NIH-Supported Researchers Map Epigenome of More Than 100 Tissue and Cell Types

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Newswise Much like mapping the human genome laid the foundations for understanding the genetic basis of human health, new maps of the human epigenome may further unravel the complex links between DNA and disease. The epigenome is part of the machinery that helps direct how genes are turned off and on in different types of cells.

Researchers supported by the National Institutes of Health Common Funds Roadmap Epigenomics Program (http://commonfund.nih.gov/epigenomics/index) have mapped the epigenomes of more than 100 types of cells and tissues, providing new insight into which parts of the genome are used to make a particular type of cell. The data, available to the biomedical research community, can be found at the National Center for Biotechnology Information website (http://www.ncbi.nlm.nih.gov/).

This represents a major advance in the ongoing effort to understand how the 3 billion letters of an individuals DNA instruction book are able to instruct vastly different molecular activities, depending on the cellular context, said NIH Director Francis Collins, M.D., Ph.D. This outpouring of data-rich publications, produced by a remarkable team of creative scientists, provides powerful momentum for the rapidly growing field of epigenomics.

Researchers from the NIH Common Funds Roadmap Epigenomics Program published a description of the epigenome maps in the journal Nature. More than 20 additional papers, published in Nature and Nature-associated journals, show how these maps can be used to study human biology.

What the Roadmap Epigenomics Program has delivered is a way to look at the human genome in its living, breathing nature from cell type to cell type, said Manolis Kellis, Ph.D., professor of computer science at the Massachusetts Institute of Technology, Cambridge, and senior author of the paper.

Understanding epigenomics

Almost all human cells have identical genomes that contain instructions on how to make the many different cells and tissues in the body. During the development of different types of cells, regulatory proteins turn genes on and off and, in doing so, establish a layer of chemical signatures that make up the epigenome of each cell. In the Roadmap Epigenomics Program, researchers compared these epigenomic signatures and established their differences across a variety of cell types. The resulting information can help us understand how changes to the genome and epigenome can lead to conditions such as Alzheimers disease, cancer, asthma, and fetal growth abnormalities.

The value of epigenomic data

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NIH-Supported Researchers Map Epigenome of More Than 100 Tissue and Cell Types