Daily Archives: August 15, 2022

Ottawa, Aug. 15, 2022 (GLOBE NEWSWIRE) -- The global psoriasis treatment market size was accounted at USD 27.36 billion in 2022. Psoriasis is a skin disease which is produced as a result of autoimmune disorder which occurs in the individual it is an inflammatory process that the body undergoes in which the skin cells are produced in excess. and the symptoms include extreme itching all over the body or in the particular part affected, pain may be associated with the condition sometimes and extreme dryness of the skin with flakiness.

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This disease does not spread through touch or contact but may be inherited from the ancestors but cannot be labeled as a genetic disorder. The red lesions which appear on the skin are accompanied by flaky skin eruptions. This disease has been divided under two headings of psoriatic arthritis and plaque psoriasis. In certain individuals so this is also associated with joint complaints which is termed as psoriatic arthritis.

Key Takeaways:

Report highlights

Regional Snapshots

The region of North America has the largest market for psoriasis treatment as a result of the huge population suffering with this autoimmune disorder. The geriatric population has also proved to be a driving factor for the growth of the psoriasis treatment market. The prevalence of psoriasis in the region of North America is such that special campaigns have been organized by the government in order to spread awareness regarding the treatment facilities and symptoms of the disease. The modern lifestyle which is followed in this region has hampered the food habits of the people which also increases the risk associated with the disease.

The European market has proved to be the next largest after the region of North America which has shown great prevalence for this disease.

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Scope of the Report

Market dynamics

Drivers

The rapidly increasing number of patients of psoriasis has helped to increase the demand for its treatment. This has led to a rapid demand and supply of medicines which are used to treat psoriasis in the market. The key market players have conducted rapid research and development programs in order to introduce effective medicines and treatment options to the patients. this autoimmune skin disorder has not remained restricted to a particular age group and has shown its prevalence in people belonging to almost every age. It has no specific causative factor but is seen to be developed as a result of autoimmune disorder in the body. The symptoms of this disease present itself in the form of dry skin eruptions and can reach a severe stage if not managed in time.

Restraints

The high cost associated with the use of modern medicines have imposed and additional pressure on the common man suffering with this autoimmune skin disorder. The lack of disposable income in the hands of the people as a result of inflation has affected the growth of the market to a great extent. The occurrence of the pandemic had a considerable effect on the psoriasis treatment market as a result of the restricted movements imposed by the government and the strict guidelines of the hospital regarding follow-ups and regular visits. As a result of this the treatment of many patients got hampered and hence the symptoms aggravated over the period of time. Though the online pharmacies played an important role in maintaining the speed of the market it did not play a significant role.

Opportunities

The rapid demand for faster and better treatment of psoriasis within a shorter period of time has proved to be a great opportunity for the market. With the increasing life expectancy, the number of elderly people suffering with this skin disorder has increased. Parenteral applications which are available in the market over the counter has proved to be the biggest opportunity for the growth of the market. Lucrative offers and schemes which are offered by the insurance companies in order to encourage the people for psoriasis treatment has proved to be a great opportunity for the market.

The long-term treatment which is associated with this autoimmune skin disorder is also a wonderful opportunity as the demand and supply keeps continuing over the period of time of treatment. With the rapid advancements seen in the method of treatment and the use of modern medicine the number of side effects associated with the use of these chemically formulated drugs have also reduced.

Challenges

The treatment of this autoimmune skin disorder takes a very long period of time which proves to be a challenge for the growth of the market. The patient usually loses confidence and patience which results in a breach of the treatment and shows a direct impact on the growth of the market. With the use of advanced medicine for the treatment of the disease the cost of the treatment also increases tremendously. This makes it impossible for the common man to opt for the treatment with the help of advanced medicines.

Recent Developments

Market Segmentation

By Drug Class

By Treatment Type

By Type

By Route of Administration

By Distribution Channel

By Geography

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Psoriasis Treatment Market Size to Hit USD 51.24 Bn by 2030 - GlobeNewswire

Ventyx Biosciences VTYX announced positive data from the Phase 1 single ascending dose (SAD) and multiple ascending dose (MAD) trial of VTX958, a novel and selective allosteric TYK2 inhibitor.

The Phase 1 clinical trial was a dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of VTX958 in single and multiple ascending doses with 96 adult healthy volunteers.

VTX958 was well tolerated across all 7 cohorts in the SAD portion and all 5 cohorts in the MAD portion of the Phase 1 trial with no discontinuations due to adverse events.

William Sandborn, President and Chief Medical Officer, commented: "Data from the Phase 1 trial of VTX958 demonstrate an excellent safety profile and class-leading TYK2 inhibition as measured by IC50and IC90coverage. We believe these data will allow us to explore high levels of target inhibition in future clinical studies, which may support clinical differentiation in relevant disease populations, such as psoriasis, psoriatic arthritis and lupus.

The company is planning to move forward VTX958 into multiple Phase 2 trials, for diseases like psoriasis, Crohn's disease and psoriatic arthritis, in thefourth quarterof 2022.

Price Action : Ventyx shares closed Mondays trading 2 percent higher at $18.60

Original post:
Ventyx Sees Initiation Of Mid-Stage Psoriasis Study In Q4 2022 Following Positive Data From Initial-Stage - Benzinga

Bullies are messing with the wrong one.

29 year old Jude Duncan of Glasgow, Scotland battles psoriasis that leaves red, flaky blotches on her skin that form scales so painful sometimes she struggles to walk. But she says those who stare and giggle at her condition are just bullies living through an Instagram filter.

For a long time I was depressed and anxious because of it.I just hid away from theworldbecause of it, she told the Glasgow Times. It was also sore and irritating. I could wake up with blood on my pillow if I scratched it in my sleep. The more depressed I got about it the worse the condition got. It felt like a vicious cycle.

The 29 year old says shes struggled with psoriasis for nine years. She first noticed a small patch appear on her forehead before it took over around 40% of her face.

I couldnt put on a foundation to cover it up so it was pretty visible and people would stare, she said. If I went on dates I would need full blown conversations about it before it, and if I didnt I would get some nasty comments.

Duncan believes her condition may have been triggered by the stress of her fourth year at university and writing her dissertation. Shes now on medication which has helped to clear up her skin and reduce her symptoms.

It took me a long time to be comfortable and happy in my skin. It is something I am going to have to keep working on, she said.

Part of her work includes speaking out during Psoriasis Action Month, with the goal of educating others to treat people with visible differences with kindness and understanding.

Now I am working to raise awareness. Just because someone looks different from you doesnt mean they are infectious or have something wrong with them, she said.

Duncan has become more confident about her condition, which in the past has left her feeling embarrassed and isolated.

The first couple years I was really insecure and ashamed of it. It became all-consuming because I worried about what people thought about my patches, she said. On the flip side though I found this amazing online community who related to me and I made great friends. It helped me build up my resilience.

Managing stress and relaxing your body is important, but certain types of food and drink, along with tobacco, can be huge culprits for triggering autoimmune conditions. For some, the sun will exacerbate symptoms. Salt water from the ocean, however, can be good for clearing up skin conditions.

Also, eating an anti-inflammatory diet can reportedly help immensely for controlling flare-ups. Some people with psoriasis try to combat its distressing effects by following a paleo diet. A paleo diet, by definition, mainly consists of meat, fish, vegetables, and fruit, and excludes dairy or grain products and processed food.

According to the Paleo Dietwebsite, Foods that cause inflammation include refined carbohydrates, wheat and other cereal grains, soda and other sugar-sweetened beverages, margarine, shortening and lard, and processed meats.

These types of foods can cause insulin (a hormone that controls our blood sugar) to spike in our bodies, which can contribute to inflammation and also alter our gut health, meaning change the ration of good bacteria vs. bad bacteria, which can wreak havoc on the body.

Overall, getting an adequate amount of rest and 7-8 hours of sleep every night is a tried and true method of putting less stress on your body, therefore lessening the severity of certain conditions like psoriasis.

Some skin infections such as staphylococcus (staph) can look like psoriasis and they can be contagious. However, psoriasis itself is not an infection and it is never contagious.

So if you have this condition or if a loved one does, there is no reason to be concerned about it being spread from person to person. If youre swimming, hugging, or playing a contact sport with someone who has psoriasis, you dont need to be fearful about getting this condition too.

If lifestyle changes are not doing the trick, or if you are unable to incorporate them during a highly stressful time, some psoriasis patients can reduce the severity of their flare-ups by using a topical solution. Still, many times treatments applied to the skins surface just arent enough to clear stubborn psoriasis. Thats where systemic treatment treatment that travels through your entire body rather than being aimed at one area can be beneficial for patients. Systemic treatments are available via oral medication and injections. Some have been around since the early 70s, while others are relatively new to the landscape.

I have patients who come in after having been to many other medical practices and not really getting much hope or really good treatments for their psoriasis,Dr. George Han, a dermatologist at Northwell Health/Lenox Hill Hospital, explains to SurvivorNet. And well give the patient a systemic medicine that these days are very effective. We have treatments where over half of the patients who have moderate to severe psoriasis are getting 100% clear.

I have patients who come in after having been to many other medical practices and not really getting much hope or really good treatments for their psoriasis,Dr. George Han, a dermatologist at Northwell Health/Lenox Hill Hospital, explains to SurvivorNet. And well give the patient a systemic medicine that these days are very effective. We have treatments where over half of the patients who have moderate to severe psoriasis are getting 100% clear.

Psoriasis can start at any age, but most often develops in adults between 20 and 30-years-old and between 50 and 60-years-old.

It affects men and women equally, and theres no cure. But a range of treatments can improve symptoms and the appearance of skin patches.

For some its just a minor irritation, but for others it can have a big impact on their quality of life.

My advice to anyone dealing with psoriasis would be to just be gentle with yourself. Youre already going through a lot but the condition doesnt define you.

She also says words matter.

Try and say positive things like if you did good self-care or find something you like about yourself.

Going forward, Jude is focusing on accepting her psoriasis in an effort to be happy and comfortable in her own skin.

Learn more about SurvivorNet's rigorous medical review process.

Link:
Woman, 29, Slams Bullies Who 'Giggle And Whisper' At Her Unsightly Psoriasis Sores And Scabs, Leaving Her Depressed And 'Struggling To Walk' -...

In patients with psoriatic arthritis (PsA), serum calprotectin levels are associated with the presence of carotid plaques, according to a study published in Frontiers in Immunology.1

In PsA patients, serum calprotectin level was independently associated with the presence of carotid plaques, probably involving platelet and endothelial cells activation, Isaac Cheng, PhD, of The Chinese University of Hong Kong in Shatin, China, and colleagues, wrote. Moreover, subclinical carotid atherosclerosis was associated with the inflammatory burden (as reflected by the disease duration) in these patients.

While the association between PsA and increased cardiovascular (CV) disease risk is well established, only limited data is available on the underlying mechanisms.

This cross-sectional study included 78patients (52.6% male, mean age 52 years) with PsA but without CV disease. Calprotectin levels in serum were quantified and high-resolution ultrasound was used to determine carotid intima-media thickness and the presence of plaque.

Of the patients, 37.2% had carotid plaques. Serum calprotectin level was significantly higher in the group with carotid plaques compared with those without carotid plaques (721.3 ng/ml vs 564.6 ng/ml, P = 0.005). Serum calprotectin level correlated with PsA disease duration and mean carotid intima-media thickness.

Least absolute shrinkage and selection operator regression was performed to screen out 19 predictive variables including age, gender, traditional CV risk factors, medication use, clinical features and disease activity. Ln-calprotectin (OR: 3.38, 95% CI [1.37, 9.47]; P = 0.026) and PsA disease duration (1.09, 95% CI [1.01, 1.18]; P = 0.013) were statistically significant in predicting carotid plaque.

Investigators developed a nomogram for discriminating the presence of carotid plaque, which they said was an easy reference for clinical practice, with good accuracy, sensitivity and specificity (AUC 0.744, sensitivity 65%, specificity 79%). They concluded that serum calprotectin level may be a useful biomarker associated with a high inflammatory burden and the presence of subclinical carotid atherosclerosis in patients with PsA.

A limitation of the study was that most of the patients had low disease activity, thus the results may not be applicable to patients with moderate or high disease activity.

Reference:

Cheng IT, Meng H, Li M, et al. Serum Calprotectin Level Is Independently Associated With Carotid Plaque Presence in Patients With Psoriatic Arthritis.Front Med (Lausanne). 2022;9:932696. Published 2022 Jul 8. doi:10.3389/fmed.2022.932696

More here:
Serum Calprotectin Levels Linked to Subclinical Carotid Atherosclerosis in Patients With Psoriatic Arthritis - Rheumatology Network