Daily Archives: June 24, 2024

WSOP 2024: Super High Roller hand leads to an awful bad beat – For The Win

Posted: June 24, 2024 at 4:52 pm

Going all in with a pair of 10s in a poker tournament is risky as heck, but when youre among the five players left in a World Series of Poker event, sometimes its not that bad.

And then this happens, and its all heartbreaking. Lets break it down.

In the $250,000 Super High Roller event, Charles Hook went all-in with 10s and eventually, Ben Tollerene called with his Ace-King offsuit. Tollerene was the chip leader at the time, so he could spare the 13.5 million it cost.

The flop was 2-4-2. That helped Hook, because that gave Tollerene just six outs. But then the turn show another 2. That gave Tollerene one more out to win another 2, giving the two of them four of a kind, but Tollerene would have the best fifth card with an Ace.

Guess what showed up on the river? Yep. You guessed it. A 2.

OUCH.

Hook ended up with over $1.2 million for his troubles, and Tollerene would eventually finish second.

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Dan Bilzerian to Compete on Hustler Casino Live Against Ninja, Neymar, & Keating – PokerNews.com

Posted: at 4:52 pm

Controversial social media playboy Dan Bilzerian has been added to Saturday's Hustler Casino Live stream that was already packed with celebs.

Two years after referring to poker players as "f*****g nerds," the former GGPoker ambassador will compete in a high stakes poker game at Hustler Casino in Los Angeles. And no doubt his presence on the livestream will bring about some criticism from some within the poker community, but also a substantial amount of viewers.

Bilzerian, often referred to as a misogynist including by some within the poker community, is a polarizing figure on social media. But he also has millions of followers on platforms such as X and Instagram.

On the felt, he's claimed to have won more than $50 million lifetime playing poker in nosebleed private games against celebrities and billionaires. Some have disputed that claim given there's no way for him to verify the results, but many believe what he's said to be true.

Bilzerian will be joined on the Hustler Casino Live felt by a number of celebs such as Twitch streamer Ninja, NBA star Jimmy Butler, boxers Ryan Garcia and Chris Eubank Jr., and soccer legend Neymar, a PokerStars ambassador. Hustler Casino Live fan favorite Alan Keating will also be in the mix.

The blinds in the game will be $50/$100 with a $10,000 minimum buy-in, but HCL co-owner Ryan Feldman said he expects every player to buy-in for at least $50,000.

Bilzerian doesn't appear often in public poker games, so this will give his fans and haters an opportunity to find out if his poker skills resemble that of which he claims. The wealthy Instagram influencer had some wonderful things to say about the poker community in June 2022 on the No Jumper Podcast.

"My goal with poker was always to play with people that were playing for fun," Bilzerian said. "I wanted to play with the rich guy that was playing for fun, not the guy that was trying to be a f*****g killer. I wanted to play against these rich guys that were going there to f*****g, like, blow off some steam, f**k with their friends, show a big bluff, f**k some massage girls, whatever, get out of the house from the wife."

"Most poker players are f*****g nerds," Bilzerian told Adam22, who is also a poker enthusiast. "I don't really hangout with that many of them, I don't really want to associate with them. I shut most of them out of my f*****g games. I never really let pros in."

Bilzerian was referring to the modern high stakes pros. He won't be facing those players in the Hustler Casino Live game on Saturday. Instead, he'll be playing against a roster full of recreational players, which should be more to his liking.

Viewership for the aforementioned stream should be up given the lineup, one that could rival the famous "MrBeast Game" in May 2022, which had over 100,000 concurrent viewers across all platforms, still a poker livestream record. Hustler Casino Live is fresh off the Million Dollar Game week earlier this month, which attracted 30,000+ concurrent viewers for much of the four shows.

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Dan Bilzerian to Compete on Hustler Casino Live Against Ninja, Neymar, & Keating - PokerNews.com

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Frank Funaro Sin the $10,000 Super Turbo Bounty ($408,658) – PokerNews.com

Posted: at 4:52 pm

Two WSOP gold bracelet winners collided in a heads-up match that lasted just eight hands, one of whom added another bracelet to their mantle. Frank Funaro defeated Shota Nakanishi on Day 2 to take down Event #57: $10,000 Super Turbo Bounty No-Limit Holdem, earning $612,997 and his second WSOP bracelet. Nakanishi fell short in second place but still earned himself $408,658 for his efforts.

Frank Funaro was already an accomplished player before this tournament, having won an online bracelet in 2022 and finishing in fifth place at the 2022 WPT World Championship for $1,301,000. But this is my best poker moment, Funaro said moments after he took his new bracelet in his hands for the first time. I feel like I've been close in a lot of these, and it feels really good to finally get one done, he added.

Because of its structure, the $10,000 Super Turbo Bounty, with its 20-minute levels, required skill and a bit of luck to win. Funaro managed to take advantage of all the components.

I tried to embrace the madness and got really lucky, he explained. I was short, I rounded it up, and then I was short again. It was a swinging Super Turbo. The table was full of professionals; it wasn't the easiest final table. But luck was on my side. There were a lot of tough spots, and they all went my way. And I thought I played relatively well, all things considered. I'm very grateful.

Funaro entered the final day sixth in chips of the remaining nine players. He managed to get things started by winning a massive flip to get himself back in the mix, then found plenty of dream double up spots after that, often having his opponents dominated preflop.

Its difficult to run deep in a tournament of this magnitude as this event attracted plenty of household names, including Phil Hellmuth, who looked poised to defend his title. Hellmuths tournament run came to an end, exiting in 15th place for $28,463.

Funaro gave us a look ahead at whats next for him this summer. Im going to the Millionaire Maker right now! Next week, my girlfriend and my brother are coming, so we'll do something next week. Overwhelmed with emotions, Funaro does not plan on slowing down now and will look to add a third WSOP bracelet to his shelf in the coming weeks.

Event #57: $10,000 Super Turbo Bounty No-Limit Holdem attracted 486 entries totaling up to a prize pool of a whopping $4,519,800. Plenty of notables entered the field including Josh Arieh, David Peters, Erik Seidel, Julien Sitbon, Joe Cada and Nacho Barbero, all of whom fell short of the money.

The bubble burst on Day 1 with Steve Buell scoring a double knockout with pocket aces, eliminating Carl Noris and Juha Helppi. Then Day 1 saw some headliners make deep runs include Martin Jacobson (19th - $23,266), Alan Sternberg (22nd - $23,266), Dario Sammartino (28th - $19,407) and Daniel Sepiol (31st - $19,407)

Day 1 finished halfway through Level 29 with nine players making the final table. Day 1 play came to a halt with Aliaksei Boika earning two double ups in the span of five hands to catapult into the chip lead with 5,360,000 chips, 34 big blinds. Ludovic Geilich was responsible for doubling up Boika, and was left looking to navigate an eight big blind final table short stack. Oliver Weis and Antoine Saout rounded out the top three.

Day 2 resumed at 2 p.m. with the final table action being streamed. Aaron Johnson (MN) was the first to be eliminated from the final nine (9th - $45,195) after he lost a flip to Michael Rocco. He was followed by Ludovic Geilich (8th - $58,616) and by two-time WSOP Main Event finalist Antoine Saout, who ran twice into aces to finish in seventh place for $77,460.

Among multiples double-ups, Steve Buell was next to follow at the payout desk, losing with tens against Oliver Weis's ace-king (sixth Place - $104,261). Aliaksei Boika wasn't more fortunate as when he was one card away from doubling up, Rocco was lucky enough to hit a straight flush on the river to send him to the rail in fifth place for $142,892.

But this straight flush didn't help much Rocco in his quest for the gold bracelet, because after Weis' elimination (4th - $199,342) in a three-way all-in situation, he was eliminated as well by Nakanishi. For the second time this summer, Rocco finished in third place in a WSOP event and won $282,983.

Once heads-up, Funaro had a big disadvantage in chips but still managed to come back in just a few hands to win his second WSOP bracelet.

This concludes the PokerNews coverage of this event. Stay tuned for continued coverage of the 2024 WSOP by following our live updates from all tournaments here.

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News: Yuri Dzivielevski wins 5th bracelet in five years – pokerstrategy.com

Posted: at 4:52 pm

The Brazilian mixed games beast shows his prowess once again in the 9-Game Mix event at the WSOP

To be the Brazillian all-time money leader is no mean feat, to get there mostly as a mixed games player is nothing short of remarkable.

Yuri Dzivielevski just took down the $3,000 Nine Game Mix bracelet for $215,982, his 5th bracelet in five years.

He now boasts bracelets in basically every format of poker when you combine the games in his three mixed games bracelets, to go along with his two online PLO bracelets.

The win also puts him in 7th for the Player of the Year race, with the $50,000 Players Championship underway now.

"I think each bracelet has a special feeling, a special memory. I cannot compare it to other bracelets. It's always an amazing feeling, I can't explain how amazing it is," he said after the win.

These are his career bracelets so far:

Is he the new mixed game GOAT? Let us know in the comments:

Barry Carter is the editor of PokerStrategy.com and the co-author of The Mental Game of Poker 1 & 2, Poker Satellite Strategy, PKO Poker Strategy, Endgame Poker Strategy, GTO Poker Simplified, Mystery Bounty Poker Strategy and Beyond GTO.

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"This is 100% cocaine behavior" – Fans react to Ryan Garcia downing alcohol while playing poker with Neymar, Jimmy … – Sportskeeda

Posted: at 4:52 pm

Fans recently expressed their thoughts on Ryan Garcia drinking alcohol while playing poker with Brazilian football legend Neymar, Miami Heat's star forward Jimmy Butler, and professional poker player Dan Bilzerian. While many mocked Garcia, others harshly chastised him for his recent behavior.

Garcia joined Neymar, Butler, and Bilzerian at the HUSTLER Casino in Los Angeles for what was dubbed the 'biggest event in poker history'. This star-studded poker game was broadcast live on the Hustler Casino livestream, attracting interest from fans all around the world. Joining this trio of world-class sportsmen were prominent personalities such as popular streamer Ninja, Chris Eubank Jr., and Jon Vlogs, creating an unusual mix of talent at the table.

@HappyPunch on X shared a clip of Garcia enjoying himself at the poker game, with the following caption:

Check out the post below:

Fans soon rushed to the comments section to share their reactions.

One fan wrote:

Another fan wrote:

Other fans wrote:

Check out some more reactions below:

Garcia, who was recently facing a one-year suspension after testing positive for performance-enhancing drugs, made his first public appearance at the high-stakes poker action since the news surfaced. Eager to go back into the ring, the American boxer seized the chance to publicly call out Devin Haney, rekindling their rivalry from their previous meeting.

Ryan Garcia's antics at the event's ceremonial weigh-ins confused spectators after missing weight for the biggest fight of his career against Devin Haney. Garcia paid a penalty fee to Haney but boasted about having an advantage on X before downing a drink on the scale in front of the crowd.

Check out the video of Ryan Garcia drinking beer at the ceremonial weigh-ins below:

Garcia then clarified on social media that he drank apple juice in a beer bottle, not alcohol.

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"This is 100% cocaine behavior" - Fans react to Ryan Garcia downing alcohol while playing poker with Neymar, Jimmy ... - Sportskeeda

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One surprising effect of wildfires: itchy, irritated skin – Harvard Health

Posted: at 4:52 pm

Are you finding yourself with itchy, irritated skin that you can't stop scratching? Or have you wondered why your child's eczema is suddenly worse and so hard to control? Mounting evidence suggests that wildfires, which are increasing in intensity and frequency, contribute to skin problems, including eczema flares.

Eczema is a common chronic skin condition that affects about one in 10 people in the US. Its hallmarks are inflamed and dry, itchy patches of skin.

Atopic dermatitis is the most common type of eczema. It can run in families, often beginning in childhood. Typically, in the northern hemisphere, it grows worse during the winter season when the weather is cold and drying. Now some experts are seeing that pattern change. At Massachusetts General Hospital, for example, one dermatologist noted an unusual spike last summer in patients with flare-ups of eczema.

In 2023, Canada experienced more than 6,000 wildfires that burned over 16 million hectares of land an area larger than the entire state of Georgia. While far away from the devastation, the smoke reached across the US and more than 2,000 miles to Europe. Poor air quality from these distant wildfires caused eye and throat irritation and difficulty breathing.

In Boston, Dr. Arianne Shadi Kourosh, a dermatologist at Massachusetts General Hospital, also began to notice skin symptoms. Normally the dermatology clinics would see fewer than 20 people during a summer month for eczema, including atopic dermatitis. Suddenly that jumped to 160.

Looking back at summer month records from the last four years, her research showed that the number of visits for these skin complaints tracked with the severity of air pollution. These findings are consistent with other research noting an uptick in eczema flares and psoriasis flares associated with wildfire pollution. But why?

Researchers theorize that airborne pollutants might set off a cascade of effects within the body by activating an oxidative stress pathway. This damages the skin barrier and prompts an inflammatory response. This cascade also may play a role in the development of eczema.

Air pollutants in wildfire smoke may harm multiple organs not just your heart and lungs, but also our skin, it seems. So, when outdoor air quality is bad due to wildfires, limiting your exposure can help reduce health risks. While we can say the same for industrial air pollution, wildfire pollution is likely worse due to its additional toxic particles.

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Olympic Gymnast Suni Lee Shares Her Eczema and Mental Health Journey – POPSUGAR

Posted: at 4:52 pm

There's a simple reason gymnasts wear leotards to compete: they're formfitting, stretchy, and won't get in the way during a front layout. But while they may be functional, they also happen to put quite a bit of skin on display something Olympian Suni Lee struggled with when she first started dealing with eczema.

"It was something that I felt ashamed of, being in a leotard and competing for Team USA," she tells PS. "Our skin is very exposed, cameras are always on us, people are always taking pictures, and it's hard when you're kind of ashamed to be looking at your own body or your skin because you can see that it's rough or flaky."

Lee started experiencing itchy, red skin that was "always uncomfortable" when she was younger, and it wasn't until she'd tried "everything" she could get over the counter before she was officially diagnosed with eczema.

The inflammatory skin disease is characterized by dry, itchy skin. At its core, it's a chronic (but manageable) condition that's caused by an overactive immune system disrupting the skin barrier. Still, certain triggers like specific foods, alcohol, and environmental irritants can cause it to flare. According to the National Eczema Association, it affects over 31 million people in the US alone. Still, it can show up differently on everyone making it hard to treat and even more difficult to talk about.

"I used to have it really bad on my arms, legs, and behind my neck it was swollen and inflamed," Lee says. "It made me not want to be seen anywhere because I knew people were looking at it because it was so inflamed. It has definitely taken a hit to my security levels when I'm competing, because it feels like people are looking at me."

The gymnast has since gotten her eczema under control, which has been immensely helpful for her overall well-being. "My doctors, dermatologists, and I have a really good system we know what works," she says. Lee recently partnered with Eli Lilly and Company, a pharmaceutical company that makes eczema drugs and Team USA's health equity sponsor, to destigmatize the conversation around atopic dermatitis, aka eczema. "I've had my fair share of insecurities with eczema, but it's not something to be ashamed or embarrassed about. And now, I want to share my story to help inspire younger generations to be comfortable in their own skin."

Research published by The Journal of Allergy and Clinical Immunology has shown that those who have eczema are at a higher risk for depression and anxiety, and according to a recent survey conducted by the National Eczema Association, 30 percent of people with atopic dermatitis deal with one or both of these mental health concerns. But ironically, mental and emotional stress is one of the top triggers for eczema flare-ups, which Lee has experienced firsthand. "I get the worst stress eczema flare-ups," she says. "At the 2021 Olympics, I was having a flare-up on my neck that I thankfully got handled right before the competition. But it happens a lot when I'm stressed and I can't sleep. I get really bad flare-ups. So then I'm constantly itching and uncomfortable."

"I was scared to talk about [mental health] for a long time, but when Simone and other athletes started talking about it, it made me feel more comfortable."

It's one of the many reasons Lee prioritizes her mental health. In addition to therapy, two practices that help manage her stress are journaling and visualization. "I'm a very private person and I keep a lot of things, so I don't really share how I totally feel all the time, so I write it all down," she says. "I write down my 'whys,' my goals, my keywords, and I visualize a lot during my routines because it's important to remember them when you're out there and nervous and trying to block everything out."

While navigating her own mental health journey, Lee has been grateful to see fellow athletes open up about theirs ahead of the 2024 Paris Olympics, where she's competing for Team USA next month. "The attitude now is just so much more positive, and it's more focused on the mental health of the athletes because if we're not in the right headspace, you can't expect us to compete the best routines in the way that we're expected to," she says. "Our needs are very important because they're things that are going to help us when we're out there competing."

In the last few years, athletes like Simone Biles, Gabby Douglas, and Naomi Osaka have spoken out about their own mental health experiences, which has helped Lee feel comfortable sharing her story. "I talk to and listen to a bunch of other athletes, and I'm constantly trying to hear and understand how some people do the things they do," she says. "And it's been so helpful because I was scared to talk about it for a long time, but when Simone and other athletes started talking about it, it made me feel more comfortable."

Zo Weiner is a freelance beauty and wellness writer. Her work has appeared in Bustle, Byrdie, Cosmopolitan, PS, GQ, Glamour, Marie Claire, Allure, Self, Brides, and Teen Vogue, among others, and she was the senior beauty editor at Well+Good.

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The Best Makeup For Eczema & How To Apply It – The Zoe Report

Posted: at 4:52 pm

Itchy, bumpy eczema patches have always crept their way onto the crooks of my elbows, between my fingers, and even behind my knees throughout my adolescence and adulthood thus far. It wasnt until I reached my twenties that I also began experiencing flares on some areas of my face, particularly on my cheeks and along my jawline. This feat has made me particularly cautious when it comes to choosing makeup products for my eczema-prone skin, and it has completely altered what I look for when shopping for new foundations, blushes, powders, you name it.

According to Dr. Hope Mitchell M.D, a board-certified dermatologist based in Ohio, Im not alone. Choosing makeup products when you have eczema can feel daunting, but a few thoughtful tips can make a big difference, she says. Its true, opting for fragrance-free or hypoallergenic formulas made with sensitive skin in mind has calmed my flares and kept my skin looking smoother, patch- and itch-free. But it took some time to get there. Here, I spoke with multiple experts to define eczema, share tips on how to choose the right makeup products for the skin condition, and application tips. Let this be your eczema-friendly makeup guide, one that Ive yearned for since my very first flare-up.

Lets start with the basics. According to Dr. Dendy Engelman M.D., a board-certified cosmetic dermatologist and Mohs surgeon at Shafer Clinic Fifth Avenue in New York City, eczema is an inflammatory skin condition that manifests as patches of dry, itchy, red, and irritated skin. For those with eczema, choosing cosmetics with nourishing, non-irritating ingredients is crucial for preventing flare-ups and minimizing irritation, she says. While eczema can be triggered by general seasonal allergies, rhinitis, or genetics, it can also flare up if your skin is sensitive to particular skin care or cosmetic ingredients.

According to the experts, its possible for makeup to cause eczema. Look out for increased redness, itching, or a burning sensation in areas where you apply your makeup, says Mitchell. You may also see small bumps, swelling, or dry, flaky patches developing shortly after application.

While this wasnt the case for me personally, the experts recommend to immediately stop using the product you might suspect is causing your eczema flare-up. Engelman also recommends patch-testing the product on another area of your body, like the inner forearm, and waiting 24 to 48 hours to determine if its causing an adverse reaction. If so, soothe the affected area with a calming moisturizer or emollient designed for sensitive skin, or apply over-the-counter hydrocortisone.

No matter the root cause of your eczema, Mitchell warns to avoid scratching the area to prevent further damage and infection. If a flare doesnt improve or gets worse, consult with a dermatologist who can help you identify which ingredients to avoid in the future, she says

Choosing makeup for eczema-prone skin all comes down to the right ingredients. Look for ingredients like ceramides and hyaluronic acid because they help hydrate and protect the skin barrier, says Mitchell. Foundations or skin tints that are hypoallergenic, fragrance-free, and made for sensitive skin also get the green light from the experts especially anything thats approved by the National Eczema Association, like the Tower 28 SunnyDays Tinted SPF 30.

Consistency and format are also important when it comes to choosing makeup for eczema-prone skin. Avoid gel-based products with alcohol, as they can strip your skin of moisture and worsen dryness and itchiness. Opt for liquid, cream, or mousse foundations as well, since powders can highlight texture issues and dryness, says Mitchell.

There are also a handful of makeup ingredients to avoid when you have eczema-prone skin. Steer clear of synthetic preservatives like methylparaben and butylparaben, which are commonly used in cosmetics as these can exacerbate eczema-prone skin, says Engelman. She also shares that chemical colorants, which are often labeled as FD&C or D&C followed by a color and number, can be irritating as well. Because fragrance can exacerbate flare-ups, its important to always opt for fragrance-free makeup whenever possible.

Mitchell also recommends staying away from sulfates, formaldehyde releasers, and lanolin, all of which may cause adverse reactions in sensitive skin. Lastly, be cautious with essential oils and botanical extracts, as they can sometimes lead to irritation, she adds.

Once youve determined what products to use, there are also a few things to be mindful of during application, according to Brielle Pollara, a New Jersey-based makeup artist. The best approach is to start by hydrating the skin really well before applying any makeup, she says. The dermatologists echo this sentiment and share that you should always begin your makeup routine with a rich, hydrating moisturizer like the Embryolisse Crme Concentrate or the Dieux Skin Instant Angel Lipid-Rich Barrier Repair Cream with Ceramides.

Next, apply an eczema-friendly skin tint, like the Ilia Super Serum Skin Tint SPF 40 Skincare Foundation or the CeraVe Hydrating Mineral Sunscreen SPF 30 Face Sheer Tint, which is one of Dr. Mitchells favorites. If you have eczema bumps or patches, Pollara recommends applying your makeup with a brush. Gently pat over the areas with a dense brush to help avoid texture [from showing] underneath the makeup, she says. For blush or bronzer, opt for formulas that are talc and silicone-free, like the Kosas Blush is Life Baked Talc-Free Dimensional + Brightening Blush and the Saie Dew Bronze Soft-Focus Effortless Liquid Bronzer.

To set your makeup, choose a hypoallergenic setting powder to reduce shine without heavy layers, says Mitchell. Personally, I love the Ami Col Skin Melt Talc-Free Loose Setting Powder, and Engelman also recommends the Glo Skin Beauty Pressed Base Powder for a weightless finish.

All in all, applying makeup to eczema-prone skin is possible with the right formulas and techniques. Reading labels carefully, patch-testing, and opting for hypoallergenic and fragrance-free products are the methods that have tamed my eczemas madness. With the right makeup regimen, you too, can kiss those itchy, bumpy patches goodbye albeit, temporarily.

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Eczema-friendly Products in Seal of Acceptance – National Eczema Association

Posted: at 4:52 pm

For people with eczema, learning about the many possible ingredients that can trigger a flare and how to avoid these ingredients when buying moisturizer, shampoo and other everyday products can feel daunting. In an effort to simplify the process, the National Eczema Association (NEA) created the Seal of Acceptance program.

You might recognize that little blue symbol the Seal on some of your favorite skincare and/or household products, but what exactly does it mean? What makes a product qualified to receive the Seal? Here, well give you a deeper look at what it means to obtain the Seal, including who reviews the products and how companies maintain the Seal standards to help you ensure youre using quality products for your life with eczema.

So what exactly is the Seal of Acceptance? Started in 2008, the Seal was created as a way to help consumers find eczema-friendly products. The Seal is a branded label displayed on personal care and household products that have been vetted by NEA. NEA awards the Seal to products that are deemed suitable for people with eczema or sensitive skin, based on sensitivity, toxicity and formulation testing data.

Only products that have applied for and pass the review process are awarded the Seal. NEA does not solicit manufacturers to apply for the Seal.

Brands or product manufacturers must fill out an application form for each product they wish to have evaluated, which includes:

Lets dig into each part of the application and review process to get a better understanding of what they are and how products obtain the Seal.

As you can imagine, evaluation of a products formulation is a big part of the Seal review process. NEA has identified 18 ingredients in its Ecz-clusion list that are known irritants and allergens that cannot be included in a product that applies for the Seal.

For a product to obtain the Seal, it cannot contain any of the following ingredients in any amount:

In addition, products must not include:

These guidelines were set by the Seal Scientific Oversight Committee. This is a panel of leading dermatologists, allergists and eczema experts. In addition to setting the ingredient guidelines, the committee established the criteria and framework for the overall Seal review process based on the most current scientific information.

For a product to obtain the Seal, it must meet the strict standards established by our Scientific Oversight Committee, including a review of ingredients and formulation data, said Christine Anderson, director of Seal of Acceptance and department operations at NEA.

Ingredients are considered in relation to sensitivity and irritation, said Anderson. The concentration levels and the purpose of the ingredient within the formula is taken into consideration as well.

To be considered for the Seal, manufacturers must have completed a clinical testing report for each individual product. Clinical testing is a way in which manufacturers make sure their products are suitable. NEA does not conduct this testing; rather, the testing is completed by an outside company who recruits people to test the formula in a controlled environment. Product manufacturers are solely responsible for identifying and working with companies to obtain this testing.

There are various types of clinical tests. NEA requires at least one of the following tests be completed by the manufacturer for each product formula:

During the testing, NEA requires that the clinical testing report include information regarding the skin tones of individuals involved in the testing process. This is reported using the Fitzpatrick Classification of Skin Types, which represents six skin types classified by pigment and ultraviolet light sensitivity.4 This requirement allows us to assess if a reasonable representation of skin types and tones are taken into consideration during testing.

The product samples are another part of the review process. NEA receives product samples from the manufacturers to ensure there is no fragrance present and to allow for reviewers to use the product as intended. The product samples, along with the clinical testing reports, are then sent to a panel of doctors who are part of the Seal reviewers selected by NEA.

This is the stage where experts weigh in on products. This includes the Seal Scientific Oversight Committee and Seal Review Panel. These doctors are selected by NEA for their expertise in dermatology, specifically eczema and sensitive skin care, and they hold MD, PhD and DO credentials.

The Seal Scientific Oversight Committee works independently of the Seal Review Panel. The Seal Scientific Oversight Committee sets the standards and criteria for the Seal Review Panel to use. The Seal Review Panel is the ultimate decision maker in whether or not a product is accepted to receive the Seal.

When selecting the Seal reviewers, NEA strives for diversity in geography, gender, specialty in medical fields (dermatologists and allergists) and race/ethnicity, while simultaneously prioritizing expertise.

The Seal Review Panel reviews all the materials holistically, including:

Products are reviewed and awarded the Seal on an ongoing basis. When a product is awarded the Seal, NEA enters into a one-year license agreement with the manufacturer allowing them to utilize the Seal logo on accepted products in the U.S. and Canada markets.

Product manufacturers are allowed to renew their license annually. However, to ensure a product still meets our high standards, a manufacturer must:

If there is a change in formula, even a minor one, the manufacturer must restart the application process with new clinical testing.

The Seal was created to help empower you to find products that are suitable for you and your family. The rigorous testing and review requirements help ensure that every product with the Seal has been vetted specifically for eczema and sensitive skin.

While the Seal can help eczema-friendly products be more easily identifiable, eczema is different for everyone and what works for one person might not work for another, said Anderson. Identifying a product with the Seal is an important first step, but it should be followed by trying the product to see how well it works for you.

The Seal of Acceptance Program is intended to provide broad guidance on personal care products suitable for individuals with eczema and/or sensitive skin when used as intended per the product label. Individuals with eczema and/or sensitive skin have the responsibility for identifying ingredients in any product that could potentially irritate their skin and/or trigger potential allergies. Healthcare-related questions should be referred to a physician or other healthcare provider, including questions regarding product ingredients, as well as whether use of the accepted product(s) is suitable.

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Eczema-friendly Products in Seal of Acceptance - National Eczema Association

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Rare gene mutation helps people resist Alzheimer’s disease – The Washington Post

Posted: at 4:51 pm

In 2019, researchers announced the discovery of an unusually resilient person a Colombian woman who carried a ticking time bomb in her genes that should have triggered an aggressive, early form of Alzheimers disease, starting in her 40s. But for three decades, the bomb didnt explode.

Scientists studied her DNA and scanned her remarkable brain, ultimately tracing her protection to a rare version of the APOE gene, called the Christchurch variant. She had two copies. The extraordinary story of Aliria Rosa Piedrahita de Villegas, who did eventually develop dementia in her 70s and died of cancer at age 77, offered inspiration for a disease that afflicts millions of people, for whom hope is often in short supply.

But she was just one patient. That left a nagging doubt: Could this case hold the key to a new way to stave off Alzheimers? Or was she a one-off?

In a study published Wednesday in the New England Journal of Medicine, researchers reported 27 members of the same extended Colombian family carry the genetic risk for Alzheimers, along with a single copy of Christchurch. Cognitive decline in this singular group was delayed by about five years suggesting that a drug that emulates the gene could have similar effects.

We are taught in medicine to be wary of not drawing too many conclusions from a single patient, said Joseph F. Arboleda-Velasquez, an associate scientist at Mass Eye and Ear in Boston and a co-author of the study. Maybe it was related to something she ate or didnt eat. Maybe its something related to the water in the house. The idea of finding 27 people some lived in the city, some lived in rural areas increases our confidence in the discovery and shows the results are reproducible.

Francisco Lopera, a neurologist at the University of Antioquia in Medelln, Colombia, began caring for patients suffering from an aggressive, inherited form of Alzheimers four decades ago.

Cognitive impairment began when people were in their mid-40s. Full-blown dementia developed before the age of 50. Patients died in their 60s. Researchers traced the disease to a mutation in the gene Presenilin 1, now known to be carried by about 1,200 people within an extended family.

Piedrahita de Villegas showed scientists that it was possible to defy this grim genetic destiny. But for an exceptional patient to turn into broader medical insight, scientists need confirmation that the gene is producing the beneficial effect and can do the same in other people.

People carry two copies of the APOE gene, one inherited from each parent. Having two copies of the Christchurch version, as Piedrahita de Villegas did, is rare, extremely rare, said Yakeel T. Quiroz, a clinical neuropsychologist at Massachusetts General Hospital. So they started to look for people with just one.

A man who carried the Alzheimers risk mutation and a copy of Christchurch provided an initial clue. Brain imaging at age 51, when he was diagnosed with mild cognitive impairment, revealed that his brain had elevated levels of plaques of the beta-amyloid protein, a telltale sign of Alzheimers. But intriguingly, he had limited tangles of a different Alzheimers related protein, called tau, and he developed mild dementia at age 54, years later than expected.

That was a signal that having one copy could have been protective, Quiroz said. The team found 26 other people with this genetic makeup. Not all the patients have developed cognitive impairment, but among those who have, symptoms were delayed, beginning five years later than those without Christchurch. Dementia was also delayed, by four years.

The discovery that a single copy of Christchurch provides a degree of protection is a hopeful clue for scientists trying to develop therapies. If two copies were necessary, the bar for a new drug might be impossibly high it would have to be extremely effective to have any benefit. But seeing a lower dose of the gene protect against the onset of disease is a good sign. It suggests even partly mimicking the Christchurch genes action could work.

I think this is a really important study, and the outcome is very meaningful, said Yadong Huang, director of the Center for Translational Advancement at Gladstone Institutes, an independent biomedical research organization based in San Francisco. Huang was not involved in the study, but his lab showed last year that the Christchurch mutation has benefits in mice prone to develop Alzheimers disease and in human brain cells in a dish. Still, he noted that until now there has been a critical gap in knowledge how it affects humans in the real world.

For years, Alzheimers research has tended to focus on clearing the sticky amyloid plaques that build up in the brain. A few therapies have shown success, but they are far from a cure. The new study shows the promise of a different biological target: drugs that imitate the rare Christchurch variant of the APOE gene.

John Hardy, a neurogeneticist at the U.K. Dementia Research Institute at the University College London said pharmaceutical companies have traditionally been less enthusiastic about APOE because it is a difficult target, but that is changing.

Interest has been growing, and this finding is part of the reason, Hardy wrote in an email.

As a next step, researchers have developed an experimental antibody drug that imitates Christchurch. When it was given to mice that were genetically tweaked to develop features of Alzheimers, they found the drug reduced buildup of tau tangles a sign that they are on the right path.

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Rare gene mutation helps people resist Alzheimer's disease - The Washington Post

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