DNA changes during pregnancy persist into childhood

Public release date: 4-Sep-2013 [ | E-mail | Share ]

Contact: Timothy S. Paul tp2111@columbia.edu 212-305-2676 Columbia University's Mailman School of Public Health

Even before they are born, babies accumulate changes in their DNA through a process called DNA methylation that may interfere with gene expression, and in turn, their health as they grow up. But until now it's been unclear just how long these changes during the prenatal period persist. In a new study, researchers at the Columbia Center for Children's Environmental Health at the Mailman School of Public Health establish that signs of DNA methylation persist through early childhood, suggesting the factors that influence these changes during or before pregnancy could have effects throughout a child's life.

The study, published in an online edition of PLOS ONE, is the first to look at DNA methylation changes over time in children.

"The current dogma is that DNA methylation marks are set during early development and are mainly persistent thereafter. However, there were no data in humans to either support or refute this hypothesis. We set out to fill this data gap," explains lead author Julie Herbstman, PhD, assistant professor of Environmental Health Sciences at the Mailman School.

Recent evidence points to environmental exposures like arsenic, lead, and air pollution as factors in epigenetic changesthe umbrella term for DNA methylation and other alterations to gene expression that don't come from DNA mutations. While the health impact of small changes in DNA methylation is not yet clear, there is concern that alterations caused by environmental exposures during important periods of development that could have effects across a lifetime. Generally, low levels of global DNA methylation have been linked to genomic instability, which can lead to DNA damage. (Global DNA methylation is defined as methylation levels measured in aggregate for all genetic material, not specific to one or more genes.)

Center researchers analyzed global DNA methylation levels in blood at two different time points. Cord blood was analyzed from 279 children who are part of the Center's Mothers & Newborns study in Northern Manhattan and the South Bronx. Of these children, 165 also had blood collected at age 3.

The authors found that cord blood methylation was correlated with and significantly predicted the level of methylation at 3 years old. This supports the hypothesis that DNA methylation changes occurring early in life may have lasting impacts.

Maternal BMI Affects Levels of DNA Methylation

The researchers examined one specific factor to see how it affected DNA methylation in childrenthe mother's body mass index prior to becoming pregnant. Children born to moms with high BMIs had low levels of global DNA methylation, an association that was seen again at age 3.

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DNA changes during pregnancy persist into childhood