Daily Archives: July 20, 2024

Promising new HIV therapy comes from llama DNA – Futurity: Research News

Posted: July 20, 2024 at 4:21 am

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Researchers have developed tiny, potent molecules that are capable of targeting hidden strains of HIV. The source? Antibody genes from llama DNA.

For the study in the journal Advanced Science, lead author Jianliang Xu, assistant professor of biology at Georgia State University, used llama-derived nanobodies to broadly neutralize numerous strains of HIV-1, the most common form of the virus.

This virus has evolved a way to escape our immune system. Conventional antibodies are bulky, so its difficult for them to find and attack the virus surface, Xu explains. These new antibodies can do this in an easier way.

Scientists in pursuit of effective HIV treatment and prevention have been working with animals in the camelid familylike llamasfor about 15 years. Thats because the shape and features of their antibodies make them nimbler and more effective at identifying and neutralizing foreign objects, like the HIV virus.

The new research presents a widely applicable method to enhance the performance of nanobodies. Nanobodies are engineered antibody fragments that are about one-tenth the size of a conventional antibody. They are derived from flexible, Y-shaped heavy chain-only antibodiesmade up of two heavy chainswhich are more effective at fighting certain viruses than conventional antibodies with light chains.

For the study, the researchers immunized llamas with a specially designed protein which results in the production of neutralizing nanobodies. Xu and his team then identified nanobodies that can target vulnerable sites on the virus. When the team engineered the nanobodies into a triple tandem formatby repeating short lengths of DNAthe resulting nanobodies demonstrated remarkable effectiveness, neutralizing 96% of a diverse panel of HIV-1 strains.

Further analysis uncovered that these nanobodies mimic the recognition of the CD4 receptora key player in HIV infection. To enhance their potency, the nanobodies were fused with a broadly neutralizing antibody (bNAb), resulting in a new antibody with unprecedented neutralizing abilities.

Instead of developing a cocktail of antibodies, now we can make a single molecule that can neutralize HIV, Xu says. We are working with a broadly neutralizing nanobody that can neutralize over 90% of the circulating HIV strains, and when we combine that with another bNAb which also neutralizes some 90%, together, they can neutralize close to 100%.

Xu began this research at the National Institutes of Health Vaccine Research Center in Bethesda, Maryland, where he collaborated with a team of more than 30 scientists. The team included Peter Kwong, professor of biochemistry and molecular biophysics at Columbia University and coauthor of the study.

Since coming to Georgia State in 2023, Xu has been mentoring PhD candidate Payton Chan. Together, they are working to expand these potential remedies. Chan says she is excited about the prospects of the innovative research.

These nanobodies are the best and most potently neutralizing antibodies to date, which I think is very promising for the future of HIV therapeutics and antibody research. I hope one day there will be approval of these nanobodies for the treatment of HIV.

According to Xu, future efforts will explore the possibility of combining llama nanobodies with other existing bNAbs to determine if some of these combinations can achieve 100% neutralization to offer new treatment options in the fight against HIV.

Source: Georgia State

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BioCardia Announces United States Patent Issuance on Morph DNA Multi-Directional Steerable Catheter Transseptal Application – Diagnostic and…

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July 17, 2024 BioCardia, Inc., a company focused on cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases announced that the Unites States Patent Office has granted Patent No: 12,036,371 titled Method of Accessing the Left Atrium with a Multi-Directional Steerable Catheter, with a patent term that will expire in 2035.

The present invention relates to medical methods for transseptal access to the heart using steerable introducers based on the Companys Morph DNA technology. This additional patent protection for BioCardias current and future products in this important existing market enhances shareholder value.

Procedures that leverage transseptal delivery include atrial fibrillation ablation, patent foramen ovale (PFO) and atrial septal defect (ASD) repair, percutaneous mitral valve repair, left atrial appendage closure, and percutaneous left ventricular assist device placement, among others. Worldwide revenue from the transseptal access systems market was $941.3 million in 2022, with the global market estimated to expand at a Compound Annual Growth Rate of 7.3%, reaching $2.1 billion by the end of 2033.

Morph DNA designs enable the tensioning elements in the catheter to rotate around the catheter shaft, allowing consistent catheter performance in any direction. The DNA name reflects this design, as these tensioning elements appear as a double helix like that in a strand of DNA. This design is intended to enable smooth navigation and prevent whip, when the build-up of mechanical forces in the device causes a catheter to suddenly jump from one orientation to another.

All of the biotherapeutic interventions we support for treatment of heart failure, refractory angina, and acute myocardial infarction going forward are expected to utilize this same introducer technology platform, said Peter Altman, PhD, BioCardias President and Chief Executive Officer. This is an elegant solution to a long-standing technical issue. The solution enhances the level of physician control in our procedures, and BioCardia is working to provide or partner this solution for the roughly five hundred thousand transseptal procedures performed in the United States each year, and for other vascular access markets that can benefit from the advantages our patented solution provides.

For more information: http://www.biocardia.com

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Google just gave us our first look at the Pixel 9 Pro Fold and confirmed the new long name – TechRadar

Posted: at 4:21 am

Google is either getting ahead of itself or simply wants to get ahead of more leaks. Just a few hours after giving us our first look at the Pixel 9 Pro, the technology giant has shared yet another teaser that confirms its second-generation Pixel Fold is incoming.

The teaser, titled "Google Pixel 9 Pro Fold, confirms the new name and gives us our best look at the device yet. It shows off the internal main display, the hinge, and the backside, which boasts a redesigned main camera module.

Of course, its also getting Google Gemini and shows off the likely headlining feature with Oh Hi, AI on the screen. Before the device appears, Google shows off its generative text capabilities as well.

The biggest revelation from this teaser, though, would be a confirmation of the new naming scheme, which moves the Pixel Fold in line with the rest of Googles smartphone family and with some of the hardware. Notably, the slimmer horizontal camera bar that resembled the Pixel 8 or Pixel 7 on the original Pixel Fold is being swapped for a square camera bump with two rows of lenses, a flash, and a microphone.

Just like the Pixel 9 Pro, the refreshed camera bump appears to be pretty thick, which will prevent the Pixel 9 Pro Fold from lying flat on a tabletjust like the original Pixel Fold and Samsungs Galaxy Z Fold. The rest of the design matches up with some earlier leaks of the device, which shows Google aims to strike a new chord with the second generation.

One thing I am not sure I can understand, though, is the updated name Pixel Fold 2 not only rolls off the tongue better but is also considerably shorter. Still, if leaks are to be believed, the Pixel 9 Pro Fold should sport larger displays on the front and inside, just like the Galaxy Z Fold 6, faster processing for a responsive experience, and plenty of power for these new AI features.

You can see the teaser in full above. Google also updated a teaser page on its online store, calling out the standard Pixel 9 Pro and Pixel 9 Pro Fold and allowing you to sign up for more information.

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Luckily, you wont have to wait much longer as Google is expected to formally unveil the Pixel 9 Pro Fold alongside the Pixel 9 Pro and likely a few other devices at its August 13, 2024, event, and TechRadar will be on the ground to unpack everything as it happens.

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Google Is Removing "Do-Nothing" Apps from the Play Store – How-To Geek

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Apps that offer limited functionality will soon be removed from the Google Play Store. This includes apps that offer very little content or engagement, such as text-only apps, single-wallpaper apps, and apps that are intentionally designed to "do nothing."

Google regularly attempts to improve the app store by updating its policies and removing unwanted apps. Millions of old apps were delisted from the Play Store in 2022, and Google implemented stricter safety requirements for the Play Store in 2023.

On August 31st, Google will implement a revised Spam and Minimum Functionality policy in an effort to further improve the Play Store. The original Spam and Minimum Functionality Policy barred "apps that are designed to do nothing," while the revised policy explicitly adds that apps without "app-specific functionality" or "an engaging user experience" also count as spam.

" Were updating the Spam and Minimum Functionality policy to ensure apps meet uplifted standards for the Play catalog and engage users through quality functionality and content user experiences Apps should provide a stable, responsive, and engaging user experience. Apps that crash, do not have the basic degree of adequate utility as mobile apps, lack engaging content, or exhibit other behavior that is not consistent with a functional and engaging user experience are not allowed on Google Play."

Interestingly, Google did not revise the "Broken Functionality" section of its Spam and Minimum Functionality policy. This is despite the fact that some major apps, including the Sonos app, are regularly criticized for broken functionality.

The downside of today's "app purge," as with previous cleanup campaigns, is that Google will inevitably cull some apps that people care about. Users may also question why "do-nothing" or "static" apps are the focus of Google's effortsaren't scam apps a more prescient concern?

To Google's credit, the Play Store SDK Requirements and Malware policy have been revised for clarity. But these policies haven't actually changed in any way, and Google says that its "enforcement standards and practices remain the same."

You can read Google's revised Spam and Minimum Functionality policy at the Play Console Help website. Please note that this policy will not be put into effect until August 31st. If an app is delisted from the Play Store before that date, it's because the app violated a different policy (or was simply removed by the developer).

Source: Google via The Verge

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Google Pixel 9 Pro official design just revealed by Google heres your first look – Tom’s Guide

Posted: at 4:21 am

With the Made by Google event less than a month away, the Pixel 9lineup has beenrevealed via leaks. Sick of those leaks, Google has decided to show off the new Pixel 9 Pro themselves.

The tech giant released a teaser video that reveals the Pixel 9 Pro, at least part of it (h/t The Verge). It also teases AI and Gemini integration, which isn't surprising considering all the announcements Google made at I/O back in May.

The video and images on apre-order page Google releasedgive a confirmed look at the redesigned camera array, which is losing the edge-to-edge bar format in favor of a more pill shape.

As for the cameras themselves, it's been rumored that the Pixel 9 Pro and 9 Pro XL will use the same 50MP sensor found in the Pixel 8 Pro. However, the entire lineup is supposed to get new Sony IMX858 sensors that should improve low-light photography.

We also get to see the phone in white, though it is expected to come out in black, green and pink.

As for the display, which we get a brief glimpse of, we've seen rumors of displays anywhere from 6.1 inches up to 6.5 inches, slightly less than the rumored 6.7 inches the XL version might feature.

Weirdly, the most consistent rumor is that the Pixel 9 and Pixel 9 Pro will have 6.1-inch displays, a slight decrease from the 6.2-inch display on the Pixel 8.

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As of this writing, the pre-order page won't let you put down for the new phone. The site says pre-orders will open up at the end of the Made by Google event, which takes place on August 13. For now, you can sign up for more information if you're so inclined.

Google is expected to launch four new Pixel phones soon at the August event: the Pixel 9, Pixel 9 Pro, the Pixel 9 Pro and the Pixel 9 Pro Fold. They should also have a new Pixel Watch 3, which might come in an extra large size.

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Heres a very clear real-world look at Googles Pixel 9 Pro Fold – The Verge

Posted: at 4:21 am

There have been leaks aplenty in recent weeks showing every angle of Googles Pixel 9, 9 Pro, and 9 Pro XL. But so far, the companys second-generation foldable phone has managed to keep better cover ahead of next months product event. So much for that! As reported by Android Authority, new regulatory photos from Taiwans National Communications Commission (NCC) have fully revealed the Pixel Fold 2 Pixel 9 Pro Fold.

The images confirm that Google is moving away from the short and squat passport-style design that helped the original Pixel Fold stand out from Samsungs tall, narrow Galaxy Fold. Now, were getting something closer to the OnePlus Open. The outer display still looks very usable in terms of how much screen real estate youve got to work with, but its definitely taller than before.

Around back, these photos also confirm that the 9 Pro Fold will ditch the camera bar, which has become one of Googles signature hardware elements. This time, itll be... well, Im not quite sure what youd call this style of camera housing. It looks big enough to prevent the phone from having an annoying wobble when laid down on a table at least. As for the inner display, again, the screen ratio is noticeably taller and narrower compared to the original Fold, and it looks as though Google has managed to shave down the bezels some.

The tradeoff there is that the inner camera is now a cutout on the upper-left part of the display, whereas, last time, it was part of the bezel, giving you an uninterrupted display. I think I prefer the latter approach, but it is what it is. Another thing that has me a little wary is the battery. Apparently Google is going with a slightly smaller capacity (4,560mAh) this time, and the first Pixel Fold (4,727mAh) wasnt exactly what Id call a longevity champ. Maybe the companys latest Tensor processor will help make up for that with some efficiency gains.

Ive used the Pixel Fold as my daily driver for a good chunk of the last year. Theres just something about it that continues to feel special. Sure, it quickly got lapped in screen brightness by the Pixel 8 and 8 Pro, the speakers sound pretty bad, and many app developers never really bothered optimizing their software for the device. Heres hoping the second try can correct a few of those downsides for a better overall package even if its still likely to cost upward of $2,000.

Aside from yet more photos of the Pixel 9, 9 Pro, and 9 Pro XL, the regulatory images also showcase a new 45-watt USB-C charger that is likely to ship with at least some of these devices. Its much more rounded than the charger that Google has been including alongside Pixel phones for several years.

Update, July 16th: The story has been updated to include details about the 45-watt charger thats also in the NCC regulatory filing.

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Google Close to Its Biggest Acquisition Ever, Despite Antitrust Scrutiny – The New York Times

Posted: at 4:21 am

Google, which became one of the worlds most valuable companies through its search engine and other consumer internet services, is nearing its largest-ever acquisition to improve what it can offer to business customers.

Google is in talks to buy Wiz, a New York-based cybersecurity start-up, according to three people with knowledge of the discussions, who were not authorized to discuss them. Wiz was last valued at $12 billion.

The companies have valued the deal at roughly $23 billion, said one of the people, easily making it Googles most expensive acquisition and nearly double what the company paid for Motorola Mobility in 2012.

While a deal looks likely, talks could still fall apart, the people said.

Google and Wiz did not respond to requests for comment. The Wall Street Journal earlier reported that the companies were discussing a deal.

Google has moved forward with negotiations despite the possibility that regulators might try to block the deal. But the company may be willing to fight to beef up its cloud-computing division, which lags behind Amazon Web Services and Microsoft Azure.

Google was sued by the Justice Department in two separate antitrust cases, one targeting its ubiquitous search engine and another seeking to break up its digital advertising-technology business. A verdict in the search case is expected this summer.

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All four rumored Google Pixel 9 models have been photographed by a regulatory agency – TechRadar

Posted: at 4:21 am

Were still almost a month away from when the Google Pixel 9 line will probably launch, but you can already get a somewhat official look at all four expected models namely the Pixel 9, the Pixel 9 Pro, the Pixel 9 Pro XL, and the Pixel 9 Pro Fold (which is thought to be the launch name of the Pixel Fold 2).

This is thanks to the NCC (a Taiwanese regulatory agency), which via Android Authority has published photos of all four of these devices.

As this is an official government agency, its likely that the images and accompanying details are accurate, though things could still be subject to change until Google announces them.

Image 1 of 4

In any case, the images some of which you can see above line up with previous leaks, showing a new camera block design for the non-foldables, which doesnt run quite to the edges of the back.

The Pixel 9 Pro Fold has bigger changes, with a square camera block on the back, while the selfie camera for the foldable screen has been moved into a punch-hole cut-out, rather than being in the bezel as it was with the original Google Pixel Fold.

The Pixel 9 Pro Folds bezels also appear to be smaller than its predecessors, and the crease looks like it might be smaller too, so Googles second foldable could be a significant visual upgrade on its first.

As well as photos, the NCC also published battery capacities for the four phones, listing the Google Pixel 9 and Pixel 9 Pro as having 4,558mAh batteries, the Pixel 9 Pro XL as having a 4,942mAh one, and the Pixel 9 Pro Fold as having a 4,560mAh one.

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These are likely the rated capacities (which are the minimum you can expect) rather than the typical capacities (which is what companies tend to advertise). For comparison though, the Pixel 8 has a 4,485mAh rated capacity and a 4,575mAh typical one, the Pixel 8 Pro has 4,950mAh rated capacity and a 5,050mAh typical one, and the Pixel Fold has a 4,727mAh rated capacity and a 4,821mAh typical one.

So based on this the Pixel 9 might have a slightly larger battery than its predecessor, while the Pixel 9 Pro XL probably has a similar capacity to the Pixel 8 Pro (which its expected to be more comparable to than the Pixel 9 Pro is), and the Pixel 9 Pro Fold could have a slightly smaller battery than the Pixel Fold.

Finally, the NCC tests reveal approximate charging speeds for the four phones. Sadly this doesnt reveal the maximum speeds on offer. But with the Pixel 9 Pro XL achieving a speed of 32.67W, its likely that it will officially support at least 35W charging, which would be slightly higher than the 30W of the Pixel 8 Pro.

As for the Pixel 9 Pro Fold, that achieves 20.25W here, though as Google never got specific about the maximum charging speed of the Pixel Fold, we dont have anything to compare it to here.

The other phones are in line with their predecessors, suggesting the Pixel 9 could have an advertised charging speed of 27W, and the Pixel 9 Pro of 30W.

We should know for sure soon, as the Pixel 9 series is expected to be unveiled on August 13.

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Exclusive: Google Ventures is backing a Danish startup ‘brewing’ CO2 thats decarbonizing the future – Fortune

Posted: at 4:21 am

What if you could turn all the bad emissions from fossil fuel-intensive industries into plastics, paints and more? Thats the dream behind Copenhagen-based climate tech startup Again, which has raised $43 million in Series A funding from Google Ventures (the venture arm of Google parent Alphabet) and HV Capital, Fortune exclusively reveals.

The company will use the funds to devote more resources to researching food and feed products that can be made of carbon dioxide.

Cofounder Max Kufner told Fortune that the company plans to roll out its first operations by the end of 2025 or early 2026 at the latest.

Agains technology pumps carbon dioxide that would otherwise be released into the atmosphere into bioreactors. Bacteria then convert this carbon into valuable products used to make plastics, paints, and soaps.

Refining petroleum to extract different chemicals is responsible for 4% of the worlds direct greenhouse gas emissions, or about 1.8 gigatonnes of carbon dioxide, making the petrochemicals industry the third most polluting in the world.

COURTESY OF AGAIN

Again has raised about $100 million to date, partly from a European Union grant and partly from venture capital funding. The company received a $10 million injection from GV, ACME Capital and Atlantic Labs to set up a production site.

Founded in 2021, the company was born from a research project developed over 10 years at the Danish Technical University, Stanford, and MIT. That gave Again a leg up when it launched, as much of the learning curve of developing the technology had been crossed, making it easier to build the company and focus on scaling up.

Torbjrn Jensen and Alex Nielsen, academics involved in the research, later became cofounders at Again, along with early-stage investor Kufner.

Climate tech has expanded 45 times in the last decade, according to Dealroom. But as global temperatures and extreme weather events continue rising, theres still a need for significantly more.

Agains technology helps solve one of climate technologys biggest barriersthe ability to scale it. One of the biggest challenges with modern climate tech companies is that theyre trying to capture carbon dioxide from the atmosphere, turn it into a very small form and pump it back into the earth, Kufner explains.

Jensen told Fortune that the process of capturing and converting carbon dioxide efficiently is what makes Again stand out.

We are basically cleaning up the emissions and we just so happen to also produce a super valuable product at the same time, he said. But it needs to be cheap, it needs to be robust, it needs just to operate 24/7 all year round.

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Google teases the Pixel 9 Pro Fold [Video] – 9to5Google

Posted: at 4:21 am

In addition to the Pixel 9 Pro tease today, Google today is Introducing the Google Pixel 9 Pro Fold this afternoon.

Besides confirming the long brand name, this a A foldable phone built for the Gemini era. We see the inner screen open in full for Oh hi, AI. However, we dont see the hole-punch front-facing camera in the top-right corner. The rounded rectangular camera bar is quite prominent, while we can somewhat make out how thin this device is unfolded.

Google again chose to showcase the Porcelain model with clear gold tones. Weve also seen in it Obsidian, with the first-generation color palette retained. Hopefully, fun colors will eventually make their way to the foldables.

Out with the old. In with the Fold.

It has the same breakup letter-magical theme, starting on the cover screen, ahead of the August 13th Made by Google 2024 event.

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