Precision medicine test for breast cancer helps guide chemotherapy decisions – Knowridge Science Report

One of the earliest widespread applications of precision medicine in cancer care is helping patients and physicians decide whether chemotherapy is needed, a new study finds.

Researchers reviewed a test that assesses the risk of breast cancer recurrence and whether chemotherapy is likely to help lower that risk in women with early stage disease.

The test looks at 21 genes known to increase risk of cancer recurrence. The idea is to avoid chemotherapy in women at such low risk that they arent likely to benefit from it and to ensure chemotherapy is recommended for women with higher risk.

Researchers surveyed 1,527 women with early stage breast cancer, noting whether they received the 21-gene recurrence score assay test and whether they subsequently received chemotherapy.

Currently, cancer care guidelines recommend the test for women with specific tumor features whose cancer has not spread to surrounding lymph nodes.

The study, published in Cancer, showed that most doctors recommended the test in line with these guidelines, though 13 percent of women with cancer in their lymph nodes still received the test.

Current guidelines typically recommend that these women should always receive chemotherapy, and therefore do not need the test. An ongoing clinical trial is looking at the value of the test for this group.

Among patients who had the test, the results aligned with the decision for or against chemotherapy: 87 percent of patients with a high score had chemotherapy.

For patients with the most favorable prognosis and the lowest test scores, only 3 percent received chemotherapy, compared to 13 percent of women who did not have the gene assay test but had a favorable prognosis.

An area of opportunity

Most patients accurately recalled receiving the test the researchers used registry and laboratory data to confirm that.

Nearly two-thirds thought the test was helpful, saying that their results helped shift their opinion for or against chemotherapy. Patients reported high satisfaction with their treatment choice.

Based on the diverse sample of patients, the researchers found that race or ethnicity did not play a role in the use of the recurrence score assay or in chemotherapy recommendations.

Although most examples of precision medicine involve clinical trials, the recurrence gene assay shows how precision medicine can be used in everyday clinical care.

Overall, the study shows use of the test, treatment recommendations and satisfaction all align. But the researchers note one opportunity.

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News source:Michigan Health. The content is edited for length and style purposes. Figure legend: This Knowridge.com image is credited to Michigan Health.

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Precision medicine test for breast cancer helps guide chemotherapy decisions - Knowridge Science Report