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Daily Archives: January 16, 2024
Operator Coalition Makes Ad Pitch for NY Online Casino – Pokerfuse
Posted: January 16, 2024 at 9:19 pm
By letting people play casino games online, we can decrease deficits and help our families and schools.
Some of the biggest gaming operators in the US want lawmakers in New York to pass online casino legislation this year and have produced a commercial to get their point across.
BetMGM, DraftKings, Fanatics, and FanDuel the four members that form the Sports Betting Alliance (SBA) produced the 30-second spot and uploaded it to YouTube on January 2 as part of their Bet on NY campaign.
Supporters of expanded igaming in New York plan to introduce legislation again during the 2024 session, and have said that any online casino bill will also include verbiage to authorize online poker. The bill would likely also allow multi-state poker.
New York faces dangerous deficits, and theres an affordability crisis across the state, the 30-second advert begins. Lifes already hard enough for people without raising taxes or cutting services.
But theres a better way to begin addressing this problem. Neighboring states authorized igaming, creating billions in taxable revenue. By letting people play casino games online, we can decrease deficits and help our families and schools.
Lets bring igaming to New York, the ad concludes, with the words Learn more at BetOnNY.com.
The video had only received 44 views by mid-day Wednesday, but that number is sure to increase substantially once the spot begins airing on television or online assuming those portions of the ad campaign by the SBA have yet to start.
For the eagle-eyed observer, the advertisement provided a lot of information about New Yorks current status and how much the state would benefit from expanded igaming.
The advertisement cited:
SBA pointed out that three of New Yorks neighbors Connecticut, New Jersey, and Pennsylvania had generated a combined $6 billion in taxable revenue in 2022. The ad also included a forecast that New York would make more than $1 billion in revenue annually from igaming.
Supporters of expanded igaming, including Sen. Joseph Addabbo Jr. (D-Howard Beach) and Assemblyman J. Gary Pretlow (D-Mount Vernon), frequently cite the $1 billion figure. The last time was for a joint opinion piece published last month in City & State.
Only one member of the SBA, BetMGM, has an online poker platform, so the advertising campaign in New York has special meaning.
If New York online poker were to be authorized along with casino gaming, it would be an enormous market with nearly 20 million residents. BetMGM would surely want a piece.
How BetMGM would gain access for online poker remains to be seen. The operator is already live in the Empire State with mobile sports betting, but its not tethered to a land-based casino.
Its possible that New York lawmakers may ultimately decide that for online casino, operators must partner with a land-based casino. But if they go that route, BetMGM is covered it would likely partner with Empire City Casino, a racino in Yonkers owned by MGM Resorts International. MGM owns half of BetMGM (Entain owns the other half).
SBA appears united on getting online casino passed. It was a different story last spring when the alliance said its members wouldnt participate in sports betting in Maine.
After citing the small size of the market and coming out against operators receiving just 30% of gross gaming revenue (although they could request 40%), DraftKings changed its mind and jumped into Maine for sports betting last November.
Please play responsibly. If you or someone you know has a gambling problem and wants help, call 1-800 GAMBLER.
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GiG furthers global presence with two new launches – iGaming Business
Posted: at 9:19 pm
Gaming Innovation Group (GiG) has announced the launch of two online casino brands, PlayR and Palasino, delivering the latest projects to go live on its powerful next generation platform technology.
PlayR.bet is making its online casino debut, strategically targeting the burgeoning Brazilian market. This move comes in the wake of the recent regulatory approval for online casinos in Brazil, sanctioned by the countrys president at the end of 2023. Leveraging the new next-generation platform provided by GiG, PlayR.bet is poised to establish a robust digital presence.
Palasino, with this launch, is taking its first steps into the online world for the Palasino Group, an established land-based operator with over 25 years of experience in the casino industry. The launch will leverage the combined power of GiG award-winning player account manager, alongside revolutionary AI solutions, GiG logic and GiG Data.
Leveraging the latest in AI and data based solutions, GiGs acquisition and retention focused technology has been specifically developed to further enhance operators capabilities in complex markets. Built to offer a significant step forward in platform technology, GiG has focused on a suite of secure, scalable, user-centric end-to-end features that are adept at maximising opportunities for growth in the most competitive regulatory environments around the globe.
These latest launches come at a time of both significantly increasing activity for the platform and sportsbook provider alongside transformative new regulatory opportunities across Europe, and both North and Latin America.
GiGs innovative, feature-led AI stack currently powers over 60 brands in some of the most complex markets worldwide. GiGs portfolio is complemented with years of experience in local regulated markets and leverages long-established partnerships with some of the leading online and land based brands.
Andrew Cochrane, chief business officer of GiGsaid: Im extremely proud of the impressive cadence our delivery team is achieving, with these recent planned launches perfectly demonstrating our capacity at exceeding customer expectations. We continue to cement our preeminent reputation at taking land-based operators online, having executed many similar successful projects over recent years with established brands across Europe, Canada and Latin America.
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Biggest Online Gambling Markets in the World – Finbold – Finance in Bold
Posted: at 9:19 pm
This post is sponsored and not a part of Finbold's editorial content. For a full disclaimer, please . If you encounter any issues, kindly report them to [emailprotected]. Crypto assets/products can be highly risky. Never invest unless youre prepared to lose all the money you invest.
In an era where digital transformations are reshaping industries, the online gambling market stands as a testament to rapid evolution and substantial growth. This vibrant and multifaceted sector, stretching across continents, has been propelled by significant contributions from various key players globally.
Lets delve into the complex and intriguing world of online gambling, exploring the market values, regulatory landscapes, and consumer behaviors that paint a vivid picture of an industry in constant flux.
The global online gambling market is a diverse and dynamic arena, with various countries contributing significantly to its growth.
Here are the biggest online gambling markets:
Each market reflects its unique regulatory, cultural, and economic contexts, creating a rich and complex global landscape of online gambling.
Brazil has recently made significant strides in the regulation of its online gambling market with the enactment of Law 14790. This move, spearheaded by President Lula, marks a major shift in the countrys approach to sports betting and iGaming.
Key aspects of the new regulation include:
This regulatory overhaul positions Brazil as a major player in the global online gambling market, with substantial economic implications and potential for growth.
The global online gambling market, characterized by its dynamic and diverse nature, is on an accelerated path of growth, driven by significant contributions from key countries. This expansion is underpinned by the intersection of technological advancements, regulatory evolutions, and a fundamental shift in consumer behavior towards a mobile-first approach.
A critical aspect of this growth is the consumers increasing preference for mobile devices in online gambling. This trend is revolutionizing the market, as the ease and convenience of smartphones enable gambling anytime and anywhere. Its reported by KTO, a prominent online casino that 86% play via mobile, 13% via desktop computers and 1% via tablets.
This mobile-first approach is compelling operators to focus on designing games and user experiences that are optimized for mobile platforms. The result is a significant shift in how games are developed and marketed, with a strong emphasis on mobile compatibility.
The online gambling market is experiencing an extraordinary period of growth and transformation, fueled by digital advancements and changing consumer behaviors. This multi-billion-dollar industry, with the United Kingdom, United States, Brazil, Australia, and other nations leading the charge, presents a diverse and dynamic landscape.
The trend towards mobile-first consumer behavior is a defining feature of this growth, compelling operators to innovate and tailor their offerings for the mobile experience. As technology continues to evolve and regulatory environments adapt, the online gambling industry stands poised for continued expansion and deeper integration into the digital fabric of global economies.
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BetMGM Casino bonus code for MLK Day: Get $25 online promo offer to play with now – SILive.com
Posted: at 9:19 pm
This year, Martin Luther King Jr. Day aligns with Kings actual birthday, which falls on January 15, which is also the third Monday of January. That means its a long weekend for many of us, and should you choose to try your luck and have some fun today, BetMGM Casinos latest promotion is definitely worth exploring when you click here .
Today, on Monday, January 15, 2024, players in Michigan, New Jersey and Pennsylvania can enhance their gaming experience with a unique opportunity. Sign up for a new BetMGM Casino account and enjoy a 100% deposit match up to $1,000 plus an extra $25 on the house. BetMGM Casino is making waves with its enticing casino bonuses, taking every gaming session to a new level.
Click here for BetMGM Casinos latest offer on MLK Day and enhance your online gaming experience.
BetMGM Casino stands out in the online gambling arena for its diverse gaming options and dedication to player security. This MLK Day 2024, its not just the top-notch gaming experience thats drawing attention, but also the appealing promotional offer that adds extra zest. Lets dive into BetMGMs latest special.
Kickstart your MLK Day gaming adventure by opening a new account and making your first deposit. BetMGM Casino matches your deposit 100%, up to a whopping $1,000. Its a fantastic way to double your gaming funds right from the start.
In addition to the deposit match, new account holders receive a $25 casino bonus, available for three days post-registration. This bonus is perfect for trying out BetMGMs wide range of slot games, offering a head start without dipping into your deposit. This is one of the best no-deposit bonus offers available in the United States at the time of writing.
Secure this online deal on MLK Day 2024 at BetMGM Casino here !
Yes, BetMGM Casino is known for its secure and equitable gaming environment, guaranteeing a trustworthy experience with fair play at its core. Its a top choice for New Jersey, Michigan and Pennsylvania players seeking a reliable online casino.
Claiming your BetMGM bonus on MLK Day is simple when you follow these steps:
No specific BetMGM Casino bonus code is required during the registration process. Just activate the deal by clicking any promotional link on this page for a hassle-free start.
BetMGM Casino and SILive.com promote responsible gaming initiatives and offer resources and support for players seeking assistance.
Join BetMGM Casino this MLK Day 2024 for a secure, exciting, and responsible online gaming experience.
Click here to claim your MLK Day bonus and enjoy a world-class gaming experience responsibly!
For details about other exciting online casino offers, please take a look at the following deals:
Gambling Today provides exclusive online casino content to SILive.com, including casino news, reviews and casino bonuses to help bettors get in on the action. Please wager responsibly.
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BetMGM Casino bonus code for MLK Day: Get $25 online promo offer to play with now - SILive.com
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FanDuel Casino bonus: Get up to $1000 back + 50 bonus spins – MLive.com
Posted: at 9:19 pm
The current FanDuel Casino bonus is gifting new players from MLive up to $1,000 paid back on their first-day net losses as well as 50 bonus spins. This promotion is a welcome offer that is solely for brand new FanDuel Casino players who meet the minimum age of 21 and who are physically located in the state of Michigan at sign-up.
Go ahead and follow the four steps in this provided guide to claim this FanDuel Casino offer:
Know that you will receive the 50 bonus spins aspect of this welcome offer immediately after your qualifying deposit is made. Furthermore, these bonus spins can only be used to play the following three slots: Cash Eruption, Cleopatra and Declaration of Spindependence.
To keep the winnings that you might earn from using these bonus spins, simply play through them just once to convert them to your cash balance. You will have seven days to use your bonus spins before they expire.
FanDuel Casino is going to refund any net losses that you accumulate throughout your first day of play. Notably, your promotional period will be triggered with your first cash wager, and it will extend for 24 hours.
Once your 24-hour promotional period concludes, you can expect to receive your non-withdrawable cash bonus within 72 hours. Importantly, you will not receive any form of casino bonus if you are up funds following your promotional periods conclusion.
Lastly, any refunded casino credits that you garner will be non-withdrawable, but any winnings gained therefrom are immediately able to be withdrawn. You have seven days to use your refunded bonus funds.
Along with the welcome bonus, other FanDuel Casino promos are continually available to all users.
FanDuel Casino offers a library consisting of over 200 different games, making it one of the best Michigan online casinos. The 50 bonus spins from their welcome offer can be played on three of the top titles:
Cash Eruption is an IGT-powered slot that features five reels, three rows, and 20 fixed paylines. The video slot is fast-paced, and it contains an average return to player of 96.00%. The maximum payout potential sits at 1,000x your total stake.
Cleopatra is a classic within the online casino industry. It too is powered by IGT, but Cleopatra boasts a maximum payout potential of 10,000x your original bet. Moreover, it holds a 95.02% RTP across its five reels, three rows and 20 fixed paylines.
Yet another IGT production, Declaration of Spindependence has five reels, three rows and 30 fixed paylines. It owns a lower RTP of 94.00%, but the maximum payout possibility is a whopping 15,000x your original stake.
Again, new players from MLive can sign up to take advantage of the FanDuel Casino bonus that refunds your first-day net losses up to $1,000 and gives you 50 bonus spins.
Sidelines Group provides MLive with original sports betting, lottery and casino content including odds, analysis, predictions and reviews to educate bettors. Please bet responsibly.
If you have a gambling problem and are located in Michigan, call 1-800-GAMBLER or contact the 24-hour helpline chat at http://www.michapg.com/treatment/.
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Casino with a minimum deposit of 10 euro – Be Global Fashion Network
Posted: at 9:19 pm
Las Atlantis Casino is the best online casino with a minimum deposit of 10 euro. Play Atlantis slots with 10 euro and not without hurting your budget. Here you will find a unique gambling experience where every euro invested can be the beginning of an exciting adventure.
Las Atlantis is not just a casino, it's a place where your entertainment becomes affordable, exciting and delivers real results. Here they pride themselves on the highest rating, offering amazing bonuses, instant transactions and generous withdrawal limits. At Las Atlantis, every player is an important part of our community, so we do everything we can to make your experience unique.
Pleasant moments at Las Atlantis are waiting for you when you decide to try your luck. Whether you are an experienced player or a beginner, the support team is always ready to help. Get ready for an exciting journey into the world of gambling, where 10 euro opens up a world of possibilities. Las Atlantis Casino is your trusted partner in creating unforgettable moments of gambling fun.
Las Atlantis Casino features a wide range of gambling entertainment for those who are looking to maximize their winnings with a minimum deposit of just 10 euro. Online slots are one of the most popular, by players, categories. They attract with simple rules and high payouts. By choosing a Las Atlantis casino with high payouts, your 10 euro deposit can increase several times over.
Types of slot machines:
1. One-armed bandits. Retro slots with minimal options but frequent prize combinations. Popular among visitors to Las Atlantis Casino with a deposit of 10 euro.
2. Classic machines. With 5 reels, walds, freespins and risk rounds. Well win players even for minimum bets.
3. Modern Slots. Modern slots with various options, special symbols and bonus rounds. Prize payouts can be received even when playing for minimum bets.
4. Jackpot slots. You can play them with a deposit of 10 euro, and win the accumulated fund in the hundreds of thousands or even millions of euros.
Las Atlantis Casino with a 10 euro deposit also offers other gambling games such as roulette, poker, blackjack, baccarat, video poker, keno, and others. Some are available in a live format, with live dealers to provide the most realistic gameplay.
To make your gaming experience at Las Atlantis as convenient as possible, we provide a variety of deposit and withdrawal options here. With a minimum deposit of 10, the casino is committed to making financial transactions safe, convenient and accessible to all players. The support team ensures that your transactions are safe and secure. Here are some of the deposit options that are offered to you:
1. Visa/MasterCard. Deposits from 30 to $1,000, instant deposits;
2. BTC/LTC/ETH/DOGE/BNB/XRP. Deposit from 20 with no limits, downtime up to 15 minutes;
3. USDT. Deposit from 40 to 1000, downtime up to 15 minutes;
4. Flexepin. Deposit from 20 to 500, instant funding;
5. Neosurf. Deposit from 10 to 250, instant funding.
And here are the options for withdrawals:
Credit Card. Withdrawal from 150 to 2,500 USD, 3-4 business days;
Bank Transfer. Withdrawal from 150 to 2,500, 5 business days;
Bitcoin. Withdrawal from 150 to 2500, 1-3 business days.
Las Atlantis guarantee 100% security of every transaction at our online casino, deposits are accepted in 10 euro. Remember that withdrawals require confirmation of your account, providing an extra layer of security.
Las Atlantis Casino, providing the opportunity to play with a minimum deposit of 10 euro, offers players a number of attractive advantages:
1. Variety of games. The casino provides unlimited access to a rich selection of games including slots, table games, video poker and more. Regardless of your preference, there is something for every player here.
2. Secure Transactions. Secure deposit and withdrawal systems provide reliability and confidence in financial transactions, allowing players to focus on the gambling experience.
3. Quality games with minimum deposits. Las Atlantis offers high quality games, keeping it affordable for those who want to start with a small investment.
4. 24/7 customer support. Professional support is available 24/7, ready to answer questions and resolve issues that arise.
5. Licensed and legal games. The casino operates under a license, which guarantees the legality and fairness of the gaming process.
6. Bonus offers and promotions. Las Atlantis players can enjoy many bonus offers, promotions and free gifts, increasing their bankroll.
7. Fast Money Transfers. Fast money transfer systems provide instant access to winnings and deposits.
8. Games on different platforms. The casino supports games on a variety of platforms, including mobile devices, giving players flexibility and convenience.
All of these factors make Las Atlantis Casino an attractive destination for those looking for exciting excitement and the opportunity to win starting as low as 10 euro.
There are many attractive reasons why you should try your luck at Las Atlantis with a minimum deposit of 10 euro. Firstly, the casino offers the opportunity to enjoy exciting gambling entertainment at a minimal cost, allowing each player to create their own unique gaming experience even on a limited budget.
In addition, Las Atlantis is not only known for its low deposits, but also for its outstanding bonuses that make your game even more exciting. Generous welcome bonuses and regular promotions provide additional funds to play with, increasing your chances of winning and making every moment at Las Atlantis memorable. Take your first step into the world of gambling with a minimum deposit and enjoy the excitement at Las Atlantis, where everyone can feel the thrill of playing for real money.
What types of games does Las Atlantis Casino offer?
Las Atlantis provides a wide range of games including slots, table games, video poker and more. All games are provided with high quality graphics and fair odds of winning.
What banking options are available at Las Atlantis for deposits and withdrawals?
Las Atlantis provides various options for deposits such as Visa/MasterCard, cryptocurrencies, USDT, Flexepin, Neosurf. Withdrawals can be made via credit cards, bank transfer and Bitcoin.
Why choose Las Atlantis to play for real money?
Las Atlantis attracts players with its $10 minimum deposit, a variety of quality games, outstanding bonuses and promotions. The casino also guarantees the safety and security of all transactions, creating a unique gaming experience for every player.
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Best US Sweepstakes and Social Casinos 2023: Top Online Casino Sites Reviewed – Analytics Insight
Posted: at 9:19 pm
It wasnt so long ago that if you were a casino enthusiast in the US, there was a strong chance you were just plain out of luck, with gambling illegal in most states. But the best US sweepstakes casinos sites including the likes of Sweeptastic where you enjoy the Sweeptastic welcome bonus of 10,000 LC upon signup and an additional 17,000 LC and 2 SC after completing your profile. Theyre free in the overwhelming majority of states and legal to use.
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Just like any casino, there are some social casinos which are better than others. However, theres dozens that are worthy of a general recommendation. This trio of top picks represents those with not just the highest of standards but the broadest possible appeal.
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All online sweepstakes casinos offer the ability to play casino games for free. But even among the very best, theres a great deal of variety. Here, youll be able to take a deeper look at three of the finest the industry has to offer and what makes them special, beyond the high baselines of quality that are required for a recommendation.
There are plenty of generous social casinos, so believe us when we say it means alot that Sweeptastic are so exceptional in this regard. They start off with an awesomely multi-faceted welcome offer, which is then backed up with a loyalty program that rewards you (almost) every time you play. And this is without mentioning all the free spins and giveaways that are part and parcel of the daily furniture at Sweeptastic.
Of course, being provided with so many coins only means so much because they have the platform and the games to back it up. Sweeptastic is wonderfully user-friendly, both on desktop and mobile, meaning it might be at the top of the list for best social casinos for newcomers. And, despite lacking a live casino, the games library is an immense mix of third-party hits and unique originals.
This accessibility is enhanced by around the clock customer support, plus simple and fast checkouts meaning any prizes you win can be obtained without fuss. Theyre not just one of the best social casinos for generosity but for the broadness of their appeal.
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One thing that separates the best sweepstakes casinos online from the rest is the give away of coins generously as can be seen in Stake.us $25 no deposit welcome offer but also provide an immense amount of value for their virtual currency. Every Stake Cash (their version of Sweeps Coins) is worth $1, meaning if you play through 100 of them to reach the minimum, you can get $100 without having to spend a thing.
And theres plenty of fantastic games to play them on. With their live casino and the likes of BgGaming, OneTouch, and Hacksaw Gaming mixing it up with Stake Originals, you have a really amazing variety of games. In fact, the only thing more impressive than the number of genres represented here is that the quality never once falls short of whats to be expected of the top sweepstakes casinos.
Pros:
Cons:
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With so many excellent social casinos, it can be tough to definitively say one is better than the rest at anything. However, youd be hard pressed to find a better slot casino than this.
Theres over 700 games here right now, and with more being added every week, that number could reach over 1,000 pretty soon. This includes about every kind of slot you could imagine from the finest creators in the world like BetSoft and Pragmatic Play, alongside unique titles and old-school classics.
They also provide a huge number of coins to get started, so you can try them out and further provide promotions with consistent extra spins, bonus rounds, and much more, alongside the thousands of coins you get just for signing up. Plus, they make the most of their huge community with competitions and social bonuses.
The appeal may be limited based on the game focus, but if what youre after is a slots casino, there are few online sweepstakes casinos that can match up.
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Winning money at the best US sweepstakes casino sites isnt complicated. It largely just requires you to collect coins and play your favorite games. However, its vital you know all the few elements of how it works the key facts of which are available below.
Finding a good social casino isnt very hard. Theres plenty out there. But finding the best social casinos that suit exactly how you prefer to play? Thats a little trickier.
But its nothing that cant be solved by taking things step-by-step.
Head over to the homepage and spend some time checking out the game library. Consider the types of games available and their software developers. Think hard about the games you like already and those you want to try out and think about whether youd be satisfied with what youre seeing.
The best US sweepstakes casino sites usually prominently advertise how they give away coins, so this shouldnt be too hard to find. Look up how you collect coins, including and beyond welcome offers. Think about if that would provide you with enough easily for how you want to play.
First, decide whether youre going to pursue cash prizes or just play for fun. If youre out to win cash prizes, look at the redemption requirements and terms and conditions. Square that with the coin giveaways and ask yourself how realistic it is to win considering your playing habits.
If you want to bet portably, youll need to make sure thats possible. If its via an app, make sure you check out its legitimacy before downloading. Most of the best social casinos have a dedicated browser version, which you can check out in moments from your device.
For any site to be considered amongst the best, theres a basic set of things they must do in order to qualify. If youre considering whether one is the ideal fit for you, ensure they have the following:
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Right now, you could take the Sweeptastic 27,777 LC + 2 SC welcome bonus or the Stake.us promo code for $25 no deposit offer with promo code TOPVIPBONUS and be playing great casino games for free within minutes. Thats the reality now. Not very long ago, it was the case that in the US, you just couldnt play casino games if youre from most states never mind for cash prizes. Online sweepstakes casinos have completely changed what casino fans in the US can expect for the better.
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How can sweeps casinos be legal in most US states?
As casino gambling isnt legal in most of the US, it can be confusing that sweeps sites are overwhelmingly available. The key thing to keep in mind is that sweepstakes/social casinos arent offering gambling, but rather the ability to play your favorite games using virtual currency for fun.
How do cash prizes work on sweepstakes casinos?
There may be some difference in individual casinos but largely, all you need to do is collect Sweeps Coins. You then play them through a set amount of times until a minimum amount is redeemable both these points will be made clear on the individual terms and conditions. You then redeem them through a simple banking process.
How do I collect coins at a social casino without spending anything?
For a site to qualify as a social/sweepstakes casino, they must offer coins both Gold Coins and Sweeps Coins for free. This can be in a variety of ways. Typically, youd get some for signing up, plus maybe more if you use a promo code. Theyre then usually given away frequently, for logging in daily would be a typical example. Giveaways also happen on social media or as part of competitions. Ultimately though, its down to the individual site to decide on how theyre provided.
Some casino sites listed in our reviews might not be available in your region. To this end, you are encouraged to verify that the offering complies with your local laws.
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Best US Sweepstakes and Social Casinos 2023: Top Online Casino Sites Reviewed - Analytics Insight
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Gaming Corps expands distribution with Alea Casino Aggregator partnership – Gambling Insider
Posted: at 9:19 pm
Notable releases from Gaming Corps, including Wild Woof, Plinkgoal, Raging Zeus Mines, Paddys Payout, Jet Lucky and Coin Miner, will contribute to Alea's game offerings.By GamblingInsider
Supplier Gaming Corps has entered into a new partnership with Alea, a casino aggregator platform. This collaboration is part of Gaming Corps' strategy to increase the distribution of its games suite, comprising Crash, Mine, Table and Slot games, as well as Plinko.
Alea hosts a platform integrable into online casinos through an API.
The addition of Gaming Corps' full games portfolio aims to increase the diversity of content available on the platform.
Mats Lundin, Gaming Corps Director of Sales, said: We are delighted to add our exciting games suite to one of the standout casino aggregator platforms in the market provided by Alea. Alea's team has taken a perfect step towards the future of iGaming by adding our diverse and growing portfolio.
"Not only do they have an amazing clientele of operators on their platform already, but they also operate in some of our key markets which makes this a perfect match.
Alea's Game Manager, Eduard Verdaguer, added: It will be a pleasure to host Gaming Corps thrilling content on our platform for our partners to offer to their players. This selection of titles will make the platform even stronger and will help us provide yet more variety to operators. We are constantly on the hunt for innovative and new content and Gaming Corps is perfect in that sense.
This partnership follows Gaming Corps' recent collaboration with Belarusian operator Brazino777, announced on 9 January 2024. Brazino777, established in 2022 and launched in Belarus last year, now hosts Gaming Corps' arcade-style casino games, expanding the Swedish company's presence in the Belarusian market.
Gaming Corps has been strategically expanding its global presence, entering the African market through a partnership with Betway Group and solidifying its European footprint with a deal with LV Bet in Latvia.
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Gaming Corps expands distribution with Alea Casino Aggregator partnership - Gambling Insider
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Scientists gather bobcat DNA from paw prints – KJZZ
Posted: at 9:18 pm
National Park Service
A bobcat at Tonto National Monument.
Scientists can now extract genetic information about bobcats from their paw prints.
The DNA can offer clues about the animals ancestry and even their microbes vital information for monitoring one of Arizonas most common predators.
As reported in a paper published the journal Biological Conservation, the technique is precise enough to distinguish a bobcat from a Canada lynx (a close cousin species with an overlapping distribution range), which would be impossible using tracks alone.
Climate change, habitat loss and biodiversity declines underscore the need for better species monitoring.
But historically that has meant in-person surveys, live traps or recordings.
Through the emerging field of environmental DNA, or eDNA, scientists are learning to gather genetic material from oil, water or even air.
In this case, a happenstance sighting of bobcats in Florida led a scientist to sample soils from their paw prints and calibrate his findings with samples from the Jacksonville Zoo and Gardens.
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Scientists gather bobcat DNA from paw prints - KJZZ
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Discovering Fusions Requires More Than DNA Testing in GI Cancers – OncLive
Posted: at 9:18 pm
As targeted therapies in colorectal, gastroesophageal, biliary tract, and other gastrointestinal (GI) cancers continue to gain traction, and as additional therapeutic targets for novel agents emerge, consistently testing for biomarkers will be key to identifying more targetable alterations for novel therapeutics and determining which patients will benefit most from these therapies, according to E. Gabriela Chiorean, MD.
With the November 16, 2023, FDA approval of pembrolizumab (Keytruda) plus fluoropyrimidine- and platinum-based chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic HER2-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma,1 another immunotherapy option has joined nivolumab (Opdivo) in the treatment paradigm.2
When considering how to best incorporate recently approved agents into care, Chiorean explained that pembrolizumab plus fluoropyrimidine- and platinum-based chemotherapy adds to the immune checkpoint inhibitor data that investigators already have with nivolumab. The 2021 approval of nivolumab in combination with fluoropyrimidine- and platinum-containing chemotherapy for patients with advanced or metastatic gastric cancer, GEJ cancer, and esophageal adenocarcinoma was supported by findings from the phase 3 CheckMate 649 study (NCT02872116). Patients with a combined positive score (CPS) of at least 5 who received the combination experienced a statistically significant improvement vs chemotherapy alone in progression-free survival (HR, 0.68; 95% CI, 0.58-0.79; P< .0001) and overall survival (OS; HR 0.71; 95% CI, 0.61-0.83; P< .0001). Irrespective of CPS score, all patients receiving the combination achieved a statistically significant improvement vs chemotherapy alone in OS (HR, 0.80; 95% CI, 0.71-0.90; P=.0002).2
Nivolumab has been approved [by the FDA] for patients with HER2-negative gastroesophageal cancer [and its] mostly used for patients with [a] CPS of more than 5, Chiorean said in an interview with OncologyLive. Chiorean is a full professor of medicine at the University of Washington, clinical director of the GI Medical Oncology Program at Fred Hutchinson Cancer Center, and director of the Clinical Research GI Oncology Program at the University of Washington/Fred Hutchinson Cancer Center in Seattle.
Pembrolizumab has been approved irrespective of CPS, but we are very aware that the benefit is mostly for patients with a CPS higher than 1 or even higher than 10, she explained. Immunotherapies for advanced gastroesophageal cancers do apply for those with positive PD-L1 expression, whether its a CPS score more than 1, more than 5, or more than 10, depending on what immune checkpoint inhibitors we use.
As gene alterations become more prevalent therapeutic targets, DNA and RNA testing is of the upmost importance. Findings from a diagnostic study published in JAMA Oncology examining paired DNA and RNA sequencing of 43,524 individuals who underwent germline testing for hereditary cancer revealed that RNA evidence was necessary for the classification of 17.1% of pathogenic or likely pathogenic splicing variants. Additionally, 71.1% of existing splicing variants of uncertain significance were resolved by evidence from RNA tests. Investigators concluded that concurrent RNA and DNA sequencing improves detection of novel variants and classification of existing ones.3
Its exciting to apply these new therapeutics based on the targeted alterations that we findwe just have to test everybody, Chiorean said. We also have to be very careful to include both DNA testing as well as RNA testing because we may miss certain genetic alterations if we exclusively use DNA tests. There are RNA-based tests that can be more effective in finding genetic fusions, such as NRG1 fusions and RET fusions. These fusions are important because now we have agents targeting them.
Pralsetinib (Gavreto) and selpercatinib (Retevmo) are both targeted agents included in the National Comprehensive Cancer Network guidelines for the treatment of patients with unresectable and metastatic biliary tract cancers with RET fusions.4 Additionally, selpercatinib holds an indication for patients with locally advanced or metastatic solid tumors with RET fusions who have progressed on or following prior systemic treatment or who have no satisfactory alternative treatment options.5
We need to make sure we test [for] everythingmicrosatellite instability[MSI] status, tumor mutational burden, DNA, and RNAin order to discover all the possible targetable alterations of our patients, because there are more and more treatments available, both in clinical trials and with FDA approvals.... Every tumor needs to be sequenced and when its not available we need to test [for] these molecular abnormalities with liquid biopsies [and] with circulating tumor [ct]DNA, Chiorean said.
Approximately 50% of patients with colorectal cancer (CRC) will develop colorectal liver metastasesclinically heterogeneous lesions associated with poor prognosis.6,7 In a retrospective study conducted in China that examined the genomic alterations of CRC liver metastases in 144 patients using next-generation sequencing, investigators found that the most prevalent alterations were TP53 (83%), APC (69%), KRAS (43%), and SMAD4 (17%).7
We know that certain cancers are more likely to shed ctDNA in the bloodpancreatic cancer tends to be a cancer [that is] less positive [for] ctDNA, but in CRCs, especially in those with liver metastases, liquid biopsies are very useful, Chiorean said.
Shooting For The Stars With Biomarkers
Moreover, we are trying to conduct more tests regarding how we can declare whether the patient is immune competent vs not. How do we determine the immune microenvironment that could be more amenable to be targeted with immunotherapies or not? Chiorean asked. These are very new biomarkers, which are not genetic based; they are more [representative of] a profile having to do with a tumor microenvironment and the host that the patient represents. We are doing a lot of research in this arena in terms of finding new markers for immune therapeutics [and] for stroma-targeted therapies.
In addition to the GI biomarkers of HER2 overexpression, MSI-high status, and PD-L1 expression, emerging biomarkers include CLDN18.2, which is present in approximately 30% of gastric/GEJ cancers, and FGFR2, which is rarer and reported in approximately less than 10% of gastric cancers.8
In July 2023, the FDA granted priority review to the biologics license application seeking the approval of the first-in-class monoclonal antibody zolbetuximab for the first-line treatment of patients with locally advanced unresectable or metastatic HER2-negative gastric or GEJ adenocarcinoma and CLDN18.2-positive tumors.9
Additionally, in April 2021, the novel FGFR2 inhibitor bemarituzumab plus modified fluoropyrimidine, leucovorin, and oxaliplatin (mFOLFOX6) received breakthrough therapy designation from the FDA for the frontline treatment of patients withFGFR2b-overexpressing, HER2-negative metastatic and locally advanced gastric and GEJ adenocarcinoma following positive results from the phase 2 FIGHT study (NCT03694522).10 Bemarituzumab is currently under investigation with mFOLFOX6 in the phase 3 FORTITUDE-101 trial (NCT05052801) and with mFOLFOX6 and nivolumab in the phase 3 FORTITUDE-102 trial (NCT05111626).10
In addition, because [we can make] adoptive immunotherapies more active and reactive against the patients cancer using the patients human leukocyte antigen [HLA] testing, HLA testing is becoming more important. Knowing the proteins that present an antigen to the immune system such that patients may become able to participate in adoptive immunotherapy trials [is important]. Biomarkers are being extended beyond next-generation sequencing, Chiorean noted.
Chiorean noted that upcoming presentations at the 9th Annual School of Gastrointestinal Oncology (SOGO), which is scheduled to take place on February 24, 2024, in Los Angeles, California, will address these novel treatment options in addition to various aspects of multidisciplinary care, ranging from the nonoperative or operative management of stage IV CRC to using targeted [therapy] and/or immunotherapy in early-stage gastroesophageal as well as hepatobiliary cancers. [The treatment of patients with] hepatobiliary cancers is typically very multidisciplinary because it involves surgery, interventional radiology, radiation oncology, and medical oncology.
The American Cancer Society listed 11 regimens used to treat stage IV colon cancer in August 2023, noting that these were only some of the most commonly used regimens. Radiation and surgery were also cited as options in certain cases.11
A lot of debate exists in terms of managing stage IV CRC that has been resected, oligometastatic disease that has been resected, [and] the role of ctDNA. These sessions will be of huge interest [at SOGO 2024] in order to understand the players that have to be engaged in making treatment decisions for our patients, Chiorean said.
At SOGO 2024, sessions will include The Role of ctDNA in Colon Tumor Management presented by Sidharth R. Anand, MD, MBA, who is a medical oncologist and hematologist at UCLA Health in Los Angeles, California, and Management of Stage IV no evidence of disease [NED] CRC presented by Marwan G. Fakih, MD, who is a medical oncologist, professor in the Department of Medical Oncology & Therapeutics Research, associate director for Clinical Sciences, medical director of the Briskin Center for Clinical Research, division chief of GI Medical Oncology, and co-director of the Gastrointestinal Cancer Program, all at City of Hope in Duarte, California.
[We] are looking at the RAS inhibitors, pan-RAS inhibitors, [and] KRAS G12C inhibitors, both as monotherapy as well as in combination therapies, Chiorean noted. Certainly, were also looking at cancer vaccines [and] at oncolytic viruses. These are very exciting agents that may [become a part of] combination therapeutics with immune checkpoint inhibitors or even chemotherapies. Indeed, there are several classes of agents, both targeted as well as immune-based therapies, that are very exciting and I look forward to 2024 [to see] more, hopefully positive results.
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Discovering Fusions Requires More Than DNA Testing in GI Cancers - OncLive
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