Monthly Archives: September 2023

Addressing Misconceptions, Concerns Around Biosimilar Use – Dermatology Times

Posted: September 23, 2023 at 9:58 am

Research has shown that biosimilars are highly similar to their originator product in terms of safety and efficacy. Misconceptions about biosimilars in the dermatology community and concerns around their use in psoriasis were evaluated with a review of the data to clarify their use; the results were presented in 2 posters.

The rst poster reviewed the biosimilar approval process to clarify dermatologists misconceptions about biosimilars. Dermatologists have approached biosimilar medicines with caution, the researchers wrote.1

A recent Cardinal Health report corroborated the sentiment that dermatologists are hesitant to switch to biosimilars. According to the report, only 31% of dermatologists considered themselves very familiar with biosimilars compared with 81% of gastroenterologists, 76% of rheumatologists, and 33% of ophthalmologists.2

The authors of the first poster presented at the American Academy of Dermatology (AAD) meeting used a PubMed search to identify studies on the molecular design, preclinical and clinical testing requirements, and approval processes of biosimilars. They described how the complexity of biologics means that even batches of innovator biologics can vary during preclinical testing. Biosimilars undergo strict preclinical testing and must demonstrate near similarity to the current originator product in quality factors such as receptor binding and pharmacokinetics, the researchers wrote.1

Although clinical testing is less stringent for a biosimilar compared with the originator product, the purpose of the clinical testing is to conrm the safety and efficacy of the biosimilar. Then, the use of extrapolation allows for biosimilars to be approved for all indications of the originator product without further testing. As a result, the emphasis of biosimilar product testing is on preclinical rather than clinical testing, the authors noted.1

Physicians who recognize that biologics are too complex to duplicate and who desire indication-specic clinical data on biosimilars might be satised knowing biosimilars provide more evidence of similarity than we have for different batches of the innovator product, they concluded. Regulations that are more stringent for biosimilars than for different batches of innovator products may not be logical.1

In the second poster, researchers addressed concerns about the use of biosimilars approved to treat psoriasis using extrapolated evidence from other diseases. They compared efficacy/effectiveness, safety, and drug survival of biosimilars to treat plaque psoriasis with originator products using data from 13 randomized controlled trials (RCTs) and 3 cohort studies. Of the RCTs, 10 were for adalimumab, 2 were for etanercept, and 1 was for iniximab. Of the cohort studies, 1 was for adalimumab, 1 was for etanercept, and 1 was for both etanercept and iniximab.3

Eleven trials compared biosimilars with the originator in patients who had never been on the originator product (initiators); 9 trials analyzed switching from the originator product to the biosimilar (switchers). The initiator trials all had similar rates of 75% improvement in the Psoriasis Area and Severity Index and similar adverse events by week 16. The switched trials also had similar outcomes by week 52.3

One of the cohort studies reported more adverse events among the group of adalimumab patients switching from the originator to the biosimilar, although the other 2 cohort studies showed no signicant differences in safety and effectiveness. The majority of available evidence suggests similarities between biosimilars and originators, the researchers concluded. Future pharmacovigilance studies are needed to evaluate the long-term, real-world use of biosimilars for psoriasis treatment.3

References

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Native American and Indigenous Communities Face Dermatologic … – Dermatology Times

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Key Takeaways

Access to medical care has been a persistent challenge for individuals within the Native and Indigenous communities, and this issue persists when it pertains to dermatological healthcare for this patient demographic. Despite increasing evidence of health status inequities affecting Indigenous populations, health services often fail to address health and social inequities as routine aspects of health care delivery, according to authors of a 2016 ethnographic study.1

Globally health and well-being of the Indigenous community falls significantly behind that of the general population, with life expectancy projected to be dramatically shorter than average.1 These challenges are compounded by discriminatory and stigmatizing experiences faced by Native and Indigenous individuals worldwide.

Research confirms that Indigenous peoples experience individual and systemic discrimination when seeking health care, despite efforts within the health care sector to promote cultural sensitivity and cultural safety, according to Browne et al.1 Health services, however, are not typically designed to take into account the experiences of Indigenous peoples. For example, despite extensive evidence linking trauma and violence to multiple health problems, including chronic pain, depression, anxiety and substance use, these dynamics are rarely considered in the design and delivery of health care for Indigenous peoples.

In Canada in particular, it is estimated that the one-year prevalence of atopic dermatitis (AD) in children living on a First Nations reserve could reach upwards of 16.5%. Most cases are classified as moderate to severe in nature.2

Additionally, research suggests that other common cutaneous conditions among members of the Indigenous communities include impetigo, skin infections, diabetic skin complications and ulcers, infestations, pediculosis capitis, psoriasis, and scabies, all of which are seen in significantly high rates, with some patients experiencing more than one condition at once.2

Environmental factors such as clean water concerns, access to and cost of skin care regimens and products, crowded living conditions, and poverty are contributors to exacerbation of skin conditions, such as AD.2

Furthermore, skin cancer prevention efforts among Native and Indigenous individuals are lacking, according to the American Academy of Dermatology (AAD).3

A 2022 study4 published in the Journal of the American Academy of Dermatology found that among the more than 9 million American Indians and Alaska Natives (AIAN) living in the United States, research and prevention efforts related to skin cancer in this population are scarce. To date, this is the largest study to explore skin cancer education, prevention, and research efforts in this patient population.3

When you look at the lack of sun protection and use of tanning beds, its not surprising to see that American Indians/Alaskan Natives are reporting more severe sun damage to their skin, such as sunburns, when spending over an hour in the sun as compared to non-white respondents, said Vinod E. Nambudiri, MD, MBA, FAAD, in a press release from the AAD.3Nambudiri is a co-author of the study.

While some people may be most concerned about the freckles, age spots and wrinkles that develop on their skin from UV exposure, its the increasing risk of skin cancer, including melanoma, the deadliest form of skin cancer, which is the most alarming, Nambudiri said.

According to an examination of data from the 2020 US Census, a total of 56 dermatologists and 3 dermatology physician assistants are located within the 100 most populous AIAN homelands. For a population that experiences increased acne scarring and mortality associated with melanoma,5 these numbers are alarming.

With decreased accessibility to dermatologic care and other factors such as cultural differences, disproportionate poverty, transportation, and inadequate health literacy, researchers say there are several factors contributing to poor skin health outcomes in this patient population.5

Another study6 found that access to dermatologic care and telehealth programs was hindered by rural living. The study found that on average, the nearest dermatology clinic from rural communities lived in predominantly by American Indian individuals was 68 miles. Of all tribal facilities and rural Indian Health Services in the continental US (n = 303), only 9% had access to a teledermatology program.6

References

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Microwave Therapy Successful for Treating Warts in Children – Dermatology Times

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In 35 pediatric patients with recalcitrant warts, 68.6% experienced complete resolution after an average of 3 microwave treatment sessions.1 Patients who responded to microwave treatment required an average of 3 sessions (range: 2-8) for complete resolution. The average age of the warts was 29 months (6 to 84 months) and most patients (94%) had failed alternative treatments.

Researchers reviewed the case notes of patients treated at a tertiary dermatology unit where hypothermia was induced using Swift through repeated applications that lasted 1 to 2 seconds. Energy was supplied at a frequency of 8 GHz and an average power of 7W. Each wart was treated with microwave therapy an average of 4 times at each visit.

Following the initial treatment, follow-up sessions were scheduled approximately every 4 weeks for assessment and to determine if additional treatments were needed. Eight of the 35 patients did not tolerate microwave treatment due to pain and discontinued treatments.

Plantar warts are generally more resistant to therapy than common warts. In the study cohort, 20 patients presented with plantar warts and clearance was achieved in 14 (70%) of those cases. This compares favourably to traditional treatments such as salicylic acid (31%) and cryotherapy (34%)and is consistent with previous rates of clearance using microwave therapy in adults.

Treatment with cantharadin 1%, podophyllin 20%, and salicylic acid 30% solution showed an 86.5% clearance rate for all warts in children but adverse events such as blistering occurred in 41.2% of patients. Microwave treatments did not cause ulceration or blistering but did cause short-term pain during treatment that resulted in some patients discontinuing treatments.

Microwave treatment of warts has advantages, including no pre-treatment preparation and no special dressings or precautions following treatment. Each application takes approximately 2 seconds and most patients required only 4 sessions. No scarring or pigmentary changes were reported.

Limitations of the study included the retrospective study design and an absence of head-to-head comparisons. Authors determined that microwave treatment is asuccessful optionfor clearing recalcitrant warts in children.

Reference

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9 Best Antifungal Body Washes Review – The Jerusalem Post

Posted: at 9:58 am

Our Top Picks

If you're looking for relief from skin irritations and fungal infections, antifungal body wash can be incredibly beneficial. After researching and testing various products, we've found the best antifungal body washes on the market. It's important to choose a product that is effective in treating fungal infections and gentle on the skin. The scent is also a factor to consider, as many antifungal body washes have a medicinal smell. Our top-ranked products offer a range of benefits, from effectiveness to gentle formulas to pleasant scents. If you suffer from skin irritations or fungal infections, our recommendations are a great place to start your search.

The Antifungal Antibacterial Soap & Body Wash is a natural solution for a variety of fungal and bacterial skin conditions. Made with tea tree oil, it effectively treats jock itch, athlete's foot, nail fungus, ringworm, and even eczema and back acne. The 8-ounce bottle is the perfect size for daily use, and the natural ingredients make it safe for all skin types. Say goodbye to uncomfortable and embarrassing skin conditions with this powerful body wash.

Rated 9.8 based on 10

JPOST

Pros

Natural ingredients, Effective against multiple conditions, Can be used on body and feet

Cons

Strong tea tree scent

The Antifungal Body Wash & Soap is a versatile solution for a range of skin issues. Made with tea tree oil and other natural ingredients, it effectively combats fungal infections, bacteria, and body odor. This body wash can be used for tinea versicolor, back acne, folliculitis, jock itch, ringworm, and athlete's foot. It's gentle enough for daily use and comes in a convenient pump bottle. Customers rave about its effectiveness and pleasant scent, making it a must-have for anyone dealing with these skin concerns.

Rated 9.4 based on 10

JPOST

Pros

Effective against various conditions, Contains tea tree oil, Gentle on skin

Jivi Antifungal Body Wash is a powerful solution for treating various fungal infections such as athlete's foot, toenail fungus, ringworm, jock itch, and more. Made with tea tree oil and other natural ingredients, this body wash effectively eliminates fungal growth while nourishing and moisturizing the skin. Its 12 fl oz size makes it ideal for daily use, and its green packaging is eco-friendly. With Jivi Antifungal Body Wash, you can say goodbye to pesky fungal infections and hello to healthy, glowing skin.

Rated 9.2 based on 10

JPOST

Pros

Treats various fungal infections, Contains natural tea tree oil, Gentle on skin

Cons

Scent might not be preferred

The Signature Black Bottle Body Wash is a clinically proven antifungal soap that effectively treats common skin conditions such as jock itch, athlete's foot, and ringworm. Infused with tea tree oil, this body wash is gentle on the skin while still being tough on fungus. The 9 oz. bottle is the perfect size for everyday use and the rich lather leaves skin feeling clean and refreshed. Say goodbye to stubborn skin conditions with the Signature Black Bottle Body Wash.

Rated 8.8 based on 10

JPOST

Pros

Clinically effective ingredients, Tea tree oil for skin, Effective against various infections

Cons

Strong medicinal scent

Truremedy Naturals Remedy Soap Tea Tree Oil Antibacterial Body Soap is a powerful antifungal body wash that helps with a variety of skin issues such as body odor, athlete's foot, jock itch, ringworm, yeast infections, and other skin irritations. Made with all-natural ingredients including tea tree oil, eucalyptus oil, and peppermint oil, this body wash is gentle on the skin while still providing effective relief. The 12 oz bottle is the perfect size for daily use and the convenient pump makes it easy to dispense. Say goodbye to uncomfortable skin issues with Truremedy Naturals Remedy Soap.

Rated 8.5 based on 10

JPOST

Pros

Antibacterial and antifungal, Helps with various skin issues, Contains tea tree oil

LOVE, LORI Tea Tree Body Wash is a must-have for anyone looking to improve their skin health. This 12oz bottle of antibacterial body wash is not only effective against jock itch and athlete's foot, but also helps treat acne and eczema. The tea tree oil in this antifungal soap and shower gel provides a refreshing and invigorating scent while also providing powerful cleansing properties. This product is perfect for anyone who wants to feel clean and refreshed after a shower, while also improving their overall skin health.

Rated 8.4 based on 10

JPOST

Pros

Antibacterial and antifungal properties, Helps with jock itch and athletes foot, Can improve acne and eczema

Cons

May not work for everyone

The New York Biology Tea Tree Body Wash is a must-have for anyone looking for a moisturizing and soothing body wash. Perfect for both men and women, this body wash helps with a variety of skin concerns, including itchy skin, jock itch, athletes foot, nail fungus, eczema, body odor, and ringworm. With its natural ingredients and 16 fl oz size, it is a great value for anyone looking for a high-quality body wash.

Rated 8 based on 10

JPOST

Pros

Soothes itchy skin, Helps with multiple conditions, Moisturizes body

Cons

Strong tea tree scent

The DERMOIA Eczema Body Wash for Adults is an excellent choice for those with sensitive skin. With its hypoallergenic and fragrance-free formula, this tea tree body wash is gentle yet effective in treating eczema and jock itch. The 1.00 pound pack of 1 is perfect for daily use and is suitable for both men and women. Its antifungal properties make it a go-to product for those with skin conditions, and its natural ingredients ensure it's safe for prolonged use. Overall, the DERMOIA Eczema Body Wash for Adults is a great investment for anyone looking for a reliable and effective body wash.

Rated 7.7 based on 10

JPOST

Pros

Antifungal properties, Hypoallergenic and fragrance-free, Suitable for sensitive skin

Cons

May not work for everyone

If you're looking for an effective solution to treat toenail fungus, look no further than the Toenail Fungus Treatment - Body and Foot Antifungal Wash. This potent formula is designed to eliminate fungus and odors, while also treating conditions like athlete's foot, ringworm, and jock itch. Made with natural and safe ingredients, this antifungal wash is easy to use and can help restore the health and appearance of your feet and nails. So why suffer with unsightly and uncomfortable fungal infections when you can use this powerful treatment to get relief? Try it today and see the results for yourself!

Rated 7.5 based on 10

JPOST

Pros

Effective against various fungi, Soothes and moisturizes skin, Eliminates foot odor

Cons

May require consistent use

Q: What is an antifungal body wash?

A: An antifungal body wash is a type of soap that is formulated to specifically target and eliminate fungal infections on the skin. It contains active ingredients like tea tree oil, ketoconazole, and selenium sulfide that work to kill fungus and prevent it from spreading.

Q: Who should use antifungal body wash?

A: Antifungal body wash is recommended for anyone who is experiencing a fungal infection on their skin. This can include athletes who are prone to fungal infections from sweating, people who have compromised immune systems, and individuals who have been diagnosed with a fungal skin condition like ringworm or jock itch.

Q: How do I use antifungal body wash?

A: To use antifungal body wash, wet your skin and apply a small amount of the soap to a washcloth or loofah. Gently lather the soap onto your skin, paying special attention to areas that are prone to fungal infections like your feet, groin, and armpits. Rinse thoroughly with warm water and pat your skin dry. Use the body wash daily until your fungal infection has cleared up, and then continue to use it as a preventative measure.

After conducting thorough research and analysis of various antifungal body wash products, it is clear that this category offers a range of options for individuals looking to combat fungal infections and skin irritations. Many of the reviewed products contain tea tree oil, which is known for its antifungal and antibacterial properties. While some products are specifically targeted towards certain conditions such as athlete's foot or jock itch, others offer moisturizing and gentle cleansing for dry and sensitive skin. Overall, we encourage readers to consider incorporating antifungal body wash into their hygiene routine and to choose a product that fits their individual needs.

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Patients With Severe Psoriasis Have Higher Risk of Heart Disease … – AJMC.com Managed Markets Network

Posted: at 9:58 am

The largest study to date on the relationship between severe psoriasis and coronary microvascular dysfunction (CMD) found patients with severe psoriasis had increased risk for heart disease. The cross-sectional cohort study is published in the Journal of Investigative Dermatology.1

Psoriasis skin, eczema, rash and other skin diseases. A woman hides her face, she is ashamed of her autoimmune genetic disease. Imperfect beauty. | Image credit: stockmaster - stock.adobe.com

Patients with a reduced CFR [coronary flow reserve] underwent angio-CT to exclude a stenosis of the coronary arteries, and no patients showed coronary artery disease, said Lead investigator Stefano Piaserico, MD, PhD, Dermatology Unit, Department of Medicine, University of Padova, in a statement.2 Therefore, all patients with an impaired CFR in our cohort were affected by coronary microvascular dysfunction.

Although previous studies have shown patients with severe psoriasis have increased cardiovascular morbidity and mortality, little research has been conducted on the specific mechanisms that cause this increased risk, especially for coronary microvascular dysfunction.

In the current study, the researchers aimed to assess the prevalence of reduced coronary flow reserve (CFR) using transthoracic echocardiography among patients with severe psoriasis without clinical cardiovascular disease (CVC), and its association with psoriasis and patient characteristics.

CFR pertains to the capacity of the coronary circulation to dilate and increase flow following an increased myocardial metabolic demand. Healthy CRF levels range from 3 to 6. In this study, the researchers conducted a univariate analysis of variables in patients with normal (n = 307) and reduced CRF (n =141) of 2.5 or lower.

A total of 503 patients were enrolled in the study and 55 were excluded due to technical difficulties, leaving 448 patients with complete data on CFR and disease characteristics. This cohort of patients had a mean (SD) age of 45 ( 13) years and was mainly composed of male patients (69%). Additionally, mean BMI was 29 6.4 kg/m2, 24% had hypertension, 37% had hyperlipidemia, 11% had diabetes mellitus, and 57.8% were current or former smokers.

Of these patients, 141 (31.5%) showed CMD, or CFR of 2.5 or less. None of these patients had coronary stenoses at the time of the MSCT scan. Furthermore, psoriasis activity was greater in patients with CMD who were older and had slightly higher BMI compared with patients without CMD.

Psoriasis severity (odds ratio [OR], 1.06; 95% CI, 1.03-1.09; P < .001) and the duration of the disease (OR, 1.05; 95% CI, 1.02-1.07; P < .001) were both independently associated with lower CRF, as was the presence of psoriatic arthritis (OR, 1.94; 95% CI, 1.14-3.30; P = .015).

Furthermore, conventional cardiovascular risk factors, such as tobacco use, hyperlipidemia, and diabetes mellitus, were not independently associated with reduced CFR in patients with severe psoriasis.

The researchers acknowledged some limitations to the study, including that only a small portion of the studys patients were being treated for psoriasis, some patients were treated for cardiovascular risk factors at the time of the study, and the assessment of CMD did not use other techniques besides transthoracic Doppler echocardiography.

Despite these limitations, the researchers believe the study highlights the potential mechanisms that increase the risk of cardiovascular complications among patients with severe psoriasis.

"We should diagnose and actively search for microvascular dysfunction in patients with psoriasis, as this population is at particularly high risk, said Piaserico in a statement.2 We might hypothesize that an early and effective treatment of psoriasis would restore the dysfunction and eventually prevent the future risk of myocardial infarction and heart failure associated with it.

References

1. Piaserico S, Papadavid E, Cecere A, et al. Coronary microvascular dysfunction in asymptomatic patients with severe psoriasis. Journal of Investigative Dermatology. 2023;20(9). doi:10.1016/j.jid.2023.02.037

2. New evidence confirms patients with severe psoriasis are at a higher risk for heart disease. EurekAlert! September 20, 2023. Accessed September 19, 2023. https://www.eurekalert.org/news-releases/1001707

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9 Best Online Blackjack Sites to Play for Real Money – BSC NEWS

Posted: at 9:58 am

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Wild Casino is an online casino that was founded in 2017. It is owned and operated by the same team that operates the popular sportsbooks BetOnline.ag and SportsBetting.ag. Wild Casino does not offer sports betting, but it does offer a wide variety of casino games, including blackjack.

The blackjack games at Wild Casino are powered by RealTime Gaming (RTG). RTG is a well-respected casino software provider that is known for its fair games and high-quality graphics. Wild Casino offers a variety of blackjack variants, including American blackjack, European blackjack, and double exposure blackjack online.

The blackjack online odds at Wild Casino are slightly worse than the odds at land-based casinos. This is because Wild Casino has a house edge of 0.5%, while the house edge in land-based casinos is typically around 0.4%. However, the blackjack games at Wild Casino are still fair and offer a good chance of winning.

Welcome Bonus: Wild Casino offers a 250% match bonus on your first deposit up to $1,000. This means that if you deposit $100, you will receive a bonus of $250, for a total of $350 to play with.

Reload Bonuses: Wild Casino offers reload bonuses to existing players. These bonuses are usually a percentage match up to a certain amount on your deposit. For example, you might get a 50% match bonus on your next deposit up to $500.

Cashback: Wild Casino offers a cashback bonus to all players. The cashback bonus is a percentage of your losses returned to you, up to a certain amount. For example, you might get 10% cashback on your losses up to $100.

VIP Program: Wild Casino has a VIP program that rewards players for their loyalty. The VIP program offers a variety of benefits, including: Increased deposit limits, Exclusive bonuses, a Personal account manager, and VIP tournaments

Wagering Requirement: 35x bonus + deposit playthrough required.

Return To Play(RTP): The average RTP for the casino is around 96.3%

Banking methods: Credit Card, Bitcoin, Ethereum, Litecoin, Ripple, Stellar, Bank Wire, Money Order

Mobile Compatibility: Bovada has a mobile-friendly website that allows you to play Wild Casino games on your smartphone or tablet. The mobile website is optimized for smaller screens and offers the same features as the desktop version. You can play Wild Casino games for real money or for fun on the mobile website.

=> Click here to visit the official website Wild Casino

Mirax is a relatively new brand in the blackjack world, but it has quickly made a name for itself as a top-of-the-line product. The Mirax blackjack tables are designed with the player in mind, with features that make the game more enjoyable and fair.

One of the things that sets Mirax tables apart is their use of a continuous shuffling machine (CSM). This ensures that the cards are shuffled thoroughly and randomly, which helps to prevent any cheating or collusion. The CSM also speeds up the game, so players can get more hands in per hour.

Another great feature of Mirax tables is their use of automatic card readers. This eliminates the need for human dealers to touch the cards, which helps to keep the game clean and sanitary. The card readers also make it easier for players to track their bets and keep an eye on the game.

Welcome Bonus Package:

First deposit bonus: 100% up to $200, plus 50 free spins

Second deposit bonus: 50% up to $300, plus 50 free spins

Third deposit bonus: 25% up to $150, plus 50 free spins

Fourth deposit bonus: 100% up to $200, plus 50 free spins

Monday Lootbox:

Bonus Light: 25, 50, or 100 free spins when you deposit at least $1.25 or 20 EUR with the bonus code LIGHT.

Lootbox Pro: 150 or 250 free spins when you deposit at least $3.75 or 50 EUR (or more) with the bonus code PRO.

Reload Bonus: 50% up to $75, plus 50 free spins.

Referral Bonus: 20% bonus on your friend's first deposit, up to $100.

VIP Program: The VIP program offers a variety of benefits, including exclusive bonuses, faster withdrawals, and personal account managers.

Wagering Requirement: 45x wagering requirement on bonus and winnings.

Return To Play(RTP): The average RTP for the casino is around 96.2%

Banking methods:Visa, Mastercard, Skrill, Neteller, ecoPayz, Bitcoin, Ethereum, Litecoin

Mobile Compatibility:Mirax Casino is fully mobile-compatible, so players can enjoy all of the casino's games on their smartphones and tablets. The mobile casino is easy to use and has a great selection of games.

=> Click here to visit the official website Mirax

Cafe Casino is an online casino that offers blackjack and other casino games. It is owned and operated by Old Town Media LLC, a company licensed and regulated by the Kahnawake Gaming Commission.

Cafe Casino offers a variety of blackjack games, including single-deck, double-deck, and multi-deck blackjack. The games have different rules and payouts, so reading the rules before playing is essential.

The blackjack games at Cafe Casino are fair and random. The casino uses a random number generator to ensure that the outcome of each hand is unpredictable. Cafe Casino also offers a variety of blackjack bonuses and promotions. These bonuses can help you increase your bankroll and improve your chances of winning.

Welcome Bonus: New players can claim a 250% match bonus up to $1,500 on their first deposit.

Reload Bonuses: Existing players can claim reload bonuses of up to 50% on their deposits.

VIP Program: Cafe Casino has a VIP program that rewards players for their loyalty. The VIP program has 10 levels, and each level offers different benefits, such as higher cashback rates, more free spins, and faster withdrawal times.

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9 Best Online Blackjack Sites to Play for Real Money - BSC NEWS

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How to Find a Safe Sportsbook for Blackjack Games? – GameIndustry.com

Posted: at 9:58 am

Blackjack is a classic casino game whose popularity never decreases. Even in online casinos, this game continues to be one of the most played casino games. Thus, its safe to say that many people seek to play this game in any medium possible. Relating this, one of the most popular casino mediums now is online casinos.

Due to the rapidly increasing modernization in society, casino fans are also adapting and trying online casinos. Aside from its very convenient blackjack gaming experience, online casinos offer a wide array of benefits to its players as well. If youre also a blackjack fan, here are a few things you can do to find the best online casino.

Your best bet in finding the safest online casino is searching online casino communities. Various social media platforms have different casino communities that bring players or people with similar interests together.

In these communities, people can ask for suggestions, offer recommendations, and share their experiences. You can directly ask the community about your concern or search their past posts to discover if someone has already shared their experiences about your prospective online casino.

Keep notes on what people are saying about the site. Does the positive outweigh the negative? Do the cons significantly matter to your blackjack playing experience on the site? Will the site be a distraction as you concentrate on when to split your cards in your blackjack game? Consider all the factors they mentioned and whether it will be worth your while.

However, if youre still starting and are unsure which casino sites to consider, you can also ask for suggestions from the same community. Remember that youre finding the best online casino for your blackjack game. You can narrow your search to their blackjack game experiences instead.

Another thing you should check as well is the casino sites license. As long as they are regulated under the law, you can play at ease, protected by it. Before an online casino site receives a license, they must first go through an intensive assessment to examine how reliable and just their services are. That said, with a license, you can safely assume they have passed many assessments and requirements.

Casino site owners will usually display the licenses to showcase their ability to operate their site. You can usually check the casino sites license on the About Me page or the websites footer.

The terms and conditions are the sites fundamentals. To enjoy the most of what the site offers, you must initially understand its T&Cs. However, many people ignore this very long statement the longer they stay online. Remember that youre dealing with real money, and if youre not careful, you might lose them.

The terms and conditions will inform you how to protect your account while staying on the site. Also, it gives you information on how they will handle your money and the details they collected. Unless you agree with how they process things, you should read every section of the terms and conditions to protect you.

Two-factor authentication is another layer of security that will ensure your safe login into the online casino site. This authentication is usually after you log in with your username, email, and password, where the site will then send a verification link to a one-time-pin (OTP) that you need to click or input to the second part of the login process.

Find an online casino that offers two-factor authentication to be at ease with their security. One of the usual issues in online casinos is stealing usernames and passwords to hack into the account easily. If they ever do so, they will still be blocked before they can enter the site with your account.

A safe and secure casino site ensures customer support is on standby in case any of their players require help. This should be one of the primary qualifications an excellent and reliable sportsbook should have. Since youll be somewhere far from the actual site of the land-based casino house, youll be playing alone. However, with the help of chat support, you can play with confidence.

You can check if the casino site does have immediate chat support by contacting them in the contact details they offer on their site. You can ask your concerns and take note of how long they will respond to your queries. On the other hand, some sites present virtual chat on the site itself. You can try asking your queries and note how accurate or related the answers they provide are.

Another option you can do is by reading other peoples testimonies online. Just like how you research online communities for an excellent online casino, you can also try to read about their experience in chat support.

The blackjack game is an entertaining casino that needs a safe and secure online casino to play without worries. To do so, you must carefully follow the list above and take all the time to find the best online casino for you. Once you find the best casino for you, you can make your online blackjack experience worthwhile.

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How to Find a Safe Sportsbook for Blackjack Games? - GameIndustry.com

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Baccarat remains top casino table game in Indiana – The Times of Northwest Indiana

Posted: at 9:58 am

Baccarat was the most popular table game at Indiana casinos during the 2023 state budget year displacing the long-running favorite, blackjack, for a second consecutive year.

The Indiana Gaming Commission's (IGC) recently released annual report shows $673.2 million was wagered on baccarat in Hoosier State casinos between July 1, 2022, and June 30, 2023, compared to $653 million in blackjack bets placed during the same period.

Data show both baccarat (3.7%) and blackjack (5.2%) play were down last year compared to 2022. But 2023 baccarat play still was an incredible 55.7% higher than the $432.3 million wagered on the game at Indiana casinos in 2021, and 47.8% greater than the $455.4 million of pre-pandemic baccarat bets in 2019.

The growth largely was due to interest in baccarat among guests at the Hard Rock Casino Northern Indiana, which openedMay 14, 2021, adjacent to Interstate 80/94 at Burr Street, as a replacement for the former Majestic Star Casinos on Lake Michigan in Gary.

According to the Indiana Gaming Commission, a total of $323 million or nearly half the statewide baccarat drop was wagered at Hard Rock's 22 baccarat tables during the 2023 state budget year.

Matt Schuffert, president of Hard Rock Casino Northern Indiana, said attracting players who enjoy the simplicity of baccarat and its luck factor has been a top priority.

"We attribute our success to several factors, including the authenticity of our YouYu noodle bar, having the highest limits in the market, and a team of marketing strategists that know this market very well," Schuffert said.

"The Hard Rock brand definitely resonates with this customer. Also, having a brand new casino in a market that has been open for over 25 years certainly helps."

IGC data show the Horseshoe Casino in Hammond ($126.2 million) and Ameristar Casino in East Chicago ($102.8 million) similarly saw significant baccarat play last year, as well as more bets on baccarat than at their blackjack tables.

Indeed, after adding in the $19,447 wagered on baccarat at the Blue Chip Casino in Michigan City, Northwest Indiana's four casinos were responsible for 82% of the total money bet on baccarat last year in the Hoosier State, records show.

Baccarat is popular because, among other reasons, it offers players the best chance to hang on to more of their money than any other table game.

Every casino game is designed to favor the house. But Indiana baccarat players, on average, got back 81.4% of their wagers last year, compared to a 78.8% return to player for blackjack, 76.8% for craps, 73.8% for roulette and 73% for house-banked poker games.

In fact, even though more money last year was wagered at Indiana's 84 baccarat tables than the 274 blackjack tables, blackjack produced for the casinos $138.3 million in "win," or revenue after paying successful bettors, versus $125.5 million in baccarat win, according to the IGC.

Records show Indiana slot machines had a 90.2% return to player last year, while the Hoosier Lottery paid back just 65.6% of its revenue as player prizes.

Baccarat is a relatively simple game. At its most basic level, a baccarat player bets on whether the "banker" or the "player" will have a hand that draws closest to nine.

Unlike blackjack, where players try to beat the dealer by getting their cards near 21 without going over, each baccarat player uses the same set of cards, and the decision of whether the baccarat dealer draws additional cards on behalf of either the "banker" or the "player" automatically is determined by the rules of the game.

Advanced baccarat players also can take advantage of a seemingly unlimited number of side bets with huge potential payoffs depending on the size of the wager and the unlikelihood of the outcome.

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Baccarat remains top casino table game in Indiana - The Times of Northwest Indiana

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Boosting Your Odds of Winning at Online Casino Games in Canada … – Dolphins Talk

Posted: at 9:58 am

Professional Guidance for Enhancing Your Success in Online Casino Games

Gambling has long been a favored pastime for many Canadians, but navigating the complex world of online casino games can be daunting. For those seeking to maximize their chances of triumph and increase their earnings, seeking professional guidance on winning strategies can be immensely valuable. Its crucial to fully grasp the variety of online casino games available to harness the benefits of consulting services. Reputable online casinos in Canada offer various games, including slots, blackjack, roulette, baccarat, and card games.

Once youve identified your preferred game, you can explore strategies seasoned players use to gain a competitive edge. For instance, acknowledging that they predominantly rely on luck is essential when playing slots. However, specific tactics, like opting for machines with higher payout rates or adopting a strategy of smaller, more frequent bets, can mitigate variance and enhance your chances of success.

Similarly, mastering blackjack necessitates understanding basic strategies to avoid costly mistakes. Consulting services can furnish valuable advice on harnessing this knowledge to capitalize on favorable situations and minimize losses during unfavorable ones. Regarding roulette, distinct strategies apply depending on whether you opt for American or European-style tables. Consulting services can provide tailored guidance on navigating each variant and even offer insights into spotting patterns within the wheel spin data, a skill known as wheel clocking among experts.

Lastly, baccarat, with its intricate gameplay, requires skill to excel. Fortunately, numerous high-quality tutorials are available through trusted sources like YouTube videos or books authored by renowned experts, aimed at guiding you toward mastering this captivating form of gambling entertainment. Consulting services will likely cover all facets of mastering baccarat, including accurately reading hands and predicting banker moves.

In summary, engaging in professional consultancy before immersing yourself in online gaming is wise, whether a novice or an experienced player. After all, why leave anything to chance?

Online slots are a beloved form of online casino entertainment in Canada, allowing players to scoop substantial prizes and jackpots with just a few clicks. While chance remains a pivotal factor in determining your slot success, there are specific strategies to boost your winning odds. Here, we will explore tips for maximizing your achievements when playing online slots.

Foremost, its crucial to remember that slot machines are inherently games of chance regardless of the strategies employed. This implies that you might still encounter losses over time, even with the most robust system. Nonetheless, comprehending the fundamental aspects of slot machine gameplay can significantly improve your odds and ensure that every spin proves as lucrative as possible.

To maximize your chances of winning at online slots, consider capitalizing on bonuses and promotions best Canadian casinos offer, such as free spins or loyalty reward programs. Many casinos regularly present these enticing bonuses, so monitoring their promotions for new opportunities is advisable.

Moreover, watch for progressive jackpot games, where players can secure substantial sums with modest bets. These games boast higher payout rates than traditional slot machines, heightening your prospects of securing wins. Its also prudent to research different slot variations before committing funds to gameplay. Various software providers design unique versions, so reviewing each games features and advantages ensures an enjoyable experience while enhancing potential returns.

Finally, bankroll management is of paramount importance. Always establish limits on how much money you intend to spend during each session and steadfastly adhere to those limits. This approach prevents losses from spiraling out of control, fostering a more stress-free gaming experience when enjoying online casino games in Canada.

Online blackjack is a cherished classic among Canadian casino enthusiasts, characterized by its straightforward rules and accessible gameplay. Mastering winning strategies is essential to emerge as a seasoned online blackjack player. Here are some tips for honing your path to success when indulging in online blackjack in Canada:

Following these guidelines will set you on the right course to becoming a proficient online blackjack player in Canada. Remember that practice is the key to mastery, and repeated exposure will enable you to grasp the nuances and subtleties of this classic game. Embark on your journey today, and may fortune favor your endeavors!

Strategic Betting Techniques for Winning Big in Canadian Online Roulette

Participating in games of chance, such as roulette, can be rewarding. However, its essential to recognize that the house always maintains an advantage, and there are no foolproof methods to guarantee success every time you play. Nonetheless, seasoned players employ specific strategies and techniques to boost their chances of triumph in Canadian online roulette.

The initial strategy involves meticulously studying the game before placing any bets. Players should pay close attention to how frequently particular numbers or colors emerge during a session and endeavor to discern patterns in the results across multiple sessions. Additionally, freely accessible online resources can offer valuable insights into specific betting systems, such as the Martingale system. This system aids in determining when to adjust wagers based on past outcomes.

Another prevalent strategy is wheel tracking, which entails simultaneously monitoring spins from multiple roulette tables to pinpoint the most frequent wins on each wheel type, whether American or European. This technique empowers players to make more informed bets by recognizing which wheel sections have historically produced more winners. Its a skill demanding intense concentration since it necessitates tracking numerous wheels concurrently.

For those seeking a more substantial advantage, consulting services cater to playing roulette online with real-money stakes. They provide invaluable insights into facets like bankroll management and risk assessment, particularly when engaging in high-stakes games such as progressive jackpots or multi-table tournaments (MTTs). These services typically deliver comprehensive analysis reports outlining current trends within specific Canadian casino sites and recommendations for adjusting your betting strategy.

In conclusion, securing substantial wins in roulette is challenging, but applying strategic betting techniques can provide an edge over fellow players, whether they employ similar tactics or not. Consulting services specialized in this domain ensure you stay well-informed about current trends, aiding in better decision-making when placing wagers online and ultimately leading to more significant payouts in the long run.

In the vast landscape of online casinos, finding a trustworthy platform that aligns with your gaming preferences can be a daunting task. To simplify this process, CasinoHEX Canada provides comprehensive and unbiased reviews of various Canadian online casinos. These reviews give you an in-depth understanding of the game selection, software, bonuses, security, and customer support of each platform.

Adam Lane, a reputable casino reviewer, contributes significantly to these reviews. With his deep industry knowledge and analytical skills, Adam dissects various aspects of online casinos. His reviews are known for their accuracy, reliability, and easy-to-understand language, helping players, especially beginners, make informed decisions about where to gamble online. His work ensures players have access to the best in-class Canadian online casino experiences, combining entertainment with safety.

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Boosting Your Odds of Winning at Online Casino Games in Canada ... - Dolphins Talk

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The Dark Economics of Russell Brand – WIRED

Posted: at 9:57 am

There was a brief, strange moment in 2015 when Russell Brand mattered in mainstream British politics. With an election looming, the opposition Labour Party was trailing in the polls against a coalition government that was the very definition of establishmentled by an Eton- and Oxford-educated prime minister in David Cameron and his Westminster- and Cambridge-educated deputy, Nick Clegg, now president of global affairs at Meta. So the Labour leader, Ed Miliband, went seeking the endorsement of Brand, the actor, comedian, and emerging online provocateur whose anti-corporatist screeds to his 9.5 million Twitter followers and 100,000 YouTube subscribers gave him the appearance of a power player. Miliband got Brands endorsement but lost the election.

Since then, Brands reach has exploded. His YouTube channel now has 6.6 million subscribers, his X account more than 11 million followers. But his anti-establishment message has morphed, from a broader, almost coherent response to the politics of fiscal austerity that shaped the UK after the 2008 financial crisis to a series of cultish, conspiracy-driven narratives that draw in Covid denialism, Russian disinformation, and the far-right-inspired Great Reset theory, united by the meta-conspiracy that the mainstreamthe eliteshave darker agendas based on control.

On Saturday, the UKs Channel Four aired an hour-long documentary in which several women accused Brand of rape and sexual assault. Before the broadcast, the comedian came out swinging. In a video on his YouTube channel, titled So, This Is Happening, Brand not only denied the accusations, but leveled some of his own: [It] makes me question, is there another agenda at play? he said.

One of Brands alleged victims, speaking on the BBC, called his statement insulting and laughable. But within the alt-media, there was a show of support from figures including Andrew Tate, the misogynist influencer who is awaiting trial for rape and human trafficking in Romania, Tucker Carlson, the former Fox News anchor, who now runs a conspiracy-inflected show on X, and Alex Jones, fined $1.5 billion for lies about the victims of a school shooting. Xs owner, Elon Musk, posted underneath Brands video: Of course. They dont like competitionreferring, apparently, to those same dark forces referenced by the comedian. The camaraderie between conspiracy theorists, the alt-right, and the manosphere, is grimly predictable. Their shared narrative is one of alienation from the mainstream, outsiderdom, and dark forces massing to thwart them. Opposite day, but with real consequences for people, as Marc Owen Jones, an expert on disinformation and social media at Hamad bin Khalifa University in Qatar, puts it.

Its also their audience strategy and the foundation of their business model. Conspiracy influencers are content producers. Moments that generate intense emotionseven if the content producer is, themself, the focus of the scandalare fantastic for engagement, and they feed the grim economics of the conspiracy business.

Brands YouTube channel is a compendium of contemporary bullshit. Covid lockdowns were exercises in social control. The US has biolabs in Ukraine; the Wests support for Ukraine is capitalist imperialism. Central bank digital currencies are the governments attempts to control your money. Evolving gender norms are causing a crisis in masculinity and declines in fertility. There are routine crossovers between Brands content and the wider conspiracy cinematic universe, with clips on his channels of conspiracy theorist Robert Kennedy Junior, far-right Hungarian president Viktor Orban, and Carlson, who recorded an interview with Brand in August.

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The Dark Economics of Russell Brand - WIRED

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