The Sportsbook Wire team is here to help you with yourWeek 5 NFL picks. Our writers offer up their selections on the money line, spread and Over/Under for every game on the Week 5 slate. Visit SportsbookWire.com for more NFL picks and predictions throughout the season.
The Arizona Cardinals (4-0) are the final undefeated team of the 2021 NFL season, but they still share just the eighth-best odds to win Super Bowl LVI in February. The Kansas City Chiefs and Tampa Bay Buccaneers returned to their winning ways in Week 4 and remain atop the odds for the Big Game.
Check out our staff predictions before locking in your Week 5 NFL picks.
Also see: Week 5 odds and lines
Odds provided by Tipico Sportsbook.
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