Functional divergence of the pigmentation gene melanocortin-1 receptor (MC1R) in six endemic Macaca species on Sulawesi Island | Scientific Reports -…

Barsh, G. S. The genetics of pigmentation: From fancy genes to complex traits. Trends Genet. 12, 299305 (1996).

CAS PubMed Article Google Scholar

Robbins, L. S. et al. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72, 827834 (1993).

CAS PubMed Article Google Scholar

Donatien, P. D. et al. The expression of functional MSH receptors on cultured human melanocytes. Arch. Dermatol. Res. 284, 424426 (1992).

CAS PubMed Article Google Scholar

Klungland, H., Vage, D. I., Gomez-Raya, L., Adalsteinsson, S. & Lien, S. The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination. Mamm. Genome 6, 636639 (1995).

CAS PubMed Article Google Scholar

Melin, A. D. et al. The relationship between MC1R mutation and plumage color variation in pigeons. Nature 17, 211214 (2008).

Google Scholar

Manceau, M., Domingues, V. S., Linnen, C. R., Rosenblum, E. B. & Hoekstra, H. E. Convergence in pigmentation at multiple levels: Mutations, genes and function. Philos. Trans. R. Soc. B Biol. Sci. 365, 24392450 (2010).

CAS Article Google Scholar

Rmpler, H. et al. Nuclear gene indicates coat-color polymorphism in mammoths. Science 313, 62 (2006).

PubMed Article Google Scholar

Kerje, S., Lind, J., Schtz, K., Jensen, P. & Andersson, L. Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken. Anim. Genet. 34, 241248 (2003).

CAS PubMed Article Google Scholar

Kijas, J. M. H. et al. Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. Genetics 150, 11771185 (1998).

CAS PubMed PubMed Central Article Google Scholar

Vge, D. I., Klungland, H., Dongsi, L. & Cone, R. D. Molecular and pharmacological characterization of dominant black coat color in sheep. Mamm. Genome 10, 3943 (1999).

PubMed Article Google Scholar

Beaumont, K. A. et al. Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Hum. Mol. Genet. 14, 21452154 (2005).

CAS PubMed Article Google Scholar

Bastiaens, M. T. et al. Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair. Am. J. Hum. Genet. 68, 884894 (2001).

CAS PubMed PubMed Central Article Google Scholar

Bree, E., Rmpler, H., Schneberg, T. & Hoekstra, H. E. Molecular and functional basis of phenotypic convergence in white lizards at White Sands. Proc. Natl. Acad. Sci. U.S.A. 107, 21132117 (2010).

ADS Article Google Scholar

Haitina, T., Ringholm, A., Kelly, J., Mundy, N. I. & Schith, H. B. High diversity in functional properties of melanocortin 1 receptor (MC1R) in divergent primate species is more strongly associated with phylogeny than coat color. Mol. Biol. Evol. 24, 20012008 (2007).

CAS PubMed Article Google Scholar

Nakayama, K., Shotake, T., Takeneka, O. & Ishida, T. Variation of the melanocortin 1 receptor gene in the macaques. Am. J. Primatol. 70, 778785 (2008).

CAS PubMed Article Google Scholar

Hamada, Y., Watanabe, T., Takenaka, O., Suryobroto, B. & Kawamoto, Y. Morphological studies on the Sulawesi macaques I: Phyletic analysis of body color. Primates 29, 6580 (1988).

Article Google Scholar

Evans, B. J. et al. Mitogenomics of macaques (Macaca) across Wallaces Line in the context of modern human dispersals. J. Hum. Evol. 146, 102852 (2020).

PubMed Article Google Scholar

Takenaka, O. et al. Origin and evolution of the Sulawesi macaques 1. Electrophoretic analysis of hemoglobins. Primates 28, 8798 (1987).

Article Google Scholar

Evans, B. J. et al. Speciation over the edge: Gene flow among non-human primate species across a formidable biogeographic barrier. R. Soc. Open Sci. 4, 170351 (2017).

ADS PubMed PubMed Central Article CAS Google Scholar

Evans, B. J., Supriatna, J., Andayani, N. & Melnick, D. J. Diversification of sulawesi macaque monkeys: Decoupled evolution of mitochondrial and autosomal DNA. Evolution 57, 19311946 (2003).

PubMed Article Google Scholar

Harding, R. M. et al. Evidence for variable selective pressures at MC1R. Am. J. Hum. Genet. 66, 13511361 (2000).

CAS PubMed PubMed Central Article Google Scholar

Mundy, N. I. & Kelly, J. Evolution of a pigmentation gene, the melanocortin-1 receptor, in primates. Am. J. Phys. Anthropol. 121, 67 (2003).

CAS PubMed Article Google Scholar

Valverde, P., Healy, E., Jackson, I., Rees, J. L. & Thody, A. J. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat. Genet. 11, 328330 (1995).

CAS PubMed Article Google Scholar

Wolf Horrell, E. M., Boulanger, M. C. & DOrazio, J. A. Melanocortin 1 receptor: Structure, function, and regulation. Front. Genet. 7, 116 (2016).

Article CAS Google Scholar

Frndberg, P. A., Doufexis, M., Kapas, S. & Chhajlani, V. Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist. Biochem. Biophys. Res. Commun. 281, 851857 (2001).

PubMed Article CAS Google Scholar

Catania, A., Airaghi, L., Colombo, G. & Lipton, J. M. Alpha-melanocyte-stimulating hormone in normal human physiology and disease states. Trends Endocrinol. Metab. 11, 304308 (2000).

CAS PubMed Article Google Scholar

McRobie, H. R., King, L. M., Fanutti, C., Symmons, M. F. & Coussons, P. J. Agouti signalling protein is an inverse agonist to the wildtype and agonist to the melanic variant of the melanocortin-1 receptor in the grey squirrel (Sciurus carolinensis). FEBS Lett. 588, 23352343 (2014).

CAS PubMed Article Google Scholar

Eizirik, E. et al. Molecular genetics and evolution of melanism in the cat family. Curr. Biol. 13, 448453 (2003).

CAS PubMed Article Google Scholar

Miao, Y. W. et al. The role of MC1R gene in buffalo coat color. Sci. China Life Sci. 53, 267272 (2010).

CAS PubMed Article Google Scholar

Monti, D. M. et al. Physiological change in an insular lizard population confirms the reversed island syndrome. Biol. J. Linn. Soc. 108, 144150 (2013).

Article Google Scholar

Bradley, B. J., Gerald, M. S., Widdig, A. & Mundy, N. I. Coat color variation and pigmentation gene expression in rhesus macaques (Macaca mulatta). J. Mamm. Evol. 20, 263270 (2013).

Article Google Scholar

Mundy, N. I. & Kelly, J. Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates. Mamm. Genome 17, 12051213 (2006).

CAS PubMed Article Google Scholar

Manceau, M., Domingues, V. S., Mallarino, R. & Hoekstra, H. E. The developmental role of agouti in color pattern evolution. Science 331, 10621065 (2011).

ADS CAS PubMed Article Google Scholar

Watanabe, K. & Matsumura, S. The borderlands and possible hybrids between three species of macaques, M. nigra, M. nigrescens, and M. hecki, in the northern peninsula of Sulawesi. Primates 32, 365370 (1991).

Article Google Scholar

Watanabe, K., Matsumura, S., Watanabe, T. & Hamada, Y. Distribution and possible intergradation between Macaca tonkeana and M. ochreata at the borderland of the species in Sulawesi. Primates 32, 385389 (1991).

Article Google Scholar

Riley, E. P., Suryobroto, B. & Maestripieri, D. Distribution of Macaca ochreata and identification of mixed Ochreata-Tonkeana groups in South Sulawesi, Indonesia. Primate Conserv. 22, 129133 (2007).

Article Google Scholar

Riley, E. P. The endemic seven: Four decades of research on the: Sulawesi macaques. Evol. Anthropol. 19, 2236 (2010).

Article Google Scholar

Schillaci, M. A., Froehlich, J. W., Supriatna, J. & Jones-Engel, L. The effects of hybridization on growth allometry and craniofacial form in Sulawesi macaques. J. Hum. Evol. 49, 335369 (2005).

PubMed Article Google Scholar

Evans, B. J., Supriatna, J. & Melnick, D. J. Hybridization and population genetics of two macaque species in Sulawesi, Indonesia. Evolution 55, 16861702 (2001).

CAS PubMed Article Google Scholar

Widayati, K. A. et al. Functional divergence of the bitter receptor TAS2R38 in Sulawesi macaques. Ecol. Evol. 9, 1038710403 (2019).

PubMed PubMed Central Article Google Scholar

Supriatna, J. Macaca ochreata. The IUCN Red List of Threatened Species, Vol. 8235. https://doi.org/10.2305/IUCN.UK.2008.RLTS.T12557 (2008).

Longmire, J. L. et al. Use of Lysis Buffer in DNA Isolation and Its Implication for Museum Collections (Museum of Texas Tech University, 1997).

Book Google Scholar

Rozas, J. et al. DnaSP 6: DNA sequence polymorphism analysis of large data sets. Mol. Biol. Evol. 34, 3299. https://doi.org/10.1093/molbev/msx248 (2017).

CAS Article PubMed Google Scholar

Leigh, J. W. & Bryant, D. POPART: Full-feature software for haplotype network construction. Methods Ecol. Evol. 6, 11101116 (2015).

Article Google Scholar

Yang, Z. PAML 4: Phylogenetic analysis by maximum likelihood. Mol. Biol. Evol. 24, 15861591 (2007).

CAS PubMed Article Google Scholar

Choi, Y. & Chan, A. P. PROVEAN web server: A tool to predict the functional effect of amino acid substitutions and indels. Bioinformatics 31, 27452747 (2015).

CAS PubMed PubMed Central Article Google Scholar

Lu, D., Vage, D. I. & Cone, R. D. A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor. Mol. Endocrinol. 12, 592604 (1998).

CAS PubMed Article Google Scholar

Damian, M. et al. High constitutive activity is an intrinsic feature of ghrelin receptor protein: A study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs. J. Biol. Chem. 287, 36303641 (2012).

CAS PubMed Article Google Scholar

Ritz, C., Baty, F., Streibig, J. C. & Gerhard, D. Dose-response analysis using R. PLoS ONE 10, 113 (2015).

Article CAS Google Scholar

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Functional divergence of the pigmentation gene melanocortin-1 receptor (MC1R) in six endemic Macaca species on Sulawesi Island | Scientific Reports -...