Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration – Nature.com

Hotez, P. J. et al. The Global Burden of Disease Study 2010: interpretation and implications for the neglected tropical diseases. PLoS Negl. Trop. Dis. 8, e2865 (2014).

World Health Organization. Prevention and Control of Schistosomiasis and Soil-transmitted Helminthiasis: Report of a WHO Expert Committee (World Health Organization, 2002).

Montresor, A., Engels, D., Ramsan, M., Foum, A. & Savioli, L. Field test of the dose pole for praziquantel in Zanzibar. Trans. R. Soc. Trop. Med. Hyg. 96, 323324 (2002).

CAS PubMed Article PubMed Central Google Scholar

World Health Organization. Helminth Control in School-aged Children: A Guide for Managers of Control Programmes (World Health Organisation, 2006).

World Health Organization. Schistosomiasis and soil-transmitted helminthiases: numbers of people treated in 2019. Wkly. Epidemiol. Rec. 95, 629640 (2020).

Google Scholar

Kabatereine, N. B. et al. Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren. Bull. World Health Organ 85, 9199 (2007).

PubMed PubMed Central Article Google Scholar

Bronzan, R. N. et al. Impact of community-based integrated mass drug administration on schistosomiasis and soil-transmitted helminth prevalence in Togo. PLoS Negl. Trop. Dis. 12, e0006551 (2018).

PubMed PubMed Central Article Google Scholar

Deol, A. K. et al. Schistosomiasisassessing progress toward the 2020 and 2025 global goals. N. Engl. J. Med. 381, 25192528 (2019).

World Health Organization. Accelerating work to overcome the global impact of neglected tropical diseases: a roadmap for implementation. https://apps.who.int/iris/bitstream/handle/10665/338712/WHO-HTM-NTD-2012.5-eng.pdf (2012).

World Health Organization. A road map for neglected tropical diseases 20212030. https://www.who.int/neglected_diseases/Ending-the-neglect-to-attain-the-SDGsNTD-Roadmap.pdf (2020).

Mutuku, M. W. et al. A search for snail-related answers to explain differences in response of Schistosoma mansoni to praziquantel treatment among responding and persistent hotspot villages along the Kenyan shore of Lake Victoria. Am. J. Tropical Med. Hyg. 101, 6577 (2019).

CAS Article Google Scholar

Assar, R. K. et al. Characteristics of persistent hotspots of Schistosoma mansoni in western Cte dIvoire. Parasit. Vectors 13, 337 (2020).

PubMed PubMed Central Article CAS Google Scholar

Kittur, N. et al. Persistent hotspots in schistosomiasis consortium for operational research and evaluation studies for gaining and sustaining control of schistosomiasis after four years of mass drug administration of praziquantel. Am. J. Trop. Med. Hyg. 101, 617627 (2019).

PubMed PubMed Central Article Google Scholar

Wiegand, R. E. et al. A persistent hotspot of Schistosoma mansoni infection in a five-year randomized trial of praziquantel preventative chemotherapy strategies. J. Infect. Dis. 216, 14251433 (2017).

PubMed PubMed Central Article Google Scholar

Hedtke, S. M. et al. Genomic epidemiology in filarial nematodes: transforming the basis for elimination program decisions. Front. Genet. 10, 1282 (2019).

CAS PubMed Article PubMed Central Google Scholar

Doyle, S. R. & Cotton, J. A. Genome-wide approaches to investigate anthelmintic resistance. Trends Parasitol. 35, 289301 (2019).

CAS PubMed Article PubMed Central Google Scholar

Crellen, T. et al. Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection. Sci. Rep. 6, 113 (2016).

Article CAS Google Scholar

Gower, C. M. et al. Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: implications for epidemiology, evolution and control. Acta Trop. 128, 261274 (2013).

PubMed Article PubMed Central Google Scholar

Standley, C., Kabatereine, N., Lange, C., Lwambo, N. & Stothard, J. Molecular epidemiology and phylogeography of Schistosoma mansoni around Lake Victoria. Parasitology 137, 19371949 (2010).

CAS PubMed Article PubMed Central Google Scholar

Faust, C. L. et al. Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda. Parasit. Vectors 12, 607 (2019).

PubMed PubMed Central Article Google Scholar

Stothard, J. R. et al. Molecular epidemiology of Schistosoma mansoni in Uganda: DNA barcoding reveals substantial genetic diversity within Lake Albert and Lake Victoria populations. Parasitology 136, 18131824 (2009).

CAS PubMed Article PubMed Central Google Scholar

Norton, A. J. et al. Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania. Am. J. Trop. Med. Hyg. 83, 951957 (2010).

PubMed PubMed Central Article Google Scholar

Blanton, R. E. et al. Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil. Int. J. Parasitol. 41, 10931099 (2011).

PubMed PubMed Central Article Google Scholar

Gower, C. M. et al. Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme. Parasit. Vectors 10, 593 (2017).

PubMed PubMed Central Article CAS Google Scholar

Chevalier, F. D. et al. Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment. PLoS Pathog. 15, e1007881 (2019).

CAS PubMed PubMed Central Article Google Scholar

Platt, R. N. et al. Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites. Mol. Biol. Evol. 36, 21272142 (2019).

PubMed PubMed Central Article CAS Google Scholar

Shortt, J. A. et al. Population genomic analyses of schistosome parasites highlight critical challenges facing endgame elimination efforts. Sci. Rep. 11, 6884 (2021).

ADS CAS PubMed PubMed Central Article Google Scholar

Truscott, J. E. et al. A comparison of two mathematical models of the impact of mass drug administration on the transmission and control of schistosomiasis. Epidemics 18, 2937 (2017).

CAS PubMed PubMed Central Article Google Scholar

Bouzat, J. L. Conservation genetics of population bottlenecks: the role of chance, selection, and history. Conserv. Genet. 11, 463478 (2010).

Article Google Scholar

Andrews, P. Praziquantel: mechanisms of anti-schistosomal activity. Pharmacol. Ther. 29, 129156 (1985).

CAS PubMed Article PubMed Central Google Scholar

Cioli, D. & Pica-Mattoccia, L. Praziquantel. Parasitol. Res. 90, S3S9 (2003).

Caffrey, C. R. Schistosomiasis and its treatment. Future Med. Chem. 7, 675676 (2015).

CAS PubMed Article PubMed Central Google Scholar

Kaplan, R. M. & Vidyashankar, A. N. An inconvenient truth: global worming and anthelmintic resistance. Vet. Parasitol. 186, 7078 (2012).

PubMed Article PubMed Central Google Scholar

Rose, H. et al. Widespread anthelmintic resistance in European farmed ruminants: a systematic review. Vet. Rec. 176, 546 (2015).

CAS PubMed Article PubMed Central Google Scholar

Schwab, A. E., Boakye, D. A., Kyelem, D. & Prichard, R. K. Detection of benzimidazole resistance-associated mutations in the filarial nematode Wuchereria bancrofti and evidence for selection by albendazole and ivermectin combination treatment. Am. J. Trop. Med. Hyg. 73, 234238 (2005).

CAS PubMed Article PubMed Central Google Scholar

Fallon, P. G. & Doenhoff, M. J. Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am. J. Trop. Med. Hyg. 51, 8388 (1994).

CAS PubMed Article Google Scholar

Couto, F. F. B. et al. Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails. Mem. Inst. Oswaldo Cruz 106, 153157 (2011).

CAS PubMed Article PubMed Central Google Scholar

Mwangi, I. N. et al. Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug. Int. J. Parasitol. Drugs Drug Resist. 4, 296300 (2014).

PubMed PubMed Central Article Google Scholar

Lamberton, P. H. L., Faust, C. L. & Webster, J. P. Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study. Infect. Dis. Poverty 6, 110 (2017).

PubMed PubMed Central Article Google Scholar

Stelma, F. F. et al. Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni. Am. J. Trop. Med. Hyg. 53, 167170 (1995).

CAS PubMed Article Google Scholar

Melman, S. D. et al. Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni. PLoS Negl. Trop. Dis. 3, e504 (2009).

PubMed PubMed Central Article CAS Google Scholar

Crellen, T. et al. Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple rounds of mass drug administration. Clin. Infect. Dis. 63, 11511159 (2016).

CAS PubMed PubMed Central Google Scholar

King, C. H., Muchiri, E. M. & Ouma, J. H. Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. Emerg. Infect. Dis. 6, 585594 (2000).

CAS PubMed PubMed Central Article Google Scholar

Gryseels, B. et al. Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence. Trop. Med. Int. Health 6, 864873 (2001).

CAS PubMed Article Google Scholar

Fenwick, A. & Webster, J. P. Schistosomiasis: challenges for control, treatment and drug resistance. Curr. Opin. Infect. Dis. 19, 577582 (2006).

PubMed Article Google Scholar

Albonico, M. et al. Monitoring the efficacy of drugs for neglected tropical diseases controlled by preventive chemotherapy. J. Glob. Antimicrob. Resist 3, 229236 (2015).

CAS PubMed PubMed Central Article Google Scholar

Fukushige, M., Chase-Topping, M., Woolhouse, M. E. J. & Mutapi, F. Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): a systematic review and meta-analysis of factors influence its efficacy. PLoS Negl. Trop. Dis. 15, e0009189 (2021).

CAS PubMed PubMed Central Article Google Scholar

Hodgkinson, J. E. et al. Refugia and anthelmintic resistance: concepts and challenges. Int. J. Parasitol. Drugs Drug Resist. 10, 5157 (2019).

PubMed PubMed Central Article Google Scholar

Walker, M. et al. New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel. Parasit. Vectors 9, 41 (2016).

PubMed PubMed Central Article CAS Google Scholar

Kittur, N. et al. Defining persistent hotspots: areas that fail to decrease meaningfully in prevalence after multiple years of mass drug administration with praziquantel for control of schistosomiasis. Am. J. Trop. Med. Hyg. 97, 18101817 (2017).

PubMed PubMed Central Article Google Scholar

Levecke, B. et al. Evaluation of the therapeutic efficacy of praziquantel against schistosomes in seven countries with ongoing large-scale deworming programs. Int. J. Parasitol. Drugs Drug Resist. 14, 183187 (2020).

CAS PubMed PubMed Central Article Google Scholar

Nei, M., Maruyama, T. & Chakraborty, R. The bottleneck effect and genetic variability in populations. Evolution 29, 110 (1975).

PubMed Article PubMed Central Google Scholar

Gattepaille, L. M., Jakobsson, M. & Blum, M. G. B. Inferring population size changes with sequence and SNP data: lessons from human bottlenecks. Heredity 110, 409419 (2013).

CAS PubMed PubMed Central Article Google Scholar

Kohn, A. B., Anderson, P. A. V., Roberts-Misterly, J. M. & Greenberg, R. M. Schistosome Calcium Channel Subunits: unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel. J. Biol. Chem. 276, 3687336876 (2001).

Read more here:
Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration - Nature.com