Fernandes, P. Use of antibiotic core structures to generate new and useful macrolide antibiotics. In Antibiotics Current Innovations and Future Trends (eds Snchez, S. & Demain, A. L.) (Caister Academic Press, 2015).
Bush, N. G., Diez-Santos, I., Abbott, L. R. & Maxwell, A. Quinolones: mechanism, lethality and their contributions to antibiotic resistance. Molecules 25, 5662 (2020).
Article CAS PubMed PubMed Central Google Scholar
Agouridas, C. et al. Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens. J. Med. Chem. 41, 40804100 (1998).
Article CAS PubMed Google Scholar
Seiple, I. B. et al. A platform for the discovery of new macrolide antibiotics. Nature 533, 338345 (2016).
Article CAS PubMed PubMed Central Google Scholar
Pavlovic, D., Fajdetic, A. & Mutak, S. Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. Bioorg. Med. Chem. 18, 85668582 (2010).
Article CAS PubMed Google Scholar
Fan, B. Z. et al. Design, synthesis and structureactivity relationships of novel 15-membered macrolides: quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. Eur. J. Med. Chem. 193, 112222 (2020).
Article CAS PubMed Google Scholar
Barry, A. L. & Jones, R. N. Comparative in vitro activity of amifloxacin and five other fluoroquinolone antimicrobial agents and preliminary criteria for the disk susceptibility test. Eur. J. Clin. Microbiol. 6, 179182 (1987).
Article CAS PubMed Google Scholar
Yourassowsky, E., Van der Linden, M. P., Crokaert, F. & Glupczynski, Y. In vitro activity of pefloxacin compared to other antibiotics. J. Antimicrob. Chemother. 17, 1928 (1986).
Article CAS PubMed Google Scholar
Dinos, G. P. The macrolide antibiotic renaissance. Br. J. Pharmacol. 174, 29672983 (2017).
Article CAS PubMed PubMed Central Google Scholar
Vazquez-Laslop, N. & Mankin, A. S. How macrolide antibiotics work. Trends Biochem. Sci. 43, 668684 (2018).
Article CAS PubMed PubMed Central Google Scholar
Lin, J., Zhou, D., Steitz, T. A., Polikanov, Y. S. & Gagnon, M. G. Ribosome-targeting antibiotics: modes of action, mechanisms of resistance, and implications for drug design. Annu. Rev. Biochem. 87, 451478 (2018).
Article CAS PubMed PubMed Central Google Scholar
Schlunzen, F. et al. Structural basis for the antibiotic activity of ketolides and azalides. Structure 11, 329338 (2003).
Article CAS PubMed Google Scholar
Dunkle, J. A., Xiong, L., Mankin, A. S. & Cate, J. H. Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc. Natl Acad. Sci. USA 107, 1715217157 (2010).
Article CAS PubMed PubMed Central Google Scholar
Bulkley, D., Innis, C. A., Blaha, G. & Steitz, T. A. Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc. Natl Acad. Sci. USA 107, 1715817163 (2010).
Article CAS PubMed PubMed Central Google Scholar
Svetlov, M. S. et al. Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat. Chem. Biol. 17, 412420 (2021).
Article CAS PubMed PubMed Central Google Scholar
Beckert, B. et al. Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics. Nat. Commun. 12, 4466 (2021).
Article CAS PubMed PubMed Central Google Scholar
Tu, D., Blaha, G., Moore, P. B. & Steitz, T. A. Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell 121, 257270 (2005).
Article CAS PubMed Google Scholar
Hansen, J. L. et al. The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol. Cell 10, 117128 (2002).
Article CAS PubMed Google Scholar
Svetlov, M. S. et al. High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition. RNA 25, 600606 (2019).
Article CAS PubMed PubMed Central Google Scholar
Chen, C. W. et al. Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. Nat. Commun. 14, 4196 (2023).
Article CAS PubMed PubMed Central Google Scholar
Jenni, S. & Ban, N. The chemistry of protein synthesis and voyage through the ribosomal tunnel. Curr. Opin. Struct. Biol. 13, 212219 (2003).
Article CAS PubMed Google Scholar
Kannan, K., Vzquez-Laslop, N. & Mankin, A. S. Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel. Cell 151, 508520 (2012).
Article CAS PubMed Google Scholar
Davis, A. R., Gohara, D. W. & Yap, M. N. Sequence selectivity of macrolide-induced translational attenuation. Proc. Natl Acad. Sci. USA 111, 1537915384 (2014).
Article CAS PubMed PubMed Central Google Scholar
Kannan, K. et al. The general mode of translation inhibition by macrolide antibiotics. Proc. Natl Acad. Sci. USA 111, 1595815963 (2014).
Article CAS PubMed PubMed Central Google Scholar
Sothiselvam, S. et al. Binding of macrolide antibiotics leads to ribosomal selection against specific substrates based on their charge and size. Cell Rep. 16, 17891799 (2016).
Article CAS PubMed PubMed Central Google Scholar
Almutairi, M. M. et al. Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucleic Acids Res. 45, 95739582 (2017).
Article CAS PubMed PubMed Central Google Scholar
Franceschi, F., Kanyo, Z., Sherer, E. C. & Sutcliffe, J. Macrolide resistance from the ribosome perspective. Curr. Drug Targets Infect. Disord. 4, 177191 (2004).
Article CAS PubMed Google Scholar
Versalovic, J. et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. Antimicrob. Agents Chemother. 40, 477480 (1996).
Article CAS PubMed PubMed Central Google Scholar
Wand, G. & Taylor, D. E. Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics. Antimicrob. Agents Chemother. 42, 19521958 (1998).
Article Google Scholar
Shallom, S. J. & Zelazny, A. M. Detection of mixed populations of clarithromycin-susceptible and -resistant Mycobacterium abscessus strains. J. Clin. Microbiol. 60, e0169421 (2022).
Article PubMed Google Scholar
McGuire, J. M. et al. Ilotycin, a new antibiotic. Antibiot. Chemother. (Northfield) 2, 281283 (1952).
CAS PubMed Google Scholar
Kirst, H. A. Introduction to the macrolide antibiotics. In Macrolide Antibiotics (eds Schnfeld, W. & Kirst, H. A.) (Birkhuser Verlag, 2002).
Iacoviello, V. R. & Zinner, S. H. Macrolides: a clinical overview. In Macrolide Antibiotics (eds Parnham, M. J. & Bruinvels, J.) (Birkhuser Verlag, 2002).
Tanikawa, T. et al. Synthesis and antibacterial activity of acylides (3-O-acyl-erythromycin derivatives): a novel class of macrolide antibiotics. J. Med. Chem. 44, 40274030 (2001).
Article CAS PubMed Google Scholar
Liang, J. H. et al. Structureactivity relationships of novel alkylides: 3-O-arylalkyl clarithromycin derivatives with improved antibacterial activities. Eur. J. Med. Chem. 49, 289303 (2012).
Article CAS PubMed Google Scholar
Magee, T. V. et al. Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. Bioorg. Med. Chem. Lett. 23, 17271731 (2013).
Article CAS PubMed Google Scholar
Tang, D. et al. Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. Bioorg. Med. Chem. Lett. 18, 50785082 (2008).
Article CAS PubMed Google Scholar
Bryskier, A. & Denis, A. Ketolides: novel antibacterial agents designed to overcome resistance to erythromycin A within Gram-positive cocci. In Macrolide Antibiotics (eds Schnfeld, W. & Kirst, H. A.) (Birkhuser Verlag, 2002).
Fernandes, P., Martens, E., Bertrand, D. & Pereira, D. The solithromycin journeyit is all in the chemistry. Bioorg. Med. Chem. 24, 64206428 (2016).
Article CAS PubMed Google Scholar
Capobianco, J. O. et al. Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44, 15621567 (2000).
Article CAS PubMed PubMed Central Google Scholar
Llano-Sotelo, B. et al. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob. Agents Chemother. 54, 49614970 (2010).
Article CAS PubMed PubMed Central Google Scholar
Douthwaite, S. Structureactivity relationships of ketolides vs. macrolides. Clin. Microbiol. Infect. 7, 1117 (2001).
Article CAS PubMed Google Scholar
Svetlov, M. S., Cohen, S., Alsuhebany, N., Vazquez-Laslop, N. & Mankin, A. S. A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria. Proc. Natl Acad. Sci. USA 117, 19711975 (2020).
Article CAS PubMed PubMed Central Google Scholar
Ma, C. X. et al. Design, synthesis and structureactivity relationships of novel macrolones: hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. Eur. J. Med. Chem. 169, 120 (2019).
Article PubMed Google Scholar
Liu, X. P. et al. Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. Bioorg. Med. Chem. Lett. 68, 128761 (2022).
Article CAS PubMed Google Scholar
Hutinec, A. et al. Novel 8a-aza-8a-homoerythromycin4-(3-substituted-amino)propionates with broad spectrum antibacterial activity. Bioorg. Med. Chem. Lett. 20, 32443249 (2010).
Article CAS PubMed Google Scholar
Drlica, K., Malik, M., Kerns, R. J. & Zhao, X. Quinolone-mediated bacterial death. Antimicrob. Agents Chemother. 52, 385392 (2008).
Article CAS PubMed Google Scholar
Aldred, K. J., Kerns, R. J. & Osheroff, N. Mechanism of quinolone action and resistance. Biochemistry 53, 15651574 (2014).
Article CAS PubMed Google Scholar
Miotto, P., Cirillo, D. M. & Migliori, G. B. Drug resistance in Mycobacterium tuberculosis: molecular mechanisms challenging fluoroquinolones and pyrazinamide effectiveness. Chest 147, 11351143 (2015).
Article PubMed Google Scholar
Machalek, D. A. et al. Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis. Lancet Infect. Dis. 20, 13021314 (2020).
Article CAS PubMed Google Scholar
Lungu, I. A., Moldovan, O. L., Biris, V. & Rusu, A. Fluoroquinolones hybrid molecules as promising antibacterial agents in the fight against antibacterial resistance. Pharmaceutics 14, 1749 (2022).
Article CAS PubMed PubMed Central Google Scholar
Pavlovic, D. & Mutak, S. Discovery of 4-ether linked azithromycinquinolone hybrid series: influence of the central linker on the antibacterial activity. ACS Med. Chem. Lett. 2, 331336 (2011).
Article CAS PubMed PubMed Central Google Scholar
- Discovering the mysteries of human DNA - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Scientists go deeper into DNA - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Instant Egghead - Genes vs. DNA vs. Chromosomes - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- DNA Calls Out Lineup Of Rappers For Future Battles - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- What is DNA? - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Turn Your DNA Into Fine Art, BMW Zagato Roadster - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- DNA - OFFICIAL URLTV SUMMER MADNESS 2 RECAP! - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- "Binary DNA" - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- 16x9 - DNA Prophecies: Code reveals your future - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Gilbert Gottfried - Space DNA, Sexy Weight Loss, Badonkadonk Booty - Gilbert Gets It - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Animated Health Video Production | DNA Services of America - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Michael Tsarion ~ Mayans ~ 2012 ~ DNA - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Mini-drones to take your DNA? - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- C2CAM - DNA Research - 07-09-2012 - Coast To Coast AM - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Inside The DNA Of MDNA - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- KOTD - Rap Battle - DNA vs Eurgh - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Starchild DNA Showing "Wright" Stuff - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Chrome Cats - DNA of a Winner(Official Video) - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- DNA leads to arrest in 1980 murder of Oxnard girl [Last Updated On: September 8th, 2012] [Originally Added On: September 8th, 2012]
- 'Junk' DNA: Not So Useless After All [Last Updated On: September 8th, 2012] [Originally Added On: September 8th, 2012]
- Decoding Human DNA [Last Updated On: September 9th, 2012] [Originally Added On: September 9th, 2012]
- Planet of the Apes: What is that big hunk of 'junk' DNA up to ? [Last Updated On: September 10th, 2012] [Originally Added On: September 10th, 2012]
- Genetics Breakthrough Changes Thinking About DNA [Last Updated On: September 11th, 2012] [Originally Added On: September 11th, 2012]
- 'Junk DNA' and the mystery of mankind's missing genes [Last Updated On: September 11th, 2012] [Originally Added On: September 11th, 2012]
- Real-time observation of single DNA molecule repair [Last Updated On: September 12th, 2012] [Originally Added On: September 12th, 2012]
- Court hears DNA findings in child sex case [Last Updated On: September 12th, 2012] [Originally Added On: September 12th, 2012]
- 2012 International Symposium on Human Identification Features Emerging and Best Practice Forensic DNA Techniques ... [Last Updated On: September 12th, 2012] [Originally Added On: September 12th, 2012]
- DNA could help ID a king [Last Updated On: September 13th, 2012] [Originally Added On: September 13th, 2012]
- DNA with a Twist [Last Updated On: September 13th, 2012] [Originally Added On: September 13th, 2012]
- Three reasons to like junk DNA [Last Updated On: September 13th, 2012] [Originally Added On: September 13th, 2012]
- LBNL Seeks Licensees for Highly Specific and Sensitive DNA Extraction Method [Last Updated On: September 13th, 2012] [Originally Added On: September 13th, 2012]
- Under-twisted DNA origami delivers cancer drugs to tumors [Last Updated On: September 13th, 2012] [Originally Added On: September 13th, 2012]
- DNA ‘junk' contains a treasure of information about disease [Last Updated On: September 14th, 2012] [Originally Added On: September 14th, 2012]
- Research: Hopping DNA supercoils [Last Updated On: September 14th, 2012] [Originally Added On: September 14th, 2012]
- DNA evidence missing in Assange case [Last Updated On: September 16th, 2012] [Originally Added On: September 16th, 2012]
- Missing DNA evidence in Assange case [Last Updated On: September 16th, 2012] [Originally Added On: September 16th, 2012]
- No Assange DNA on torn condom - report [Last Updated On: September 16th, 2012] [Originally Added On: September 16th, 2012]
- Calif. DNA Collection From Arrestees Challenged [Last Updated On: September 17th, 2012] [Originally Added On: September 17th, 2012]
- Federal appeals court to hear challenge to California DNA collection law [Last Updated On: September 17th, 2012] [Originally Added On: September 17th, 2012]
- Applied DNA Sciences Contracts With Inventionland [Last Updated On: September 18th, 2012] [Originally Added On: September 18th, 2012]
- Applied DNA Sciences, Textile Centre of Excellence Unveil Textiles Anti-Counterfeiting Platform [Last Updated On: September 18th, 2012] [Originally Added On: September 18th, 2012]
- Rapist caught by DNA test jailed [Last Updated On: September 18th, 2012] [Originally Added On: September 18th, 2012]
- FBI eager to embrace mobile 'Rapid DNA' testing [Last Updated On: September 19th, 2012] [Originally Added On: September 19th, 2012]
- Expansion of criminal DNA collection proposed [Last Updated On: September 19th, 2012] [Originally Added On: September 19th, 2012]
- Assessment of HPV DNA Alone Insufficient to Identify HPV-Driven Head and Neck Cancers [Last Updated On: September 19th, 2012] [Originally Added On: September 19th, 2012]
- George Zimmerman's DNA, not Trayvon Martin's, found on gun [Last Updated On: September 20th, 2012] [Originally Added On: September 20th, 2012]
- George Zimmerman: No DNA evidence of a struggle for his gun [Last Updated On: September 20th, 2012] [Originally Added On: September 20th, 2012]
- DNA evidence links Vallejo man to January stabbing in SLO, police say [Last Updated On: September 20th, 2012] [Originally Added On: September 20th, 2012]
- Legal hurdles threaten to slow FBI's 'Rapid DNA' revolution [Last Updated On: September 21st, 2012] [Originally Added On: September 21st, 2012]
- Judge denies motions to dismiss DNA evidence in Hudson murder case [Last Updated On: September 22nd, 2012] [Originally Added On: September 22nd, 2012]
- Researchers report novel approach for single molecule electronic DNA sequencing [Last Updated On: September 22nd, 2012] [Originally Added On: September 22nd, 2012]
- Novel approach for single molecule electronic DNA sequencing [Last Updated On: September 22nd, 2012] [Originally Added On: September 22nd, 2012]
- DNA helps Wyckoff police nab 'motorcycle burglar' [Last Updated On: September 22nd, 2012] [Originally Added On: September 22nd, 2012]
- Novel DNA barcode engineered: New technology could launch biomedical imaging to next level [Last Updated On: September 25th, 2012] [Originally Added On: September 25th, 2012]
- DNA Microarray 2012: A Focus on Sales Growth [Last Updated On: September 25th, 2012] [Originally Added On: September 25th, 2012]
- DNA in 1980 Maine murder case shown to match defendant [Last Updated On: September 25th, 2012] [Originally Added On: September 25th, 2012]
- DNA recovered during Rayney probe [Last Updated On: September 26th, 2012] [Originally Added On: September 26th, 2012]
- FBI makes headway on DNA testing backlog, report says [Last Updated On: September 26th, 2012] [Originally Added On: September 26th, 2012]
- Male DNA found for first time in female brains [Last Updated On: September 27th, 2012] [Originally Added On: September 27th, 2012]
- Bearing Sons Leaves Male DNA Traces in Mom's Brain [Last Updated On: September 28th, 2012] [Originally Added On: September 28th, 2012]
- Many female brains contain male DNA [Last Updated On: September 28th, 2012] [Originally Added On: September 28th, 2012]
- New drive to take criminals' DNA [Last Updated On: September 28th, 2012] [Originally Added On: September 28th, 2012]
- DNA remains focus in Highway of Tears cases [Last Updated On: September 28th, 2012] [Originally Added On: September 28th, 2012]
- Analysing The Evidence On DNA [Last Updated On: September 29th, 2012] [Originally Added On: September 29th, 2012]
- DNA Clears Death Row Inmate [Last Updated On: September 29th, 2012] [Originally Added On: September 29th, 2012]
- Burn victim identified by DNA in maggots [Last Updated On: September 29th, 2012] [Originally Added On: September 29th, 2012]
- DNA fails to match couple on two other skeletons [Last Updated On: September 29th, 2012] [Originally Added On: September 29th, 2012]
- DNA Dynamics Update on Sports Title [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- DNA solves teen's 1974 murder [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- Some Women's Brains Contain Male DNA: Study [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- DNA exonerates man after 15 years on death row - Video [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- DNA link prompts charges in cold case rapes - Video [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- DNA testing has its limits [Last Updated On: October 1st, 2012] [Originally Added On: October 1st, 2012]
- DNA evidence exonerates 300th prisoner nationwide [Last Updated On: October 1st, 2012] [Originally Added On: October 1st, 2012]
- DNA testing facility in Pune to speed up cases in Mumbai [Last Updated On: October 1st, 2012] [Originally Added On: October 1st, 2012]
- Rape DNA process 'not adequate' [Last Updated On: October 2nd, 2012] [Originally Added On: October 2nd, 2012]
- IntegenX Announces U.S. Launch of the RapidHIT™ 200 System – Rapid DNA Technology That Will Revolutionize the Use of ... [Last Updated On: October 2nd, 2012] [Originally Added On: October 2nd, 2012]
- 300th person exonerated by DNA evidence [Last Updated On: October 2nd, 2012] [Originally Added On: October 2nd, 2012]
- Inherited Diseases Found Sooner in Newborns With DNA Scan [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- Woman charged in husband's death gives DNA sample [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]