DNA variants explain over 10 percent of inherited genetic risk for heart disease

Public release date: 8-Nov-2012 [ | E-mail | Share ]

Contact: Cathy Yarbrough press@ashg.org 858-243-1814 American Society of Human Genetics

About 10.6% of the inherited genetic risk for developing coronary artery disease (CAD) can be explained by specific DNA variations, according to research reported today at the American Society of Human Genetics 2012 meeting.

The research, conducted by scientists in the CARDIoGRAMplusC4D consortium, pinpointed 20 previously unidentified mutations during a two-stage meta-analysis of 63,746 patients with CAD, which causes more deaths worldwide than any other disease.

These genetic variants generally were infrequently found in the DNA of the 130,681 individuals without heart disease who were in the control group.

The new mutations have boosted to 47 the total number of DNA variants that have thus far been linked to an increased risk for developing CAD, said Panos Deloukas, Ph.D., who co-led the study and heads the Genetics of Complex Traits in Humans research group at the Wellcome Trust Sanger Institute, Cambridge, UK.

Scientists had previously estimated that 30 to 60% of the variation in CAD might be attributable to genetic risk factors, according to a study published in 2005*. The research reported at ASHG 2012 expands the number of specific genes that are likely involved.

"We no longer assume that coronary heart disease is triggered by just a handful of genes, each with a strong effect on a person's risk for the disease," said Dr. Deloukas. "Our research supports the current assumption that heart disease risk is determined by a large group of genes, each with a modest effect on risk."

Identifying the genetic mutations that set the stage for CAD enables researchers to investigate the underlying mechanisms of the disease, which may lead to therapeutic targeting through drugs, he said.

Many of the newly identified variations are in genes that operate in biological pathways involved in the body's metabolism of lipids or fats as well as in inflammation.

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DNA variants explain over 10 percent of inherited genetic risk for heart disease