.

In June and July, Scroll.in had extensive conversations with survivors and senior crew members of the vessels stranded in Cyclone Tauktae. Their accounts of the sequence of events between May 13 and 18 suggest that the blame for failing to prevent the tragedy lies beyond just the captains of the stranded vessels, and extends all the way up to the ONGC and Afcons.

The health and safety page of the ONGCs website opens with a popular quote about safety: All accidents are preventable.

In the aftermath of Cyclone Tauktae, this statement rings with irony.

The India Meteorological Department first issued warnings about a tropical storm moving towards southern India in the Arabian Sea on May 13. The next day, as the storm moved towards Kerala with a wind speed of 25 knots, it was named Cyclone Tauktae.

Over the next three days, Tauktae intensified rapidly as it moved northwards along Indias western coast, prompting the IMD to upgrade it from a severe cyclonic storm to a very severe one and finally, at its peak on May 17, an extremely severe cyclonic storm. State authorities in Kerala, Karnataka, Goa, Maharashtra and Gujarat responded to the IMDs red alerts by suspending flights, evacuating coastal residents, pausing all fishing activities and placing military and disaster response forces on standby.

The ONGC has maintained that it had immediately alerted everyone at Mumbai High about IMDs first cyclone warnings on May 13. The ONGCs fixed installations were asked to go into sea survival mode where all operations are halted in preparation for adverse weather and 99 floating vessels at the oil fields were advised to move towards safe locations.

This, according to the ONGC, was the extent of its role, since operations of many of the vessels were under the charge of Afcons and the companies it had subcontracted. In a statement to the Indian Express on May 21, an ONGC official claimed, we are not mariners, we are oil and gas experts.

Does the ONGCs responsibility simply end there?

An official within the company claimed that it does. ONGC can only issue advisories and suggestions about the weather, the official told Scroll.in on the condition of anonymity. Afcons had full responsibility for acting on the advisories for all the vessels it had chartered during that time.

According to the official, the ONGC receives regular and detailed weather updates from international meteorological agencies, and the updates are conveyed to all their offshore rigs, installations and vessels every day. In case of cyclone warnings, all rigs are required to stop work, installations have to secure their operations and vessels are asked to move to a safe zone, the official said. We followed all these procedures.

The official clarified that the ONGCs standard operating procedures for adverse weather do not specify exact safe zones to move to, and that those decisions are left to the vessels. We are not an agency that can tell them forcefully to go from here to there. The vessels are guided by DG Shipping [the Directorate General of Shipping] and the Navy, the official said.

Amitabh Kumar, the Director General of Shipping, who is one of the three members of the high-power committee inquiring into the incident, declined to answer any queries. The inquiry is still ongoing, and it will take some time, Kumar said. Till then I cannot answer anything.

Rahman Shaikh, however, does not accept the argument that the ONGC is only responsible for issuing advisories. The oil fields belong to ONGC, said Shaikh. If ONGC had simply ordered all the vessels to evacuate its fields, they would have to do it.

A survivor from Gal Constructor, one of the barges stranded during the cyclone, also echoed this view. ONGC is the master of everything at Mumbai High, said the survivor, who asked not to be identified. They can pass any order, and drive any vessel out of their fields. Afcons works under ONGC.

These assertions are particularly significant given that, according to Shaikh, a senior crew member on Papaa-305 had emailed the ONGC seeking advice on May 14, the day after the first weather warnings were issued and almost three days before the cyclone hit the barge.

The barge had been anchored right next to an oil rig platform at Heera Field, and when the first weather warnings were issued on May 13, the captain, Rakesh Ballav, decided to move the barge 200 metres away from the platform, to prevent any collisions during the storm. The next morning, the senior crew members convened to take stock of the situation.

Sachindra Prasad Singh was the deck officer of Papaa-305. His many tasks included overseeing navigation, handling security equipment and coordinating between different departments on a vessel.

At 9.28 am on May 14, on the instructions of the captain, Singh sent an email to several officials at the ONGC, as well as the email address Lewpp2@ongc.co.in. LEWPP refers to the name of the platform maintenance project: Life Extension of Well Platform Project 2. The email described the cyclone predictions made by private weather forecast company Storm Geo, which included wind speeds of up to 50 knots and wave swell of between seven and nine metres, and asked for urgent advice or instructions.

Based on these extreme environmental conditions & further discussion with Barge Master on this he stated that he need sufficient time to pick up anchors and move to safe distance from platform, the email said. Therefore, we request you to guide or instruct the concerned parties to take appropriate action and to ensure the safety of all personnels and assets. (sic)

According to Shaikh, the concerned parties mentioned in the email refer to Afcons representatives at Heera Field, who would then instruct the captain to move the barge. The idea was that ONGC should say something, since it is their barge, said Shaikh, who was not copied on the email himself.

Deck officer Singh died when the barge capsized three days later. But Shaikh claims that to the best of his knowledge, Singhs email did not receive a response from the ONGC. We specifically asked the deck officer on 15th morning if ONGC had mailed back, and he said they had not, said Shaikh.

Harish Awal, the ONGCs group general manager and official spokesperson, did not respond to queries on the phone and asked Scroll.in to email him. As of the time of publication, he had not responded to emailed queries.

On June 2, however, the ONGC suspended three of its executive directors in charge of drilling, safety and executive exploration. According to a report in the Indian Express, a source in the petroleum ministry claimed that the officials were suspended pending inquiry, to ensure a free and fair inquiry. However, an employees union within the ONGC, the Association of Scientific and Technical Officers, has condemned it as unjustified disciplinary action. In a letter to the companys chairman, the union has called for the suspension to be revoked, and for Afcons alone to be held responsible for failing to adhere to the ONGCs weather warnings and safety advisories.

Afcons has claimed that the ONGC unions allegations are unsubstantiated and misinformed. It is well known and documented that all barges charted by Afcons were instructed to demobilise from the work area and did so by May 14/15, well before the onset of the full fury of Cyclone Tauktae, an Afcons spokesperson told the media in response to the unions letter.

However, conversations with survivors of three stranded vessels, as well as the owner of one vessel, suggest that Afcons not only failed to heed cyclone warnings but also chose to prioritise work targets over the safety of hundreds of workers and seafarers.

At 6.45 am on May 15, as they waited for the ONGCs response to the deck officers email, Shaikh and other senior crew members on Papaa-305 gathered for their regular morning meeting. Those present at the meeting included barge master Rakesh Ballav, assistant barge master Devesh Mishra and deck officer Sachindra Singh, and Nilesh Biswas, the Afcons representative on the barge in charge of communicating Afcons instructions to the crew and overseeing the technical work.

At the meeting, Rakesh Ballav asked the Afcons representative if anyone from ONGC or Afcons had asked us to pull out of the field, said Shaikh. The Afcons representative said no, there is no such news from anywhere.

Devesh Mishra did not respond to calls or messages from Scroll.in, while Nilesh Biswas lost his life when the barge eventually capsized.

By the evening of May 15, an unfortunate decision was made.

At around 6 pm, the barge master had calls with somebody from the Afcons head office and someone from the barge owners [Durmasts] office. I dont know what they discussed on that call, but afterwards it was decided that the barge would stay where we were, 200 metres from the platform in Heera Field, said Shaikh. I think they decided that the weather was manageable.

As a safety precaution, Papaa-305s designated tugboat, Nove, was asked to be on standby five nautical miles (9 km) away from the barge.

The captain of tugboat Nove, Sujeet Singh, seemed to have a better idea about the conversation that Ballav had with Afcons on May 15.

On May 15th morning, around 7.30 am, the captain of Papaa-305 called me to say that we were going to leave for Mumbai because of the cyclone, and I should be ready for anchor handling, said Sujeet Singh, who has 18 years of maritime experience and has captained Nove for the past two years.

Anchor handling is a lengthy process in which a tugboat secures or removes the anchors of engine-less barges or oil rigs. For eight-anchor barges like Papaa-305, it is a whole days work, and Noves 13-member crew began greasing their anchor handling equipment on May 15 to prepare for it.

But then later in the evening, the Papaa-305 captain called and said we were going to stay there itself [in Heera Field]. He said there are just four or five more days of work left, which we will finish after the cyclone, and then return to Mumbai on May 25 or 26, said Sujeet Singh. As the captain of the tugboat assigned to Papaa-305, Singh claimed he was not in direct touch with Afcons representatives, but took his instructions from the captain of the barge.

Onboard Papaa-305, when workers like Prasad realised that other vessels in the oil field were moving towards the Mumbai shore, they urged their seniors to take them to safety too. They told us we were going to stay and finish the platform work soon.

What happened next has been chronicled, in all its terrifying detail, in dozens of media reports and survivor accounts of the May 17 barge accident.

The cyclone arrived on the night of May 16 with wind speeds of between 40 and 50 knots, and grew progressively worse by the hour. At 2 am on May 17, two of Papaa-305s eight anchors snapped. Around that time, the barge master called Nove for help, but Nove said it was 12 nautical miles away, said Shaikh. The master asked them to come closer, but Nove refused, because of the strong winds and high swell.

By 4 am, three more anchors were lost and by 8 am, as wind speeds increased to 70 knots, all of Papaa-305s anchors had snapped. The barge was shaking so violently in the waves that a 17-tonne container slid off the deck into the sea. Soon after, the drifting barge collided with the oil platform. The collision did not, fortunately, trigger a fire, but it spelt doom for Papaa-305, which began to flood and sink.

Prasad and other technical workers, who until then had been asked to stay in their rooms, were issued orders to abandon the ship. They had to don life jackets and make their way towards the life rafts on the deck.

There were 32 life rafts for the 261 people on board each raft could hold at least 10 people, according to Sheikh. Each side of the deck had 16 rafts, but with the barge tilting in the waves, those on the starboard side were not accessible at all. We tried inflating the other life rafts, but only the first two worked. The rest of the rafts did not inflate they had holes in them, said Prasad.

Sixteen life rafts could not be accessed. Fourteen were punctured and could not be used. The only option that most of those on board had was to jump into the water in their life jackets and pray for the rescue ships to arrive.

But because of the severe weather conditions, they could not reach us easily, said Shaikh, who was among the last to jump from the sinking vessel.

Some survivors spent eight hours in the choppy sea before they were rescued; others, like Shaikh, had to battle the waves for between 12 and 14 hours. All through this ordeal, Shaikh and other survivors reported similar experiences: they tried to hold hands with others and stay together in groups so that they could be easily spotted by rescuers, but were forced apart by the waves and had to watch their colleagues disappear.

Somewhere at a long distance, Sujeet Singh and his crew on Nove watched helplessly as Papaa-305 sank. They had asked us for help, but how could we get to them? There was so much wind and swell, said Singh, his voice breaking over the phone as he spoke to Scroll.in from his hometown in Haryana. We tried our best to get close anyone would try to save a drowning man. But the waves kept throwing us in different directions, and we were struggling to just keep cruising and stay in control of our vessel.

Since Nove managed to save itself and did not need to be rescued, it was not listed as one of the vessels stranded in the cyclone. But if the tugboat had been directed to tow Papaa-305 to safety on May 15 instead of staying just nine km away, 75 lives on the barge could have been saved. In addition, the 13 men on Nove would not have had to spend two days of terror trying to stay afloat through the cyclone though they were fortunate that their vessel did not capsize and their crew did not suffer injuries or fatalities.

Besides Papaa-305 and Nove, four other vessels had to live through this nightmare.

Sagar Bhushan, a flat-bottomed drill ship chartered by Afcons, stayed anchored at the companys Bassein Field with 101 people on board. During the cyclone on May 17, all of its eight anchors gave way, and the vessel began to drift northwards in the Gulf of Khambhat.

Support Station 3, a construction barge chartered by Afcons, which had 196 on board, began moving out of Mumbai Highs South Field on May 16, but got stuck at Heera Field on the way to Mumbai as the cyclone struck. It, too, lost its anchors and drifted northwards, constantly at risk of colliding into rocks and other obstacles, and of capsizing in the choppy waves.

Fortunately, those onboard Sagar Bhushan and Support Station 3 were rescued by the Navy on May 18.

Accommodation barge Gal Constructor was also stationed at South Field, around 160 km from Mumbais coast, with 137 people on board. The barge, along with its tugboat Varapradha, could have been safe inside Mumbais Princess Dock by the night of May 16 had it not been for delays and questionable decisions made by Afcons officials.

Gal Constructors captain, Goa-based Agnelo Rebello, said he did not wish to speak with the media about his experience anymore, but referred us to his interview in the Indian Express, published on June 2.

In the interview, he claimed that he had informed the Afcons representative at South Field about the need to move his vessel to the Mumbai port on May 13 itself. As a captain with 37 years of maritime experience, he had seen several cyclones before and knew Tauktae was going to be very dangerous.

But Afcons, he claimed, asked him to stay within the operational area of the oil field. The company gave Gal Constructors crew the example of Papaa-305, which it claimed had already agreed to stay in Heera Field through the cyclone. But the barges captain insisted on leaving for Mumbai, and on the night of May 14, Afcons sent tugboat Varapradha to tow Gal Constructor.

We could not get to Gal Constructor earlier because the Afcons representative first sent us to do anchor handling for another vessel, MV Workboat 1, said Francis Simon, the chief engineer of Varapradha and one of its only two survivors. MV Workboat 1 had its own propulsion and engine, but needed help with its anchors. Once Workboat 1 was on its way towards the shore, Simon and his team spent all night and most of May 15 de-anchoring Gal Constructor.

The tug then took over 30 hours to tow the barge to Mumbai. It was 7.30 pm on May 16 by the time the two vessels reached Bombay Floating Lights, the entryway to the water channels leading to Princess Dock in Mumbai and Jawaharlal Nehru Port Trust in Nhava Sheva. To enter any of the safe, inner-anchorage areas of the ports, vessels need prior approval from port authorities and must book a pilot from the port to guide the way.

But according to Rebello in his Indian Express interview, Afcons did not secure permissions for Gal Constructor to enter any of the inner-anchorage areas, despite his requests that it do so. Instead, possibly to save money and time, he claimed that Afcons directed the barge and tugboat to anchor further south, around 10 km away from Alibaugs Revdanda port.

Afcons Infrastructures official spokesperson, Bivabasu Kumar, told Scroll.in that the company would not be able to answer any queries about the incident. This incident is being probed by a high-powered committee, and we have already submitted voluminous information to them, Kumar said. Prima facie we do not want to make comments to individual journalists, but you can email your questions. As of the time of publication, the company had not responded to emailed queries.

Both Gal Constructor and Varapradha suffered the consequences of being denied safe shelter in a port.

On the morning of May 17, Gal Constructors anchors snapped and the vessel was left to the mercy of the sea. The barge drifted northwards from Revdanda, got stuck in sand at Colaba in southern Mumbai a few hours later, then was dislodged by the waves and carried further north. The vessel, which was constantly in danger of capsizing, could not easily be reached by rescuers, and finally ran aground on a rocky shore in Palghar, 100 km north of Mumbai. After more than two days of distress and hunger, on May 18, all 137 men on board were airlifted to safety.

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The decisions that led to Indias worst offshore disaster - Scroll.in

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Where’s The Money? | Ways to keep your phone safe – WCNC.com

Posted: July 25, 2021 at 3:43 pm

Your phone is an extension of your online life. Here are three ways to make sure your devices are protected against hackers.

CHARLOTTE, N.C. With the recent news of pipelines being hacked and major companies having to pay ransom to get their files back, it might leave you wondering how secure your devices are.

It has become way more than just a mobile phone. In all reality, our phones are an extension of our online life. We bank on it, we monitor financial investments on it, and we might even save password lists to a variety of sites.

First, who is vulnerable? The answer is everyone. Will you know if you have been hacked or had spyware put on your phone? Likely no, which is why this information is so important.

Know that spyware can collect all of your information, stuff like passwords, contacts, photos, videos, and documents that you have stored on your phone or computer.

So, how can you make sure your phone is secure? Here are three things you can do to make sure your phone, and the information on it, are locked down tight.

Lastly, dont click on odd emails or messages from long-lost friends that suddenly drop in out of the blue with a link to photos or some other link they want you to click on. Also, be wary of the click here for the good deal coupon." It can show up from any store. Before you click, google the ad to see if its real, but dont just blindly click.

We dont want to admit it, but operator error and password laziness are the two things that make us the most vulnerable.

WCNC Charlotte is always asking "where's the money?" If you need help, reach out to the Defenders team by emailingmoney@wcnc.com.

Contact Bill McGinty atbmcginty@wcnc.comand follow him onFacebook.

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Where's The Money? | Ways to keep your phone safe - WCNC.com

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EP. 8: Targeted Therapies for Myelofibrosis – Targeted Oncology

Posted: at 3:43 pm

Srdan Verstovsek, MD: In the treatment of myelofibrosisthat is the most difficult to manage of the MPNs [myeloproliferative neoplasms]there is certainly a major change in the management of myelofibrosis with the application of the JAK2 inhibitors. If we are talking about treatment for PV [polycythemia vera] in the second-line setting, a quarter of the patients or perhaps more, would need something beyond this frontline therapy of hydroxyurea. With ET [essential thrombocythemia], there is a similar situation. Regarding myelofibrosis, I think we can say that development ofJAKinhibitors is earth-shaking for the outcome of these patients. I think you would agree with that statement.

Andrew Kuykendall, MD: Yes, it has completely changed the game for, as we said, these salvage approaches. We have gone from sometimes very gruesome approaches of taking peoples massively enlarged spleens out to now being able to provide a pill that, for the vast majority of patients, is going to improve their spleen size just by taking it twice a day. I imagine it is a pretty big change for patients.

Srdan Verstovsek, MD: Yes, and again, it is active regardless of mutational status and whether you have primary myelofibrosis, or have it secondary to PV or to ET. The benefits are seen across the board to a similar extent, and on average, from clinical studies, for about 3 years, and a good proportion of the patients have that benefit prolonging their life. I think the evidence, particularly over the last couple of years, speaks to that prolongation of life as a benefit that we did not really imagine because we were talking about controlling the symptoms and the spleen. Now, we are looking at the Medicare database and the SEER [Surveillance, Epidemiology, and End Results] database; we have all these large, federal databases that are suggesting people actually live longer.

Andrew Kuykendall, MD: It is really encouraging, obviously. That is the goal of all these medications, to have people live longer and live better. For ruxolitinib, we knew people were living better, but there is good evidence that people are living longer, too. As someone who has closely reviewed the COMFORT trials, it is almost hard to understand how there was a survival benefit when patients were allowed to cross over after 6 months, and most patients did. It reinforces the benefit of getting these patients on ruxolitinib earlier, if they are appropriate candidates for it. There is clearly a benefit to getting treated earlier. To show a survival benefit in a study that allows crossover after 6 months is challenging to do, but when it is shown, it shows the benefit of early initiation.

Srdan Verstovsek, MD: The early initiation, I think, is one of the key factors for achieving that longevity because if you are introducing the therapy late, you are facing patients who are very debilitated, who particularly have anemia and thrombocytopenia that affect the delivery of the therapy. Early intervention is needed even when patients are not extraordinarily sick, especially those who have an indication for therapy with symptomatic splenomegaly and general systemic symptoms. If they do not have excessive anemia or thrombocytopenia, your management will be easier; you can get a better dose of ruxolitinib and a better chance for extensive improvement of the patients metabolism, function of the organs, performance status, and spleen size, making the spleen as small as possible.

The analysis of the benefits stretch from, you have a high albumin, high cholesterol, your weight goes upI think that is a very well-known patient complaint, gaining too muchbut performance status improves, kidney function improves, and the spleen is much smaller. Then, people can sustain life with much better quality for much longer, and I think that is the goal of our efforts today, versus 10 years ago. We would say, Do not wait. Early intervention matters. You will make people happier sooner. Why do you need to wait for people to be dying? Intervene early, and that will translate, as you optimally treat the patients with the safest, highest dose to decrease the spleen as much as you can, to life extension. I think that is something we need to strive for, to be widely accepted, to up the bar from quality of life improvement to life extension.

Andrew Kuykendall, MD: I definitely agree. I think the one thing we focus on is the survival benefit, as was seen in patients who were eligible for the study, patients who had big spleens. I think there is a lot of discussion around what really constitutes a symptomatic spleen. Sometimes patients do not know, or physicians do not know, but a big spleen is usually symptomatic. I had a recent patient I saw in the clinic who had a spleen that was extending past his belly button, but he said it was not causing him any symptoms. He did not really understand why he was having increased urinary frequency, or frequent diarrhea, or why his kidney function was going up, but he said the spleen that was across his midline was not symptomatic. I think we probably waited a little too long to treat a patient like that; sometimes just asking a patient if they are symptomatic or not probably is not right. These big spleens, once they are 5 cm, or palpable under the rib, usually cause some degree of discomfort, even if its minimized by patients.

Srdan Verstovsek, MD: You extended this discussion to proper assessment of patients. We should be asking questions or utilizing what we were saying before when discussing ET and PV; we need to be assessing the quality of life with the proper questionnaire, which should become part of the electronic medical record, so we can respectively follow the quality of life as the patient answers those questions. You have a point from 0 to 100, and then you can track it like you tack the CBC [complete blood count]. Unfortunately, we do not have anything like that for the spleen itself. These are the limitations of what is happening right now, but with education, I think the assessment of patients quality of life and early intervention through recognition of the bad quality of life sooner rather than later will be ultimate goal. There are studies, as you know, done with low-risk patients, we still go by the risk of dying, but low-risk patients should not be symptomatic. They are, though, if you ask the questions, right? You have to ask the questions, and that is why the NCCN [National Comprehensive Cancer Network] guidelines say that, for even lower-risk patients, if they are symptomaticwhich is the keyyou need to ask the questions. There is a role for ruxolitinib.

Andrew Kuykendall, MD: If you are ever wondering what the flaw is in using risk models for determining treatment withJAKinhibitors, splenomegaly is not included in any of the risk models. That is one of the main reasons we are using those drugs. Low risk, high risk, whatever risk it isif they are symptomatic based on the symptom score or they have problematic or bigger spleens, then they are candidates, and they can benefit from these drugs.

Transcript edited for clarity.

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EP. 8: Targeted Therapies for Myelofibrosis - Targeted Oncology

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