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Daily Archives: August 27, 2022
Antonio Banderas and the art of self-parody – The New Statesman
Posted: August 27, 2022 at 12:04 pm
The phenomenon of actors playing funhouse-mirror versions of themselves has been turbocharged over the past 30 years from Being John Malkovich to This is the End, via TV comedies such as The Larry Sanders Show, Curb Your Enthusiasm and The Trip. Johnny-come-latelys, the lot of them: the practice goes back at least as far as 1964, with Billy Wilders glorious Kiss Me, Stupid, which starred Dean Martin (born Dino Crocetti) as a womanising crooner named Dino.
Now its the turn of Antonio Banderas to make merry with his persona. In Official Competition, a sharp-clawed comedy from the Argentine film-making duo Gastn Duprat and Mariano Cohn, he is Flix Rivero, a movie star with a lucrative US career. When he is cast in a prestigious literary adaptation opposite the highfalutin Ivn Torres (Oscar Martnez), commerce meets art. Ivn is all about rehearsal and immersion; Flix, who reaches for the menthol stick when tears are required, wonders why they cant just get on with it.
The director who has brought them together to play warring siblings, and to exploit their off-screen tension, is Lola Cuevas (Penlope Cruz), the nutty maverick auteur behind The Inverted Rain (a perfect spoof arthouse title). With a wicked glint in her eye, Lola forces them to rehearse with a giant boulder suspended above them on a crane (Use it, use it!), and makes Ivn go over the same piece of dialogue repeatedly until he invests it with the necessary layers of conflicting emotion. The line is: Good evening.
[See also: Meghan Markles Archetypes podcast review]
Ivn has nothing but disdain for actors who defect to Hollywood. I dont want to be the Latino who puts a little bit of colour into entertainment for those numbskulls! he huffs. Hearing this, we cant help but scroll through Banderass English-language credits the Zorro films, the Shrek series and its Puss in Boots spin-offs and marvel at what a good sport he is.
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There is also a scene in which Flix parades armfuls of awards, some of which (Goyas, Golden Globes) Banderas really has won or been nominated for. Ivn claims not to care about such trifles, though privately he rehearses a speech, brandishing a kettle in place of a trophy, in which he scorns the idea of artistic competition. (He even makes an adorable little cheering sound at the end, to suggest an off-screen audience awestruck by his integrity.) Like Banderas, Martnez is spoofing his public image: he is a highly regarded theatre actor in his native Argentina and not short of silverware himself. (His last film with Duprat and Cohn, The Distinguished Gentleman, won him the Best Actor prize at the Venice Film Festival.)
The initial joke of Official Competition is that this whole film-making endeavour has been conceived simply to burnish the reputation of a pharmaceuticals billionaire, Humberto Surez (Jos Luis Gmez), who cant decide whether to build a bridge to ensure his immortality or finance a movie. The eventual and far superior gag is that Lolas apparently cuckoo methods start to bear fruit: both men become more limber under her tutelage. The visual humour as she puts them through their paces is heightened by the austere setting of the Surez foundation. Its pristine, soulless spaces (glass-walled rooms, stone forecourts cleanly delineated by knife-like shadows) suggest both opulence and spiritual emptiness.
Reality makes itself felt only fleetingly: once in a brief shot of a homeless person outside a burger bar, and again in the reflection of a plane crossing the sky overhead, which recalls the plane mounted above Lolas bed in a nosediving position. Christ is crucified on it, arms spread out across its wings a gaudy pop-art homage to the statue of Christ the Redeemer dangling from a helicopter at the start of La Dolce Vita.
Official Competition appears at first to be a standard movie-business takedown la The Player, but it has far more faith in the art form than that. Among its tastiest pleasures is the chance to see Cruz and Banderas sparking together on screen at last; theyve both benefited extensively from the patronage of Pedro Almodvar, yet have coincided only briefly in two of his films, Im So Excited! and Pain and Glory. Now they can properly let their hair down, literally so in the case of Cruz, dragging on cheroots and tossing around her untamed copper torrent of Louis XIV curls.
Official Competition is in cinemas now
[See also: House of the Dragon: sex, violence and top notes of incest]
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Antonio Banderas and the art of self-parody - The New Statesman
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Are There Laws on the High Seas? | Britannica
Posted: at 12:03 pm
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All governments manage their territories with laws. This is easy enough to understand with respect to solid ground: when you look at a map, borders usually mark where the authority of one country ends and anothers begins. But what about maritime countries, which either border or are completely surrounded by the sea? Do their laws stop at the shoreline? Would that mean that the seas beyond are lawless?
The high seas are not lawless. Well, not completely. According to international law, a maritime country extends outward some distance from its shoreline. During the 20th century several attempts to develop an international law of the sea have been made under the aegis of the United Nations. The results of the third and most-recent United Nations Convention on the Law of the Sea (which took place in Montego Bay, Jamaica, in 1982) were largely successful, with more than 160 countries having signed the agreement by 2017. Several countries, including the United States and others with significant ocean-facing and sea-facing coastlines (such as Colombia, Venezuela, and Turkey) had yet to sign the agreement, however.
Generally speaking, the law of the sea stipulates that maritime countries essentially control their territorial waters from the shore out to a distance of 12 miles (19.3 km), the 12-mile limit.Within this zone, all laws of that country apply: the country can build, extract natural resources, and either encourage or forbid sea passage through it (or flights over it) just as if it were a parcel of land. Maritime countries are also entitled to an exclusive economic zone (EEZ) made up of the water column and the seabed out to a distance of 200 miles (about 322 km). (The sizes of some EEZs may be limited by the presence of the EEZs of other countries, in which case the overlapping area is often divided equally between the various parties.) The maritime country that owns the EEZ also owns the sea life and mineral resources found within it, but it cannot prevent ships, aircraft, and other vessels from foreign countries from passing through it and over it.
Nevertheless, there is still a lot of ocean beyond the worlds 12-mile limits and EEZs.How are legal matters handled in the vast stretches of ocean beyond?In these regions, vessels and aircraft from any country are free to pass through, fly over, fish, and extract mineral resources. With respect to crimes committed in these areas, the laws of the country owning the vessel or structure upon which the crime has been committed hold sway.This may seem pretty straightforward, but vessels in the sea are often on the move, which creates jurisdictional headaches for investigators and government officials. For example, which countrys laws apply when a person from Country X commits a murder aboard a cruise ship owned by Country Y in international waters, but between the time of the crime and its discovery the ship enters the territorial waters of Country Z?
With respect to international crimessuch as piracy, human trafficking, and crimes against humanityany country or international organization can theoretically claim authority over the matter using the concept of universal jurisdiction. This concept could be used to justify the right of one party or another to thwart the criminal activity as it happens, bring charges against the assailants, and try the assailants in their own national (or international) courts. Since the laws of individual countries and international courts are not recognized by all countries, however, there is often no fully accepted referee. Government officials in one country might choose not to recognize the legal authority of another.
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Why Protecting the High Seas Matters – United States Department of State – Department of State
Posted: at 12:03 pm
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Representatives from countries around the world and dozens of civil society organizations are huddled and working around the clock at UN headquarters in New York this week for negotiations on the conservation and sustainable use of marine biological diversity of areas beyond national jurisdiction (BBNJ). The BBNJ Agreement, also referred to as the High Seas Treaty, is one of several important environmental negotiations concluding in the next four months. In addition to this treaty, we are also hoping to conclude one on conserving and restoring biodiversity,we are launching a two-year negotiation of an agreement to tackle the plastic pollutioncrisis, and continue the hard work of implementing the Paris Agreement now that we finished all the rules for implementation at the meeting last November. The decisions we take in these agreements and negotiations will have a make or break impact on the health of the place we all call home.
The high seas span two-thirds of the ocean and cover half the planet.
The first one of these covers what is known as the high seas that currently has only limited governance and is often unmonitored. Right now, there are rules and regulations only covering certain commercial activities like fishing, dumping, seabed mining, and shipping but there is not a single international agreement governing conservation or protection of high seas biodiversity hot spots, and there are only limited regulations for endangered marine biodiversity itself things like migratory birds, sea turtles, and marine mammals have limited protections. Here are 5 reasons why the BBNJ Agreement matters.
It is often said that the ocean is too big to fail. That is simply not true the ocean is more fragile than most people understand. It is also more essential. It provides the oxygen we breathe and food for tens of millions of people. And it has been a source of inspiration for humanity. In fact, as Dr. Jane Lubchenco says, the ocean is too big to ignore. And this week in New York City, the United States will help to lead the way in making sure it is ignored no more.
About the Author: Monica P. Medina was confirmed as Assistant Secretary for Oceans and International Environmental and Scientific Affairs on September 28, 2021.
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Why Protecting the High Seas Matters - United States Department of State - Department of State
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UN High Seas Treaty postponed until further negotiations – TVP World
Posted: at 12:03 pm
168 world governments had been negotiating the details of a new UN High Seas Treaty to safeguard the high seas and marine life, during a two-week session in New York, however, they could not come to an agreement in the end.
The negotiations focused on four key areas:
Marine protected areas
Environmental impact assessments
Providing finance and capacity building to developing countries
Sharing of marine genetic resources
Fishing catch limitations, shipping lane routes, and exploratory activities like deep-sea mining, which could be hazardous to marine life, would all be affected by the new treaty.
The high seas, which are international waterways where all nations have the right to fish, ship, and conduct research, were created by this agreement.
The growing hazards of climate change, overfishing, and shipping traffic pose a threat to marine species that exist outside of the 1.2 percent of protected areas.
Prior to the summit, more than 70 nations, including the UK, had previously decided to safeguard 30 percent of the worlds seas.
According to research published earlier this year and funded by the National Oceanic and Atmospheric Administration, 10 to 15 percent of marine species are already on the verge of extinction.
Between now and January, many international meetings on numerous topics are planned, including the UN General Assembly meeting and the COP27 annual climate conference.
Even if the treaty is signed, further work to protect the high seas will still need to be done.
source:BBC
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A New Era of Adventure on the High Seas – Leisure Group Travel
Posted: at 12:03 pm
The debut of Seabourns sixth ship, the Seabourn Venture, signals a new era in adventure travel for the ultra-luxury cruise line. The worlds newest expedition ship embarked on her first official voyage on July 27. The godmother of the Seabourn Venture, Alison Levine, is an expert climber and bestselling author who has led climbs on the highest peaks of each continent.
A PC6 Polar Class ship, the Seabourn Venture is capable of sailing in all parts of the world. She features modern technology and hardware that extends her global deployment and capabilities.
The Seabourn Venture has 132 oceanfront suites, each with a private veranda, and accommodates 264 guests. There are eight different dining venues, including sushi and pho restaurants. These are complimentary and let guests dine when and with whom they wish. Complimentary premium spirits and fine wines are available. Tipping is neither required nor expected.
The Restaurant on the Seabourn Venture will offer fine dining.
The Seabourn Venture is staffed with a 26-person expedition team that brings destinations to life. Team members include submarine pilots, lead kayakers, bear guides, dive masters, marine biologists, geologists, surface supervisor officers, climatologists, and ornithologists. Their valuable insights are offered via formal presentations and in casual conversations over meals and during leisure experiences.
The Seabourn Venture has been created to provide super-exclusive, off-the-ship adventures for guests. Inclusive expedition experiences include Zodiacs, scuba diving, and snorkeling, plus other complimentary excursions. Optional expedition excursions are available for an additional charge.
The Seabourn Venture is equipped with a great selection of water toys. Besides 24 Zodiacs and kayaks, there are two custom-built submarines, each with a capacity for six persons.
Hosted by members of the expedition team, the Seabourn Venture has an open bridge policy providing first hand access to the ships command center and officers navigating the journey. (This is at the discretion of the captain.)
The Seabourn Ventures Constellation Lounge
Public spaces on the Seabourn Venture have narratives of their own, combining the spirit of adventure and thrill of discovery with Seabourn-style luxury and comfort. The Expedition Lounge, located on Deck 4, is adjacent to the Discovery Center, where guests gather to enjoy the natural history and cultural programming. The Bow Lounge, with the closest access to the water, is a prime setting for watching marine life. The Constellation Lounge, the highest indoor viewing point, is located on the top deck, with stunning 270-degree views and an intimate interior dressed up in dark blue and red, inspired by the constellations in the evening night skies. The Club is a space for guests to enjoy afternoon tea and pre-dinner music.
When the Seabourn Venture sailed out on July 27, she was doing a 12-day Northern Isles expedition cruise, departing from Tromso, Norway, and then sailing on to the Arctic and Svalbard Archipelago. One of the worlds northernmost inhabited areas, the archipelago is home to polar bears, puffins, and other wildlife.
In October, the Seabourn Venture will do 10-to-14-night sailings to the Caribbean and then head south to Central America, Ecuador, Colombia, Chile, and Peru. From November 2022 to February 2023, the Seabourn Venture will sail on 11-to-22-day voyages to Chile, Antarctica, South Georgia, and the Falkland Islands. In March and April 2023, she will offer 7-to-12-night sailings in Brazil and the Amazon.
The Seabourn Pursuit will call in Iceland in 2023.
The Seabourn Ventures sister ship, the Seabourn Pursuit, is currently under construction and set to launch in 2023. Like the Seabourn Venture, shell carry two custom-built submarines as well as 24 zodiacs and kayaks. And she will have a 26-person expert expedition team.
The Seabourn Pursuit will explore the waters and beautiful landscapes of Iceland, Greenland, and Norway through the spring months and into early summer 2023. In August 2023, one highlight will be the Northwest Passage journey from Kangerlussuaq, Greenland to Nome, Alaska.
Seabourn is renowned for luxury amenities, onboard service, and a high level of cuisine. The Thomas Keller steakhouses on their ships, including the Seabourn Ovation, are one example. But combining luxury with super-exclusive adventures on its purpose-built expedition ship, the Seabourn Venture, introduces a new dimension, one to definitely consider when planning your groups next cruise.
By Cindy Bertram
Cindy Bertram has 15+ years of cruise industry expertise in marketing, content creation, sales, and training as well as social media. Her MBA from Loyola University Chicago complements her high creative edge and liberal arts BA. She can be reached atcindy@ptmgroups.com.
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Courage on the high seas – The Spectator
Posted: at 12:03 pm
The Salt Roads: How Fish Made a Culture
John Goodlad
Birlinn, pp. 254, 17.99
The Shetland Islands and the Faroes may seem to be somewhere out there in distant waters, marginal and in the greater scheme of things not very important in the history of the world. But from a maritime perspective it is precisely the fact that they are suspended in mid-ocean, surrounded by water that teems with fish (if one knows where to look) that has given them a role in human history out of all proportion to their size. In his fascinating account of the part played by these islands in the harvesting of cod and herring from the North Atlantic, John Goodlad raises vital questions about the worlds food supplies. He also brings to light the heroic endeavours of the poor and humble fisherfolk who mastered fierce Atlantic storms and experienced shipwreck in order to bring food to our everyday table.
Beguiled by the sight of modern massive trawlers that use sonar to identify shoals, and are often in consequence guilty of massive overfishing, we forget the sheer physical struggle that was demanded of Shetlanders when they used to set out in their small sailing boats, not unlike those of their Viking ancestors. They could read the seas without any sophisticated instruments and they identified where the fish might lie through canny instinct. They hauled in their catch by hand, while being tossed around by the waves.
We also forget how important fish has been, and remains, in feeding the world. Goodlad reports that fish remains the prime source of protein across the globe, with 180 million tons being consumed annually, significantly more than chicken or red meat: Without fish, the worlds population could not be fed. This means that those who regard eating fish as a crime against nature have gravely over-simplified the problem of making fish sustainable. The author believes this must be done through good management. Fish stocks can recover from overfishing, and the intelligent farming of fish could become a vital resource. Perhaps, though, he needs to pay more attention to the pollution of the oceans, as a result of which fish are ingesting plastic micro-pellets and failing to achieve the size they used to reach. The 80 kilogram halibut of past times have all but disappeared.
Salt also figures largely in the history Goodlad tells, for fish was a product that needed to be carefully preserved after catch. The search for Atlantic cod was already well underway by the end of the 15th century, when Hanseatic merchants visited Shetland to buy salt fish and John Cabot witnessed the shoals off Newfoundland. Soon after, or maybe secretly before Cabot, Basque fishermen arrived in the same waters.
Cod has the advantage of storing its oil in its liver, while its flesh is pure protein, and that makes it suitable for drying in the cold winds of the North Atlantic and for salting. To this day, bacalhau is the national dish of Portugal, and reconstituted stoccafisso, or stockfish cod dried until it has the texture of cardboard still features on menus in Venice.
Occasionally ranging as far as Greenland in their search for cod, Shetlanders were able to tap into this market after the Napoleonic wars. Peace with Spain meant they could sell their produce there, though in the early days the quality was not as high as that fished by the Basques. Shifting their search closer to home, they discovered great shoals off the Faroes, and their salt cod improved to the point where they were even able to convince their Basque rivals to buy it.
These changes took place against a grim background of famines, bankruptcies and shipwrecks. Goodlads wonderful book offers a powerful evocation of a hard life in the unforgiving terrain of the Shetlands and the Faroes. For Shetlanders, fish were for centuries the main means to a livelihood, and the conditions under which local lairds employed their fishermen made the struggle even harder their fishermen is the right phrase, since their legal condition was, Goodlad observes, little better than that of serfs. Attempts to challenge the Dutch command of the herring fisheries faltered, but eventually herring rather than cod became the favoured catch.
This was not an easy switch to make. Herring, a very oily fish, deteriorates quickly, and as far back as the late Middle Ages the Dutch had perfected a way of salting and curing herrings that earned its supposed inventor, Willem Beuckelszoon, the dubious honour of being counted as the 157th most famous Dutch citizen in a poll conducted a few years ago.
Herring was the staple fish in northern Europe, just as cod was in southern Europe, and Shetlanders intruded themselves into the Scottish herring fisheries which, on the eve of the first world war, were sending about 2 million barrels to the Baltic every year. Much of it was then transported by sleigh deep into the eastern European interior, since it was enormously in demand in the Jewish shtetls of Belarus and Ukraine, as it also was among students of Scottish universities, who would arrive each term loaded with herrings and oatmeal.
There is much in this book about life and culture in the Shetlands and Faroes. The sense of a common Viking heritage can be gauged from the presence of plenty of Norse vocabulary in Shetlandic speech (which is based on Scots, the old Scandinavian language known as Norn having died out). Goodlad suggests that, if the economically dynamic Faroes can go their own way as a semi-independent nation with aspirations to full sovereignty, the same could happen in Scotland. More to the point, surely, is the future of Shetland and Orkney in an independent Scotland. With such a strong sense of their distinctive identity and history they might well wish to remain part of Britain, or might acquire a status similar to the Isle of Man, another formerly Norse territory. Or be handed back to Norway after 550 years? Perhaps not.
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The Simpsons’ Playdate With Destiny Short Was A Product Of Serendipity – /Film
Posted: at 12:01 pm
In 2012, back when they were still under the 20th Century Fox banner, the studio did something a little different and released a "Simpsons" short film called "Maggie Simpson in The Longest Daycare" to theaters, which preceded "Ice Age: Continental Drift." The four-minute short follows Maggie on her first day of daycare at the Ayn Rand School of Tots, which favors groups of children over others.
The appeal of "The Longest Daycare" is that it doesn't feature a single line of dialogue, focusing instead on Maggie's silent attachment to a blue butterfly that a unibrowed baby wants to squash. Even when there's no spoken banter for these characters, the subtle inflections on Maggie's face coupled with the rapid-paced background gags prove how adept this team is at getting a laugh. The short was even nominated for an Oscar, but lost to Disney's "Paperman."
Maggie would return to the big screen nearly a decade later with another silent short entitled "Playdate With Destiny," which featured the youngest Simpson finding herself in a meet-cute romance with a boy at the park named Hudson. According to an interview with The AV Club, executive producer Al Jean claims the short had been in development for years. It was likely for another episode in the series' 31st season ("The Incredible Lightness of Being a Baby").
But there was an exciting development for the team behind the short when they learned where it would ultimately end up.
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Filthy Animals Pries Open The Violent, Animalistic Notions In Human Relationships – Gaysi
Posted: at 12:01 pm
Reviews
In Filthy Animals, a collection of short stories, Brandon Taylor is at his most original and inventive.
Brandon Taylors Filthy Animals (Daunt Books Originals, 2021), which won this years Story Prize and was on the Dylan Thomas Prize shortlist, is a collection of 11 short stories, of which a few are interlinked. While each story in this collection is chiselled to perfection and displays Taylors hallmark oeuvre as his characters arcs and their behaviours in the myriad relationships they develop over time, stand out.
In Taylors fiction, relationships neither get conducted in the boring, believable way they tend to do in most fiction writing, nor do they crumble under the weight of meaning as stories about love, longing, and finding ones place in society often seem to carry. Instead, its the vilest of human conduct that Taylor masterfully renders in these stories, prying open the animalistic instincts in human companionships.
He not only exposes the interiority and duality in his characters but also weaves their unsaid motivations wonderfully. Sample the first story, Potluck. Lionel a Mathematics doctorate turned Proctor, whos fresh out of the hospital after trying to kill himself finds that not recognising anyone apart from the host both a comfort and a warning.
Why should one feel this way, you might think? Is it because Lionel is an introvert? Or a Black person? Or someone who is difficult to talk to as professional dancers Sophie and Charles, whom he meets in this gathering, believe?
It may be because even though he leads what appears like a mediocre existence, Lionel refuses to be part of the mindlessness that surrounds him, yet he partakes in the everyday because thats what it takes to survive. For example, Lionel was ashamed of proctoring only when he had to tell other people about it, and only when those people knew that he had once been a graduate student with good brain chemistry.
Theres something intriguing about Taylors prose: it criticises without claiming a territorial hold on the viewpoint. Nor does Taylor overburden his stories with whats expected of a Black queer writer. In comparison, consider the following two novels that become unreadable midway because their authors didnt know how to keep their characters removed from their politics: Atlas Shrugged by Ayn Rand and The Ministry of Utmost Happiness by Arundhati Roy.
When an author snatches away from its character the autonomy to decide for themselves or interferes with their natural progression, then such characters become unrealistic and inauthentic to read. And thats what separates Taylor from his contemporaries: he listens to his characters inherent need to bring themselves out in the story, fully.
Indulge in these moments in his stories. Observing Charles, Lionel finds that Charles has the kind of body you could only get at great personal risk. He was good-looking, in a way that seemed incongruous with ordinary life. Or this, about unprivileged childhoods: That was the blessing of certain childhoods. The illusion of your invincibility. Your safety. Some people didnt know the danger they were in until years later, looking back. These sentences convey the whole background power imbalance, sexual tension, and need for validation in so few words, and need no glorious explanations. Theres beauty in their muteness.
Perhaps it is in this measured way that Taylor crafts his characters that hes able to extract raw emotions in a dialogic manner without appearing philosophical and conveys the meaning without being melodramatic. Sometimes it is the ridiculously mundane that Taylor presents in his story, and you cant help but marvel at the observation and accompanying thought with it. Heres one incident from Proctoring: Lionel swirled the coffee in the cup, aware of the gesture as he performed it, knowing that it had little utility, that it was something performed to make him look a certain way, pensive, thoughtful.
Theres something wounded in each of his characters, too, but he doesnt let them exhibit their hurt. Be it the babysitter in Little Beast who feels its a disservice to let children go on thinking the whole world can be something it cannot or Marta in Anne of Cleves who becomes uncomfortable after meeting her ex-lover, knowing that a part of important information has escaped her: that shell be outed for now he knows everything. Theres unusual humour at play, too. Theres this moment when Lionel feels like laughing, wondering that he hasnt taken his own suicide seriously enough.
Two stories, in particular, were gut-wrenching to read: As Though that Were Love and the titular Filthy Animals. While the choice of Mercy Me the violent game that Simon and Hartjes play is so clever in the first story that this hunger for power and superiority renders it animal recognition, in the second the palpability of violence, which doesnt leave any trace, makes it a fascinating read.
I wouldnt use the word brave to describe this collection, for in one of the stories Lionel says: People called you brave for going on because it affirmed their own value system. They considered their own life worth living, and so they considered every life worthy. It is in fact located beyond the instruments of value system and judgement.
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Filthy Animals Pries Open The Violent, Animalistic Notions In Human Relationships - Gaysi
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Scientists Just Genetically Edited a Million Years of Evolution Into Mouse DNA – ScienceAlert
Posted: at 11:57 am
Changing the number of chromosomes an animal has can take millions of generations to happen in nature through the course of evolution and now, scientists have been able to make these same changes in lab mice in a relative blink of an eye.
The new technique using stem cells and gene editing is a major accomplishment, and one that the team is hoping will reveal more about how the rearrangement of chromosomes can influence the way that animals evolve over time.
It's in chromosomes those strings of protein and DNA inside cells that we find our genes, inherited from our parents and blended together to make us who we are.
For mammals like mice and us humans, chromosomes typically come paired. There are exceptions, such as in sex cells.
Unfertilized embryonic stem cells are usually the best starting place for tinkering with DNA. Lacking that additional set of chromosomes provided by a sperm cell, though, deprives the cells of an important step in negotiating which genes in which chromosomes will be marked active to do the job of building a body.
This process called imprinting was a stumbling block for engineers keen to restructure large chunks of the genome.
"Genomic imprinting is frequently lost, meaning the information about which genes should be active disappears in haploid embryonic stem cells, limiting their pluripotency and genetic engineering," says biologist Li-Bin Wang from the Chinese Academy of Sciences.
"We recently discovered that by deleting three imprinted regions, we could establish a stable sperm-like imprinting pattern in the cells."
Without those three naturally imprinted regions, lasting chromosome fusion was possible. In their experiments, the researchers fused two medium-sized chromosomes (4 and 5) and the two largest chromosomes (1 and 2) in two different orientations, resulting in three different arrangements.
The fusion of chromosomes 4 and 5 was the most successful in terms of the genetic code being passed on to the mice offspring, although breeding was slower than normal.
One of the 1 and 2 fusions produced no mice offspring, while the other produced mice offspring that were slower, larger, and more anxious than those from the fusion of chromosomes 4 and 5.
According to the researchers, the drops in fertility are down to how the chromosomes separate after alignment, which doesn't happen in the normal way. It shows that chromosomal rearrangement is crucial to reproductive isolation a key part of species being able to evolve and stay separate.
"The laboratory house mouse has maintained a standard 40-chromosome karyotype or the full picture of an organism's chromosomes after more than 100 years of artificial breeding," says biologist Zhi-Kun Li, also from the Chinese Academy of Sciences.
"Over longer time scales, however, karyotype changes caused by chromosome rearrangements are common. Rodents have 3.2 to 3.5 rearrangements per million years, whereas primates have 1.6."
To put this into context, rare leaps in chromosomal rearrangement have helped direct the evolutionary paths of our own ancestors. Chromosomes that remain separate in gorillas, for instance, are fused into one in our human genome.
Those types of changes can occur once every few hundred millennia. While the genetic edits made here in the lab were on a relatively small scale, the signs are that they could have some dramatic effects on the animals involved.
It's still early days this is a scientific first after all but further down the line, there might be the opportunity to correct misaligned or malformed chromosomes in human bloodlines. We know that in individuals, chromosome fusions and relocations can lead to health problems including childhood leukemia.
"We experimentally demonstrated that the chromosomal rearrangement event is the driving force behind species evolution and important for reproductive isolation, providing a potential route for large-scale engineering of DNA in mammals," says Li.
The research has been published in Science.
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Scientists Just Genetically Edited a Million Years of Evolution Into Mouse DNA - ScienceAlert
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50 Times People Took A DNA Test And Found Out More Than They Wanted To – Bored Panda
Posted: at 11:57 am
How much do you know about your family tree? Could you name every branch going back for generations, or do you only know the names of a few leaves hanging close to you? Thankfully, whether your ancestors kept meticulous records or you were adopted and relocated halfway across the world as an infant, DNA technology has become incredibly advanced, and we all have access to our backgrounds through simply submitting a mouthful of saliva.
Unfortunately, however, the results of a DNA test are not always what curious participants had hoped for. After optimistically submitting their samples hoping to find out precisely which Eastern European cuisine they should be preparing on holidays, some people receive their results and are left questioning everything they know about their family members. Weve gathered some of the most amusing, shocking and upsetting discoveries made from taking DNA tests, that have been shared on the 23andMe subreddit, and listed them below for you to read. I sincerely hope you dont have any devastating stories of your own from having tests like this done, but if you do, know that youre not alone.
Keep reading to also find an interview with host of the DNA Surprises Podcast, Alexis Hourselt, and then if youre interested in reading even more stories about DNA tests revealing scandalous family secrets, we recommend checking out this Bored Panda article next.
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50 Times People Took A DNA Test And Found Out More Than They Wanted To - Bored Panda
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