Monthly Archives: April 2024

The Canyon Endurace CF SLX 8 AXS Aero features that classic Canyon look, with added comfort, and a super-clean monocoque cockpit. Its also got a convenient tool roll integrated into the top tube. Can this combination outperform the all-road competition, and does it live up to its Endurace name?

This bike was tested as part of the 2024 all-road shootout you can find an overview of the test field here: 2024 all-road shootout The four hottest all-road bikes head to head.

The Endurace has a very long tradition in Canyons portfolio. The first model was launched as far back as 2016. Even then, the focus was on long distances, for what used to be called marathon. Either way, the Canyon Endurace is and has always been a bike for long days in the saddle. Also on board since 2016: the now iconic Canyon S15 seat post. And, as hard as it is to believe, they even had models with rim brakes and mechanical shifting back then! But how does the current version fare, priced at 5,499, featuring an integrated tool roll, weighing 8.30 kg, and available exclusively with a wireless drivetrain and disc brake?

High-tech performance meets modern flair in the Canyon Endurace CF SLX 8 AXS Aero. Thats according to some. To others, it looks like a cold, functional engineering design. In any case, the new Endurace has an edgy, rocket-ship look that isnt necessarily aggressive but definitely hints at performance. The structured surface on the fork, seat stays, and seat tube isnt just eye-catching, it also offers aero gains, according to Canyon. Unfortunately, the Desert Grey colour isnt exactly a feast for the eyes. It looks quite vintage and gives the bike a 1996 Opel Astra vibe. Of course, this is a matter of taste, though we feel that it detracts from the bikes otherwise modern look. Fortunately, there are other colours to choose from. Be that as it may, pairing the bronze shimmer with tan-wall tires is a definite no-go! With aero in the name, the Canyon Endurace CF SLX 8 AXS Aero isnt complete without aero details. These include elongated tubing profiles, a cut-out for the rear wheel, and flat faces. The one-piece handlebar and stem unit also matches the bikes aero ambitions.

The spec of the Canyon Endurace CF SLX 8 AXS Aero leans more toward road cycling, especially compared to the other three all-road bikes on test. The deep profile rims, svelte look, and 30/32 mm front and rear tires are clearly at home on the asphalt. However, there is clearance for 35 mm tires, which would cater to gravel road excursions. A knock-block steering limiter prevents the handlebar from damaging the frame. Youve got a 12-speed SRAM Force AXS groupset paired with a 1033 t cassette and 46/33 t crankset ensuring rapid shifting, as well as a power metre. The gearing suits the build and offers sufficient range, provided you dont leave the road. The DT Swiss ERC 1400 DICUT wheelset is an excellent choice, featuring 35 mm deep profile rims with a relatively wide 22 mm internal width, which is in line with the current trend of increasing tire widths. Canyon also include a chainstay protector, which makes perfect sense, despite the road-oriented build. The Canyon S15 VCLS 2.0 CF seat post also matches the bikes looks while offering added comfort.

5,499

Fork Canyon FK0129 CF Disc Seatpost Canyon S15 VCLS 2.0 CF 27.2 mm Brakes SRAM Force AXS HRD 160 mm Drivetrain SRAM Force AXS 12s 2 x 12 Chainring 46/33T Stem Canyon CP0018 Aerocockpit 100 mm Handlebar Canyon CP0018 Aerocockpit 410 mm Wheelset DT Swiss ERC 1400 Dicut 12 x 100/12 x 142 mm Through Axle Tires Schwalbe Pro One TLE 700 x 32c 30 32 Cranks SRAM Force AXS Powermeter 46/33 172.5 mm Cassette SRAM XG 1270 10-33T

Size 3XS 2XS XS S M L XL 2XL

very compact geometry road setup through and through tool kit in the top tube supremely comfortable

Once youve swung your leg over the saddle and are rolling along, the Canyon Endurace CF SLX 8 AXS Aero will soon have you in a compact and comfortable riding position. Its rather aggressive, nevertheless. As such, the name EnduRace suits the bike perfectly in this respect. In contrast to the comfort-oriented Specialized Roubaix, it feels significantly more like it wants to race, which is further underlined by the handling. The bike is stiff and responsive, resulting in a very direct power transfer. It feels super lively upon acceleration as well as on the climbs, raring to go at every opportunity. Add to that the agile and direct steering, letting you control the Canyon Endurace CF SLX 8 AXS Aero with pin-point precision. This combination lets you summit mountains and hills in no time, and ride down even quicker. The hardest part is reigning in your enthusiasm and not pedalling all out all the time. Its a completely different riding experience, especially compared to the more comfortable FOCUS PARALANE 8.9.

The seat post and cockpit on the Canyon Endurace CF SLX 8 AXS Aero compensate for what the stiff frame lacks in terms of compliance. In fact, the Canyon S15 VCLS 2.0 CF seat post made the Endurace by far the most comfortable bike on test, at least at the rear. It takes the sting out of all road conditions, no matter how rough or poorly maintained. The Continental GP5000 tires offer plenty of grip and excellent rolling characteristics on asphalt, though youll want to avoid gravel and dirt roads with this setup. A second wheelset with grippier 35 mm tires, like the Schwalbe G One RS, could make the Endurace significantly more versatile. Lets address the tool roll in the top tube. On the one hand, its extremely convenient and easy to reach, but on the other hand, it is always in your field of view. The tool set includes all the essentials, made up of eight bits, one ratchet, tire levers, a CO cartridge, and Dynaplug, available for an additional 14.95. The set comes to 192 g. Unfortunately, it can be a bit fiddly to use, and the flap got jammed several times during our test. The plastic closure is more reminiscent of a battery compartment on a childrens toy than a premium bike. Overall, its a good idea, but the execution leaves room for improvement.

We cant think of a better name for this bike than Endurace!

The Canyon Endurace CF SLX 8 AXS Aero is a fast endurance bike for winding and fast descents. Its ideal for those who like to ride long AND fast, and predominantly on asphalt. However, with a second set of 35 mm gravel tires, you could turn the Endurace into a gravel racer. It doesnt invite you to cruise along and take in the sights, but rather to churn out watts and eat up kilometres. Group rides, all-day epics, and long-distance events are where its most comfortable.

Tuning tip: Black tires and an Opel Astra in the matching colour

Canyon Endurace CS SLX 8 AXS Aero

Size: 3XS 2XS XS S M L XL 2XL Weight: 8,3 Price: 5,499

The Canyon Endurace CF SLX 8 AXS Aero certainly lives up to its name. It combines race-oriented elements with long distance comfort. Its a bike that makes you want to ride long distances at a fast pace. However, this build is aimed more at asphalt. Before venturing off onto dirt roads, you will need to swap out the tires on the Endurace and max out the 35 mm tire clearance. With the Canyon Endurace CF SLX 8, all-road actually means road, and EnduRace.

For more information visit canyon.com

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Words: Martin Staffa Photos: Jan Richter

Original post:

Canyon Endurace CF SLX 8 AXS Aero All in the name of speed and distance? - GRAN FONDO Cycling Magazine

Im Yoon-ah, popularly known as YoonA, is a renowned South Korean actress and a member of the globally acclaimed girl group Girls Generation, or SNSD. In the South Korean entertainment industry, YoonA emerges as a star and an icon.

While YoonA's talents shone on stage and screen, it was her prowess in commercial endorsements that truly set her apart. Even before her official Girls' Generationdebut, she appeared in CFs. From the outset of her career, she demonstrated a natural ability to embody diverse brand images, seamlessly transitioning from cute and bubbly to sophisticated and glamorous as the occasion demanded. Her undeniable influence in the world of commercial endorsements earned her the well-deserved title of "CF Queen."

YoonA has done numerous endorsements as a member of Girls Generation, and her individual CF count is nearly 40. Some of the notable brands she endorsed are SK Telecom, Cartier Jewelry, Michael Kors, Qeelin, S-Oil, Everlands Caribbean Bay, Lee Jeans, Pandora, Ragnarok Mobile, Este Lauder, etc.

YoonA's influence transcends the border of South Korea, and she was appointed as a global ambassador for reputable brands like Miu Miu, Korea Tourism Organization, CROCS, EIDER, INNISFREE, etc.

Despite the ever-changing landscape of the entertainment industry, YoonA has remained a consistent presence in the advertising world, maintaining her relevance and desirability year after year.

Continued here:

The Reign of Girls Generation's YoonA in Endorsements: The CF Queen - allkpop

To capture the hearts and minds of consumers through a shared love for ftbol, Lowes is delivering a hat trick for ftbol fans. Lowes is partnering with the best ftbol player in the world, Lionel Messi, Major League Soccer Club Inter Miami CF and the upcoming CONMEBOL Copa Amrica 2024 USA.

Through a multiyear agreement, Messi also becomes a member of Lowes Home Team, making him the first ftbol player to join the lineup of top NFL and NBA athletes who have helped improve communities around the country since 2020.

Lionel Messi is the GOAT of the assist, said Jen Wilson, Lowe's senior vice president of enterprise brand and marketing. Partnering with him is the perfect reflection of Lowes shared passion for assisting our customers, whether for their business or home.

To kick off his first season, Lowes and Messi will assist Lowes loyalty customers with extra perks. Starting today, all loyalty members will receive 100 points to get them closer to their next reward through Lowes new loyalty program for homeowners, MyLowes Rewards, and Lowes MVPs Pro Rewards for Pros. MyLowes Rewards members must claim points on their account dashboard by May 18.*

Ftbol, much like home improvement, is all about teamwork and the assistance between people, Messi said. I am happy to partner with Lowes, a brand that understands the importance of collaboration and helping people succeed.

Inter Miami has quickly become the focal point of ftbol in North America. The new partnership between Lowes and Inter Miami will drive engagement with ftbol fans with signage and in-stadium activations, community programming, ticket hospitality, player appearances at Lowes locations throughout the Miami market and more.

Inter Miami has worked towards becoming a global reference point of ftbol, so that when people think of ftbol, they think of Inter Miami, said Inter Miami CF Chief Business Officer, Xavier Asensi. Our partnership with Lowes is another proof point of attaining this ambition. We are excited to partner with Lowes, an organization that matches our goal to continue to set the benchmark for the sport and deliver for our ftbol family.

Lowes will also team up with CONMEBOL Copa Amrica 2024 USA, which returns to the United States with Argentina defending its crown beginning June 20. Lowes has a series of exciting initiatives to celebrate the magic of Messi:

To celebrate ftbols rich culture and community, we wanted to partner with an athlete and ftbol affiliations that resonate deeply with our customers, said Gerardo Soto, Lowe's vice president of brand marketing and sports partnerships. These new partnerships provide an opportunity to build trust and credibility with a broader customer base through the athletes and sporting events that matter to them.

The partnerships add to Lowes existing collaboration with Charlotte FC, Lowes hometown Major League Soccer club. As the Official Home Improvement Partner of Inter Miami CF and CONMEBOL Copa Amrica 2024 USA, Lowes will enhance the ftbol experience for fans while bringing them closer to the excitement of Messi's gameplay.

For more information about Lowes partnerships and upcoming ftbol initiatives, visit Lowes.com/hometeam.

* Loyalty Programs subject to Terms & Conditions. Visit Lowes.com/Terms for details. Subject to change.

**All Bonus Points will expire on December 31, 2024, unless extended by Lowes. Reward Center items may vary. Visit Lowes.com/terms for full details.

See the original post:

Lowe's Teams Up with Lionel Messi, Inter Miami CF and CONMEBOL Copa Amrica 2024 USA to Win Over Ftbol ... - Inter Miami CF

A novel treatment strategy for cystic fibrosis (CF) thats based on a cellular structure called the porosome showed promise in cell and animal models of CF caused by the common F508del mutation.

In the cell model, this approach was more potent than tezacaftor and ivacaftor, which are CFTR modulators used in approved CF therapies,according to data presented by Porosome Therapeutics, the company developing the approach.

Findings were showcased at the April summit of the American Physiological Society in Long Beach, California, in the poster Cystic fibrosis rescued using a reprogrammed porosome secretory machinery.

These new results mark a major breakthrough in our efforts to find a path to a cure, not only for CF but for a wide range of debilitating diseases and chronic conditions, Guillermo Marmol, president and CEO of Porosome Therapeutics, said in a press release sent to Cystic Fibrosis News Today. Marmol noted that the company is focused on bringing this approach into clinical testing in people.

We are diligently conducting further studies to comprehensively assess the safety, stability, and optimal dosage of this approach, said Bhanu P. Jena, PhD, the companys founder and chairman.

CF is caused by mutations in the gene that encodes the CFTR protein. This protein normally helps regulate the flow of chloride ions across the cell membrane. Problems in the workings of CFTR lead to the production of abnormally thick, sticky mucus, which builds in organs to drive most disease symptoms.

The porosome is a complex of dozens of proteins, including CFTR, that work together to regulate the movement of molecules out of cells. The therapeutic approach described here basically involves taking porosomes from cells with healthy CFTR protein and transplanting them into CF cells.

Reconstitution of functional porosomes having normal CFTR, therefore holds great promise in treating CF with all different types of CFTR mutations, the researchers wrote.

Researchers first tested this approach in a cell model of CF caused by the most common CF-causing mutation, F508del. As in CF patients, cells in this particular model characteristically secrete lower-than-normal levels of certain mucus proteins, including MUC5B and MUC5AC.

The porosome-based treatment increased secretion of these mucus proteins from CF cells. Notably, the porosome therapy had a significantly more potent effect on mucus protein secretion compared to tezacaftor and ivacaftor, which in CFTR modulators work by boosting the functionality of the faulty CFTR protein.

These findings indicate that porosome-reconstitution therapy is a powerful approach, the researchers wrote.

Scientists next tested the porosome-based treatment in a mouse model of CF caused by the F508del mutation.

In these experiments, they evaluated the effect of the treatment on CFTR function using a well-established measure called the nasal potential difference, which records the small electrical charge that occurs in the airway lining inside the nose. Results indicated that the porosome therapy normalized CFTR function.

Porosomes obtained from functional [healthy] human bronchial epithelial cells were used to treat the nasal passages of CF-affected mice. Remarkably, within 24 hours of treatment, this reconstitution of the porosome rescued chloride secretion in the nasal passage, Jena said.

See the rest here:

Porosome treatment targeting CFTR shows promise in CF models - Cystic Fibrosis News Today