Allen Institute and Google team up to build platform exploring the immune system – GeekWire

TEA-seq, one of the tools available on the Human Immune System Explorer. Cell types are in different colors, with each dot corresponding to a single cell. Clusters of cells have similar RNA profiles. (Allen Institute Image)

The Allen Institute for Immunology unveiled a new interactive platform on Wednesday to showcase the human immune system, the Human Immune System Explorer.

Built in partnership with Google, the explorer is a central place for researchers and the public to find analysis tools, resources and data. The platform adds to the growing toolkit of similar resources across the Allen Institute, such as the Allen Cell Explorer and the Allen Brain Map.

Its also the first time the Allen Institute has leveraged Googles cloud offerings like Vertex AI to build such a platform. Googles team meets weekly with institute researchers.Theyve just been deeply committed to working with people in the Allen Institute, said Paul Meijer, director of software development, database and pipelines at the immunology institute.

As the platform matures, Meijer anticipates it will be broadly used by immunology researchers worldwide, who will add their data to the platform. It will track different cell types, molecules and other aspects of immunity in healthy people and in people with conditions like COVID-19 and cancer. Here are some of the platforms current features:

The platform ultimately aims to help simplify the cataloging, visualization and analysis of the massive amounts of data being collected in human studies of the immune system. The institute aims to promote open, collaborative and multi-disciplinary science.

Allen Institute researchers, for instance, are involved in a study examining the immune system in patients with long COVID. Scientists are cataloging proteins present on the surface of patient immune cells over the course of the first infection and for weeks afterwards. They recently found sets of proteins associated with long COVID suggesting that some affected people have high levels of inflammation. That data was recently released in a preprint study and will soon be entered into the new platform.

In a tweet, Google cloud CEO Thomas Kurian said he was inspired by his teams work with the Allen Institute. The past few years have put a spotlight on the importance of collaborating to diagnose and treat diseases, he said.

A multidisciplinary team of lab scientists and 10 software developers built the new platform over about three years, said Meijer. The team science and team development effort has been the real power that we have at the Allen Institute for Immunology, he said.

The researchers are also committed to increasing the diversity of human subjects represented on the platform. Ultimately users may be able to filter datasets by peoples pre-existing conditions, social conditions, or other factors.

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Allen Institute and Google team up to build platform exploring the immune system - GeekWire