Scientists Have Sequenced the DNA of a 2000-Year-Old Human From Pompeii – SciTechDaily

The discoveries show that ancient DNA can be recovered from Pompeiian human bones, providing new insight into this historic communitys genetic history and lifestyles.

Research that was recently published in Scientific Reports presents the first human genome that has been successfully sequenced from a person who passed away in Pompeii, Italy, after Mount Vesuvius explosion in the year 79 CE. Only little segments of mitochondrial DNA from Pompeiian human and animal remains have been sequenced up to this point.

The DNA of two peoples bones that were discovered in Pompeiis House of the Craftsman was studied and extracted by Gabriele Scorrano and colleagues. The bones length, form, and structure revealed that one pair belonged to a male who was between 35 and 40 years old when he passed away, while the other set belonged to a femalewho was over 50. The authors were able to extract and sequence ancient DNA from both people, but since the sequences from the females bones had gaps in them, they could only sequence the entire genome from the males remains.

The male subjects DNA was compared to 1,030 ancient and 471 current western Eurasian subjects, and it was found that the male subjects DNA was most comparable to that of modern central Italians and other people who resided in Italy during the Roman Imperial era. However, studies of the males Y chromosome and mitochondrial DNA revealed sets of genes that are often prevalent in Sardinian people but not in other people who resided in Italy during the Roman Imperial era. This shows that the Italian Peninsula may have seen high levels of genetic diversity at the time.

Additional analyses of the male individuals skeleton and DNA identified lesions in one of the vertebrae and DNA sequences that are commonly found in Mycobacterium, the group of bacteria that the tuberculosis-causing bacteria Mycobacterium tuberculosis belongs to. This suggests that the individual may have been affected by tuberculosis prior to his death.

The authors speculate that it may have been possible to successfully recover ancient DNA from the male individuals remains as pyroclastic materials released during the eruption may have provided protection from DNA-degrading environmental factors, such as atmospheric oxygen. The findings demonstrate the possibility to retrieve ancient DNA from Pompeiian human remains and provide further insight into the genetic history and lives of this population, they add.

Reference: Bioarchaeological and palaeogenomic portrait of two Pompeians that died during the eruption of Vesuvius in 79 AD by Gabriele Scorrano, Serena Viva, Thomaz Pinotti, Pier Francesco Fabbri, Olga Rickards, and Fabio Macciardi, 26 May 2022, Scientific Reports.DOI: 10.1038/s41598-022-10899-1

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Scientists Have Sequenced the DNA of a 2000-Year-Old Human From Pompeii - SciTechDaily