Daily Archives: December 18, 2022

Types of Psoriasis: Pictures, Symptoms and Treatments – Healthline

Posted: December 18, 2022 at 2:30 pm

Psoriasis is a chronic skin disease. Its considered an immune-mediated disease. This means the immune system acts abnormally.

Psoriasis typically affects the skin, causing skin cells to build up faster than usual. It can also affect other organ systems, especially the joints.

According to a 2021 study, about 7.5 million U.S. adults 20 years or older have psoriasis a 3 percent prevalence rate (occurrence of a condition). By race and ethnicity, the prevalence rates are:

Psoriasis causes your skin to develop scaly patches that can be itchy and painful.

Psoriasis tends to be pink or red on people with light or fair skin tones, with silvery-white scale. On medium skin tones, it can appear salmon-colored with silvery-white scale. On darker skin tones, the psoriasis could look violet, brown, or reddish brown often with light-colored or grayish-colored plaques.

There are different types of psoriasis, and its possible to have more than one type.

Theres limited research and information about managing and diagnosing psoriasis in People of Color. A 2014 study found the prevalence of psoriasis among adults ages 20 and older to be 3.2 percent, and found the rates vary by race and ethnicity:

These numbers may not tell the entire story, as People of Color may be disproportionately undertreated and misdiagnosed. This is because psoriasis isnt always recognized on darker skin tones as it is for people with lighter skin tones.

Read on to learn more about these different types and how theyre treated.

The most common symptoms of psoriasis include:

The symptoms of psoriasis also vary based on the type. There are eight types of psoriasis:

Psoriasis can lead to mental stress, anxiety, and low self-esteem. Depression is also common in people who have psoriasis.

Other diseases, such as Crohns disease, celiac disease, metabolic syndrome, and cardiovascular disease, have been linked with psoriasis.

There are also subcategories of psoriasis types. These appear differently depending on the location of the body. Psoriasis isnt contagious regardless of type.

Psoriasis patches on darker skin tones may also be more widespread, which can make it difficult to diagnose.

Generally, psoriasis patches appear more purple or brown on darker skin tones, often with thick silvery plaques.

Plaque psoriasis, or psoriasis vulgaris, is the most common form of psoriasis. An estimated 80% to 90% of people with psoriasis have plaque psoriasis. Its characterized by thick red or purplish patches of skin, often with a silvery-white or gray scales.

These patches often appear your elbows, knees, lower back, or scalp.

Patches are usually 1 to 10 centimeters wide, but can also be larger and cover more of your body. If you scratch at the scales, the symptoms will often get worse.

As a way to ease discomfort, a doctor may recommend applying moisturizers to keep the skin from becoming too dry or irritated. These moisturizers include an over-the-counter (OTC) cortisone cream or an ointment-based moisturizer.

A doctor may also work to identify your unique psoriasis triggers, including stress or lack of sleep.

Other treatments may include:

Medication may differ for guttate or erythrodermic psoriasis.

In some cases, you may need light therapy. This involves exposing the skin to both ultraviolet (UV)A and UVB rays. Sometimes, treatments combine prescription oral medications, light therapies, and prescription ointments to reduce inflammation.

With moderate to severe cases, you may be prescribed systemic medication in the form of oral, injectable, or intravenous (IV) medication.

Guttate psoriasis appears in small red spots on the skin. In darker skin tones, these spots can appear violet or brown. Its the second most common type, affecting around 8% of people with psoriasis. Most of the time, it starts during childhood or young adulthood.

The spots are small, separate, and drop-shaped. They often appear on the torso and limbs, but they can also appear on your face and scalp. Spots are usually not as thick as plaque psoriasis, but they can develop into plaque psoriasis over time.

Guttate psoriasis happens after certain triggers. These triggers include:

To treat guttate psoriasis, a doctor may prescribe steroid creams, light therapy, and oral medications. Determining the underlying cause of the infection can also help clear guttate psoriasis. If a bacterial infection caused the condition, antibiotics may help.

Flexural or inverse psoriasis often appears in skinfolds, such as under the breasts or in the armpits or groin area. This type of psoriasis is red or purple and often shiny and smooth.

The sweat and moisture from skinfolds keeps this form of psoriasis from shedding skin scales. Sometimes, its misdiagnosed as a fungal or bacterial infection. The skin-on-skin contact can make inverse psoriasis very uncomfortable.

Most people with inverse psoriasis also have a different form of psoriasis in other places on the body.

The treatments for inverse psoriasis are like plaque psoriasis treatments. They can include:

A doctor may prescribe a lower potency steroid cream to avoid your skin from thinning too much. You may also benefit from taking or applying medications that reduce yeast or bacteria growth.

Pustular psoriasis can be severe at times. This form of psoriasis may develop quickly in the form of many white pustules surrounded by red or darkened skin.

Pustular psoriasis may affect isolated areas of your body, like your hands and feet, or cover most of the skins surface. These pustules can also join together and form scaling. However, if it affects all areas of the body such as the Von Zumbusch subtype it can be life threatening because it has severe systemic effects.

Some people experience cyclic periods of pustules and remission. While the pus is noninfectious, this condition can cause flu-like symptoms such as:

There are three kinds of pustular psoriasis:

Each of the three forms of pustular psoriasis can have different symptoms and severity.

Treatment may include OTC or prescription corticosteroid creams, oral medications, or light therapy. Biologics may also be recommended.

Identifying and treating the underlying cause may also help reduce reoccurrence of pustular psoriasis.

Erythrodermic psoriasis, or exfoliative psoriasis, is a rare type of psoriasis that looks bright red or dark purplish in people with darker skin tones along with shedding of the skin. The condition is serious and is a medical emergency. You may need to be hospitalized, as your body may not be able to manage your body temperature.

This form of psoriasis is widespread, with red or purple skin and silvery scales. It may cover large portions of your body. Exfoliation often occurs in larger pieces than the small scales typical to most psoriasis.

Erythrodermic psoriasis can develop from:

This condition often needs attention at a hospital. There, youll receive a combination of therapies.

This can include an application of medicated wet dressings, topical steroid applications, biologics, or prescription oral medications until symptoms have improved.

Make an appointment with a doctor if you think you have erythrodermic psoriasis.

Psoriatic arthritis (PsA) is a painful and physically limiting condition that affects between 30% and 33% of people with psoriasis. There are five types of PsA with varying symptoms. Theres also no cure for this condition.

Psoriasis is an autoimmune disease, so it can trigger your body to attack your joints and skin. It can affect many joints and often becomes quite severe in the hands and affect the nails. Skin symptoms usually appear before joint symptoms.

Treatments for psoriatic arthritis can include nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) and naproxen sodium (Aleve). NSAIDs can help reduce the incidences of swelling and pain associated with psoriatic arthritis.

Prescription medications, such as an oral corticosteroid, may also help reduce inflammation that leads to psoriatic arthritis. Prescription topical medications used to treat psoriatic arthritis include salicylic acid, calciopotriene, and tazarotene.

A unique category of medications known as disease-modifying antirheumatic drugs (DMARDs) can help reduce inflammation and joint damage. Biologics, which are a subcategory of DMARDs, may be prescribed to reduce inflammation at a cellular level.

Although not an official type of psoriasis, nail psoriasis is a manifestation of psoriasis. The condition can often be confused with fungal infections and other infections of the nail.

Nail psoriasis can cause:

Sometimes, the nail can even crumble and fall off. Theres no cure for psoriatic nails, but some treatments may improve the health and appearance of nails.

Treatments for nail psoriasis are like the ones used for plaque psoriasis. It may take time to see the effects of these treatments as nails grow very slowly. Treatment options include:

Scalp psoriasis is common in people with plaque psoriasis. For some people, it may cause severe dandruff. For others, it can be painful, itchy, and very noticeable at the hairline. Scalp psoriasis can extend to your neck, face, and ears in one large patch or many smaller patches.

In some cases, scalp psoriasis can complicate regular hair hygiene. Excessive scratching can cause hair loss and scalp infections. The condition may also cause feelings of social stress.

Topical treatments are most commonly used for scalp psoriasis. They may require an initial 2 months of intensive applications, plus permanent, regular maintenance. Treatment options include:

Light therapy, oral medications, and biologics also may be recommended depending on the responsiveness to treatment.

Theres no one cure for any form of psoriasis, but remission and significant healing is possible. Your doctor will work with you to create a treatment plan that helps manage your condition. You can also take steps at home to manage psoriasis.

These can include:

Doctors may slowly build up to the most effective treatment plan for your psoriasis symptoms. Most start with a topical or light therapy treatment and only progress to systemic medications if the first line of treatment is unsuccessful.

Stress, anxiety, depression, and other mental health conditions can be commonly found in people with psoriasis. You may benefit from therapy or support groups where you can meet other people experiencing similar issues or concerns.

You can also talk with a healthcare professional about seeing a therapist who has experience with psoriasis. Theyll be able to help identify ways to cope.

Visit the National Psoriasis Foundation for the latest information on research, events, and programs.

There are different types of psoriasis that present different symptoms. While theres no cure for psoriasis, treatment can help relieve and manage your symptoms. Talk with a doctor if youre concerned about your skin.

The type of psoriasis you have, and its severity, will determine your treatment. Generally speaking, milder cases with smaller psoriasis patches can often be treated topically. More serious cases, with larger patches, may require systemic treatment.

Many people believe that psoriasis is contagious, but it wont spread from person to person. Researchers believe that a combination of genetics and environmental and immune system factors cause psoriasis.

Thanks to the advocacy work of dozens of psoriasis activists and organizations, psoriasis is also gaining more support and awareness. Talk with a doctor if you believe you have psoriasis. Theyll be able to provide treatment options and coping methods.

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Types of Psoriasis: Pictures, Symptoms and Treatments - Healthline

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Regenerative Medicine Advanced Therapy Designation | FDA

Posted: at 2:29 pm

As described in Section 3033 of the 21st Century Cures Act, a drug is eligible for regenerative medicine advanced therapy (RMAT) designation if:

Based on FDAs interpretation of Section 506(g) of the Federal Food, Drug, and Cosmetic Act (as added by Section 3033 of the 21st Century Cures Act), certain human gene therapies and xenogeneic cell products may also meet the definition of a regenerative medicine therapy. For more information on FDAs definition of regenerative medicine therapies, refer to the Guidance for Industry, Expedited Programs for Regenerative Medicine Therapies for Serious Conditions.

The request for RMAT designation must be made either concurrently with submission of an Investigational New Drug application (IND) or as an amendment to an existing IND. We will not grant a RMAT designation if an IND is on hold or is placed on hold during the designation review.

You may submit a request for RMAT designation to:

Food and Drug AdministrationCenter for Biologics Evaluation and ResearchOffice of Tissues and Advanced TherapiesDocument Control Center10903 New Hampshire AvenueWO71, G112Silver Spring, MD 20993-0002

If the RMAT designation request is submitted to your IND as an amendment, the cover letter should specify that the submission contains a REQUEST FOR REGENERATIVE MEDICINE ADVANCED THERAPY DESIGNATION in bold, uppercase letters. If the request is submitted with an initial IND, the cover letter should specify that the submission contains both an INITIAL INVESTIGATIONAL NEW DRUG SUBMISSION and REQUEST FOR REGENERATIVE MEDICINE ADVANCED THERAPY DESIGNATION in bold, upper case letters.

No later than 60 calendar days after receipt of the designation request, the Office of Tissues and Advanced Therapies (OTAT) will notify the sponsor as to whether RMAT designation has been granted. If OTAT determines that the RMAT designation request was incomplete or that the drug development program does not meet the criteria for RMAT designation, OTAT will include a written description of the rationale for such determination.

10/06/2021

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Regenerative Medicine Advanced Therapy Designation | FDA

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Gohmert: Without a change to how children are taught, ‘We’re going to have to get rid of the Second Amendment’ – Fox News

Posted: at 2:27 pm

Gohmert: Without a change to how children are taught, 'We're going to have to get rid of the Second Amendment' Fox News

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Gohmert: Without a change to how children are taught, 'We're going to have to get rid of the Second Amendment' - Fox News

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Minim, Inc. and Cadence Connectivity, Inc. Enter Second Amendment to Loan and Security Agreement with Silicon Valley Bank – Marketscreener.com

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Minim, Inc. and Cadence Connectivity, Inc. Enter Second Amendment to Loan and Security Agreement with Silicon Valley Bank Marketscreener.com

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Ukraine war live updates: Latest news on Russia and the war in Ukraine

Posted: at 2:24 pm

U.S. to expand combat training for Ukrainian troops

US Chairman of the Joint Chiefs of Staff, General Mark Milley, US Defence Secretary Lloyd J. Austin III, Lloyd Austin and Ukrainian Defence Minister Oleksiy Reznikov on October 12, 2022 in Brussels, Belgium. The North Atlantic Council (NAC) at the level of Defence Ministers convene at the NATO headquarters in Brussels for a two-day summit as the war in Ukraine continues into a seventh month.

Omar Havana | Getty Images

The Pentagon will expand military combat training for Ukrainian forces, using the slower winter months to instruct larger units in more complex battle skills, U.S. officials said.

The U.S. has already trained about 3,100 Ukrainian troops on how to use and maintain certain weapons and other equipment, including howitzers, armored vehicles and the High Mobility Artillery Rocket System, known as HIMARS. But senior military leaders for months have discussed expanding that training, touting the need to improve the ability of Ukraine's company- and battalion-sized units to move and coordinate attacks across the battlefield.

A battalion can include as many as 800 troops; a company is much smaller, with a couple hundred forces.

According to officials, the training will take place at the Grafenwoehr training area in Germany. And the aim is to use the winter months to hone the skills of the Ukrainian forces so they will be better prepared to counter any spike in Russian attacks or efforts to expand Russia's territorial gains.

Associated Press

European Council President Charles Michel and Ukrainian Prime Minister Denys Shmyhal attend a news briefing, as Russia's attack on Ukraine continues, in Odesa, Ukraine May 9, 2022.

Ukrainian Governmental Press Service | Reuters

The European Union said it approved a new package of sanctions aimed at ramping up pressure on Russia for its war in Ukraine.

The package, whose details have not been revealed, was approved after days of deliberations during a meeting of the 27-nation bloc's ambassadors.

The Czech Republic, which holds the rotating presidency of the EU Council, said the package will be confirmed by written procedure on Friday. Details will then be published in the bloc's legal records.

The European Commission, the EU's executive branch, last week proposed travel bans and asset freezes on almost 200 more Russian officials and military officers as part of the new round of measures.

The targets of the latest recommended sanctions included government ministers, lawmakers, regional governors and political parties.

Associated Press

The Malta flagged bulk carrier Zante en-route to Belgium transits the Bosphorus carrying 47,270 metric tons of rapeseed from Ukraine after being held at the entrance of the Bosphorus due to Russia pulling out of the Black Sea Grain agreement on November 02, 2022 in Istanbul, Turkey.

Chris Mcgrath | Getty Images

Four ships carrying wheat and vegetable oil have left ports in Ukraine, the organization managing agricultural exports from the country said.

The ships are destined for India and Turkey.

TheBlack Sea Grain Initiative, a deal brokered in July among Ukraine, Russia, Turkey and the United Nations, saw three key Ukrainian ports reopen after a Russian naval blockade stopped exports for months. More than 13.9 million tons of grain and other products have left Ukraine since the agreement took effect.

The deal among the signatories is set to expire in about three months.

Amanda Macias

Under-Secretary-General for Humanitarian Affairs and Emergency Relief Coordinator Martin Griffiths speaks during an interview with Reuters, amid Russia's attack on Ukraine, in Kyiv, Ukraine December 15, 2022.

Stringer | Reuters

United Nations aid chief Martin Griffiths said it was unlikely the Black Sea grain deal would be expanded in the near term to include more Ukrainian ports or reduce inspection times.

Kyiv has called for an expansion of the deal with Moscow which was mediated by the United Nations and Turkey and allows Ukraine, a major global grain exporter, to ship food products from three of its Black Sea ports despite Russia's invasion.

"I don't see that happening in the next, near term," the U.N. under-secretary-general for humanitarian affairs and emergency relief coordinator told Reuters in an interview in the Ukrainian capital.

"I think it would be great if it could be expanded, the more grain that gets out into the world, the better clearly from our point of view, from the world's point of view. But I don't think that's immediately likely."

Reuters

Ukrainians take shelter from Russian attacks in Bakhmut, Ukraine.

Ukrainian civilians cross a bridge in Bakhmut, Ukraine on December 15, 2022.