Daily Archives: April 27, 2024

Joel Embiids son, Arthur, was born on Sept. 17, 2020, about three months before the first COVID-19 vaccine became available. The world was a cauldron of civic unrest and pandemic turmoil. Embiids NBA career largely had been a disappointment. He named his son after his little brother, who, six years earlier at the age of 13, had been killed by a passing truck while walking home from school in Cameroon.

A month earlier, in the NBAs COVID bubble in a playoff run delayed by the pandemic, Embiid had averaged 30 points and 12.3 rebounds in a first-round sweep at the hands of the Boston Celtics. The Sixers played without injured point guard Ben Simmons, and Embiid was not as good as his numbers.

Everything changed when he became a dad a month later.

He began to eat better, sleep more, beef on social media less. He began to refine all aspects of his game. He began to study opponents. By the end of last season, Embiid was the NBA MVP, and he thanked his son for the inspiration.

Losing my brother, and then giving his name to my son meant a lot. My son is the reason why Im really sitting here, Embiid said at the time. When I found out we were having a kid, I just remember I was like, Ive got to be a great role model and Ive got to set a good example. I want him to understand that his dad not only was pretty good, but he also worked hard and he went and took everything he wanted.

My whole mindset just changed. Everything about me just changed. The way I went about my business, my life, everything changed because I wanted to be a great father, set a good example.

Were seeing the effects of that change now.

It took a decade since he left Kansas and four years since the birth of his son, but Embiid finally understands what it takes to be a champion. It means ignoring the pain and soreness of a surgically repaired knee. It means ignoring fear and discomfort. It means, no matter how much you hurt and no matter how tired you are, you grab moments by the throat and pull the lesser players along.

Embiids left knee hurt. Embiids left eye was impaired due to a bout with Bells palsy hes been dealing with for more than a week. Youd never have known it.

Trailing the series 2-0, in a sport that has never seen a comeback from a 3-0 hole, Embiid scored 50 points, his best postseason output by 10, and saved the Sixers season.

READ MORE: Joel Embiid powers through Bells palsy for 50 as Sixers smack Knicks in the head. Literally.

This is what Michael Jordan and Dwayne Wade did. This is what Kobe did. This is what LeBron and Steph and Timothy Theodore Duncan did. This is how Hakeem Olajuwon, Embiids closest comp, won twice. They played through pain and injury and illness. That group of seven players account for 27 of the last 33 NBA championships.

Embiid had little in common with them before Arthurs birth. Five years ago, theres no way hed be playing. On Tuesday, in Game 3 of the first round of the Eastern Conference playoffs, he came closer to them than he ever has been before. Can he do it again on Sunday afternoon? He will try.

I want to play as much as possible. I only have about, maybe, eight years left. So I have to enjoy this as much as possible and I want to win, Embiid said. Im just trying to keep pushing. Im not going to quit. If its on one leg, Im still going to go out there and try, but thats not an excuse. Got to keep playing better, and better, and better.

Thats what a champion says.

Embiid underwent surgery 2 1/2 months ago to repair a torn meniscus in his left knee. He irritated the joint when he landed after a self-pass slam dunk in in the first half of Game 1 in on Saturday. In the same arena in which Willis Reed became the games emblem of toughness, Embiid emerged from the locker room just before the third quarter resumed. He stunk, and the Sixers lost, but he returned. He played better Monday night, but again faded in the second half. Thursday in Philly was a different story.

Embiid scored 33 points on 8-of-10 shooting in the second half. He made all five of his three-pointers. He flummoxed double-teams; he had three assists. He had three rebounds, but he dominated the paint.

He was, for one night, everything the Sixers could hope for him to be.

Big fella came out and was just ballin for us tonight, said Tobias Harris, Embiids longest-tenured teammate. Everybody down the line was able to figure their role.

Harris joined the Sixers in 2019, perhaps Embiids worst hour. A virus and knee tendinitis led to an average of 17.6 points and 8.7 rebounds in a seven-game second-round loss to eventual-champion Toronto on a Sixers team that, with Jimmy Butler, Harris, and JJ Reddick, was the best combination of talent since Josh Harris bought the team in 2011. Infamously, after the Game 7 loss in Toronto, outside the locker room just after the game, he wept in the arms of his fiance. Hall of Fame big men Shaquille ONeal and Charles Barkley, the foremost NBA analysts on the planet, questioned Embiids hunger and leadership. The points they made were fair ... until Arthur arrived.

Embiid tore the meniscus in his right knee in the first round of the 2021 playoffs. His effectiveness diminished as the second round advanced, and when the Hawks won Game 7, Embiid told us that the game turned when Simmons refused to dunk the basketball in the games final minutes. This was the first glimmer of leadership; he never criticized teammates. Simmons never played another game for the Sixers.

Embiid, already playing with a thumb that needed surgery, fractured his right orbital bone in the first round of the 2022 playoffs. He missed the first two games of the second round and the Sixers and new point guard James Harden could not overcome the toughness of Miami. Embiid got tougher.

Last year, he sprained his right knee in Game 3 of the first round and missed the first game of the second round. He rallied, but by the end of the second round against the Celtics hed run out of gas.

Every single year you start asking yourself questions: Why? Embiid said. Gotta keep putting my body on the line, for my family. ... Im not going to quit. When Im done Im going to be proud of myself, and my people are going to be proud of me.

Sure enough, this year has been different. For the first time in eight trips to the postseason hes averaging more points in the playoffs than in the regular season. Hes also playing more minutes than in any regular season or playoff run.

And hes done it with one eye, on one leg. Give him a patch and a parrot and hed be Long John Silver.

Legends are born of such moments as Thursday. Jordans 38-point flu game in the 1997 NBA Finals. Isiah Thomas 45-point ankle game in the 1988 Finals. Reed playing with a torn thigh muscle in Game 7 of the 1970 Finals, the Knicks first title.

Granted, we might be making too much of a single game, but lord, what a game: a must-win 50-piece, on a bad leg, with a frozen face, and the heart of a champion.

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Joel Embiid finally discovers he has the DNA of a champion. Down 2-1, can he lead the Sixers past the Knicks? - The Philadelphia Inquirer

From movies set in dystopian futures to real-life courtroom dramas, DNA, or deoxyribonucleic acid, has fueled storytellers imaginations for decades. The molecule responsible for shaping our understanding of biological inheritance has inspired everything from comic book tales about the birth of mutants to blockbuster films about resurrecting dinosaurs in a theme park, each captivating audiences worldwide.

Today (April 25) is National DNA Day, a day commemorating the completion of the Human Genome Project in 2003 and the discovery of DNAs double helix in 1953. To find out more about this remarkable molecules impact on pop culture and society, The Daily sat down with Divita Mathur, assistant professor in the Department of Chemistry at Case Western Reserve University.

Read on to learn more from Mathur about how DNA intertwines with our daily lives.

Namor, the original Aquaman from the Marvel universe, was first conceived in the comic world before World War II and can be considered the first mutant being to be created in American pop culture. Mutants are born from what DNA naturally doesgenetic recombination and mutations. Now we have some very popular universes of mutants, including the Spider-Verse, Teenage Mutant Ninja Turtles, and X-Men.

When a very animated cartoon DNA in the 1993 movie Jurassic Park explained that a 66-million-year-old mosquito fossilized in a drop of amber was about to be squeezed to harvest dinosaur blood/DNA (spoiler alert!), audiences across the globe immediately came on board with having dinosaurs walk amongst men again. Even an asteroid that wiped the giant beasts off the planet could not fry natures hard-drive for storing genetic information: DNA. The movie went on to skip a few steps and took liberal creative license with others, but we learned that DNA is pretty resilient. Fifteen years later and after improved CGI effects, Avatars Navi in 2009 were infiltrated by humans who stole Navi DNA to become one of themand gave us another record-smashing movie franchise.

The movie that gave DNA most street cred is Gattaca (1997). What a clever name that uses DNAs four-letter alphabetA, T, C, G! Gattaca is the leader of the dystopian movie genre that espouses control over humankind using the most unique fingerprint we possessour DNA code. Subsequently, DNA databasesor Denabasesare adopted by other movies such as Blade Runner 2049 to register every citizen using their DNA, kind of like your drivers license, fingerprint, social security number, and retina scan all rolled into one. Dystopian worlds with DNA-reading machines as IDs are pretty ironclad in their control over the masses, until artificial intelligence-driven organic robot humanoids go rogue.

Evidently, 40+ drops of blood sampled from the murder scene of Nicole Brown Simpson and Ron Goldman were screened and presented as DNA evidence in the all-consuming trial: The People v. O.J. Simpson. Believing that DNA evidence gets the final word, both sides of the aisle somehow leveraged the evidence in their favor, leading to the famous acquittal and a larger debate over the role of such forensic evidence in highly televised trials. Before the turn of the century, DNA evidence revealed President Bill Clintons perjury and the media and publics gross prejudice against Monica Lewinsky, adding fuel to an already eyeball-grabbing scandal involving a U.S. president.

Benign (or so we thought) versions of Denabases exist now, thanks to the democratization of DNA sequencing to find out ones ancestry by simply mailing ones spit to a company. Trace amounts of a killers DNA from a crime scene can end up matching a growing family tree on a genealogy database and can be used to track them down. It has spawned a new genre of crime-solving documentaries that have brought serial killers to justice because their distant cousins innocuously and voluntarily submitted their spit/DNA to an ancestry database. The Golden State Killer is one such popular victim of the genetic genealogy fad and the protagonist of a gripping documentary.

Looking to dive into genetics in pop culturespecifically in literature? Marie Vibbert has you covered. Vibbert is the webmaster for the College of Arts and Sciences at Case Western Reserveand also a science fiction author, having written more than 90 short stories and three novels.

Vibbert recommends the following books with genetics in their plots:

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Unraveling DNA's role in pop culturefrom superheroes to crime scenes - The Daily | Case Western Reserve University

Generative A.I. technologies can write poetry and computer programs or create images of teddy bears and videos of cartoon characters that look like something from a Hollywood movie.

Now, new A.I. technology is generating blueprints for microscopic biological mechanisms that can edit your DNA, pointing to a future when scientists can battle illness and diseases with even greater precision and speed than they can today.

Described in a research paper published on Monday by a Berkeley, Calif., startup called Profluent, the technology is based on the same methods that drive ChatGPT, the online chatbot that launched the A.I. boom after its release in 2022. The company is expected to present the paper next month at the annual meeting of the American Society of Gene and Cell Therapy.

Much as ChatGPT learns to generate language by analyzing Wikipedia articles, books and chat logs, Profluents technology creates new gene editors after analyzing enormous amounts of biological data, including microscopic mechanisms that scientists already use to edit human DNA.

These gene editors are based on Nobel Prize-winning methods involving biological mechanisms called CRISPR. Technology based on CRISPR is already changing how scientists study and fight illness and disease, providing a way of altering genes that cause hereditary conditions, such as sickle cell anemia and blindness.

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Generative A.I. Arrives in the Gene Editing World of CRISPR - The New York Times

As we celebrate World DNA Day, I am living proof of DNAs profound impact on our criminal legal system.

My name is Michelle Murphy. I am one of 15 women exonerated in the United States with the help of post-conviction DNA testing and I am the first and only woman in Oklahoma to be exonerated by DNA testing.

In 1994, at just 17, I was a single mother of two, navigating a challenging world, dreaming of a better future for my children and myself. But my life took a tragic turn when my infant son was murdered, a crime for which I was wrongly accused of committing. My coerced confession during a distressing police interrogation was used to convict me, and I was sentenced to life without parole. Falsely confessing to a crime I did not commit is not a unique phenomenon, and one of the leading causes of wrongful conviction.

It was clear that DNA evidence, crucial in my case due to the presence of blood at the crime scene, would be pivotal. Although lab tests conducted by the prosecution proved my DNA wasnt present at the crime scene, this crucial information was kept from my defense team. However, during the trial, the prosecution misleadingly suggested to the jury that the blood from the scene was mine, using this to claim I was guilty.

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DNA Testing Proved My Innocence of My Son's Murder - Innocence Project

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Excerpt from:
Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure - Nature.com

In July 1957, 22 prominent scientists gathered quietly at a private lodge in Pugwash, a small town in Canadas Nova Scotia province. They had answered a call to action by Albert Einstein, inviting scientists to shape guardrails that would contain the danger of nuclear weapons. The Pugwash Conference earned a Nobel Peace Prize, and more importantly, it laid the foundations for the nuclear non-proliferation treaties, which saved our world from risks of annihilation.

Today, governments and businesses are frantically searching for ways to limit the many feared perils of AIespecially those from Artificial General Intelligence (AGI), the next phase of AI evolution. AGI will perform a wide range of cognitive tasks with an efficiency and accuracy far superior to current AI systems. This next stage of A.I., often referred to by Silicon Valley enthusiasts as God-like, is expected to surpass human intelligence and efficiency by a substantial margin. It is rumored that an internal report on the risks of AGI may be what ignited the recent board drama at OpenAI, the maker of ChatGPT. But while the race to build AGI is still in progress, we can be certain that whoever controls it will have enormous sway on society and the economy, potentially exerting influence on the lives of humans everywhere.

In the past year, numerous and uncoordinated efforts by government and business to contain AI sprang across the world, in the U.S., China, the EU, and the U.K. Businesses have been pleading with governments to regulate their AI creations, whilst knowing full well that governments will never succeed in regulating effectively at the speed of A.I. evolution. The EU recently completed a multi-year effort to deliver the AI Act. However, the shifts in generative AI capabilities mean that by the time it is enacted in 2025, the new AI Act may already be outdated.

Governments are not equipped to outgallop fast-moving technologies with effective rules and policiesespecially in the early hyperfast stages of development. Moreover, AI technologies have a transnational borderless reach, limiting the effectiveness of national and regional rule systems to govern them. As for businesses, they are in intense competition to dominate and profit from these technologies. In such a race, fueled by billions of investments, safety guardrails are inevitably a low priority for most businesses.

Ironically, governments and businesses are in fact the two stakeholders who are most in need of guardrails to prevent them from misusing A.I. in surveillance, warfare, and other endeavors to influence or control the public.

A careful analysis of how prior technologies and scientific innovations were tamed in the 20th century offers a clear answer to this dilemma. Guardrails were designed by scientists who know their own creations and understand (better than most) how they might evolve.

At Pugwash, influential scientists came together to develop strategies to mitigate the risks of nuclear weapons, significantly contributing to the formulation of arms control agreements and fostering international dialogue during the tense Cold War era.

In February 1975, at the Asilomar Conference in California, it was again scientists who met and successfully established critical guidelines for the safe and ethical research of DNA, thereby preventing potential biohazards. The Asilomar guidelines not only paved the way for responsible scientific inquiry but also informed regulatory policies worldwide. More recently, it was again the scientists and inventors of the Internet, led by Vint Cerf, who convened and shaped the framework of guardrails and protocols that made the Internet thrive globally.

All these successful precedents are proof that we need businesses and governments to first make space and let A.I. scientists shape a framework of guardrails that contain the risks without limiting the many benefits of A.I. Businesses can then implement such a framework voluntarily, and only when necessary, governments should step in to enforce the implementation by enacting policies and laws based on the scientists framework. This proven approach worked well for nuclear technology, DNA, and the Internet. It should be a blueprint to build safer AI.

A Pugwash Conference for AI scientists is therefore urgently needed. The conference should include no more than two dozen scientists, in the mold of Geoffrey Hinton who chose to quit Google in order to speak his mind on AIs promise and perils.

Like Pugwash, the scientists should be chosen from all the key countries where advanced A.I. technologies are developing, in order to at least strive for a global consensus. Most importantly, the choice of the participants at this seminal A.I. conference must reassure the public that the conferees are shielded from special interests, geopolitical pressures, and profit-centric motives.

While hundreds of government leaders and business bosses will cozy up to discuss A.I. at multiple annual international events, thoughtful and independent A.I. scientists must urgently get together to make A.I. good for all.

Fadi Chehad is chairman, cofounder, and managingpartner of Ethos Capital. He founded several software companies and was a fellow at Harvard and Oxford. From 2012 to 2016 he led ICANN, the technical institution that sets the global rules and policies for the internets key resources.

The opinions expressed in Fortune.com commentary pieces are solely the views of their authors and do not necessarily reflect the opinions and beliefs ofFortune.

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Scientists inspired the right guardrails for nuclear energy, the internet, and DNA research. Let them do the same for AI - Fortune

Strelitzia is a genus of five species of perennial plants, native to South Africa. It belongs to the plant family Strelitziaceae. A common name of the genus is bird of paradise flower/plant, because of a resemblance of its flowers to birds-of-paradise. In South Africa, it is commonly known as a crane flower. Wikipedia

The most up-to-date understanding of the flowering plant tree of life is presented in a new study published today in the journal Nature by an international team of 279 scientists, including three University of Michigan biologists.

Using 1.8 billion letters of genetic code from more than 9,500 species covering almost 8,000 known flowering plant genera (ca. 60%), this achievement sheds new light on the evolutionary history of flowering plants and their rise to ecological dominance on Earth.

Led by scientists at the Royal Botanic Gardens, Kew, the research team believes the data will aid future attempts to identify new species, refine plant classification, uncover new medicinal compounds, and conserve plants in the face of climate change and biodiversity loss.

The major milestone for plant science, involving 138 organizations internationally, was built on 15 times more data than any comparable studies of the flowering plant tree of life. Among the species sequenced for this study, more than 800 have never had their DNA sequenced before.

The sheer amount of data unlocked by this research, which would take a single computer 18 years to process, is a huge stride toward building a tree of life for all 330,000 known species of flowering plantsa massive undertaking by Kews Tree of Life Initiative.

Analyzing this unprecedented amount of data to decode the information hidden in millions of DNA sequences was a huge challenge. But it also offered the unique opportunity to reevaluate and extend our knowledge of the plant tree of life, opening a new window to explore the complexity of plant evolution, said Alexandre Zuntini, a research fellow at Royal Botanic Gardens, Kew.

Tom Carruthers, postdoctoral researcher in the lab of U-M evolutionary biologist Stephen Smith, is co-lead author of the study with Zuntini, who he previously worked with at Kew. U-M plant systematist Richard Rabeler is a co-author.

All 64 orders, all 416 families and 58% (7,923) of genera are represented. The young tree is illustrated here (maximum constraint at the root node of 154Ma), with branch colours representing net diversification rates. Black dots at nodes indicate the phylogenetic placement of fossil calibrations based on the updated AngioCal fossil calibration dataset. Note that calibrated nodes can be older than the age of the corresponding fossils owing to the use of minimum age constraints. Arcs around the tree indicate the main clades of angiosperms as circumscribed in this paper. ANA grade refers to the three consecutively diverging orders Amborellales, Nymphaeales and Austrobaileyales. Plant portraits illustrating key orders were sourced from Curtiss Botanical Magazine (Biodiversity Heritage Library). These portraits, by S. Edwards, W. H. Fitch, W. J. Hooker, J. McNab and M. Smith, were first published between 1804 and 1916 (for a key to illustrations see Supplementary Table 2). A high-resolution version of this figure can be downloaded from https://doi.org/10.5281/zenodo.10778206 (ref. 55).

Flowering plants feed, clothe and greet us whenever we walk into the woods. The construction of a flowering plant tree of life has been a significant challenge and goal for the field of evolutionary biology for more than a century, said Smith, co-author of the study and professor in the U-M Department of Ecology and Evolutionary Biology. This project moves us closer to that goal by providing a massive dataset for most of the genera of flowering plants and offering one strategy to complete this goal.

Smith had two roles on the project. First, members of his labincluding former U-M graduate student Drew Larsontraveled to Kew to help sequence members of a large and diverse plant group called Ericales, which includes blueberries, tea, ebony, azaleas, rhododendrons and Brazil nuts.

Second, Smith supervised the analyses and construction of the project dataset along with William Baker and Felix Forest of the Royal Botanic Gardens, Kew, and Wolf Eisenhardt of Aarhus University.

One of the biggest challenges faced by the team was the unexpected complexity underlying many of the gene regions, where different genes tell different evolutionary histories. Procedures had to be developed to examine these patterns on a scale that hadnt been done before, said Smith, who is also director of the Program in Biology and an associate curator in biodiversity informatics at the U-M Herbarium.

As co-leader of the study, Carruthers main responsibilities included scaling the evolutionary tree to time using 200 fossils, analyzing the different evolutionary histories of the genes underlying the overall evolutionary tree, and estimating rates of diversification in different flowering plant lineages at different times.

Hebarium speciment from 1832 Trepocarpus aethusae RBG Kew

Constructing such a large tree of life for flowering plants, based on so many genes, sheds light on the evolutionary history of this special group, helping us to understand how they came to be such an integral and dominant part of the world, Carruthers said. The evolutionary relationships that are presentedand the data underlying themwill provide an important foundation for a lot of future studies.

The flowering plant tree of life, much like our own family tree, enables us to understand how different species are related to each other. The tree of life is uncovered by comparing DNA sequences between different species to identify changes (mutations) that accumulate over time like a molecular fossil record.

Our understanding of the tree of life is improving rapidly in tandem with advances in DNA sequencing technology. For this study, new genomic techniques were developed to magnetically capture hundreds of genes and hundreds of thousands of letters of genetic code from every sample, orders of magnitude more than earlier methods.

A key advantage of the teams approach is that it enables a wide diversity of plant material, old and new, to be sequenced, even when the DNA is badly damaged. The vast treasure troves of dried plant material in the worlds herbarium collections, which comprise nearly 400 million scientific specimens of plants, can now be studied genetically.

In many ways this novel approach has allowed us to collaborate with the botanists of the past by tapping into the wealth of data locked up in historic herbarium specimens, some of which were collected as far back as the early 19th century, said Baker, senior research leader for Kews Tree of Life Initiative.

Our illustrious predecessors, such as Charles Darwin or Joseph Hooker, could not have anticipated how important these specimens would be in genomic research today. DNA was not even discovered in their lifetimes. Our work shows just how important these incredible botanical museums are to groundbreaking studies of life on Earth. Who knows what other undiscovered science opportunities lie within them?

Across all 9,506 species sequenced, more than 3,400 came from material sourced from 163 herbaria in 48 countries.

Sampling herbarium specimens for the study of plant relationships makes broad sampling from diverse areas of the world much more feasible than if one had to travel to get fresh material from the field, said U-Ms Rabeler, a research scientist emeritus and former collection manager at the U-M Herbarium.

For the tree of life project, Rabeler helped verify the identity of herbarium specimens selected for sampling and analyzed the resulting data.

Flowering plants alone account for about 90% of all known plant life on land and are found virtually everywhere on the planetfrom the steamiest tropics to the rocky outcrops of the Antarctic Peninsula. And yet, our understanding of how these plants came to dominate the scene soon after their origin has baffled scientists for generations, including Darwin.

Flowering plants originated more than 140 million years ago after which they rapidly overtook other vascular plants including their closest living relativesthe gymnosperms (nonflowering plants that have naked seeds, such as cycads, conifers and ginkgo).

Darwin was mystified by the seemingly sudden appearance of such diversity in the fossil record. In an 1879 letter to Hooker, his close confidant and director of the Royal Botanic Gardens, Kew, he wrote: The rapid development as far as we can judge of all the higher plants within recent geological times is an abominable mystery.

Using 200 fossils, the authors scaled their tree of life to time, revealing how flowering plants evolved across geological time. They found that early flowering plants did indeed explode in diversity, giving rise to more than 80% of the major lineages that exist today shortly after their origin.

However, this trend then declined to a steadier rate for the next 100 million years until another surge in diversification about 40 million years ago, coinciding with a global decline in temperatures. These new insights would have fascinated Darwin and will surely help todays scientists grappling with the challenges of understanding how and why species diversify.

Assembling a tree of life this extensive would have been impossible without Kews scientists collaborating with many partners across the globe. In total, 279 authors were involved in the research, representing many different nationalities from 138 organizations in 27 countries.

The plant community has a long history of collaborating and coordinating molecular sequencing to generate a more comprehensive and robust plant tree of life. The effort that led to this paper continues in that tradition but scales up quite significantly, said U-Ms Smith.

The flowering plant tree of life has enormous potential in biodiversity research. This is because, just as one can predict the properties of an element based on its position in the periodic table, the location of a species in the tree of life allows us to predict its properties. The new data will thus be invaluable for enhancing many areas of science and beyond.

To enable this, the tree and all of the data that underpin it have been made openly and freely accessible to both the public and scientific community, including through the Kew Tree of Life Explorer.

Open access will help scientists to make the best use of the data, such as combining it with artificial intelligence to predict which plant species may include molecules with medicinal potential.

Similarly, the tree of life can be used to better understand and predict how pests and diseases are going to affect plants in the future. Ultimately, the authors note, the applications of this data will be driven by the ingenuity of the scientists accessing it.

Phylogenomics and the rise of the Angiosperms, Nature (open access)

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Suri Cruise inherited more than just her mother Katie Holmess faceher fabulous sense of style was also clearly woven into her DNA. The mother-daughter duo turned a coffee run into a runway, each of them showing off their personal style.

Wearing a very Holmesian outfit, the actor donned a cozy gray crewneck sweater, which she layered over a striped button-up shirt. She paired her layered look with a pair of indigo blue jeans and black Adidas Sambasa stalwart shoe in her closet full of funky loafers and cork wedges. Holmes gave her preppy look a touch of boho chic with her accessorizing, adding a pair of oversized sunglasses and a black leather hobo bag slung over her shoulder.

Cruise, meanwhile, is all in on the boho revival. The freshly minted 18-year-old was too young to fully participate in the last bohemian moment, and is making up for lost time. She wore a tiered maxi dress with a red pattern with a pair of well-worn light brown Frye boots. Layering up on a chilly morning, Cruise layered an olive corduroy jacket underneath a denim overcoat.

Like her daughter, Holmes has also been known to love a good boho moment now and again. A longtime fan of Chlo, shes worn iterations of the brand from Phoebe Philos tenure to Gabriella Hearsts. Chemena Kamali, Chlos new creative director, recently posted a photo on Instagram of her own mother, dubbing her Chlo at heart. Might we suggest Kamali kick off the new Chlo era with a mother-daughter campaign starring, say, Katie Holmes and Suri Cruise?

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New DNA evidence has led police to arrest a75-year-old Auburn man who allegedly raped an underage victim in the woods near Lee Road 57 over 20 years ago, authorities said.

Bobby Lee Pitts was charged with first-degree kidnapping, rapeand sodomy in the 2003 incident. He is being held in the Lee County Detention Center without bond.

"I hope this sends a powerful message that no matter how much time has passed, we will never relent in our pursuit of justice. Every case matters deeply to us, and we will continue to pursue truth and accountability. Today, we stand firm in our promise," Auburn Police Chief Cedric Anderson said.

Anders said the arrest does more than give thevictim and their family closure.

"Its a testament to the unwavering commitment of our police department," the police chief said.

Auburn police launched an investigation into the incident onOct. 4, 2003. They met with a underaged victim who reported being sexual assaulted in a wooded area near Lee Road 57. The victim told police that theassailant forced them into the woods and subjected them to multiple acts of sexual violence.

At the time of the crime, police couldn't identify a suspect based on the physical evidence and description of the attacker.

APD cold case investigators submitted evidence through the Alabama Department of Forensic Sciences to the FBIs Combined DNA Index System. In January, APD received results fromforensic examinationthat authorities said identified Pitts as the offender.

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How do we understand past societies? For centuries, our main sources of information have been pottery sherds, burial sites and ancient texts.

But the study of ancient DNA is changing what we know about the human past, and what we can know. In a new study, we analysed the genetics of hundreds of people who lived in the Carpathian Basin in southeastern central Europe more than 1,000 years ago, revealing detailed family trees, pictures of a complex society, and stories of change over centuries.

The Avars were a nomadic people originating from eastern central Asia. From the 6th to the 9th century CE, they wielded power over much of eastern central Europe.

The Avars are renowned among archaeologists for their distinctive belt garnitures, but their broader legacy has been overshadowed by predecessors such as the Huns. Nevertheless, Avar burial sites provide invaluable insights into their customs and way of life. To date, archaeologists have excavated more than 100,000 Avar graves.

Now, through the lens of archaeogenetics, we can delve even deeper into the intricate web of relationships among individuals who lived more than a millennium ago.

Much of what we know about Avar society comes from descriptions written by their enemies, such as the Byzantines and the Franks, so this work represents a significant leap forward in our understanding.

We combined ancient DNA data with archaeological, anthropological and historical context. As a result, we have been able to reconstruct extensive pedigrees, shedding light on kinship patterns, social practices and population dynamics of this enigmatic period.

We sampled all available human remains from four fully excavated Avar-era cemeteries, including those at Rkczifalva and Hajdnns in what is now Hungary. This resulted in a meticulous analysis of 424 individuals.

Around 300 of these individuals had close relatives buried in the same cemetery. This allowed us to reconstruct multiple extensive pedigrees spanning up to nine generations and 250 years.

Our research uncovered a sophisticated social framework. Our results suggest Avar society ran on a strict system of descent through the fathers line (patrilineal descent).

Following marriage, men typically remained within their paternal community, preserving the lineage continuity. In contrast, women played a crucial role in fostering social ties by marrying outside their familys community. This practice, called female exogamy, underscores the pivotal contribution of women in maintaining social cohesion.

Additionally, our study identified instances where closely related male individuals, such as siblings or a father and son, had offspring with the same female partner. Such couplings are called levirate unions.

Read more: In a Stone Age cemetery, DNA reveals a treasured 'founding father' and a legacy of prosperity for his sons

Despite these practices, we found no evidence of pairings between genetically related people. This suggests Avar societies meticulously preserved an ancestral memory.

These findings align with historical and anthropological evidence from societies of the Eurasian steppe.

Our study also revealed a transition in the main line of descent within Rkczifalva, when one pedigree took over from another. This occurred together with archaeological and dietary shifts likely linked to political changes in the region.

The transition, though significant, cannot be detected from higher-level genetic studies. Our results show an apparent genetic continuity can mask the replacement of entire communities. This insight may have far-reaching implications for future archaeological and genetic research.

Our study, carried out with researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany and at Etvs Lornd University in Budapest, Hungary, is part of a larger project called HistoGenes funded by the European Research Council.

This project shows we can use ancient DNA to examine entire communities, rather than just individuals. We think there is a lot more we can learn.

Now we aim to deepen our understanding of ancestral Avar society by expanding our research over a wider geographical area within the Avar realm. This broader scope will allow us to investigate the origins of the women who married into the communities we have studied. We hope it will also illuminate the connections between communities in greater detail.

Additionally, we plan to study evidence of pathogens and disease among the individuals in this research, to understand more about their health and lives.

Read more: Ancient DNA reveals children with Down syndrome in past societies. What can their burials tell us about their lives?

Another avenue of research is improving the dating of Avar sites. We are currently analysing multiple radiocarbon dates from individual burials to reveal a more precise timeline of Avar society. This detailed chronology will help us pinpoint significant cultural changes and interactions with neighbouring societies.

The authors would like to acknowledge the contributions to this work of Zsfia Rcz, Tivadar Vida, Johannes Krause and Zuzana Hofmanov.

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Ancient nomads you've probably never heard of disappeared from Europe 1,000 years ago. Now, DNA analysis ... - The Conversation