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Daily Archives: November 23, 2022
Should You Be Adding SBM Offshore (AMS:SBMO) To Your Watchlist Today? – Simply Wall St
Posted: November 23, 2022 at 4:32 am
Should You Be Adding SBM Offshore (AMS:SBMO) To Your Watchlist Today? Simply Wall St
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Atopic eczema – NHS
Posted: at 4:30 am
Atopic eczema (atopic dermatitis) is the most common form of eczema, a conditionthat causes the skin to become itchy, dry and cracked.
Atopic eczema is more common in children, often developing before their first birthday. But it may also develop for the first time in adults.
It's usually a long-term (chronic) condition, although it can improve significantly, or even clear completely, in some children as they get older.
Atopic eczemacauses the skin to become itchy, dry, cracked and sore.
Some people only have small patches of dry skin, but others may experience widespread inflamed skin all over the body.
Inflamed skin can become red on lighter skin, and darker brown, purple or grey on darker skin. This can also be more difficult to see on darker skin.
Although atopic eczema can affect any part of the body,it most often affects the hands, insides of the elbows, backs of the knees and the face and scalp in children.
People with atopic eczema usuallyhave periods when symptoms are less noticeable, as well as periods when symptoms become more severe (flare-ups).
See a GP if you have symptoms of atopic eczema. They'll usually be able to diagnose atopic eczema by looking at your skin and asking questions, such as:
Typically, to be diagnosed with atopic eczema you should have had an itchy skin condition in the last 12 months and 3 or more of the following:
The exact cause of atopic eczema is unknown, but it's clear it is not down to one single thing.
Atopic eczema often occurs in people who get allergies. "Atopic" means sensitivity to allergens.
Itcan run in families, and oftendevelops alongside other conditions, such asasthma and hay fever.
The symptoms of atopic eczemaoften have certaintriggers, such as soaps, detergents, stress and the weather.
Sometimesfood allergies can play a part, especially in young children with severe eczema.
You may be asked to keep a food diaryto try to determine whether a specific food makes your symptoms worse.
Allergy testsare not usually needed, although they're sometimes helpful in identifyingwhether a food allergy may be triggering symptoms.
Treatment for atopic eczema canhelp to relieve the symptoms and many cases improve over time.
Butthere's currently no cure andsevere eczema often has a significant impact on daily life, whichmay be difficult tocope with physically and mentally.
There's also an increased risk of skin infections.
Many different treatments can be used to control symptoms and manage eczema, including:
Eczema is the name for a group of skin conditions that cause dry, irritated skin.
Other types of eczema include:
Page last reviewed: 05 December 2019Next review due: 05 December 2022
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Seborrheic dermatitis – Symptoms and causes – Mayo Clinic
Posted: at 4:30 am
Overview Seborrheic dermatitis on the face Open pop-up dialog box
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Seborrheic dermatitis causes a rash of oily patches with yellow or white scales. The rash may look darker or lighter in people with brown or Black skin and redder in those with white skin.
Seborrheic (seb-o-REE-ik) dermatitis is a common skin condition that mainly affects your scalp. It causes scaly patches, inflamed skin and stubborn dandruff. It usually affects oily areas of the body, such as the face, sides of the nose, eyebrows, ears, eyelids and chest. This condition can be irritating but it's not contagious, and it doesn't cause permanent hair loss.
Seborrheic dermatitis may go away without treatment. Or you may need to use medicated shampoo or other products long term to clear up symptoms and prevent flare-ups.
Seborrheic dermatitis is also called dandruff, seborrheic eczema and seborrheic psoriasis. When it occurs in infants, it's called cradle cap.
Seborrheic dermatitis signs and symptoms may include:
The signs and symptoms of seborrheic dermatitis tend to flare with stress, fatigue or a change of season.
See your health care provider if:
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The exact cause of seborrheic dermatitis isn't clear. It may be due to the yeast Malassezia, excess oil in the skin or a problem in the immune system.
Risk factors for seborrheic dermatitis include:
Sept. 27, 2022
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Seborrheic dermatitis - Symptoms and causes - Mayo Clinic
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Oatmeal skincare is the perfect solution for sensitive skin (+ best products to try) – Lifestyle Asia Singapore
Posted: at 4:30 am
Oatmeal skincare is the perfect solution for sensitive skin (+ best products to try) Lifestyle Asia Singapore
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Democrat Hassan Claims Gen. Bolduc’s Attacker Was Libertarian Activist
Posted: at 4:29 am
Republican Gen. Don Bolduc (R-NH) was physically attacked by a libertarian activist before Wednesdays debate, according to opponent Sen. Maggie Hassans (D-NH) campaign staff.
Hassans campaign communications director Kevin Donohoetweetedthat the assailantwhophysically attacked the general outside last nights debate was a Libertarian activist.
Kate Constantini, Bolduc for Senate spokeswoman, told Breitbart News that law enforcement was quickly on the scene and apprehended the individual.
Prior to the debate, an individual in the crowd gathered outside attempted to punch the General and was quickly apprehended and arrested,Constantiniexplained. We are grateful to the quick response from law enforcement on the scene, she said about theGoffstown police department.
As the General said on stage tonight, its time to lower the temperature of the political discourse in this country,she added.
DERRY, NH OCTOBER 15: Republican senate nominee Don Bolduc shakes hands with attendees during a campaign event on October 15, 2022 in Derry, New Hampshire. Bolduc, and Army General who won the GOP primary will take on Sen. Maggie Hassan (D) in November. (Photo by Scott Eisen/Getty Images)
The attack occurred without mention from the debate moderators or WMUR ABC, even though the attack occurred before the debate. The network asked candidates about the rise in violence against politicians, mentioning January 6 and the attack against Paul Pelosi, but failed to mention the incident that occurred minutes before against the Republican candidate.
The debate took place one hour before President Joe Biden condemned Republicans for political violence in a speech at Union Station in Washington, D.C.
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Democrat Hassan Claims Gen. Bolduc's Attacker Was Libertarian Activist
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Foreign Policy | Libertarian Party
Posted: at 4:29 am
The United States relies too heavilyon our military might in foreign policy. For more than a decade, our country has been waging active wars in the Middle East. This has left our military tired, with several thousand dead, and many more thousands wounded physically and mentally.
A decade ago, the United States entered into nation building thinking that it would help improve corners of the world that terrorists find opportunistic. Sadly, some of the nation building which our country entered into with genuinely good intentions has backfired. We now know that no matter how sophisticated our military is and no matter how much money we spend, nation building is far more complicated that we originally thought. Additionally, it may likely create more terrorists than it quells.
Imagine if China had a military base in Montana. Or Russia had a military base in Texas. How would Americans feel about that? We would likely feel insulted, oppressed, and mad. Some Americans would likely seek to actively opposed those bases. And the escalation would continue. That is what we have seen in the Middle East with our involvement there.
Libertarians believe that war is justified only in defense. We are opposed to a draft. If a war is just and necessary, Americans of all backgrounds will volunteer to fight it. We believe that a draft enforced by law is no different from slavery.
Libertarians believe that American foreign policy should focus more heavily on developing communications among peoples and finding peaceful resolutions to disagreements. We believe in maintaining a military that can defend us well if we are attacked and we believe part of that is ensuring that our troops are not so war-weary as they have been in recent years.
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Medicine MBChB – University Of Worcester
Posted: at 4:28 am
A week in the life of a medical student A week in the life of a Three Counties Medical School student - Phase One
At the start of each week you will need to read the Study Guide which sets out the learning outcomes and learning opportunities for the week. On Monday the first formal session is in a lecture format and is called Map Reading because the tutor will go through the journey planned for the week - where you will go, what you will see and what you will bring back home.
The next session is Problem Based Learning (PBL). Here you will be in a group of about eight students with a facilitator who is a doctor. The facilitator is not there to teach; indeed, he or she will spend most of the time listening.
You will be discussing two or three Presentations, realistic patient scenarios that a doctor might encounter.
The aim is to identify what you know and what you do not know in order to understand the problem or problems (there are usually several) that the patient presents. The facilitator will keep you on track. The Presentations are carefully constructed to point to the learning required in the week. You will end up with a number of learning outcomes, things you dont know or understand.
The next session is learning about the consultation, the key interaction between doctor and patient. This will be either talking to a simulated patient (usually an actor) or performing a physical examination. This will be examining each other but we have guidelines on how this is done to avoid embarrassment.
Most of the rest of the week is about finding out the answers to the questions posed in the PBL groups. Some of this is in the form of a carousel where you will learn about normal and abnormal structure and function. This might include anatomical models or images. Another is called applied physiology and procedural skills where you will learn skills and procedures such as venepuncture. These are all linked to the learning outcomes for the week and the PBL presentations.
One week in three you will be on a placement in primary care where you are likely to meet patients with similar problems to those in the PBL group and discuss your progress with the Year Long Case Studies.
At the end of the week there is a wrap up session where we all go back to the Map and see what we have learned. Then its another PBL session where you discuss what you have learned; do we all now understand the Presentations, is there anything else we dont know? We then have another session on the consultation.
Every week will be as varied as the patients but here are some of the experiences you can expect. Not all will happen each week!
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Medicine MBChB - University Of Worcester
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Republic of Florence – Wikipedia
Posted: at 4:28 am
City-state on the Apennine Peninsula between 1115 and 1569
The Republic of Florence, officially the Florentine Republic (Italian: Repubblica Fiorentina, pronounced[repubblika fjorentina], or Repubblica di Firenze), was a medieval and early modern state that was centered on the Italian city of Florence in Tuscany.[1] The republic originated in 1115, when the Florentine people rebelled against the Margraviate of Tuscany upon the death of Matilda of Tuscany, who controlled vast territories that included Florence. The Florentines formed a commune in her successors' place.[3] The republic was ruled by a council known as the Signoria of Florence. The signoria was chosen by the gonfaloniere (titular ruler of the city), who was elected every two months by Florentine guild members.
During the Republic's history, Florence was an important cultural, economic, political and artistic force in Europe. Its coin, the florin, became a world monetary standard.[4] During the Republican period, Florence was also the birthplace of the Renaissance, which is considered a fervent period of European cultural, artistic, political and economic rebirth.[5]
The republic had a checkered history of coups and countercoups against various factions. The Medici faction gained governance of the city in 1434 under Cosimo de' Medici. The Medici kept control of Florence until 1494. Giovanni de' Medici (later Pope Leo X) reconquered the republic in 1512.
Florence repudiated Medici authority for a second time in 1527, during the War of the League of Cognac. The Medici reassumed their rule in 1531 after an 11-month siege of the city, aided by Emperor CharlesV. Pope ClementVII, himself a Medici, appointed his relative Alessandro de' Medici as the first "Duke of the Florentine Republic", thereby transforming the Republic into a hereditary monarchy.
The second Duke, CosimoI, established a strong Florentine navy and expanded his territory, conquering Siena. In 1569, the pope declared Cosimo the first grand duke of Tuscany. The Medici ruled the Grand Duchy of Tuscany until 1737.
The city of Florence was established in 59 BC by Julius Caesar. Since 846 AD, the city had been part of the Marquisate of Tuscany. After the female ruler of the marquisate, Matilda of Tuscany, died in 1115, the city did not submit readily to her successor Rabodo (r. 11161119), who was killed in a dispute with the city.
It is not known precisely when Florence formed its own republican/oligarchical government independent of the marquisate, although the death of Rabodo in 1119 should be a turning point. The first official mention of the Florentine republic was in 1138, when several cities around Tuscany formed a league against Henry X of Bavaria. The country was nominally part of the Holy Roman Empire.[3]
According to a study carried out by Enrico Faini of the University of Florence,[8] there were about fifteen old aristocratic families who moved to Florence between 1000 and 1100: Amidei; Ardinghi; Brunelleschi; Buondelmonti; Caponsacchi; Donati; Fifanti; Gherardini of Montagliari; Guidi; Nerli; Porcelli; Sacchetti; Scolari; Uberti; and Visdomini.
The newly independent Florence prospered in the 12th century through extensive trade with foreign countries. This, in turn, provided a platform for the demographic growth of the city, which mirrored the rate of construction of churches and palazzi. This prosperity was shattered when Emperor Frederick I Barbarossa invaded the Italian peninsula in 1185. As a result, the margraves of Tuscany re-acquired Florence and its townlands. The Florentines re-asserted their independence when Holy Roman Emperor Henry VI died in 1197.[3]
Florence's population continued to grow into the 13th century, reaching a level of 30,000 inhabitants. As has been said, the extra inhabitants supported the city's trade and vice versa. Several new bridges and churches were built, most prominently the cathedral of Santa Maria del Fiore, begun in 1294. The buildings from this era serve as Florence's best examples of Gothic Architecture. Politically, Florence was barely able to maintain peace between its competing factions. The precarious peace that existed at the beginning of the century was destroyed in 1216 when two factions, known as the Guelphs and the Ghibellines, began to war. The Ghibellines were supporters of the noble rulers of Florence, whereas the Guelphs were populists.
The Ghibellines, who had ruled the city under Frederick of Antioch since 1244, were deposed in 1250 by the Guelphs. The Guelphs led Florence to prosper further. Their primarily mercantile orientation soon became evident in one of their earliest achievements: the introduction of a new coin, the florin, in 1252. It was widely used beyond Florence's borders due to its reliable, fixed gold content and soon became one of the common currencies of Europe and the Near East. The same year saw the creation of the Palazzo del Popolo.[9] The Guelphs lost the reins of power after Florence suffered a catastrophic defeat at the Battle of Montaperti against Siena in 1260. The Ghibellines resumed power and undid many of the advances of the Guelphs, for example the demolition of hundreds of towers, homes, and palaces. The fragility of their rule caused the Ghibellines to seek out an arbitrator in the form of Pope Clement IV, who openly favoured the Guelphs, and restored them to power.
The Florentine economy reached a zenith in the latter half of the 13th century, and its success was reflected by the building of the famed Palazzo della Signoria, designed by Arnolfo di Cambio. The Florentine townlands were divided into administrative districts in 1292. In 1293, the Ordinances of Justice were enacted, which effectively became the constitution of the republic of Florence throughout the Italian Renaissance.[10] The city's numerous luxurious palazzi were becoming surrounded by townhouses built by the ever prospering merchant class.[3] In 1298, the Bonsignori family of Siena, one of the leading banking families of Europe, went bankrupt, and the city of Siena lost its status as the most prominent banking center of Europe to Florence.
In 1304, the war between the Ghibellines and the Guelphs led to a great fire that destroyed much of the city. Napier gives the following account:
Battles first began between the Cerchi and Giugni at their houses in the Via del Garbo; they fought day and night, and with the aid of the Cavalcanti and Antellesi the former subdued all that quarter: a thousand rural adherents strengthened their bands, and that day might have seen the Neri's destruction if an unforeseen disaster had not turned the scale. A certain dissolute priest, called Neri Abati, prior of San Piero Scheraggio, false to his family and in concert with the Black chiefs, consented to set fire to the dwellings of his own kinsmen in Orto-san-Michele; the flames, assisted by faction, spread rapidly over the richest and most crowded part of Florence: shops, warehouses, towers, private dwellings and palaces, from the old to the new market-place, from Vacchereccia to Porta Santa Maria and the Ponte Vecchio, all was one broad sheet of fire: more than nineteen hundred houses were consumed; plunder and devastation revelled unchecked amongst the flames, whole races were reduced in one moment to beggary, and vast magazines of the richest merchandise were destroyed. The Cavalcanti, one of the most opulent families in Florence, beheld their whole property consumed, and lost all courage; they made no attempt to save it, and, after almost gaining possession of the city, were finally overcome by the opposite faction.
The golden florin of the Republic of Florence was the first European gold coin struck in sufficient quantities to play a significant commercial role since the 7th century. As many Florentine banks were international companies with branches across Europe, the florin quickly became the dominant trade coin of Western Europe for large scale transactions, replacing silver bars in multiples of the mark (a weight unit equal to eight ounces).
In fact, with the collapse of the Bonsignori family[it], several new banking families sprang up in Florence: the Bardis, Peruzzis and the Acciaioli. The friction between the Guelphs and the Ghibellines did not cease, authority still passed between the two frequently.
Florence's reign as the foremost banking city of Europe did not last long; the aforesaid families were bankrupt in 1340, not because of Edward III of England's refusal to pay his debts, as is often stated (the debt was just 13,000) but because of a Europe-wide economic recession. While the banks perished, Florentine literature flourished, and Florence was home to some of the greatest writers in Italian history: Dante, Petrarch and Boccaccio. They were Europe's first vernacular writers, choosing the Tuscan dialect of Italian (which, as a result, evolved into the standard Italian language) over Latin.
Florence was hit hard by the Black Death. Having originated in the Orient, the plague arrived in Messina in 1347. The plague devastated Europe, robbing it of an estimated 1/3 of its population. This, combined with the economic downturn, took its toll on the city-state. The ensuing collapse of the feudal system changed the social composition of Europe forever; it was one of the first steps out of the Middle Ages.
The war with Avignon papacy strained the regime. In 1378 discontented wool workers revolted. The Ciompi revolt, as it is known, established a revolutionary commune. In 1382 the wealthier classes crushed the seeds of rebellion.
The famous Medici bank was established by Giovanni di Bicci de' Medici in October 1397. The bank continued to exist (albeit in an extremely diminished form) until the time of Ferdinando II de'Medici in the 17th century. But, for now, Giovanni's bank flourished.
Beginning in 1389, Gian Galeazzo Visconti of Milan expanded his dominion into the Veneto, Piedmont, Emilia and Tuscany. During this period Florence, under the leadership of Maso degli Albizzi and Niccol da Uzzano was involved in three wars with Milan (139092, 139798, 140002). The Florentine army, commanded by John Hawkwood, contained the Milanese during the first war.[17] The second war started in March 1397. Milanese troops devastated the Florentine contado, but were checked in August of that year.
The war expenses exceeded one million florins and necessitated tax raises and forced loans. A peace agreement in May 1398 was brokered by Venice, but left the struggle unresolved. Over the next two years Florentine control of Tuscany and Umbria collapsed. Pisa and Siena as well as a number of smaller cities submitted to Gian Galeazzo, while Lucca withdrew from the anti-Visconti league, with Bologna remaining the only major ally. In November 1400 a conspiracy involving both exiles and internal opponents was uncovered. Two Ricci were implicated as leaders of a plot to eliminate the regime's inner circle and open the gates to the Milanese. Confessions indicated that the plan had wide support among the elites, including a Medici and several of the Alberti.
The republic bankrolled the emperor-elect Rupert. However, he was defeated by the Milanese in the fall of 1401. Visconti then turned to Bologna. On June 26, 1402, combined Bolognese-Florentine forces were routed atCasalecchio, near Bologna, which was taken on the 30th. The road to Tuscany was open. However, Florence was saved after an outbreak of plague had spread from Tuscany to Emilia and Lombardy: Gian Galeazzo died from it on 3 September 1402.[17]
The Visconti domains were divided between three heirs. Gabriele Maria Visconti sold Pisa to the Republic of Florence for 200,000 florins. Since the Pisans did not intend to voluntarily submit to their long-time rivals, the army under Maso degli Albizzi took Pisa on 9 October 1406 after a long siege, that was accompanied by numerous atrocities.[17]
The state authorities had been approached by the Duchy of Milan in 1422, with a treaty, that prohibited Florence's interference with Milan's impending war with the Republic of Genoa.Florence obliged, but Milan disregarded its own treaty and occupied a Florentine border town. The conservative government wanted war, while the people bemoaned such a stance as they would be subject to enormous tax increases. The republic went to war with Milan, and won, upon the Republic of Venice's entry on their side. The war was concluded in 1427, and the Visconti of Milan were forced to sign an unfavourable treaty.
The debt incurred during the war was gargantuan, approximately 4,200,000 florins. To pay, the state had to change the tax system. The current estimo system was replaced with the catasto. The catasto was based on a citizen's entire wealth, while the estimo was simply a form of income tax. Apart from war, Filippo Brunelleschi created the renowned dome of the Santa Maria del Fiore, which astounded contemporaries and modern observers alike.
The son of Giovanni di Bicci de' Medici, Cosimo de' Medici succeeded his father as the head of the Medici Bank. He played a prominent role in the government of Florence until his exile in 1433, after a disastrous war with Tuscany's neighbour, the Republic of Lucca. Cosimo's exile in Venice lasted for less than a year, when the people of Florence overturned Cosimo's exile in a democratic vote. Cosimo returned to the acclaim of his people and the banishment of the Albizzi family, who had exiled him.
The Renaissance began during Cosimo's de facto rule of Florence, the seeds of which had arguably been laid before the Black Death tore through Europe. Niccol Niccoli was the leading Florence humanist scholar of the time. He appointed the first Professor of Greek, Manuel Chrysoloras (the founder of Hellenic studies in Italy), at the University of Florence in 1397. Niccoli was a keen collector of ancient manuscripts, which he bequeathed to Cosimo upon his death in 1437. Poggio Bracciolini succeeded Niccoli as the principal humanist of Florence. Bracciolini was born Arezzo in 1380. He toured Europe, searching for more ancient Greco-Roman manuscripts for Niccoli. Unlike his employer, Bracciolini also authored his own works. He was made the Chancellor of Florence shortly before his death, by Cosimo, who was his best friend.
Florence hosted the Great Ecumenical Council in 1439; this council was launched in an attempt to reconcile the Byzantine Eastern Orthodox Church with Roman Catholicism. Pope Eugenius IV convened it in reply to a cry for assistance from the Emperor of the Eastern Roman Empire (also known as the Byzantine Empire) John VIII Palaiologos. John VIII's empire was slowly being devoured by the Ottoman Turks.The council was a huge boost to Florence's international prestige. The council deliberated until July 1439. Both parties had reached a compromise, and the Pope agreed to militarily aid the Byzantine Emperor. However, upon John VIII's homecoming to Constantinople, the Greeks rejected the compromise, leading to riots throughout what remained of the Byzantine Empire. John VIII was forced to repudiate the agreement with the Roman church to appease the rioters. As a result, no Western aid was forthcoming and the Byzantine Empire's fate was sealed. Fourteen years later in 1453, Constantinople fell to the Ottomans.
Cosimo's fervent patronage transformed Florence into the epitome of a Renaissance city. He employed Donatello, Brunelleschi, and Michelozzo. All these artistic commissions cost Cosimo over 600,000 florins.
Foreign relations, both as a backdrop to Cosimo's rise to power and during first twenty years of his rule, were dominated by the Wars in Lombardy. This series of conflicts between the Venetian Republic and the Duchy of Milan for hegemony in Northern Italy lasted from 1423 to 1454 and involved a number of Italian states, that occasionally switched sides according to their changing interests. Filippo Maria Visconti of Milan invaded Florence twice in the 1430s, and again in 1440, but his army was finally defeated in the battle of Anghiari. The Milanese invasions were largely instigated by the exiled Albizzi family. Death of Filippo Maria in 1447 led to a major change in the alliances. In 1450 Cosimo's current ally Francesco Sforza established himself as the Duke of Milan. Florentine trade interests made her support Sforza's Milan in the war against Venice, while the fall of Constantinople in 1453 dealt a blow to Venetian finances. Eventually, the Peace of Lodi recognized Venetian and Florentine territorial gains and the legitimacy of the Sforza rule in Milan.[28] The Milan-Florence alliance played a major role in stabilizing the peninsula for the next 40 years.
The political crisis of 1458 was the first serious challenge to the Medici rule. The cost of wars had been borne by the great families of Florence, and disproportionately so by Medici's opponents. A number of them (Serragli, Baroncelli, Mancini, Vespucci, Gianni) were practically ruined and had to sell their properties, and those were acquired by Medici's partisans at bargain prices. The opposition used partial relaxation of Medici control of the republic institutions to demand political reforms, freedom of speech in the councils and a greater share in the decision-making. Medici's party response was to use threats of force from private armies and Milanese troops and arranging a popular assembly dominated by Cosimo's supporters. It exiled the opponents of the regime and introduced the open vote in councils, "in order to unmask the anti-Medician rebels".[28]
From 1458 Cosimo withdrew from any official public role, but his control of Florence was greater than ever. In the spring of 1459 he entertained the new pope Pius II, who stopped in Florence on his way to the Council of Mantua to declare a crusade against the Ottomans, and Galeazzo Maria Sforza, Francesco's son, who was to escort the pope from Florence to Mantua. In his memoirs, Pius said that Cosimo "was considered the arbiter of war and peace, the regulator of law; less a citizen than master of his city. Political councils were held in his home; the magistrates he chose were elected; he was king in all but name and legal status. Some asserted that his tyranny was intolerable."
Piero the Gouty was the eldest son of Cosimo. Piero, as his sobriquet the gouty implies, suffered from gout and did not enjoy good health. Lorenzo the Magnificent was Piero's eldest son by his wife Lucrezia Tornabuoni. Piero's reign furthered the always fractious political divisions of Florence when he had called up huge debts owed to the Medici Bank. These debts were owed primarily by a Florentine nobleman, Luca Pitti. Lucca called for an armed insurrection against Piero, but a co-conspirator rebutted this. Duke Francesco Sforza of Milan died in 1466, and his son Galeazzo Maria Sforza became the new Milanese duke. With the death of Francesco Sforza, Florence lost a valuable ally among the other Italian states.
In August 1466, the conspirators acted. They received support from the Duke of Ferrara, who marched troops into the Florentine countryside with the intent of deposing Piero. The coup failed. The Florentines were not willing to support it, and soon after their arrival, Ferrara's troops left the city. The conspirators were exiled for life. While the internal problems were fixed, Venice took the opportunity to invade Florentine territory in 1467. Piero appointed Federigo da Montefeltro, Lord of Urbino, to command his mercenaries. An inconclusive battle ensued, with the Venetians forces retreating. In the winter of 1469 Piero died.
Lorenzo succeeded his father, Piero. Lorenzo, as heir, was accordingly groomed by his father to rule over Florence.
Lorenzo was the greatest artistic patron of the Renaissance. He patronised Leonardo da Vinci, Michelangelo and Botticelli, among others. During Lorenzo's reign, the Renaissance truly descended on Florence. Lorenzo commissioned a multitude of amazing pieces of art and also enjoyed collecting fine gems. Lorenzo had many children with his wife Clarice Orsini, including the future Pope Leo X and his eventual successor in Florence, Piero the Unfortunate.
Lorenzo's brother Giuliano was killed before his own eyes in the Pazzi conspiracy of 1478. This plot was instigated by the Pazzi family. The coup was unsuccessful, and the conspirators were executed in a very violent manner. The scheme was supported by the Archbishop of Pisa, Francesco Salviati, who was also executed in his ceremonial robes. News of this sacrilege reached Pope Sixtus IV (who had also supported the conspiracy against the Medicis). Sixtus IV was "outraged" and excommunicated everyone in Florence. Sixtus sent a papal delegation to Florence to arrest Lorenzo. The people of Florence were obviously enraged by the Pope's actions, and the local clergy too. The populace refused to resign Lorenzo to the papal delegation. A war followed, which lasted for two years until Lorenzo tactfully went about diplomatically securing a peace. Lorenzo died in 1492 and was succeeded by his son Piero.
Piero ruled Florence for a mere two years. Charles VIII of France invaded Italy in September 1494. He demanded passage through Florence to Naples, where he intended to secure the throne for himself. Piero met Charles at the fringes of Florence to try and negotiate. Piero capitulated to all Charles' demands, and upon arriving back in the city in November, he was branded as a traitor. He was forced to flee the republic with his family.
After the fall of the Medici, Girolamo Savonarola ruled the state. Savonarola was a priest from Ferrara. He came to Florence in the 1480s. By proclaiming predictions and through vigorous preaching, he won the people to his cause. Savonarola's new government ushered in democratic reforms. It allowed many exiles back into Florence, who were banished by the Medici. Savonarola's ulterior goal, however, was to transform Florence into a "city of god". Florentines stopped wearing garish colours, and many women took oaths to become nuns. Savonarola became most famous for his "Bonfire of the Vanities", where he ordered all "vanities" to be gathered and burned. These included wigs, perfume, paintings, and ancient pagan manuscripts.[45]Savonarola's rule collapsed a year later. He was excommunicated by Pope Alexander VI in late 1497. In the same year, Florence embarked on a war with Pisa, which had been de facto independent since Charles VIII's invasion three years before. The endeavour failed miserably, and this led to food shortages. That, in turn, led to a few isolated cases of the plague. The people blamed Savonarola for their woes, and he was tortured and executed in the Piazza della Signoria by being burned at the stake by Florentine authorities, in May 1498.
In 1502, the Florentines chose Piero Soderini as their first ruler for life. Soderini succeeded where Savonarola had failed, when the Secretary of War, Niccol Machiavelli, recaptured Pisa. It was at this time that Machiavelli introduced a standing army in Florence, replacing the traditional use of hired mercenaries.
Soderini was repudiated in September 1512, when Cardinal Giovanni de' Medici captured Florence with Papal troops during the War of the League of Cambrai. The Medici rule of Florence was thus restored.
Soon after retaking Florence, Cardinal Giovanni de' Medici was recalled to Rome. Pope Julius II had just died, and he needed to be present for the ensuing Papal conclave. Giovanni was elected Pope, taking the name Leo X. This effectively brought the Papal States and Florence into a political union. Leo X ruled Florence by proxy, first appointing his brother Giuliano de' Medici to rule in his stead, and then in 1513, replacing Giuliano with his cousin, Lorenzo II de' Medici.[50]
Lorenzo II's government proved unpopular in Florence.[50] According to U.S. President and historian John Adams, "at this time the citizens of the state of Florence were in secret very discontented, because the Duke Lorenzo, desiring to reduce the government to the form of a principality, appeared to disdain to consult any longer with the magistrates and his fellow-citizens as he used to do, and gave audiences very seldom, and with much impatience; he attended less to the business of the city, and caused all public affairs to be managed by Messer Goro da Pistoia, his secretary."[50] In 1519, Lorenzo died from syphilis, shortly before his wife gave birth to Catherine de' Medici, the future Queen of France.[51]
Following the death of Lorenzo II, Cardinal Giulio de' Medici governed Florence until 1523, when he was elected Pope Clement VII. U.S. President John Adams later characterized his administration of Florence as "very successful and frugal."[50] Adams chronicles Cardinal Giulio as having "reduced the business of the magistrates, elections, customs of office, and the mode of expenditure of public money, in such a manner that it produced a great and universal joy among the citizens."[50]
On the death of Pope Leo X in 1521, Adams writes there was a "ready inclination in all of the principal citizens [of Florence], and a universal desire among the people, to maintain the state in the hands of the Cardinal de' Medici; and all this felicity arose from his good government, which since the death of the Duke Lorenzo, had been universally agreeable."[50]
When Cardinal Giulio was elected Pope Clement VII, he appointed Ippolito de' Medici and Alessandro de' Medici to rule Florence, under the guardianship of Cardinal Passerini. Ippolito was the son of Giuliano de' Medici, while Alessandro was allegedly the son of Clement VII. Cardinal Passerini's regency government proved highly unpopular.[53]
In May 1527, Rome was sacked by the Holy Roman Empire. The city was destroyed, and Pope Clement VII was imprisoned. During the tumult, a faction of Republicans drove out the Medici from Florence. A new wave of Puritanism swept through the city. Many new restricting fundamentalist laws were passed.
In 1529, Clement VII signed the Treaty of Barcelona with Charles V, under which Charles would, in exchange for the Pope's blessing, invade Florence and restore the Medici. They were restored after a protracted siege.
Following the Republic's surrender in the Siege of Florence, Charles V, Holy Roman Emperor issued a proclamation explicitly stating that he and he alone could determine the government of Florence. On 12 August 1530, the Emperor created the Medici hereditary rulers (capo) of the Republic of Florence. The title "Duke of the Florentine Republic" was chosen because it would bolster Medici power in the region.
Pope Clement VII intended his relative Alessandro de' Medici[a] to be the ruler of Florence, but also wanted to give the impression that the Florentines had democratically chosen Alessandro as their ruler. Even after Alessandro's accession in 1530 (he reigned as Duke of the Florentine Republic from 1532 on), Imperial troops remained stationed in Florence. In 1535, several prominent Florentine families, including the Pazzi (who attempted to kill Lorenzo de' Medici in the Pazzi Conspiracy) dispatched a delegation under Ippolito de' Medici, asking Charles V to depose Alessandro. Much to their dismay, the Emperor rejected their appeal. Charles had no intention of deposing Alessandro, who was married to Charles' daughter Margaret of Parma.
Alessandro continued to rule Florence for another two years until he was murdered on January 1, 1537 by his distant relative Lorenzino de' Medici.
As Alessandro left no legitimate issue, the question of succession was open. Florentine authorities selected Cosimo I in 1537. At the news of this, the exiled Strozzi family invaded and tried to depose Cosimo, but were defeated at Montemurlo.[60] Cosimo completely overhauled the bureaucracy and administration of Florence. In 1542, the Imperial troops stationed in Florence by Charles V were withdrawn.
In 1548, Cosimo was given a part of the Island of Elba by Charles V, and based his new developing navy there. Cosimo founded the port city of Livorno and allowed the city's inhabitants to enjoy freedom of religion. In alliance with Spain and the Holy Roman Empire, Cosimo defeated the Republic of Siena, which was allied with France, in the Battle of Marciano on August 2, 1554. On April 17, 1555, Florence and Spain occupied the territory of Siena, which, in July 1557 Philip II of Spain bestowed on Cosimo as a hereditary fiefdom. The ducal family moved into the Palazzo Pitti in 1560. Cosimo commissioned the architect Vasari to build the Uffizi, as offices for the Medici bank, continuing the Medici tradition of patronage of the arts.
In 1569, Cosimo was elevated to the rank of the Grand Duke of Tuscany in 1569 by Pope Pius V. This marks the end of the Florence Republic, and the beginning of the Grand Duchy of Tuscany.
Medici rule continued into the Grand Duchy of Tuscany until the family became extinct in 1737.
Florence was governed by a council called the signoria, which consisted of nine men. The head of the signoria was the gonfaloniere, who was chosen every two months in a lottery, as was his signoria. To be eligible, one had to have sound finances, no arrears or bankruptcies, he had to be older than thirty, had to be a member of Florence's seven main guilds (merchant traders, bankers, two clothe guilds, and judges). The lottery was often pre-determined, and the results were usually favourable to influential families. The roster of names in the lottery were replaced every five years.
The main organs of government were known as the tre maggiori. They were: the twelve good men, the standard bearers of the gonfaloniere, and the signoria. The first two debated and ratified proposed legislation, but could not introduce it. The gonfaloniere's initial two month-term in office was expanded upon the fall of Savonarola in 1498, to life, much like that of the Venetian doge. The signoria held meetings each day in the Palazzo della Signoria. Various committees controlled particular aspects of government, e.g. the Committee of War. For administrative purposes, Florence was divided into four districts, which were divided into four sub-districts. The main purpose of these counties was to ease the gathering of local militias.
To hold an elective office, one had to be of a family that had previously held office. The Medici family effectively ruled Florence on a hereditary basis, from 1434 to 1494, and 15121527.
After Alessandro de' Medici was installed as the "Duke of the Florentine Republic" in 1530, in April 1532, Pope Clement VII convinced the Bala, Florence's ruling commission, to draw up a new constitution, which formally created a hereditary monarchy. It abolished the age-old signoria (elective government) and the office of gonfaloniere (titular head-of-state elected for a two-month term) and replaced it with three institutions:
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Taoist sexual practices – Wikipedia
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Religious sexual practices
Taoist sexual practices (traditional Chinese: ; simplified Chinese: ; pinyin: fngzhngsh; lit. 'arts of the bedchamber') are the ways Taoists may practice sexual activity. These practices are also known as "joining energy" or "the joining of the essences". Practitioners believe that by performing these sexual arts, one can stay in good health, and attain longevity or spiritual advancement.[1][2][3]
Some Taoist sects during the Han dynasty performed sexual intercourse as a spiritual practice, called hq (, lit. "joining energy").[citation needed] The first sexual texts that survive today are those found at Mawangdui[citation needed]. While Taoism had not yet fully evolved as a philosophy at this time, these texts shared some remarkable similarities with later Tang dynasty texts, such as the Ishinp (). The sexual arts arguably reached their climax between the end of the Han dynasty and the end of the Tang dynasty[citation needed].
After AD 1000, Confucian restraining attitudes towards sexuality became stronger, so that by the beginning of the Qing dynasty in 1644, sex was a taboo topic in public life[citation needed]. These Confucians alleged that the separation of genders in most social activities existed 2,000 years ago and suppressed the sexual arts. Because of the taboo surrounding sex, there was much censoring done during the Qing in literature, and the sexual arts disappeared in public life[citation needed]. As a result, some of the texts survived only in Japan, and most scholars had no idea that such a different concept of sex existed in early China.[4]
The basis of all Taoist thinking is that qi () is part of everything in existence.[5] Qi is related to another energetic substance contained in the human body known as jing (), and once all this has been expended the body dies. Jing can be lost in many ways, but most notably through the loss of body fluids. Taoists may use practices to stimulate/increase and conserve their bodily fluids to great extents. The fluid believed to contain the most jing is semen. Therefore, Taoists believe in decreasing the frequency of, or totally avoiding, ejaculation in order to conserve life essence.[6]
Many Taoist practitioners link the loss of ejaculatory fluids to the loss of vital life force: where excessive fluid loss results in premature aging, disease, and general fatigue. While some Taoists contend that one should never ejaculate, others provide a specific formula to determine the maximum number of regular ejaculations in order to maintain health.[7][8]
The general idea is to limit the loss of fluids as much as possible to the level of your desired practice. As these sexual practices were passed down over the centuries, some practitioners have given less importance to the limiting of ejaculation. This variety has been described as "...while some declare non-ejaculation injurious, others condemn ejaculating too fast in too much haste."[8] Nevertheless, the "retention of the semen" is one of the foundational tenets of Taoist sexual practice.[9]
There are different methods to control ejaculation prescribed by the Taoists. In order to avoid ejaculation, the man could do one of several things. He could pull out immediately before orgasm, a method also more recently termed as "coitus conservatus."[10] A second method involved the man applying pressure on the perineum, thus retaining the sperm. While if done incorrectly this can cause retrograde ejaculation, the Taoists believed that the jing traveled up into the head and "nourished the brain."[11] Cunnilingus was believed to be ideal by preventing the loss of semen and vaginal liquids.
Another important concept of "the joining of the essences" was that the union of a man and a woman would result in the creation of jing, a type of sexual energy. When in the act of lovemaking, jing would form, and the man could transform some of this jing into qi, and replenish his lifeforce. By having as much sex as possible, men had the opportunity to transform more and more jing, and as a result would see many health benefits.[6]
The concept of yin and yang is important in Taoism and consequently also holds special importance in sex. Yang usually referred to the male sex, whereas yin could refer to the female sex. Man and woman were the equivalent of heaven and earth, but became disconnected. Therefore, while heaven and earth are eternal, man and woman suffer a premature death.[12] Every interaction between yin and yang had significance. Because of this significance, every position and action in lovemaking had importance. Taoist texts described a large number of special sexual positions that served to cure or prevent illness, similar to the Kama Sutra.[13]
There was the notion that men released yang during orgasm, while women shed yin during theirs. Every orgasm from the user would nourish the partner's energy.[14]
For Taoists, sex was not just about pleasing a man.[15] The woman also had to be stimulated and pleased in order to benefit from the act of sex. Sun (), female advisor to the Yellow Emperor (Huangdi), noted ten important indications of female satisfaction.[16] If sex were performed in this manner, the woman would create more jing, and the man could more easily absorb the jing to increase his own qi.[17]
According to Jolan Chang, in early Chinese history, women played a significant role in the Tao () of loving, and that the degeneration into subordinate roles came much later in Chinese history.[18] Women were also given a prominent place in the Ishinp, with the tutor being a woman. One of the reasons women had a great deal of strength in the act of sex was that they walked away undiminished from the act. The woman had the power to bring forth life, and did not have to worry about ejaculation or refractory period. To quote Laozi from the Tao Te Ching: "The Spirit of the Valley is inexhaustible... Draw on it as you will, it never runs dry."[19]
Women also helped men extend their lives. Many of the ancient texts were dedicated explanations of how a man could use sex to extend his own life but, his life was extended only through the absorption of the woman's vital energies (jing and qi). Some Taoists came to call the act of sex "the battle of stealing and strengthening".[20] These sexual methods could be correlated with Taoist military methods. Instead of storming the gates, the battle was a series of feints and maneuvers that would sap the enemy's resistance.[21] Fang described this battle as "the ideal was for a man to 'defeat' the 'enemy' in the sexual 'battle' by keeping himself under complete control so as not to emit semen, while at the same time exciting the woman until she reached orgasm and shed her Yin essence, which was then absorbed by the man."[22]
Jolan Chang points out that it was after the Tang dynasty (AD 618906) that "the Tao of Loving" was "steadily corrupted", and that it was these later corruptions that reflected battle imagery and elements of a "vampire" mindset.[23] Other research into early Taoism found more harmonious attitudes of yin-yang communion.[24]
This practice was not limited to male on female, however, as it was possible to women to do the same in turn with the male yang. The deity known as the Queen Mother of the West was described to have no husband, instead having intercourse with young virgin males to nourish her female element.[25]
Some Ming dynasty Taoist sects believed that one way for men to achieve longevity or 'towards immortality' is by having intercourse with virgins, particularly young virgins. Taoist sexual books by Liangpi[26] and Sanfeng[27] call the female partner ding () and recommend sex with premenarche virgins.
Liangpi concludes that the ideal ding is a pre-menarche virgin just under 14 years of age and women older than 18 should be avoided.[28] Sanfeng went further and divided ding partners into three ranks of descending importance: premenarche virgins aged 14-16, menstruating virgins aged 16-20 and women aged 21-25.[29][30]
According to Ge Hong, a 4th-century Taoist alchemist, "those seeking 'immortality' must perfect the absolute essentials. These consist of treasuring the jing, circulating the qi, and consuming the great medicine."[31] The sexual arts concerned the first precept, treasuring the jing. This is partially because treasuring the jing involved sending it up into the brain. In order to send the jing into the brain, the male had to refrain from ejaculation during sex. According to some Taoists, if this was done, the jing would travel up the spine and nourish the brain instead of leaving the body. Ge Hong also states, however, that it is folly to believe that performing the sexual arts only can achieve immortality and some of the ancient myths on sexual arts had been misinterpreted and exaggerated. Indeed, the sexual arts had to be practiced alongside alchemy to attain longevity. Ge Hong also warned it could be dangerous if practiced incorrectly.[31]
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Microorganism – Wikipedia
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Microscopic living organism
A microorganism, or microbe,[a] is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells.
The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from sixth century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s, Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera, diphtheria, and anthrax.
Because microorganisms include most unicellular organisms from all three domains of life they can be extremely diverse. Two of the three domains, Archaea and Bacteria, only contain microorganisms. The third domain Eukaryota includes all multicellular organisms as well as many unicellular protists and protozoans that are microbes. Some protists are related to animals and some to green plants. There are also many multicellular organisms that are microscopic, namely micro-animals, some fungi, and some algae, but these are generally not considered microorganisms.[further explanation needed]
Microorganisms can have very different habitats, and live everywhere from the poles to the equator, deserts, geysers, rocks, and the deep sea. Some are adapted to extremes such as very hot or very cold conditions, others to high pressure, and a few, such as Deinococcus radiodurans, to high radiation environments. Microorganisms also make up the microbiota found in and on all multicellular organisms. There is evidence that 3.45-billion-year-old Australian rocks once contained microorganisms, the earliest direct evidence of life on Earth.[1][2]
Microbes are important in human culture and health in many ways, serving to ferment foods and treat sewage, and to produce fuel, enzymes, and other bioactive compounds. Microbes are essential tools in biology as model organisms and have been put to use in biological warfare and bioterrorism. Microbes are a vital component of fertile soil. In the human body, microorganisms make up the human microbiota, including the essential gut flora. The pathogens responsible for many infectious diseases are microbes and, as such, are the target of hygiene measures.
The possible existence of microscopic organisms was discussed for many centuries before their discovery in the seventeenth century. By the sixth century BC, the Jains of present-day India postulated the existence of tiny organisms called nigodas.[3] These nigodas are said to be born in clusters; they live everywhere, including the bodies of plants, animals, and people; and their life lasts only for a fraction of a second.[4] According to the Jain leader Mahavira, the humans destroy these nigodas on a massive scale, when they eat, breathe, sit, and move.[3] Many modern Jains assert that Mahavira's teachings presage the existence of microorganisms as discovered by modern science.[5]
The earliest mention of micro organisms is found in hindu scriptures like the Atharvaveda, compiled 1200 BCE-1000 BCE, where Rishi Kanva refers to the microbes as Kirmis. He, along with his descendants Yamadagnni and Agasti, composed mantra suktas which highlight microbial infections and possible ways to cure them.[6]
Rishi Agastya composed a mantra in Rig Veda which refers to two types of harmful creatures for ones body. The first being visible and second being so minuscule that they are invisible to the naked eyes.[7]
The Shanti Parva of Ved Vyas Mahabharata mentions organisms that are so minuscule that they can't be seen with naked eyes but only inferred.
There are many creatures that are so minute that their existence can only be inferred. With the failing of the eyelids alone, they are destroyed.
[8]
The earliest known idea to indicate the possibility of diseases spreading by yet unseen organisms was that of the Roman scholar Marcus Terentius Varro in a first-century BC book entitled On Agriculture in which he called the unseen creatures animalcules, and warns against locating a homestead near a swamp:[9]
and because there are bred certain minute creatures that cannot be seen by the eyes, which float in the air and enter the body through the mouth and nose and they cause serious diseases.[9]
In The Canon of Medicine (1020), Avicenna suggested that tuberculosis and other diseases might be contagious.[10][11]
Akshamsaddin (Turkish scientist) mentioned the microbe in his work Maddat ul-Hayat (The Material of Life) about two centuries prior to Antonie van Leeuwenhoek's discovery through experimentation:
It is incorrect to assume that diseases appear one by one in humans. Disease infects by spreading from one person to another. This infection occurs through seeds that are so small they cannot be seen but are alive.[12][13]
In 1546, Girolamo Fracastoro proposed that epidemic diseases were caused by transferable seedlike entities that could transmit infection by direct or indirect contact, or even without contact over long distances.[14]
Antonie van Leeuwenhoek is considered to be one of the fathers of microbiology. He was the first in 1673 to discover and conduct scientific experiments with microorganisms, using simple single-lensed microscopes of his own design.[15][16][17][18] Robert Hooke, a contemporary of Leeuwenhoek, also used microscopy to observe microbial life in the form of the fruiting bodies of moulds. In his 1665 book Micrographia, he made drawings of studies, and he coined the term cell.[19]
Louis Pasteur (18221895) exposed boiled broths to the air, in vessels that contained a filter to prevent particles from passing through to the growth medium, and also in vessels without a filter, but with air allowed in via a curved tube so dust particles would settle and not come in contact with the broth. By boiling the broth beforehand, Pasteur ensured that no microorganisms survived within the broths at the beginning of his experiment. Nothing grew in the broths in the course of Pasteur's experiment. This meant that the living organisms that grew in such broths came from outside, as spores on dust, rather than spontaneously generated within the broth. Thus, Pasteur refuted the theory of spontaneous generation and supported the germ theory of disease.[20]
In 1876, Robert Koch (18431910) established that microorganisms can cause disease. He found that the blood of cattle that were infected with anthrax always had large numbers of Bacillus anthracis. Koch found that he could transmit anthrax from one animal to another by taking a small sample of blood from the infected animal and injecting it into a healthy one, and this caused the healthy animal to become sick. He also found that he could grow the bacteria in a nutrient broth, then inject it into a healthy animal, and cause illness. Based on these experiments, he devised criteria for establishing a causal link between a microorganism and a disease and these are now known as Koch's postulates.[21] Although these postulates cannot be applied in all cases, they do retain historical importance to the development of scientific thought and are still being used today.[22]
The discovery of microorganisms such as Euglena that did not fit into either the animal or plant kingdoms, since they were photosynthetic like plants, but motile like animals, led to the naming of a third kingdom in the 1860s. In 1860 John Hogg called this the Protoctista, and in 1866 Ernst Haeckel named it the Protista.[23][24][25]
The work of Pasteur and Koch did not accurately reflect the true diversity of the microbial world because of their exclusive focus on microorganisms having direct medical relevance. It was not until the work of Martinus Beijerinck and Sergei Winogradsky late in the nineteenth century that the true breadth of microbiology was revealed.[26] Beijerinck made two major contributions to microbiology: the discovery of viruses and the development of enrichment culture techniques.[27] While his work on the tobacco mosaic virus established the basic principles of virology, it was his development of enrichment culturing that had the most immediate impact on microbiology by allowing for the cultivation of a wide range of microbes with wildly different physiologies. Winogradsky was the first to develop the concept of chemolithotrophy and to thereby reveal the essential role played by microorganisms in geochemical processes.[28] He was responsible for the first isolation and description of both nitrifying and nitrogen-fixing bacteria.[26] French-Canadian microbiologist Felix d'Herelle co-discovered bacteriophages and was one of the earliest applied microbiologists.[29]
Microorganisms can be found almost anywhere on Earth. Bacteria and archaea are almost always microscopic, while a number of eukaryotes are also microscopic, including most protists, some fungi, as well as some micro-animals and plants. Viruses are generally regarded as not living and therefore not considered to be microorganisms, although a subfield of microbiology is virology, the study of viruses.[30][31][32]
Single-celled microorganisms were the first forms of life to develop on Earth, approximately 3.5 billion years ago.[33][34][35] Further evolution was slow,[36] and for about 3billion years in the Precambrian eon, (much of the history of life on Earth), all organisms were microorganisms.[37][38] Bacteria, algae and fungi have been identified in amber that is 220million years old, which shows that the morphology of microorganisms has changed little since at least the Triassic period.[39] The newly discovered biological role played by nickel, however especially that brought about by volcanic eruptions from the Siberian Traps may have accelerated the evolution of methanogens towards the end of the PermianTriassic extinction event.[40]
Microorganisms tend to have a relatively fast rate of evolution. Most microorganisms can reproduce rapidly, and bacteria are also able to freely exchange genes through conjugation, transformation and transduction, even between widely divergent species.[41] This horizontal gene transfer, coupled with a high mutation rate and other means of transformation, allows microorganisms to swiftly evolve (via natural selection) to survive in new environments and respond to environmental stresses. This rapid evolution is important in medicine, as it has led to the development of multidrug resistant pathogenic bacteria, superbugs, that are resistant to antibiotics.[42]
A possible transitional form of microorganism between a prokaryote and a eukaryote was discovered in 2012 by Japanese scientists. Parakaryon myojinensis is a unique microorganism larger than a typical prokaryote, but with nuclear material enclosed in a membrane as in a eukaryote, and the presence of endosymbionts. This is seen to be the first plausible evolutionary form of microorganism, showing a stage of development from the prokaryote to the eukaryote.[43][44]
Archaea are prokaryotic unicellular organisms, and form the first domain of life in Carl Woese's three-domain system. A prokaryote is defined as having no cell nucleus or other membrane bound-organelle. Archaea share this defining feature with the bacteria with which they were once grouped. In 1990 the microbiologist Woese proposed the three-domain system that divided living things into bacteria, archaea and eukaryotes,[45] and thereby split the prokaryote domain.
Archaea differ from bacteria in both their genetics and biochemistry. For example, while bacterial cell membranes are made from phosphoglycerides with ester bonds, archaean membranes are made of ether lipids.[46] Archaea were originally described as extremophiles living in extreme environments, such as hot springs, but have since been found in all types of habitats.[47] Only now are scientists beginning to realize how common archaea are in the environment, with Thermoproteota (formerly Crenarchaeota) being the most common form of life in the ocean, dominating ecosystems below 150 m in depth.[48][49] These organisms are also common in soil and play a vital role in ammonia oxidation.[50]
The combined domains of archaea and bacteria make up the most diverse and abundant group of organisms on Earth and inhabit practically all environments where the temperature is below +140C. They are found in water, soil, air, as the microbiome of an organism, hot springs and even deep beneath the Earth's crust in rocks.[51] The number of prokaryotes is estimated to be around five nonillion, or 5 1030, accounting for at least half the biomass on Earth.[52]
The biodiversity of the prokaryotes is unknown, but may be very large. A May 2016 estimate, based on laws of scaling from known numbers of species against the size of organism, gives an estimate of perhaps 1trillion species on the planet, of which most would be microorganisms. Currently, only one-thousandth of one percent of that total have been described.[53] Archael cells of some species aggregate and transfer DNA from one cell to another through direct contact, particularly under stressful environmental conditions that cause DNA damage.[54][55]
Bacteria like archaea are prokaryotic unicellular, and having no cell nucleus or other membrane-bound organelle. Bacteria are microscopic, with a few extremely rare exceptions, such as Thiomargarita namibiensis.[56] Bacteria function and reproduce as individual cells, but they can often aggregate in multicellular colonies.[57] Some species such as myxobacteria can aggregate into complex swarming structures, operating as multicellular groups as part of their life cycle,[58] or form clusters in bacterial colonies such as E.coli.
Their genome is usually a circular bacterial chromosome a single loop of DNA, although they can also harbor small pieces of DNA called plasmids. These plasmids can be transferred between cells through bacterial conjugation. Bacteria have an enclosing cell wall, which provides strength and rigidity to their cells. They reproduce by binary fission or sometimes by budding, but do not undergo meiotic sexual reproduction. However, many bacterial species can transfer DNA between individual cells by a horizontal gene transfer process referred to as natural transformation.[59] Some species form extraordinarily resilient spores, but for bacteria this is a mechanism for survival, not reproduction. Under optimal conditions bacteria can grow extremely rapidly and their numbers can double as quickly as every 20 minutes.[60]
Most living things that are visible to the naked eye in their adult form are eukaryotes, including humans. However, many eukaryotes are also microorganisms. Unlike bacteria and archaea, eukaryotes contain organelles such as the cell nucleus, the Golgi apparatus and mitochondria in their cells. The nucleus is an organelle that houses the DNA that makes up a cell's genome. DNA (Deoxyribonucleic acid) itself is arranged in complex chromosomes.[61]Mitochondria are organelles vital in metabolism as they are the site of the citric acid cycle and oxidative phosphorylation. They evolved from symbiotic bacteria and retain a remnant genome.[62] Like bacteria, plant cells have cell walls, and contain organelles such as chloroplasts in addition to the organelles in other eukaryotes. Chloroplasts produce energy from light by photosynthesis, and were also originally symbiotic bacteria.[62]
Unicellular eukaryotes consist of a single cell throughout their life cycle. This qualification is significant since most multicellular eukaryotes consist of a single cell called a zygote only at the beginning of their life cycles. Microbial eukaryotes can be either haploid or diploid, and some organisms have multiple cell nuclei.[63]
Unicellular eukaryotes usually reproduce asexually by mitosis under favorable conditions. However, under stressful conditions such as nutrient limitations and other conditions associated with DNA damage, they tend to reproduce sexually by meiosis and syngamy.[64]
Of eukaryotic groups, the protists are most commonly unicellular and microscopic. This is a highly diverse group of organisms that are not easy to classify.[65][66] Several algae species are multicellular protists, and slime molds have unique life cycles that involve switching between unicellular, colonial, and multicellular forms.[67] The number of species of protists is unknown since only a small proportion has been identified. Protist diversity is high in oceans, deep sea-vents, river sediment and an acidic river, suggesting that many eukaryotic microbial communities may yet be discovered.[68][69]
The fungi have several unicellular species, such as baker's yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe). Some fungi, such as the pathogenic yeast Candida albicans, can undergo phenotypic switching and grow as single cells in some environments, and filamentous hyphae in others.[70]
The green algae are a large group of photosynthetic eukaryotes that include many microscopic organisms. Although some green algae are classified as protists, others such as charophyta are classified with embryophyte plants, which are the most familiar group of land plants. Algae can grow as single cells, or in long chains of cells. The green algae include unicellular and colonial flagellates, usually but not always with two flagella per cell, as well as various colonial, coccoid, and filamentous forms. In the Charales, which are the algae most closely related to higher plants, cells differentiate into several distinct tissues within the organism. There are about 6000 species of green algae.[71]
Microorganisms are found in almost every habitat present in nature, including hostile environments such as the North and South poles, deserts, geysers, and rocks. They also include all the marine microorganisms of the oceans and deep sea. Some types of microorganisms have adapted to extreme environments and sustained colonies; these organisms are known as extremophiles. Extremophiles have been isolated from rocks as much as 7 kilometres below the Earth's surface,[72] and it has been suggested that the amount of organisms living below the Earth's surface is comparable with the amount of life on or above the surface.[51] Extremophiles have been known to survive for a prolonged time in a vacuum, and can be highly resistant to radiation, which may even allow them to survive in space.[73] Many types of microorganisms have intimate symbiotic relationships with other larger organisms; some of which are mutually beneficial (mutualism), while others can be damaging to the host organism (parasitism). If microorganisms can cause disease in a host they are known as pathogens and then they are sometimes referred to as microbes.Microorganisms play critical roles in Earth's biogeochemical cycles as they are responsible for decomposition and nitrogen fixation.[74]
Bacteria use regulatory networks that allow them to adapt to almost every environmental niche on earth.[75][76] A network of interactions among diverse types of molecules including DNA, RNA, proteins and metabolites, is utilised by the bacteria to achieve regulation of gene expression. In bacteria, the principal function of regulatory networks is to control the response to environmental changes, for example nutritional status and environmental stress.[77] A complex organization of networks permits the microorganism to coordinate and integrate multiple environmental signals.[75]
Extremophiles are microorganisms that have adapted so that they can survive and even thrive in extreme environments that are normally fatal to most life-forms. Thermophiles and hyperthermophiles thrive in high temperatures. Psychrophiles thrive in extremely low temperatures. Temperatures as high as 130C (266F),[78] as low as 17C (1F)[79] Halophiles such as Halobacterium salinarum (an archaean) thrive in high salt conditions, up to saturation.[80] Alkaliphiles thrive in an alkaline pH of about 8.511.[81] Acidophiles can thrive in a pH of 2.0 or less.[82] Piezophiles thrive at very high pressures: up to 1,0002,000 atm, down to 0 atm as in a vacuum of space.[83] A few extremophiles such as Deinococcus radiodurans are radioresistant,[84] resisting radiation exposure of up to 5k Gy. Extremophiles are significant in different ways. They extend terrestrial life into much of the Earth's hydrosphere, crust and atmosphere, their specific evolutionary adaptation mechanisms to their extreme environment can be exploited in biotechnology, and their very existence under such extreme conditions increases the potential for extraterrestrial life.[85]
The nitrogen cycle in soils depends on the fixation of atmospheric nitrogen. This is achieved by a number of diazotrophs. One way this can occur is in the root nodules of legumes that contain symbiotic bacteria of the genera Rhizobium, Mesorhizobium, Sinorhizobium, Bradyrhizobium, and Azorhizobium.[86]
The roots of plants create a narrow region known as the rhizosphere that supports many microorganisms known as the root microbiome.[87]
These microorganisms in the root microbiome are able to interact with each other and surrounding plants through signals and cues. For example, mycorrhizal fungi are able to communicate with the root systems of many plants through chemical signals between both the plant and fungi. This results in a mutualistic symbiosis between the two. However, these signals can be eavesdropped by other microorganisms, such as the soil bacteria, Myxococcus xanthus, which preys on other bacteria. Eavesdropping, or the interception of signals from unintended receivers, such as plants and microorganisms, can lead to large-scale, evolutionary consequences. For example, signaler-receiver pairs, like plant-microorganism pairs, may lose the ability to communicate with neighboring populations because of variability in eavesdroppers. In adapting to avoid local eavesdroppers, signal divergence could occur and thus, lead to the isolation of plants and microorganisms from the inability to communicate with other populations.[88]
A lichen is a symbiosis of a macroscopic fungus with photosynthetic microbial algae or cyanobacteria.[89][90]
Microorganisms are useful in producing foods, treating waste water, creating biofuels and a wide range of chemicals and enzymes. They are invaluable in research as model organisms. They have been weaponised and sometimes used in warfare and bioterrorism. They are vital to agriculture through their roles in maintaining soil fertility and in decomposing organic matter.
Microorganisms are used in a fermentation process to make yoghurt, cheese, curd, kefir, ayran, xynogala, and other types of food. Fermentation cultures provide flavour and aroma, and inhibit undesirable organisms.[91] They are used to leaven bread, and to convert sugars to alcohol in wine and beer. Microorganisms are used in brewing, wine making, baking, pickling and other food-making processes.[92]
Some industrial uses of Microorganisms:
These depend for their ability to clean up water contaminated with organic material on microorganisms that can respire dissolved substances. Respiration may be aerobic, with a well-oxygenated filter bed such as a slow sand filter.[93] Anaerobic digestion by methanogens generate useful methane gas as a by-product.[94]
Microorganisms are used in fermentation to produce ethanol,[95] and in biogas reactors to produce methane.[96] Scientists are researching the use of algae to produce liquid fuels,[97] and bacteria to convert various forms of agricultural and urban waste into usable fuels.[98]
Microorganisms are used to produce many commercial and industrial chemicals, enzymes and other bioactive molecules. Organic acids produced on a large industrial scale by microbial fermentation include acetic acid produced by acetic acid bacteria such as Acetobacter aceti, butyric acid made by the bacterium Clostridium butyricum, lactic acid made by Lactobacillus and other lactic acid bacteria,[99] and citric acid produced by the mould fungus Aspergillus niger.[99]
Microorganisms are used to prepare bioactive molecules such as Streptokinase from the bacterium Streptococcus,[100] Cyclosporin A from the ascomycete fungus Tolypocladium inflatum,[101] and statins produced by the yeast Monascus purpureus.[102]
Microorganisms are essential tools in biotechnology, biochemistry, genetics, and molecular biology. The yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe are important model organisms in science, since they are simple eukaryotes that can be grown rapidly in large numbers and are easily manipulated.[103] They are particularly valuable in genetics, genomics and proteomics.[104][105] Microorganisms can be harnessed for uses such as creating steroids and treating skin diseases. Scientists are also considering using microorganisms for living fuel cells,[106] and as a solution for pollution.[107]
In the Middle Ages, as an early example of biological warfare, diseased corpses were thrown into castles during sieges using catapults or other siege engines. Individuals near the corpses were exposed to the pathogen and were likely to spread that pathogen to others.[108]
In modern times, bioterrorism has included the 1984 Rajneeshee bioterror attack[109] and the 1993 release of anthrax by Aum Shinrikyo in Tokyo.[110]
Microbes can make nutrients and minerals in the soil available to plants, produce hormones that spur growth, stimulate the plant immune system and trigger or dampen stress responses. In general a more diverse set of soil microbes results in fewer plant diseases and higher yield.[111]
Microorganisms can form an endosymbiotic relationship with other, larger organisms. For example, microbial symbiosis plays a crucial role in the immune system. The microorganisms that make up the gut flora in the gastrointestinal tract contribute to gut immunity, synthesize vitamins such as folic acid and biotin, and ferment complex indigestible carbohydrates.[112] Some microorganisms that are seen to be beneficial to health are termed probiotics and are available as dietary supplements, or food additives.[113]
Microorganisms are the causative agents (pathogens) in many infectious diseases. The organisms involved include pathogenic bacteria, causing diseases such as plague, tuberculosis and anthrax; protozoan parasites, causing diseases such as malaria, sleeping sickness, dysentery and toxoplasmosis; and also fungi causing diseases such as ringworm, candidiasis or histoplasmosis. However, other diseases such as influenza, yellow fever or AIDS are caused by pathogenic viruses, which are not usually classified as living organisms and are not, therefore, microorganisms by the strict definition. No clear examples of archaean pathogens are known,[114] although a relationship has been proposed between the presence of some archaean methanogens and human periodontal disease.[115] Numerous microbial pathogens are capable of sexual processes that appear to facilitate their survival in their infected host.[116]
Hygiene is a set of practices to avoid infection or food spoilage by eliminating microorganisms from the surroundings. As microorganisms, in particular bacteria, are found virtually everywhere, harmful microorganisms may be reduced to acceptable levels rather than actually eliminated. In food preparation, microorganisms are reduced by preservation methods such as cooking, cleanliness of utensils, short storage periods, or by low temperatures. If complete sterility is needed, as with surgical equipment, an autoclave is used to kill microorganisms with heat and pressure.[117][118]
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