Genetics and Evolution – The Human Journey

Recent technological breakthroughs in genomic analysis, combined with archeological, paleoanthropological, linguistic and other information, now give us an unparalleled opportunity to trace humanitys evolution and movement in time how we developed, differentiated and interbred many times, and arrived at our present planet-wide population.

Until recently, the leading theory of human population descent, known as the serial founder model, envisioned modern humans expanding out of Africa and the Near East around 50,000 years ago and leaving descendent populations along their routes of migration. The settlements of these groups were thought to remain unmixed for tens of thousands of years, and consequently were classified according to location, superficial appearance and culture as East Asians, Caucasians, West Africans, Native Americans and Australasians.

We now know, thanks to studies of ancient DNA (aDNA), that the serial founder model is wrong. It turns out that present-day populations are actually mixtures of highly divergent populations that no longer exist. Nor are present-day populations, thanks to perennial migration and mixing, exclusive descendants of the populations that lived in the same locations ten thousand years ago.

DNA is a double helix formed by base pairs attached to a sugar-phosphate backbone. (US National Library of Medicine)

The announcement of evolutionary trees based on variation in mitochondrial DNA in a 1987 edition of Nature, followed by a study on evolution of the human Y chromosome a few years later, staggered the world. From the pattern created by the random genetic variations on both of these lineages, geneticists can conclude facts rather than suppositions and can of course construct family trees for everyone alive today.

DNA molecules make up the human genome, the genetic code that each of us inherits from our parents. DNA consists of twin chains of molecules callednucleotidesmade from the chemicals adenine (A), cytosine (C), guanine (G) and thymine (T). Each chain, broken up into 23 chromosomes, adds up to about three billion chemical blocks in length. Genesare fragments of these chains, generally around a thousand nucleotides long, each one telling something about how the body is built.

All humanity descended from a single female ancestor and her birthplace was Africa.

Each time egg and sperm are created, the approximately 3 billion base pairs of DNA comprising our genes are copied. Random variations in these inherited sequences are calledmutations or markers. They are what make us individual, and they are also the means by which individual ancestry can be determined. Since these changes occur at a known constant rateover time roughly once every thousand nucleotides the greater number of differences between two peoples mutations, the further they are away from sharing a common ancestor.

All living men are related through a single male ancestor who lived 60,000100,000 years ago.

Mitochondrial DNA (mtDNA) is inherited only through the maternal line in humans. This knowledge enabled geneticists to demonstrate that all humanity descended from a single female ancestor, now known as Mitochondrial Eve, and established that her birthplace, and that of all humanity, was Africa.

All male mammals have one Ychromosome that contains a gene called SRY, which triggers the development of a male. The Y chromosome is passed down essentially unchanged from one generation to the next; in other words, theY chromosomeDNA of all living men is related through a single male ancestor who lived 60,000100,000 years ago. This discovery enabled population geneticists to trace human ancestries through the pattern of mutations or markers carried on the male Ychromosome.

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Genetics and Evolution - The Human Journey