Category Archives: History

New research suggested the overall rates of key safety events were similar between cohorts with inflammatory bowel disease (IBD) or ulcerative colitis (UC) receiving long-term ustekinumab or placebo.

These findings may be reassuring among the patient population with a history of prior biologic failure, study investigators said.

The long-term safety profile of ustekinumab in IBD patients with a history of biologic failure was favorable and consistent with the overall IBD population and the well-established, long-term, cumulative safety profile of ustekinumab across approved disease indications, wrote study author Edward V. Loftus, MD, Mayo Clinic College of Medicine and Science.

Loftus presented these data at the 2022 Digestive Disease Week Meeting in San Diego, California.

A significant number of patients may not respond to or lose response to, or are intolerant to, biologic agents and may require switching to a different biologic. The current integrated analysis incorporated ustekinumab phase 2/3 long-term safety data from IBD studies for up to 5 years in Crohns Disease (CD) and 2 years in UC in patients with a history of prior biologic failure.

The data from 5 phase 2/3 UST IBD studies were pooled, according to investigators. In phase 3, patients were given a single intravenous placebo or UST (130 mg or 6 mg/kg) induction dose and followed by a subcutaneous maintenance dose of placebo or ustekinumab (90 mg q8w or q12w).

All patients who received 1 dose of ustekinumab and were identified as having a history of prior biologic failure were included in the data analysis. Investigators noted concomitant immunomodulators and corticosteroids were permitted. In the pooled IBD group, safety outcomes are presented as events per 100 patient-years of follow-up and 95% confidence intervals (CIs).

For up to 5 years, a total of 847 IBD patients with a history of prior biologic failure received placebo (473 patient-years) and 1596 patients received ustekinumab (1970 patient-years). The average duration of follow-up was 2-fold longer for ustekinumab compared to placebo (64.18 weeks vs 29.06 weeks).

Data show the rates per 100 patient-years were similar between placebo and ustekinumab through up to 5 years for:

Overall, rates of non-melanoma skin cancer and malignancies were reported infrequently in ustekinumab patients with IBD, with similar rates between ustekinumab and placebo. Notably, the average duration of follow-up through 5 years was 2-fold longer for ustekinumab versus placebo (64.18 vs 29.06 weeks).

The overall rates of adverse events were similar between ustekinumab and placebo for individual events. Data show the most frequently reported adverse event was nasopharyngitis, while the most frequently reported infection was nasopharyngitis and upper respiratory tract infection.

Moreover, a total of 6 deaths were reported through up to 5 years in patients with a history of prior biologic failure treated with ustekinumab (0.3 per 100 patient-years). However, all were considered to have no relation to the study agent, according to investigators.

The study, Long-Term Safety of Ustekinumab in IBD Patients with A History of Biologic Failure: Pooled Safety Analysis Through 5 Years in Crohns Disease and 2 Years in Ulcerative Colitis, was presented at DDW 2022.

More:

Safety Profile of Ustekinumab Favorable in Patients with IBD, History of BIologic Failure - MD Magazine

A defendant with a juvenile criminal history of sex crimes was in 5th District Court court Thursday on two recent cases involving rape and other charges filed last year in St. George.

Estimated read time: Less than a minute

ST. GEORGE A defendant with a juvenile criminal history of sex crimes was in court on two recent cases involving rape and other charges filed last year in St. George, a hearing conducted to determine if the defendant, who has the highest risk rating, should remain free pending trial.

The Thursday hearing involved the case of 20-year-old Avery Jared Anderson, who faces one first-degree felony rape and two second-degree felony charges sexual exploitation of a minor and aggravated assault. He also faces unlawful sexual activity with a minor more than four years younger charges that were filed in two separate cases.

The proceeding was to rule on whether to revoke Anderson's pretrial release, a motion submitted by Washington County Prosecutor Jim Weeks.

During oral arguments before District Judge Keith C. Barnes, Weeks said Anderson "is a danger to the community," while defense attorney Ricky Bonewell countered, saying, "I don't see that he's any type of a danger."

Read the full article at St. George News.

Cody Blowers is a reporter for St. George News. A graduate of Colorado Technical University, Cody earned her bachelors degree in criminal justice with a minor in paralegal studies.

Read more here:

Man with extensive history of sex crimes appears in court on new cases in St. George - KSL.com

Joe Biden listens to remarks by Finland's President Sauli Niinisto and Sweden's Prime Minister Magdalena Andersson at the White House this week. Chip Somodevilla/Getty Images hide caption

Joe Biden listens to remarks by Finland's President Sauli Niinisto and Sweden's Prime Minister Magdalena Andersson at the White House this week.

Finland and Sweden have long kept a careful balance and neutral position between the West and Russia.

But that changed after Moscow invaded Ukraine.

On Thursday, the leaders of those two Nordic nations were at the White House, where President Biden threw his full support behind their application to join the NATO military alliance.

"Let me be clear: New members joining NATO is not a threat to any nation. It never has been. NATO's purpose is to defend against aggression. That's its purpose, to defend," President Biden said.

But that is not the way that Moscow sees it. President Vladimir Putin has long accused NATO of aggressive expansion in Europe.

Mary Elise Sarotte is a historian who has documented how NATO has grown over the years, and wrote a book called, Not One Inch: America, Russia and the Making of Post-Cold War Stalemate.

Sarotte joined All Things Considered to break down key moments and misconceptions in NATO's growth in the past decades.

This interview has been edited for length and clarity.

NATO Secretary-General Jens Stoltenberg displays documents as Sweden and Finland applied for membership in Brussels, Belgium, Wednesday May 18, 2022. JOHANNA GERON/AP hide caption

NATO Secretary-General Jens Stoltenberg displays documents as Sweden and Finland applied for membership in Brussels, Belgium, Wednesday May 18, 2022.

On Vladimir Putin's claim that NATO broke a promise about not expanding eastward

The Berlin Wall had come down unexpectedly on November 9, 1989, which was a remarkable, unexpected event. And as the Berlin Wall crumbled, so too did the Cold War order. So the question was, "What next?" It was clear that Germans wanted to unify. In early speculative discussions about that, the American Secretary of State James Baker said to Mikhail Gorbachev roughly the following: "How about you let your half of Germany go and we agree that NATO moves not one inch eastward?" Gorbachev couldn't actually get that pledge formalized or agreed. In September 1990, he made a different deal: He agreed to allow Germany to unify in exchange for financial incentives. But Putin only refers to the earlier speculative conversation, not to the treaty that his country signed and ratified at the end.

On the growth of NATO's footprint since 1990

There have been multiple rounds of expansion since 1990. Technically, the first post-Cold War expansion is into eastern Germany. That was an important precedent, because when you fast forward into the 1990s, the central and eastern European states want to join. That's a second controversy, because when that starts happening, Moscow, under the leadership of Boris Yeltsin, pushes back and says, "Hey, the treaty from 1990 was only about east Germany.''

This is one of the few points that both sides can agree on in this whole controversy, that the treaty of 1990 was only about east Germany. For the Russians, that meant you could only extend to east Germany. For the West, that meant the treaty was only about east Germany, and said nothing about central, or eastern Europe, and had no impact whatsoever.

Poland, Hungary, and the Czech Republic are invited and do become members in 1999. Putin was in charge by that time and he disliked that intensely, because it meant in his view that NATO was expanding into the former Soviet Union and near to his hometown, which is now called Saint Petersburg. So NATO has gone through multiple rounds of enlargement and now there's going to be another one with Sweden and with Finland.

On the 1997 agreement between Russia and NATO to address their tensions, and Putin's interpretation of it

There was a time that Mikhail Gorbachev said, "How about we merge the Warsaw Pact and NATO?" And then Boris Yeltsin also talked to President Bill Clinton about the idea of Russia joining NATO. In fact, Yeltsin even said at one point that the real problem will be China, because then China will have a NATO border.

Russian President Vladimir Putin in Moscow on May 16, 2022. ALEXANDER NEMENOV/POOL/AFP via Getty Images hide caption

Russian President Vladimir Putin in Moscow on May 16, 2022.

In the May 1997 agreement, the West signed something called the NATO-Russia Founding Act, and Putin is instrumentalizing this history as well. He is drawing on a claim that Boris Yeltsin made afterwards which was wrong. But it was a public claim Boris Yeltsin made that the May 1997 agreement gave Russia a veto over NATO enlargement. It did not. Yeltsin said this publicly to appease his domestic opponents at the time. But that's another piece of history that Putin can instrumentalize. In short, Putin cherry picks history. But Putin is not interested in historical accuracy. He's interested in creating emotional support for the brutalities he's inflicting on Ukraine.

Read the original:

Two versions of history collide as Finland and Sweden seek to join NATO - NPR

By The Associated Press

Todays Highlight in History:

On May 21, 1881, Clara Barton founded the American Red Cross.

On this date:

In 1471, King Henry VI of England died in the Tower of London at age 49.

In 1542, Spanish explorer Hernando de Soto died while searching for gold along the Mississippi River.

In 1924, in a case that drew much notoriety, 14-year-old Bobby Franks was murdered in a thrill killing carried out by University of Chicago students Nathan Leopold Jr. and Richard Loeb (Bobbys cousin).

In 1927, Charles A. Lindbergh landed his Spirit of St. Louis monoplane near Paris, completing the first solo airplane flight across the Atlantic Ocean in 33 1/2 hours.

In 1932, Amelia Earhart became the first woman to fly solo across the Atlantic Ocean as she landed in Northern Ireland, about 15 hours after leaving Newfoundland.

In 1941, a German U-boat sank the American merchant steamship SS Robin Moor in the South Atlantic after the ships passengers and crew were allowed to board lifeboats.

In 1955, Chuck Berry recorded his first single, Maybellene, for Chess Records in Chicago.

In 1972, Michelangelos Pieta, on display at the Vatican, was damaged by a hammer-wielding man who shouted he was Jesus Christ.

In 1979, former San Francisco City Supervisor Dan White was convicted of voluntary manslaughter in the slayings of Mayor George Moscone (mahs-KOH-nee) and openly gay Supervisor Harvey Milk; outrage over the verdict sparked rioting. (White was sentenced to seven years and eight months in prison; he ended up serving five years and took his own life in 1985.)

In 1980, Star Wars Episode V Empire Strikes Back, produced by George Lucas opens in cinemas in UK and North America.

In 1991, former Indian Prime Minister Rajiv Gandhi was assassinated during national elections by a suicide bomber.

In 2000, death claimed actor Sir John Gielgud at age 96 and author Dame Barbara Cartland at age 98.

In 2020, President Donald Trump visited a Ford Motor Co. plant outside Detroit that had been repurposed to manufacture ventilators; he did not publicly wear a face mask but said he had worn one while out of public view. A Michigan judge sided with Gov. Gretchen Whitmer in a challenge by Republican lawmakers to her authority to order sweeping restrictions during the coronavirus outbreak.

Ten years ago: President Barack Obama and other world leaders meeting in Chicago locked in place an Afghanistan exit path that would keep their troops fighting there for two more years. Former Rutgers University student Dharun Ravi (dah-ROON RAH-vee), who used a webcam to spy on his gay roommate, Tyler Clementi, who then committed suicide, was sentenced to 30 days in jail (he served 20). A Yemeni man detonated a bomb during a rehearsal for a military parade, killing 96 fellow soldiers; al-Qaidas branch in Yemen claimed responsibility.

Five years ago: President Donald Trump, visiting Riyadh, implored Saudi Arabia and other Middle Eastern countries to extinguish Islamic extremism emanating from the region. North Korea fired a solid-fuel ballistic missile, saying the test was hailed as perfect by leader Kim Jong Un. The Ringling Bros. and Barnum & Bailey Circus received its final standing ovation as it performed its last show at the Nassau County Coliseum in Uniondale, New York, ending a 146-year run.

One year ago: Thousands of Palestinians rallied after a cease-fire took effect in the latest Gaza war; the 11 days of fighting left more than 250 people dead, the vast majority Palestinians, and brought widespread destruction to the Gaza Strip. President Joe Biden said there had been no shift in his commitment to Israels security, but that a two-state solution that includes a state for Palestinians remained the only answer to that conflict. Authorities said the two Bureau of Prisons workers who were supposed to be guarding Jeffrey Epstein the night he killed himself in a New York jail had admitted that they falsified records, but that they would be spared prison time under a deal with federal prosecutors; the workers were accused of sleeping and browsing the internet instead of monitoring Epstein.

Todays Birthdays: R&B singer Ron Isley (The Isley Brothers) is 81. Musician Bill Champlin is 75. Singer Leo Sayer is 74. Actor Carol Potter is 74. Former Sen. Al Franken, D-Minn., is 71. Actor Mr. T is 70. Music producer Stan Lynch is 67. Actor Judge Reinhold is 65. Actor-director Nick Cassavetes is 63. Actor Lisa Edelstein is 56. Actor Fairuza Balk is 48.

Rock singer-musician Mikel Jollett (Airborne Toxic Event) is 48. Rapper Havoc (Mobb Deep) is 48. Rock musician Tony LoGerfo (Lukas Nelson & Promise of the Real) is 39. Actor Sunkrish Bala is 38. Actor David Ajala is 36. Actor Ashlie Brillault is 35. Country singer Cody Johnson is 35. Actor Scott Leavenworth is 32. Actor Sarah Ramos is 31.

Read the original here:

Today in History: Today is Saturday, May 21, the 141st day of 2022. - wausaupilotandreview.com

Former Seattle Supersonics head coach George Karl, who is slated to be inducted into the Naismith Basketball Hall of Fame in 2022, tweeted out his belief that the Sonics and Oklahoma City Thunder should not share a history together.

This was due to the fact that the SportsCenter account tweeted a graphic of Kevin Durant and Gary Payton as the only two players in franchise history who were drafted second overall with a third one soon to join as the Thunder jumped up the 2022 NBA draft lottery and received the second overall pick.

Karl quote tweeted SportsCenter and voiced his opinion of the teams needing to separate their histories. Please dont combine Thunder and Sonics history. Thank you.

Karl coached the Sonics from 1992 to 1998, where they reached the NBA Finals in 1996 before losing to the Chicago Bulls.

This has been a hot button issue since the Thunder relocated to Oklahoma City in 2008. The team officially owns the full history of the Sonics as well since its the same franchise, but the Thunder have basically never acknowledged the history prior to the relocation. If the Sonics eventually come back as an expansion team, Im sure the team will gain the history back and this entire semantical debate can finally be put to rest.

See the original post:

George Karl does not want the Thunder and Sonics history together - OKC Thunder Wire

MANHATTAN The Manhattan History Museum has introduced new exhibits and a redecorated display space this month.

Along with its regular exhibits, two new ones are currently being showcased A Household in Time and Manhattan Township: 30,000 BCE to 1886.

A Household in Time features a trip back in time, presenting the retro-style household items used by our ancestors in their daily lives to work, play, parent and keep up the house. On display are many hand-operated devices that are precursors to modern appliances. From a crank-operated sausage maker to a pedal-powered sewing machine, this exhibit takes viewers back to an earlier time. This exhibit will be semi-permanent in that parts of it will be changed over time to present various aspects of early domestic life.

Manhattan Township: 30,000 BCE to 1886 is a journey through time. Common belief has it, before the Village of Manhattan was incorporated, much of the land was settled by Irish and German immigrants who left their homelands seeking the opportunity provided by the construction of the Illinois & Michigan Canal. Following the completion of the canal, many of the workers settled into a life of agriculture. But what forces led to the construction of the canal in this area, formed the soils and caused trails to course through the tall grasses? What prompted early settlers to brave the hardships of the treeless prairie and convert the grasslands into productive farms and thriving communities? This exhibit studies these forces. The journey through history begins with the warming of the climate at the end of the most recent Ice Age and ends with the incorporation of the village we know today.

These exhibits will run for several months at the Manhattan History Museum at 225 S. State St. For information such as scheduled openings and tour opportunities, visit the museums Facebook page by searching Manhattan Historical Society.

Read more here:

New exhibits at the Manhattan History Museum - The Herald-News

History offers no promise of an answer or a happy ending. There is not even a promise of a happy beginning: The further back we go, the less we have to go on. Worst of all, a historian cannot make anything up, but must still make everything into a story. No wonder historians tend to avoid historiography, writing about how history is written. It would give the game away.

Richard Cohens Making History is a substantial, ambitious and consistently readable inquiry into the history of history. His search for how the historical sausage gets made leads him to examine the biographies of the butchers, from Herodotus (the father of history, Cicero said, the father of lies, Plutarch said) to Nikole Hannah-Jones (the mother of more recent inventions in The 1619 Project). Academics may object that biography is vulgar, like writing for money, but the approach of Mr. Cohen, a longtime London book editor, has the weight of history behind it. Character always was destiny. It is not histories we are writing, but Lives, Plutarch wrote in the early 2nd century. The characters of the past, and the stories we tell ourselves about them, shape our present and future.

See the article here:

Making History Review: Writers of the Permanent Record - The Wall Street Journal

Horses work out on the Pimlico track early Tuesday as preparations for Saturday's Preakness Stakes are underway. (Jerry Jackson/Baltimore Sun/Tribune News Service via Getty Images)

The 147th Preakness could be run in some of the hottest weather in the history of the Triple Crown race.

The temperature at Pimlico Race Course soared above 90 degrees Fahrenheit just after 1 p.m. ET. The forecast calls for it to be 90 degrees when the horses enter the starting gate just after 7. Post time is scheduled for 7:01.

The record high on Preakness day is 96 set in 1934.

Epicenter lost the Kentucky Derby because of a hot pace. Now he'll face hot temperatures in the Preakness.

Epicenters trainer, Steve Asmussen, said he was as concerned as he possibly could be about the heat.

"We know it can be pretty sticky when it gets warm in Baltimore, so I think that all of them are going to have to deal with that," Asmussen said. "Hes a big horse turning back in 14 days, so just make sure hes drinking plenty of water and hydrated, just like your kids."

Kentucky Derby runner-up Epicenter was set as the 6-5 morning line favorite for the Preakness Stakes, which will be run without Rich Strike.

The surprise Derby winner at 80-1 is not in the field of nine for Saturdays $1.65 million race. Rich Strikes owner felt the two-week turnaround did not give the colt enough rest and plans to enter him in the Belmont.

RELATED: Explainer: How 81-1 shot Rich Strike won the Kentucky Derby

Rich Strikes absence clouds the second jewel of horse racings Triple Crown and makes this the second Preakness in four years without the Derby winner.

Last year, Medina Spirit ran and finished third at Pimlico after testing positive at Churchill Downs for a substance that was not allowed on race day and was eventually disqualified. In 2020, the races were run out of order because of the pandemic. And in 2019, neither DQed Derby champion Maximum Security nor elevated winner Country House went to the Preakness.

Post time for the Preakness is scheduled for 7:01 p.m. ET.

This story was reported from Detroit. The Associated Press contributed.

View post:

Preakness could be run in some of hottest weather in race's history - FOX 5 DC

Today in OTM History

2021: Danny Santana activated; This move didnt really work out as the Red Sox were hoping.

2020: Robbie Ross Jr. was underrapreciated; His career was short-lived, but while here he played a big role.

2019: Matt Barnes is the reason this bullpen has worked; Matt Barnes getting it done in the first half? Well I never! (Id take it this year, though.)

2015: Brady Aiken mocked to the Red Sox; They ended up with Andrew Benintendi, which I suppose is a better pick.

2014: Its time to turn to Pawtuckets rotation; In this case, that means Brandon Workman and Allen Webster.

1988: Bobby Doerr has his number retired for the Red Sox. Doerr is perhaps the most underrated all-time great in Red Sox history, with his time often overshadowed from being Ted Williams teammate.

1940: Jimmie Foxx hits a grand slam for the second straight day. He becomes only the third player in American League history to do so.

Happy would-be 113th birthday to Mace Brown, who ended his career as the Red Sox closer, though spent a couple of years fighting for the military after claiming that role.

Happy 37th birthday to Andrew Miller, who just this year retired and starting in 2012 rejuvenated his career as a reliever, becoming one of the most dominant in all of baseball.

Happy 52nd birthday to Bryce Florie, who is most famous for being hit in the eye with a line drive, which in turn made young me refuse to pitch for the rest of my life.

Many thanks to Baseball-Reference, NationalPastime.com and Today in Baseball History for assistance here, and thanks to Battery Power for the inspiration for these posts.

Read more:

Today in Boston Red Sox History: May 21 - Over The Monster

BEMIS, Tenn. One community is celebrating its Heritage Day.

Its a homecoming and a heritage festival, said Joel Jackson, chairman Bemis Historical Society.

The former town of Bemis celebrated its Heritage Day and one of its landmarks.

This is actually not our bicentennial but its our centennial of this building that were in right now, the Bemis Auditorium is what they first called it, Jackson said.

Gregory Hammond grew up in Bemis and says this day has helped him learn more about it.

Ive learned more about Bemis, than I did when I was raised here through this, through heritage, and so much went on and now I know who founded it, where it started and I was living in it, Hammond said.

Hammond says there should be more Heritage Days.

Its beautiful to memorialize the small town living, small America, Hammond said.

There was also a grand reopening of the Stella Duncan Park of Bemis with brand new equipment.

Its a whole new generation of equipment and a whole new generation of people, Jackson said.

The next Heritage Day will be June 4th celebrating Denmark and Vine Hill at the Denmark Elementary School.

See the original post here:

Community comes together to celebrate its history - WBBJ TV - WBBJ-TV