Monthly Archives: January 2023

Why IBM is no longer interested in breaking patent recordsand how it plans to measure innovation in the age of open source and quantum computing -…

Posted: January 6, 2023 at 3:06 pm

Why IBM is no longer interested in breaking patent recordsand how it plans to measure innovation in the age of open source and quantum computing  Fortune

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Bed Bath & Beyond could file for bankruptcy ‘as early as this weekend’: Macco CEO – Yahoo Finance

Posted: at 3:04 pm

  1. Bed Bath & Beyond could file for bankruptcy 'as early as this weekend': Macco CEO  Yahoo Finance
  2. Why Bed Bath & Beyond Is Weighing Bankruptcy  The New York Times
  3. Bed Bath & Beyond warns that it may go bankrupt  NPR

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Bed Bath & Beyond could file for bankruptcy 'as early as this weekend': Macco CEO - Yahoo Finance

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Gene Therapy: Genes As Medicine | Pfizer

Posted: at 2:58 pm

References:

1. NIH Genetics Home Reference. What is a Gene? https://ghr.nlm.nih.gov/primer/basics/gene. Accessed February 10, 2020.

2. Forbes. How Many Possible Combinations of DNA Are There? https://www.forbes.com/sites/quora/2017/01/20/how-many-possible-combinations-of-dna-are-there/. Accessed February 10, 2020.

3. NIH National Human Genome Research Institute. Genetic Disorders. https://www.genome.gov/For-Patients-and-Families/Genetic-Disorders. Accessed February 10, 2020.

4. NIH Genetics Home Reference. How Can Gene Mutations Affect Health and Development? https://ghr.nlm.nih.gov/primer/mutationsanddisorders/mutationscausedisease. Accessed February 10, 2020.

5. NIH Genetics Home Reference. How does Gene Therapy Work? https://ghr.nlm.nih.gov/primer/therapy/procedures. Accessed February 10, 2020.

6. NIH Genetics Home Reference. What is Gene Therapy? https://ghr.nlm.nih.gov/primer/therapy/genetherapy. Accessed February 10, 2020.

7. Data on file. Pfizer Inc, New York, NY.

8. Haasteren J, Hyde S, Gill D. Lessons Learned From Lung and Liver In-Vivo Gene Therapy: Implications for the Future. Expert Opin Biol Ther. 2018;18(9):959-972.

9. Gowing G, Svendsen S, Svendsen CS. Ex Vivo Gene Therapy for the Treatment of Neurological Disorders. Prog Brain Res. 2017;230:99-132.

10. NIH National Human Genome Research Institute. What is Genome Editing? https://www.genome.gov/about-genomics/policy-issues/what-is-Genome-Editing. Accessed February 10, 2020.

11. Carroll D. Genome Engineering with Zinc-Finger Nucleases. Genetics. 2011;188(4):773-782.

12. Unniyampurath U, Krishnan M, et al. RNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi? Int J Mol Sci. 2016;17(3):291.

13. Your Genome. Facts: What is Gene Therapy? http://www.yourgenome.org/facts/what-isgene-therapy. Accessed February 10, 2020.

14. Arruda VR, Favaro P, Finn JD. Strategies to Modulate Immune Responses: A New Frontier for Gene Therapy. Mol Ther. 2009;17(9):14921503.

15. Mingozzi F, High KA. Immune responses to AAV vectors: overcoming barriers to successful gene therapy. Blood. 2013;122(1):23-36.

16. Payne J. Antibody and antigen tests. Patient Platform Limited Web site. https://patient.info/health/antibody-and-antigen-tests. Accessed February 10, 2020.

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How to hack the Cyberpunk 2077 Militech Datashard – pcgamer

Posted: at 2:55 pm

Curious about the Cyberpunk 2077 Militech Datashard? By the sounds of it, you've just met Meredith Stout, and you're working your way through The Pickup quest. You can just hand the credchip straight over to the Maelstrom, but it's more interesting to explore all your options before skipping off to the All Foods gate.

Prepare to work some Cyberpunk 2077 hacking (opens in new tab) magic. It only takes a few seconds to remove the malware from the datashard, but it's worth doing if you're hoping to stay on the right side of the Maelstrom gang. Here's how to get the Militech Datashard in Cyberpunk 2077 and hack it to remove the malware stored on the chip.

Before heading to the All Foods building in The Pickup quest, you have the opportunity to call Meredith Stout and arrange to meet her. This optional objective appears after you speak to Dexter DeShawn in his car (The Ride quest). While the meeting is a little hostile at first, the conversation leads to you receiving a Militech Datashard that has some cash on it.

With the credchip safely in hand, you can then poke around and remove the malware on the chip. This virus is intended to catch out the Maelstromers, so tampering with it can change what happens when you meet Cyberpunk 2077's Royce (opens in new tab) later on.

After Meredith drives away, you can use your hacking knowledge to use Breach Protocol on the credchip and wipe it. Open your Journal (I) and select the Shards tab, then scroll right down to the bottom and choose the Militech Datashard. Then, press F to crack the security on the chip.

Upon breaching the credchip you'll notice that there are two sequences:

It's possible to complete both sequences, but the game-changing option is the neutralize malware sequence at the top. Here's how to hack the Militech Datashard and enter both sequences:

Now you're ready to meet Jackie at the All Foods gate and continue The Pickup mission.

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How to hack the Cyberpunk 2077 Militech Datashard - pcgamer

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The Last Of Us Updates, An Award For Cyberpunk 2077 And More Gaming News For Wednesday, January 4 – Forbes

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The Last Of Us Updates, An Award For Cyberpunk 2077 And More Gaming News For Wednesday, January 4  Forbes

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The Last Of Us Updates, An Award For Cyberpunk 2077 And More Gaming News For Wednesday, January 4 - Forbes

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Why Playing Cyberpunk 2077 As A Melee Character Is The Most Fun You Can Have With It – Kotaku Australia

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Why Playing Cyberpunk 2077 As A Melee Character Is The Most Fun You Can Have With It  Kotaku Australia

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Why Playing Cyberpunk 2077 As A Melee Character Is The Most Fun You Can Have With It - Kotaku Australia

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Trader Who Sold Bitcoin at the Top Says Ethereum Is Showing Remarkable Strength Against BTC – The Daily Hodl

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Trader Who Sold Bitcoin at the Top Says Ethereum Is Showing Remarkable Strength Against BTC  The Daily Hodl

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Trader Who Sold Bitcoin at the Top Says Ethereum Is Showing Remarkable Strength Against BTC - The Daily Hodl

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At the San Diego History Center, a historic donation – The San Diego Union-Tribune

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At the San Diego History Center, a historic donation  The San Diego Union-Tribune

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At the San Diego History Center, a historic donation - The San Diego Union-Tribune

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Arrest of squeegee kid reveals history of run-ins with drivers and police, records show – Fox Baltimore

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Arrest of squeegee kid reveals history of run-ins with drivers and police, records show  Fox Baltimore

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Arrest of squeegee kid reveals history of run-ins with drivers and police, records show - Fox Baltimore

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Colonization of Europa – Wikipedia

Posted: January 4, 2023 at 6:51 am

Proposed concepts for the human colonization of Europa

Europa, the fourth-largest moon of Jupiter, is a subject in both science fiction and scientific speculation for future human colonization. Europa's geophysical features, including a possible subglacial water ocean, make it a possibility that human life could be sustained on or beneath the surface.

Europa as a target for human colonization has several benefits compared to other bodies in the outer Solar System, but is not without challenges.

On a flyby mission around Europa in 1979, Voyager 1 and Voyager 2 took relatively detailed photographs of the moon's surface. They noted several important characteristics including dark streaks across the surface, or lineae, and an otherwise remarkably smooth icy crust. The lineae are believed to be the result of icy tectonic plates moving over a submerged ocean. Moreover, the smooth crust is believed to be the result of its recent formation.[1] Submerged water may have risen to cover the older, more damaged surface and smooth it over. These surface features indicate the existence of a subsurface ocean. Given water's importance to life on Earth, it is considered to be a possible indicator of life on other celestial bodies.

The high radiation on Europa's surface is one of the environmental challenges to colonization.[2] Europa receives 5.4 Sv (540 rem) of radiation per day,[3] which is approximately 1,800 times the average annual dose experienced by a human on Earth at sea level. Humans exposed to this level of radiation for one day would have greater than a 50% mortality rate within 30 days.

Another problem is that the surface temperature of Europa averages around 90K, or -183C.[4]

Furthermore, the low gravity of Europa may also present challenges to colonization efforts. The effects of low gravity on human health are still an active field of study, but can include symptoms such as impaired eyesight and a diminished sense of balance.[5] Negative health effects can also include muscle deterioration and bone loss. Galactic cosmic radiation along the journey is likely to lead to an increased chance of developing Alzheimer's Disease.[6][7] Astronauts in Earth's orbit have remained in microgravity for more than a year at a time and have had to develop countermeasures to address its negative effects. Experts have also hypothesized that children born and raised in low gravity would not be well adapted for life under the higher gravity of Earth.[8]

Moreover, experts have speculated that alien organisms may exist on Europa, possibly in the subsurface ocean under the moon's ice shell.[9][10] If true, this would mean human colonists may come into contact with harmful microbes.

An unstable surface could also represent a potential problem as it has been shown that Europa is geologically active. With an outer crust experts believe is made of constantly shifting plate tectonics, Europa's surface would make it difficult to maintain the structural integrity of any long-term infrastructure.[11]

The transportation of humans to Europa would be one of the primary challenges to colonization. Since Jupiter is on average 630.4 million kilometers away from Earth at a given time, it would take at least 3 years just to get into Europa's orbit plus additional time to land. In an effort to develop transportation methods to Mars and other planets, NASA has announced a program called NextSTEP that will merge the efforts of public and private industry to begin the research and architectural design necessary to create an Environmental Control and Life Support (ECLS) system.[12] The ECLS is currently being designed for Martian operations, will be called the Deep Space Transport (DST) and will allow for missions up to 2.75 years long. The transport vehicle to Europa will be similar to the DST and the International Space Station (ISS), but will also be different in several key aspects. Most importantly, the transport vehicle for Europa would need to be completely self-sufficient so that all the nutritional supplies are included at the onset of the flight, along with the ability to repair any systems that malfunction or break on the voyage. The vehicle would also need to be resistant to radiation because the levels of radiation on this trip would be significantly higher than on Earth. The shielding around the ship would have to be increased to prevent exposure to harmful radiation. While these considerations are prohibitively expensive and require development of current technologies, it is not impossible that a continuation of the DST would meet the requirements necessary to eventually complete this journey.

Like historic colonies that were established on Earth, Europa's economic development would be critical to its continual growth and success.[13] One such economic driver could be its relatively close proximity to Jupiter, the asteroid belt, and the periphery of the solar system. Earth is, on average, almost 500 million miles from Europa.[14] To alleviate the time and distance required to travel, Europa can serve as a midway colony between Earth and the aforementioned locations. "Intermediary" colonies have historic precedents. For example, Cape Town, South Africa, was established as a safe harbor for long voyages between Asia and Europe.[15]

Europa is hypothesized to have a large subsurface ocean. Water makes it possible to grow fruits, vegetables, and grains as it is an essential pillar to agriculture.[16] However, reddish-brown materials whose composition is not yet known, but that experts believe to be salt and sulfur compounds that have been mixed with ice and modified by radiation, litter Europa's surface and could make Europa's surface unsuitable for agriculture.[17] Manure and other fertilizers could be an inter-Europa commodity as it will most likely be essential to delivering the nutrients required for farming and industrial agriculture.[16]

The true breadth of ethical consequences that come from the colonization of Europa cannot be known until such a colony is fully established. The United Nations Outer Space Treaty, ratified in 1967, states that no country may take claim to space or celestial bodies like Europa.[18] It is unclear exactly how ownership over Europa colonial lands would be distributed and whether colonists will have private land ownership once a colony is established. More human centered ethical questions may arise from how extended periods in outer space will impact colonists. Migration on Earth is a well established phenomenon but it carries its own set of psychological impacts like a decrease in mental well-being due to having to adjust to a new environment, set of norms, distress, and separation from family.[19] NASA scientists predict that an altered state of gravity and radiation coupled with isolation and confinement have the potential to pose real psychological hardships on a person.[20] Such negative impacts on colonists will increase as they spend more time in space. Ethical arguments can be made as to why any entity should finance the colonization of Europa when the program has a high risk of failure and could be detrimental to the colonists' health and well-being.

The environment within a Europa colony will inevitably be altered. Colonists will most likely want to terraform the moon to make its surface and climate better suited for their colony.[21] Arguments can be made as to what right humans have, as extraterrestrial visitors, to alter the natural environment. Parallels can also be found between the negative impacts that unmonitored resource exploitation has had on Earth and the potential of such a catastrophe on Europa.

If life is found to exist on Europa, the difference in the environments of Earth and Europa would likely mean terraforming would have adverse effects on the natural inhabitants of the moon.[22] Ethical considerations regarding how to preserve natural life, whether it be primitive or in the form of microorganisms may be necessary.

Galileo Galilei first discovered Europa along with four of Jupiter's other satellites on 7 January 1610.[23] However, he only realized they were moons, rather than stars, on 15 January of that year.[24]

Pioneer 10 and Pioneer 11 were flyby missions to Jupiter in 1972 and 1973 respectively.[25]

Voyager 1 and Voyager 2 were NASA space probes launched in 1977. During a flyby mission in 1979, the Voyager probes took relatively precise photographs of the moon's surface.[1]

Europa Clipper is a NASA mission planned for launch in 2024.[1] After it is launched, the spacecraft will study Europa on flybys as it orbits Jupiter. The mission's goal is to determine whether there is a liquid water ocean submerged under Europa's icy surface. Furthermore, NASA hopes to determine whether that ocean provides suitable conditions for life.

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