The $1,000 genome could be yours—if you spend $10 million on equipment

BusinessWire

Yesterday, the company that leads the field in DNA sequencing machines announced that it was preparing to sell systems that would finally put a major milestone in reach: the $1,000 genome. This is a notable breakthrough as it's been less than a decade since a genome cost over a quarter-million dollars. While the price may be revolutionary, the system itself is an evolution of existing technology, built up to provide massive economies of scale.

The foundation of the new system is a sequencing machine that improves a bit on the company's existing hardware, providing more individual sequencing reactions at the same time in each machine (6-8 billion reactions in each machine) and speeding up the actual reactions so that more gets done within a 24-hour period. The system itself then clusters 10 of these sped-up machines. The cluster of 10, according to Matthew Herper at Forbes, will set you back $10 million.

Despite the high cost of entry, however, Illumina claims that the amortized price is included in their $1,000 figureas are the costs of preparing the DNA and consumables used during the reactions, even the labor needed to get it all to happen. In other words, a single genome will still cost a fortune; buying the system and cranking out genomes nonstop for a few years will mean that the average cost drops to near the $1,000 price tag.

The cluster itself will be impressive. Each machine will churn out 600 Gigabases each day. Each copy of the human genome is only about three billion base pairs, and sequencing each of those bases an average of 30 times is typical for a lot of genome work, which means that a single genome will only take up 15 percent of a single machine's daily capacity. Spread out over a year, Illumina estimates that the cluster can output about 18,000 genomes every year. Your mileage may vary.

A number of large genome sequencing centers have already signed up for delivery of these systems, so they'll have an almost immediate impact in the academic world. But the $1,000 genome is mostly a figure that will be appealing for consumers. Unfortunately, the enormous up-front costs of the system make it unlikely that anyone's going to be rushing out to buy one of these so that they can turn around and offer its benefits to consumers, given that the consumer market is essentially nonexistent right now.

For more details, you can read Illumina's description of the system.

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The $1,000 genome could be yours—if you spend $10 million on equipment