Doctors find more cases of ‘COVID toes’ in dermatological registry. Here’s what they learned. – USA TODAY

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Doctors are learning more about COVID-19s newest and oddest skin manifestation,dubbed COVID toes, asthe Centers for Disease Control and Prevention adds to the growing list of symptoms associated with the coronavirus.

The American Academy of Dermatology has compiled a registry of skin manifestations associated with COVID-19.About half of the more than 300 total caseson the dermatologicalregistry consist of COVID toes.

The registry is made up of entries by physicians and other health care professionals who fill out a 5-7 minutes survey about patients with confirmed or suspected COVID-19 who develop skin manifestations, as well as patients with existing dermatologicalconditions who develop COVID-19 and patients on dermatological medicationswho developed COVID-19.Entries can not be made by patients themselves.

Dr. Esther Freeman,director of Massachusetts General Hospital Global Health Dermatology and member of the AAD task force on COVID-19,said COVID toes arepinkish-reddish pernio-like lesions that canturn purple over time.

She said this shouldn't be confused with a different medical condition that occurs in critically sickpatients called purpura fulminans.

When she first started the registry with the academy, she was expecting to see viral rashesoften driven by inflammation.

What was more surprising to me was this overwhelming representation of these COVID toes, she said.

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Pernio,also called chilblains,are skinsores or bumps that occur on a patients feet when theyre exposed to cold temperatures. The reason why Freeman calls the new symptompernio-like is because she believes COVID toe lesions arent a result of cold temperatures.

While experts cant confirm why COVID toes appear, they have some educated guesses. One could be inflammation in the toes' tissue, which is similar to pernio. Another hypothesis is inflammation of the blood vessel wall, medically known as vasculitis. And finally, Freeman said it ispossible COVID toes could be caused by small blood clots that form inside the blood vessel.

Doctors at the American Academy of Dermatology have discovered trends studying the registrythat werent previously known about COVID toes. Freeman saysCOVID toes have appeared in some cases of asymptomatic patients. The majority of the toecases manifestedsimultaneously or after more common COVID-19 symptoms, rather than before.

Freeman said some patients test positive for the PCR COVID test when they develop COVID toes, indicating they may still be infectious. Others test negative, suggesting the symptom would appear later in the infection.

The timing is complex and difficult to pin down, she said.

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The majority of COVID toepatients in the registry are younger people in their 20s and 30s, Freeman said, and doctors havent seen a lot cases reportedfrom older people. She also said most patients with COVID toes are healthy and have done well in their clinical course.

I think its important not to induce panic if you were to develop these lesions on your toes, she said. Most of our patients seem to be doing well.

Freeman recommends patients speak to their health care provider if they develop these lesions to assess if they arecaused by a different medical condition, or any other reason.

But if there isnt, then they should talk about COVID testing or isolate or consider other ways to reduce the spread, she said.

Follow Adrianna Rodriguez on Twitter: @AdriannaUSAT.

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Doctors find more cases of 'COVID toes' in dermatological registry. Here's what they learned. - USA TODAY