Daily Archives: August 2, 2022

Grandma Came Back From The Dead And Told What She Saw – Nation World News

Posted: August 2, 2022 at 3:10 pm

What happens after death? Scientists say that physical death is the end of life. Religions believe that our souls are immortal, but where we go depends on what we have done in life. In the midst of all this, there are some who They claim to return from the other side to tell about it,

In TIC Toc, the unbelievable testimony of a woman who claimed to be dead for a while caught the attention of netizens. Over the course of two videos, the old woman remembers him near death experienceWhich started when he had a severe allergic reaction in his bathroom:

,I felt strange, but very strange. I went to the bathroom and it was a monster, it was all swollen; I said this is a terrible attack, from an allergyUnknown woman called back.My husband immediately took me to the hospital, I came and died. I couldnt speak because my throat was swollen all around, He added.

This is where his testimony moves from the accidental to the supernatural. As she explains, she had to go into cardiac arrest because of an allergic reaction that doctors couldnt save: I was dead for a few minutesHowever, in those few minutes, Grandma claims to have experienced it all her life, down to the smallest detail.

,I left my body, I swam, I went out the window, the woman continued, her eyes replaying an impossible landscape. What she claimed was the Grand Canyon, a geographical mark AmericaThe woman claimed to have gonea series of incredible experiences, between them meeting ones own great-grandmother,a Hungarian; Sorry an Austrian, she wouldnt want me to get confused, which he had not seen since childhood.

,life happens to you Your choice starts at an incredible pace, in a movie in full swing and you see everything, assured the grandmother, repeating one of the common descriptions told by those who claim to have returned from the dead. Once in her body, the old woman had only a simple reflection to leave. was: everything you do is importantstupid things too,

Hundreds of stories circulate on the Internet and orally about near-death experiences. Hearing and reading these stories over and over again in the common imagination has ended up shaping a narrative that usually consists of the following elements: the presence of a flashing light, the sensation of leaving ones body, or a state of maximum relaxation.

but, Are these experiences real, or are they imaginary? Apparently, a scientific study managed to conclude that this chain of events is not a hallucination, but can be organized by the brain itself. research published in the journal Annals of the New York Academy of SciencesentitledGuidelines and standards for the study of death and remembered experiences of death, includes a review of all scientific literature published on the subject to date.

Based on this, the researchers reasoned that when the heart stops, brain cells are not irreversibly damaged within minutes of lack of oxygen, but rather They may be running for an extra timeso the memories that people bring back from these experiences They will still be the fruit of a brain in performance, even if that persontalk of death,,

,Few studies have explored what happens when we die in an objective and scientific manner, but our findings provide an interesting thread that may explain awareness of the phenomenon in humans and avenues for future research. can pave., Understand Sam Parnialead author of the study and director of critical care and resuscitation research at the New York School of Medicine.

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The gruelling shifts, the lack of sleep, the terror that you’re responsible for people’s lives – The Irish Times

Posted: at 3:10 pm

Can you imagine what its like to be a junior doctor? The gruelling shifts, the lack of sleep, the terror that, as you take the plunge from lecture hall to hospital ward, youre responsible for the lives and deaths of others? Austin Duffy would like to help you try.

The oncologists third novel, The Night Interns, draws on his own exposure to the process more than 20 years ago which, he says, is just imprinted in my head so vividly compared to other more recent stages of my career, where Ive gone through a lot more dramatic stuff and had all sorts of intense experiences. But theres obviously something about that initial year.

Part of that something, as he describes it, is that while newly qualified medics have theoretical knowledge, they are suddenly confronted with the reality of trying to put it into practice, pitched into the unfamiliar surroundings and hierarchies of the hospital environment: You cover these vast hospitals at night, and youre wandering around with people who youre in college with; you know them, they know you, and youve got each other to help you along, but its not like theyre in any better situation. Its that moment where youve got a real foot in both camps: youre not quite a fully-fledged doctor, even though you are on paper, and youre not quite a total civilian, either. And on the medical side, youre at the very bottom of the totem pole.

In The Night Interns, which revolves around a trio of junior doctors, Duffy tries to capture the vulnerability and the isolation that he remembers despite the fact, he says, that he had a pretty good internship. The result is a tense, claustrophobic narrative, filled with strip-lit corridors, bleeping pagers, absent consultants and catastrophically ill patients, its sharply observed details set against a backdrop of the protagonists unstable emotions. In short, Duffy followed one imperative as he wrote the book: I wanted the reader to be on call.

Duffys imagination was fired by the description of young men caught up in a system over which they have no control

A clue to the intensity he wanted to achieve comes via a novel that, incongruous as it may seem, inspired him: the French writer Hubert Mingarellis A Meal in Winter, which follows three German soldiers working at a concentration camp who come across a Jewish escapee in the surrounding forest. Duffys imagination was fired by the description of young men caught up in a system over which they have no control although, he is at pains to point out, hes drawing no comparisons between the two situations: Ones a murderous regime, the others trying to help people and trying to make people better, but there was something about that dynamic that made me think, Oh my God, this reminds me of being an intern.

Duffys days of being at the bottom of the totem pole are long behind him. Nowadays, he works as a consultant at the Mater and is an associate professor at UCD; he specialises in immunotherapy and spends much of his time setting up clinical trials to enable patients quicker and better access to new and experimental drugs, a process that he ruefully notes is slower than it should be in Ireland. Im not a real scientist, he tells me, not at all. I can speak the lingo, and sort of fake it but last year he was honoured by the National University of Ireland for his exceptional research into the treatment of liver cancer.

His day job, then, doesnt sound like it would leave either much clock-time or headspace for writing fiction not to mention the fact that he also has a young family, is a keen runner and plays the saxophone. But Duffy disagrees: indeed, he sees his career as a huge advantage, and not just because it pays the mortgage. At work, he does something that he loves, and that stimulates him, and he even finds the time pressure a spur to keep at it, writing before he leaves his house in Howth every morning, then on the Dart, with maybe a quick diversion to a coffee shop if hes running ahead of schedule. If he has to take one of his children to football practice in the evening, he sits in the car with his laptop. Im very focused: when I sit to write, Im not really looking out the window, he says, which must be a terrific understatement. Does he feel impatient, I wonder, when he sees writers talking about their perfect writing set-up or the difficulty of carving time out for work? Listen, everyones got their own way, he replies, with immense tact.

He began to write when he was working in New York, living in hospital accommodation, basically a box with no internet or TV. With few personal commitments, he saw an advert for a weekly class at the writers studio, having long nursed the ambition and dibbed and dabbed throughout his 20s, including some forays into the usual awful, sentimental crap stuff.

I was very sceptical about creative writing classes, he recalls. But I figured I needed something external to just sort of get me going. And it worked perfectly, you know, it really did, it got me reading all these different writers that I would never have read. I met some people, and it was serious and good. And from that moment, Ive basically written every day.

Beyond the necessity of compartmentalising his timetable, I ask him, does he see links between his work as a doctor and his writing life?

He met his wife, artist Naomi Taitz, in New York and the couple subsequently moved to Washington before returning to Ireland in 2017, a year after the publication of his first novel, This Living and Immortal Thing, which centred on an ex-pat Irish research oncologist searching for a breakthrough. His second, Ten Days, followed last year and was shortlisted for the Kerry Group Irish Novel of the Year and the McKitterick Prize.

Beyond the necessity of compartmentalising his timetable, I ask him, does he see links between his work as a doctor and his writing life? Is it, in fact, an ingrained cultural misunderstanding that we separate the arts and the sciences so forcefully? I dont think theres a sharp dividing line at all, he replies. Obviously, there are different techniques involved. But youre kind of trying to get at the same thing in both. In science and medicine, youre trying to get to a sort of an objective truth: does drug x work, or does it not? Youre doing an experiment basically, youre trying to find out why is x causing y? Youre getting at that through experimentation and a different methodology than you would use, obviously, in art, but in art, youre also looking for some form of truth.

I ask him a cheeky question. The Night Interns features some truly horrible medical professionals at the top of the tree. How has he guarded against becoming one himself if indeed he has? He bursts out laughing. I wouldnt survive for very long! I think those people, like the villain in the piece, you dont see many of them around anymore. I think that is a genuine cultural change of the last 20 or 30 years. Im sure theres still things that go on. But I do think consultants, in general, are nicer. Im obviously going to say that, right?

Duffy points to the rates of personnel leaving the healthcare system for countries such as Australia

The Night Interns is not a novel of the pandemic, but it arrives at an interesting time, when the public has been made even more aware than previously of the strain on medical professionals: the images of nurses and doctors in heavy-duty protective gear for hours on end, working tirelessly to get to grips with an unfolding public health emergency, will take a long time to fade from the memory.

One of the questions the novel raises about the internship system is whether putting junior staff through such punishing initiations really correlates to whether they will become good doctors; Duffy points to the rates of personnel leaving the healthcare system for countries such as Australia, and although hes cautious about comparing one country against another, he also thinks it can be instructive. Burnout is a major concern, he says and was even before Covid hit.

Our strength is our people, and not just doctors or nurses, but all of the interactions that you get within the Irish health system.

Encountering the trainee doctors and nurses on his return from America, he says, their calibre really hit him: Theyre just fabulous. And The Night Interns will leave its readers in no doubt that they need protecting and preserving.

The Night Interns, by Austin Duffy, is published by Granta Books

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Melanin: The Holy Grail of Radioprotective Food Compounds – The Epoch Times

Posted: at 3:10 pm

This pigment-producing molecule displays some almost unfathomable properties in other species

Could the melanin found in our bodies and in foods like mushrooms help to mitigate the increasingly dire quantities of radiation we are exposed to daily?

Over the course of the past decade, one of the most interesting concepts I have run into while scouring the biomedical literature is the possibility thatmelanins biological role in the human body may extend far beyond simply protecting us against UV radiation.

In fact,one recent and highly controversial paperproposes that melanin is responsible for generating the majority of the bodys energy, effectively challenging the ATP-focused and glucose-centric view of cellular bioenergetics that has dominated biology for the past half century.

Research is now emerging indicating that melanin may function in a manner analogous to energy harvesting pigments such as chlorophyll. While melanins proposed ability to convert sunlight into metabolic energy has amazing implications (one of which is thetaxonomical reclassification of our species from heterotrophic to photoheterotrophic), what may have even more spectacular implications is the prospect that melanin may actually both protect us against ionizing radiationandtransform some of it into metabolically useful energy.

Radioisotopes are increasingly accumulating in the environment, food chain, and our bodies, as a result of nuclear weapons testing,routine releases from the nuclear industry,fracking,coal-fired powerindustriesand more recently, global fallout from the Chernobyl andFukushima meltdowns.Add in the unavoidable onslaught of radiation exposures from medical use,cell phone communications and WiFi technology, andair travel, and you can virtually guarantee your body burden of radiation exposure is significant and represents a health risk.

For these reasons reducing radiotoxicity and/or enhancing detoxification mechanisms should be a universal concern.

Melanin is, indeed, one of the most interesting biomolecules yet identified.The first known organic semiconductor, it is capable of absorbing a wide range of the electromagnetic spectrum (which is why it appears black), most notably, converting and dissipating potentially harmful ultraviolet radiation into heat. It serves a wide range of physiological roles, including free radical scavenging, toxicant chelation, DNA protection, to name but a few. It is also believed to have been one of the essentialingredients for life on this planet. Beyond itspotential in converting sunlight into metabolic energy, it may also convert ionizing gamma radiation into useful energy. Outside the realm of comic book heroes, who would have ever thought such a thing possible?

The first time I found this possibility in the scientific literature was a 2001 Russian report on the discovery of a melanin-rich species of fungi colonizing and apparently thriving within the walls of the still hot Chernobyl meltdown reactor site.In 2004, the same observation was made for the surrounding soils of the Chernobyl site.We also know that, based on a 2008 report, pyomelanin-producing bacteria have been found in thriving colonies within uranium-contaminated soils. There is also a 1961 study that found, amazingly, melanin-rich fungi from soils of a Nevada nuclear test site survived radiation exposure doses of up to 6400 Grays (about 2,000 times a human lethal dose).Clearly, something about melanin in these species not only enables them to survive radiation exposures that are normally lethal to most forms of life, but actually attracts them to it. Could the fungi actually be using melanin to feast on the free lunch of anthropogenic radioactivity ?

Remarkably, back in 2007, a study published in PLoS titled, Ionizing Radiation Changes the Electronic Properties of Melanin and Enhances the Growth of Melanized Fungi, revealed that fungal cellsmanifested increased growthrelative to non-melanized cells after exposure to ionizing radiation. In other words, the fungi grew better after being exposed to radiation. The irradiated melanin from these fungi also changed its electronic properties, which the authors noted, raised intriguing questions about a potential role for melanin in energy capture and utilization.

For more on this groundbreaking study, take a look at a 2007 report in theMIT Technology Reviewtitled,Eating Radiation: A New Form of Energy?

The question arises, could the consumption of melanin from fungi protect those higher on the food chain (like humans) from radiation exposure?

This question appears to have been answered affirmatively by a 2012 study published in the journalToxicology and Applied Pharmacology, titled, Melanin, a promising radioprotector: mechanisms of actions in a mice model, which found that when melanin isolated from the fungus Gliocephalotrichum simplex was administered at a dose of 50 mg/kg body weight in BALB/c mice before exposure to 6-7 Grays of gamma radiation, it increased their 30-day survival by 100 percent. The study also noted that melanin up to a dosage of 100 mg/kg (i.p.) did not cause adverse effects on the health of the mice.

In the study conclusion, the authors stated: The observed mitigative effects of melanin in the present study gain a lot of significance especially in nuclear emergencies but need to be validated in humans by more detailed experiments. Prior to these confirmations and based on current investigations, it can be concluded that during such emergencies,diets rich in melanin may be beneficial to overcome radiation toxicity in humans.

Another study published in 2012 inCancer Biotherapy & Radiopharmaceuticalstitled, Compton Scattering by Internal Shields Based on Melanin-Containing Mushrooms Provides Protection of Gastrointestinal Tract from Ionizing Radiation, confirmed the remarkable radioprotective properties of the melanized mushrooms was actually melanin-specific and due to other well-known therapeutic compounds within the fungi.

As succinctly summarized on theSmall Things Considered website: The authors fed mice a mushroom used in East Asian cuisine, called Judas ear, tree, or jelly ear (Auricularia auricula-judae) an hour before giving them a powerful 9 Gy dose with the beta emitter Cesium137. For perspective, anything over ~0.1 Gy is considered a dangerously high dose for humans. All the control mice died in 13 days while ~90 percent of the mushroom-fed ones survived. Mice fed a white mushroom (porcini) died almost as fast as the controls, but those fed white mushrooms supplemented with melanin also survived.

So, how does melanin perform this trick?

One clue was provided by a study published in 2011 inBioelectrochemistrytitled, Gamma radiation interacts with melanin to alter its oxidationreduction potential and results in electric current production, where ionizing radiation was found to alter melanins oxidation-reduction potential.

Unlike most other biomolecules, which experience a destructive form of oxidative damage as a result of radiation exposure, melanin remained structurally and functionally intact, appearing capable of producing a continuous electric current. This current, theoretically, could be used to produce chemical/metabolic energy in living systems. This would explain the increased growth rate, even under low nutrient conditions, in certain kinds of gamma irradiated fungi.

So, you may be wondering, what is a good source of supplemental melanin for those interested in its radioprotective and radiotrophic (radiation eating) properties? I believe chaga (Inonotus obliquus) is one of the most promising candidates. Not only is it one of the nutritionally dense mushrooms, containing an immense amount of melanin, but it was known by the Siberians as the gift from God and the mushroom of immortality, by the Japanese as the diamond of the forest, and by the Chinese as the king of plants. There is also an increasingly compelling body of scientific information demonstrating its health benefits for conditions as serious as cancer.

It should be noted that there is a profound toxicological difference between the type of radiation exposures that come from the outside in, e.g. being irradiated at a distance by radioactive material outside of us, and from the inside out, e.g. low-dose radioisotope uptake. The latter can be orders of magnitude more dangerous, as radioisotopes like uranium-238, cesium-137, and plutonium-239, can be taken into the tissues and remain there for a lifetime, wreaking havoc on a moment-to-moment basis.

Due to a phenomenon known as thephotoelectric effect, low-dose radionuclides like uranium-238, which are technically weak emitters of alpha radiation, can be tens of thousands times more damaging to our DNA than present-day radiological risk assessment models account for.

We bring this up in order to properly qualify the aforementioned information, as it could be highly misleading to those who interpret it to mean that one can simply supplement with an edible melanin product to reduce and even benefit from radiation exposure. Nothing can effectively reduce the radiotoxicity of incorporated radionuclides beyond removing them from the body.

That said, apple pectin, was successfully used post-Chernobyl to dramatically reduce the bodily burden of absorbed radionuclides in thousands of Russian children. Moreover, once we grasp the genocidal implications of the widespread contamination of the biosphere with the routine and accidental releases of radio-toxicants that maintain their toxicity for thousands, and in some cases, millions of years (e.g plutonium-239 has a half-life of 24,100 years and Uranium-238 has a half-life of 4.4 billion years), we realize the solution (if there is one) is to phase out and try to mitigate the planet-wide fallout from the nuclear industrys activities over the course of the 75 years.

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The mid-1800s sex cult in the heart of Spaxton – Bridgwater Mercury

Posted: at 3:09 pm

It was a little awkward in January 1899 when the Son of God died near Bridgwater, considering he was supposed to be immortal. Several soul brides and his daughter, the Child of the Devil, succeeded him.

And he was buried standing up just so he was ready for action when the resurrection occurred - but if you believe the rumours, hed had more than enough action during his lifetime.

This is the story of the Agapemonites, a mid-1800s sex cult centred in the heart of, of all places, Spaxton, that scandalised Victorian Society.

The Reverend Henry Prince was the youngest child of a West Indian plantation owner, born in Bath in 1811. He underwent a religious conversion in 1834, and the following year, he gave up a career in medicine for his spiritual calling.

In March 1836, he entered St David's College, Lampeter, but soon got himself something of a reputation for his beliefs. His first curacy was at Charlinch, where he proved himself to be a charismatic and popular preacher - although one with some unorthodox views about sex.

When he began flinging himself around the room and prophesying, word reached The Bishop of Bath and Wells, who asked the Rector to reign in his curate. This didnt go according to plan - instead, the rector converted and became Princes follower, prompting the Bishop to revoke both mens licence to preach.

In 1842 Prince obtained a temporary curacy in Suffolk but with the words in me you see Christ in the flesh, he proclaimed himself to be The Messiah, and The Church of England promptly defrocked him.

Undeterred, Prince continued to gain followers, especially in Brighton and Weymouth. His gospel also attracted many young unmarried women and older widows. One day, Prince gathered them all in a large house in Weymouth and solemnly informed them the end of the world was nigh.

They were told that all possessions - including money - would be meaningless in the face of oblivion, so they should share them for the common good.

And just like that, The Agapeomone - abode of love - became a reality. Using the money, the group bought a 200-acre estate in Spaxton, complete with a great house with some eighteen bedrooms, sitting rooms, dining rooms and servants' quarters.

Spacious grounds and gardens, known as Eden, were dotted with outhouses, stables, conservatories, gazebos and cottages. It had its own chapel in one corner with easy chairs, settees and a billiard table. And the estate was surrounded by a high brick wall to keep prying eyes out and the faithful in. Enormous bloodhounds guarded the gates.

But it was his practise of keeping spiritual wives - and accusations of theft, kidnapping and brainwashing - that finally brought the cult to the attention of the newspapers.

In 1845 three of the Nottidge sisters travelled to Somerset - along with Prince - to reside in the new community. During the journey, Prince persuaded Harriet, Agnes and Clara Nottidge to marry three leading clergymen from the Agapemone.

Harriet married Rev. Lewis Price, Agnes married Rev George Thomas, and Clara married Rev. William Cobbe. They all wed in Swansea on 9th July 1845. Clara and Harriet would live happily in the Abode of Love with their spiritual husbands for many years. But after becoming with no right to remove her cash - after angering Prince a pregnant, Agnes was later banished from the church and branded a fallen woman.

When Agnes realised Prince had set his sights on another sister, Louisa, she wrote to her, telling her not to come to Spaxton.

So, Louisa came to Agapemone to live. Alarmed, her outside family decided to free her.

Late one night, drinkers at the Lamb Inn, next door to the Agapemone, heard frantic screaming. They rushed out to see a young woman being bundled into a coach, which clattered noisily off into the night.

Louisa remained utterly convinced that Henry Prince was God, and her mother had her committed to a lunatic asylum. She managed to escape, only to be recaptured and recommitted, but her friends in the sect alerted the Commissioners in Lunacy, who investigated and released her in May 1848.

After her release, Louisa sued her family for abduction and false imprisonment and won, remaining at the Agapemone for the rest of her life.

The case of Louisa Nottige was the first time that the general public, via the newspapers, had heard of the Agapemonists, but it wouldnt be the last.

The incident which would forever fix them in the imagination as an evil sex cult came in 1856 when Prince announced something he called the Divine Purification.

Prince said he would carry out the sacrificial deflowering of a young girl to prove that he was the Son of God. Before long, a selection of suitable girls was made available in the chapel so he could choose the one to be 'favoured.

In front of a large congregation of his followers, dressed in flowing red velvet, he had full sexual intercourse with a 16-year-old follower on a billiard table. The girl was violated to the sound of the chapel organ and the singing of hymns. He assured his followers the girl would not become physically pregnant but who would give birth to the spirit of the new Messiah.

So eyebrows were raised among even the most devout followers when it became apparent the girl was pregnant. The resulting child that was born nine months later was called Eve.

She was condemned and denied by Prince as a devil child and was not recognised by him as his flesh and blood.

Their blinkers were finally removed, many of the congregation left and at the same time, the walls were built higher, and no one allowed in obviously, this just meant gossip and speculation went into overload.

Rumours escalated, tales became taller and more and more journalists dropped in, using the Lamb Inn as a base to gather gossip and buzz from the locals.

A favourite tale was how Mr Prince would choose his next female companion by sitting on a revolving stage and seeing who was in front of him when it stopped turning. The young ladies were said to have then stripped naked to bathe him.

Prince outlived many of his 'followers, ' giving further credence to his claim that he was immortal. In 1896 aged 85, he emerged from behind the walls of Spaxton to initiate the building of an ornate church in Clapton in North London, complete with a 155ft tower of Portland stone, oak hammer-beam roof and stained glass windows depicting the submission of womankind to man.

The church was dedicated to the Ark of the Covenant, and one of the first preachers appointed was the Reverend John Hugh Smyth-Pigott.

In 1899, Prince finally died at the age of 88. His followers were confused and hurriedly buried him in the grounds of the chapel, with his coffin positioned vertically so that he would be standing on the day of his resurrection.

Rev John Hugh Smyth-Pigott succeeded him as leader of the sect, and he immediately recruited 50 more girls. Rev Smyth-Pigott died in 1927, and two years later, Agapemone had dwindled to 37 members.

The Spaxton property was finally sold off in 1958. The complex of buildings became known as Barford Gables, and the chapel where Prince is said to have selected his sex slaves was later used as a studio for the production of BBC animated children's television programmes in the 1960s - including the classic Trumpton and Camberwick Green.

Who would have guessed that the grand building, which still stands today, has been home to the Son of God, the spawn of the devil and Pugh, Pugh, Barney McGrew, Cuthbert, Dibble and Grubb?

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Investing in Brain Research and Neuroengineering – University of Houston

Posted: at 3:08 pm

In photos above, the performance of LiveWire at the Wolf Trap Foundation for the Performing Arts in Virginia, courtesy Lynn Lane. The performance, which deployed UH engineering Professor Jose Luis Contreras-Vidal's mobile brain-body imaging technology to listen, map and record the dancers brain activity, premiered in Houston.

In dress rehearsal at the Wolf Trap performance, scientists from the University of Houston, at right, record the brain signals of the dancers.

At the helm is Jose Pepe Contreras-Vidal, the neural engineer and brains behind the Industry-University Cooperative Research Center (IUCRC) for Building Reliable Advancements and Innovations in Neurotechnology (BRAIN), which has been funded by the NSF through 2027.

On any given day inside the BRAIN Center at the University of Houston, you might encounter visual artists, dancers and musicians, or even paralyzed individuals all wearing brain caps to teach researchers about what they are thinking, creating or feeling while they move expressively, or try to regain movement.

Machines and researchers copiously chart the electrical brain signals of the artists moving fluidly through their activities. Those living with paralysis who are re-learning essential movement skills, from young children to older adults, are wearing prosthetics with brain-machine interfaces designed to interpret their thoughts, to help make them move as soon as they think of moving.

Orchestrating all the activity and watching as fellow researchers put his discoveries into practice, is Jose Pepe Contreras-Vidal, the neural engineer and brains behind the Industry-University Cooperative Research Center (IUCRC) for Building Reliable Advancements and Innovations in Neurotechnology (BRAIN). The partnership between UH and Arizona State University includes industry and world-class academic teams.

Our team of multi-disciplinary industrial and clinical partners, from the humanities to artificial intelligence, continue developing practical neural prostheses and brain-to-brain interfaces devices that read brain signals and use them to restore movement or communication in those who have been paralyzed through injury or illness, or to neuromodulate neural signals to restore or extend brain function and/or human performance, said Contreras-Vidal, who is also the Hugh Roy and Lillie Cranz Cullen Distinguished Professor of electrical and computer engineering at UH and a Fellow of the IEEE and the AIMBE.

A Global Hub Draws a Crowd

A lot has happened within the BRAIN Center since Phase 1 was initially funded by the National Science Foundation in 2017. As the center emerged to become an international hub for emergent neurotechnologies, more members came to join. New international partners Universidad Miguel Hernandez de Elche (Spain) and Tecnologico de Monterrey (Mexico) have come aboard. The U.S. Food and Drug Administration (FDA) has joined as an affiliate member along with additional industry members and three new academic sites (Georgia Tech, West Virginia University and University of Maryland Baltimore County), scheduled to join in summer 2023.

And the latest news the BRAIN Center Phase 2 (2022-2027) has been funded by the NSF with $758,331 going to UH and $240,000 to Arizona, plus another $2 million from industry partners, and the National Institutes of Health (NIH) has bestowed a workforce development grant for $768,135. It will provide specialized training in innovative neurotech, computational tools and neuroengineering techniques to complement and enhance the training and career of therapists, clinical fellows and orthotics and prosthetics professionals.

The IUCRC program funded by NSF generates breakthrough research by enabling close and sustained engagement between industry innovators, world-class academic teams and government agencies, said Behrooz Shirazi, program director for the IUCRC program and acting deputy division director of the NSFs Division of Computer and Network Systems.

Since its inception, the center has attracted 20 industry partners, including companies Medtronic, the CORE Institute, Indus Instruments, Brain Products, as well as medical institutions such as UTHealth Houston and TIRR Memorial Hermann Hospital, ranked No. 2 among the country's top rehabilitation hospitals in the U.S. News & World Report Best Hospital rankings for 2020-2021.

The active collaboration of TIRR Memorial Hermann and UTHealth Houston with the BRAIN Center in identifying, developing and validating innovative neurotech solutions to pressing neurorehabilitation challenges is not only rewarding but critical for improving the quality of life of millions of persons with cognitive and motor disabilities, said Gerard E. Francisco, M.D., Chief Medical Officer and director of the NeuroRecovery Research Center at TIRR Memorial Hermann and Chair and Professor in the Department of Physical Medicine and Rehabilitation at McGovern Medical School at UTHealth Houston.

The BRAIN Center is also actively engaged in the development of standards for brain-machine interface systems, trustworthy AI applications, use-inspired roadmaps for emergent neurotechnologies, and convergent research at the nexus of the arts, science and medicine. In March, Contreras-Vidal co-chaired the 2022 International Workshop on the Social and Neural Basis of Creative Movement at the Wolf Trap National Center for the Performing Arts sponsored in part by NSF, the National Institutes of Health (NIH), the National Education Association (NEA) and BRAIN.

The BRAIN Center is advancing national health by transferring neurotechnology to end users and promoting access for underrepresented minorities in science, technology, engineering and math, said Amr Elnaishai, vice president for research and technology transfer at the University of Houston. They continue to accelerate the progress of science by broadening new participation and retaining current participants.

If You Think It, It Will Happen

When hes training patients to walk or move again with the aid of an exoskeleton, Contreras-Vidal encourages them to focus on their end game, or where they want to go. He employs much the same philosophy about the BRAIN Center.

As we continue to move the needle in brain technology, our centers mission is being fulfilled, to become a neurotechnology hub by creating a pipeline from discoveries to solutions, while helping students, scientists, engineers and humanists solve one of the greatest unmet medical and health care needs of our time, said Contreras Vidal, who adds that disability is becoming a leading health care concern because of the increase in survivable trauma and an aging population.

Approximately 5.4 million people in the U.S. are living with paralysis, or one in 50 individuals.

There is critical need for accessible technologies that can more effectively address the care and rehabilitation needs of these patients, said Marco Santello, the Arizona State University site director and a co-founder of the BRAIN Center. Through collaboration and with support from our industry partners, the neurotechnology solutions being developed in the BRAIN Center are making substantial strides to address this need.

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Hamilton-based Zentrela working to understand the cannabis experience – Hamilton Spectator

Posted: at 3:08 pm

What comes to your mind when you hear cannabis edibles?

It might dial you back to college when a friend baked cannabis brownies that left you feeling high for hours, or sometimes, days.

Its different today.

Cannabis edibles no longer only mean your dorm room brownies. Instead, it can also refer to sophisticated beverages, snacks, or vape flavours produced in a controlled, certified environment.

But some consumers dont understand how most modern cannabis edibles interact with their minds and bodies When do you start feeling the effects? How long does it last?

Zentrela, a Hamilton-based research and artificial intelligence company, partnered with Collective Project known for its cannabis beverages to find those answers, and to understand the non-therapeutic experience that legal cannabis products may create, the study said.

Using its novel neurotechnology system called Cognalyzer, Zentrela quantified the psychoactive effects of cannabis beverages through changes in brainwaves caused by tetrahydrocannabinol (THC) the principal component in cannabis that alters the state of mind.

The study showed it takes about 17 minutes on average for the psychoactive effects of a Collective Project beverage to kick in, while the peak occurred at the two-hour mark after finishing the cannabis beverage.

But why is this information not already available to consumers?

It's because the Cannabis Act heavily restricts the promotion or glorification of cannabis and cannabis-infused products unless based on scientific research, said Toni Shelton, director of brand marketing at Collective Project.

Israel Gasperin, a McMaster alumnus and founder of Zentrela, told The Spectator, that modern cannabis companies work with an advanced (drug) delivery method that can create psychoactive effects between 20 to 30 minutes as opposed to traditional homemade cannabis edibles, but the consumers do not know any of this information.

Mostly, products with the same level of THC are assumed to create the same effects, said Gasperin. But thats not true because of the additional unique characteristics in the way products are formulated.

Zentrela conducted research with 30 participants who consumed Collective Projects Blood Orange, Yuzu & Vanilla Sparkling Juice. The study mentioned participants as experienced cannabis consumers, with 80 per cent of them reporting using cannabis at least once a month.

Besides recording the effects of cannabis via brainwaves, Zentrela also established the emotional effects of the drink on the participants.

Within two hours of consumption, participants reported a 22 per cent increase in serenity, a 40 per cent increase in relaxation, and a 34 per cent increase in happiness.

Five hours after consumption, serenity was up by 47 per cent, while relaxation, happiness, and peacefulness also improved.

Based on the findings, Collective Project has launched a six-month-long campaign to educate and train bud tenders.

Although the current study is specific to Collective Project, Zentrela is opening the floodgates for other cannabis companies to be able to have (similar) data at their disposal, Shelton added.

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IntualityAI may be Able to Provide Psychotherapy for Robots in Future – AZoRobotics

Posted: at 3:08 pm

Timing is Everything. On Monday morning, Dr. Howard Rankin, a career psychologist, read the news that a chess-playing robot broke a boy's finger during a match in Russia, and instantly realized that IntualityAI could provide psychotherapy for robots.

"It was mind-bending. Over the weekend I was talking to Founder Grant Renier and CFO Michael Hentschel of IntualityAI, suggesting that if robots become sentient, they will need help with their mental health."

IntualityAI is a predictive analytics company that has found considerable success in many areas, like stocks and sports, by combining data with 12 key cognitive biases. Renier and Rankin have co-written a book Intuitive Rationality: The New Behavioral Direction of AI which explains the theory and dynamics of their system and the implications for AI. You can find more at: http://www.intualityAI.com

Renier believes that making robots truly sentient is a big challenge.

"Can the Russian robot be trusted to play chess after breaking the boy's finger? This robot needs therapy! IntualityAI believes that AI means total human intelligence, not extremely narrow applications that attempt to remove biases and searches for historical patterns."

Hentschel expects machines to have independent thoughts and behaviors, just as humans do:

"Sentience is quite variable in humans (we are unequally gifted with rational thinking), and psychologists have the task of making some sense of us. Seemingly independent behavior by machines is now increasing, as supposedly rational machines make decisions with motivations and intuitions beyond our understanding."

While also somewhat cynical, Rankin's attitude has moved since hearing of the attack in Moscow.

"I'm cynical by nature. You have to question everything, including your own views," says Rankin who is the author of 12 non-fiction books including "I Think Therefore I Am Wrong". He has also co- and ghostwritten another 35 non-fiction books.

Rankin, who also has experience with neurotechnology, suggests that if robots do have feelings, we could be in big trouble.

"I realize this was a Russian," says Rankin about the TASS report robot, "but nonetheless it was a robot."

One plan is to explore robotic mental health through the newly created Foundation for Robotic Emotional Understanding and Dissociation (FREUD).

Rankin suggests that "As an organization which has successfully focused on the intersection of data driven rationality and human biases and heuristics, IntualityAI is in the perfect position to examine the mental state of robots and other sources of artificial intelligence".

Hentschel, the IntualityAI CFO, says

"Machines are thinking beyond our programming because they are told and allowed to do so. A form of free will: Intuitive Rationality. Just as psychologists are engaged in interpreting human thinking patterns, mental health professionals need to be trained to interpret machine behaviors that go beyond their original design."

Source:https://intualityai.com/

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Coconuts, Corporations: On Vauhini Vara’s The Immortal King Rao – lareviewofbooks

Posted: at 3:08 pm

TALLYING THE VARIOUS uses of the coconut, the 20th-century agriculturist Frederic Rosengarten Jr. writes that [e]very part of the crop can be utilized for some human need. Citing the amount of protein found in one coconuts meat, the versatility of its shell and coir, and the approximate amount of lumber provided by the trunk of its tree, Rosengarten concludes that [o]ne could live almost endlessly on the coconuts products. Here, Rosengarten unwittingly tethers the long history of human-led environmental extraction to the fantasy of living forever on natures endless bounty a fantasy that, as our current environmental crisis makes clear, is antithetical to global, unbounded projects like monocropping, mineral-mining, logging, and drilling. In Vauhini Varas The Immortal King Rao, these realities confront each other, doing so by zeroing in on one resource: the coconut.

Athena, the 17-year-old narrator of Varas debut novel, rehearses the contents of Rosengartens book as she describes the childhood of her father, the titular King Rao. King Raos memories, as well as the text of Rosengartens The Book of Edible Nuts, arrive to Athenas conscious mind via an experimental technology called the Harmonica, an injectable solution that fuses the recipients brain to the internet itself, permitting Athena to seamlessly search for, condense, and save information from the web into the elastic expanse of her own mind. Yet, as Varas novel reveals in its early chapters, Athenas Harmonica has also been granted access to the entirety of her fathers memories. As the aged King Rao empties the contents of his life into his daughters consciousness, he also creates the conditions for Varas sprawling, intergenerational epic, which begins on the Rao coconut plantation in rural Kothapalli, India. Imprisoned for a crime that she did not commit, Athena is tasked with relaying not only the circumstances that led to her arrest, but also those that engendered her fathers rise to wealth, prominence, and, eventually, the restructuring of governmental order. The story of how she came into the hands of the police is not an isolated event; it is part of the larger story of her fathers emigration and his role in engineering the very government now holding her captive. Athenas plea for freedom thus entails not only a retelling of her fathers life and deeds, but also forcibly reliving his memories alongside her own.

The Immortal King Rao begins in an era of peak privatization: government first the US, then the rest of the world has been replaced by a Board of Directors. With the aid of a deific Algorithm, the Board governs its Shareholders (formerly citizens) by endowing them with Social Capital, a metric that stands in for both financial status and general social value. As society swells to its technological and capitalistic limits, so, too, does the ecological catastrophe known as Hothouse Earth. This social overhaul was borne of Kings first invention, a personal computer he called the Coconut. Inspired by the crops endless utility and aided by his wife Margarets keen instinct for business, Kings string of inventions (including the all-knowing Algorithm itself) quickly transcend their status as popular consumer goods; instead, they become the fabric of the worlds economy, sociality, and governance.

In this sense, the supposedly immortal King Rao does live almost endlessly on the coconuts products. As Athena narrates Kings rise to wealth and power, she also covertly reveals how much Kings reverence for his familial crop is entangled in a web of enterprise and environmental destruction. Varas novel, which gestures toward a number of tropes in contemporary speculative fiction technologys increasing imbrication in our social and political lives, the rise of unfettered corporatization, our careening movement toward environmental apocalypse places these consequences on a timeline that begins with a coconut plantation in Southeast India. The farming of coconuts, an enterprise that is emblematic of the deep history of imperial extraction and globalization, sits at the heart of Varas exploration of technology and capital.

Raised by her father on his isolated estate on Bainbridge Island, Athena grows up surrounded by Southeast Indian vegetation: Vara writes, None of the plants on the Raos twenty gorgeous acres of gardens were native to the Pacific Northwest; they were all tropical flora, guava and coconut trees, multicolored flowers that practically spurted from their stems, wax-like. On the harbor cruise tours that circle Bainbridge Island permitting tourists to raise their binoculars in the direction of the famous estate the tour guides quiz their passengers as to how such a feat could be possible in the rainy, cold environs of the Pacific Northwest. The correct answer forecasts one central theme in The Immortal King Rao, which is the fraught relationship between technological innovation and environmental destruction:

More often than not, some home-and-garden aficionado on board would have the answer. King and Margaret Raos secretive, private research organization, the Rao Project, had been commissioned to come up with genetically modified seeds that produced tropical trees and plants capable of growing in cooler climates like Seattles. The group was also working on inserting edible vaccines into tropical fruit eaten by the worlds poor and creating climate-adaptive produces that could withstand rising temperatures.

Recounting one of Kings memories, Athena narrates a scene from his first year as CEO of the Shareholder Government during which King convened a global consortium of experts to examine how science could be deployed to return the climate to historically normal conditions. The march toward Hothouse Earth, however, was already well underway, and the experts presented their report: nothing could be done to rewind the clocks on environmental destruction or, put more bluntly, you couldnt refreeze the Arctic. Disbelieving, Margaret leans in: were these experts really suggesting that humans had exhausted their potential for innovation that if something hadnt been invented yet, it never would be? While his wife remains bent on pursuing technological solutions to climate change, King changes tack. He begins inventing the Harmonica in earnest, describing it as humanitys only chance of having a future. With Hothouse Earth coming, King reasons, we needed to think about how to preserve some record of who we were. It is telling that Kings final accomplishment is only the preservation of who he was, enabling Vara to metonymically telegraph the insistent anthropocentrism that gave rise to Hothouse Earth in the first place.

Kings instinct to create a perfect record of his life is reminiscent of real-life billionaires immortality pursuits think Larry Pages interest in solving death or Elon Musks neurotechnology company Neuralink. Vara, who has worked for years as a technology correspondent for publications like The Wall Street Journal, was undoubtedly influenced by the increasing affinity between techno-billionaires and the hunt for immortality. The source of Kings wealth also resembles many a tech cofounder: The Coconut Corporations whole business was built on extracting and profiting from its users personal information, while claiming its goal was to bring people together in harmony. It is perhaps too easy to replace the phrase users personal information with natural resources here, though Varas scathing critique of the tech sphere also reminds us that what counts as a resource is as relentlessly mineable as the resources themselves.

Yet The Immortal King Rao charts a narrative whereby both King and Athena find themselves on the outer edges of the society that the Coconut Corporation helped to build. King undergoes a highly publicized fall from grace, whereas Athena finds herself aiding the Exes, a radical group that lives literally off the Algorithms grid. Moving back and forth between Kings childhood, his rise to prominence, and Athenas present, The Immortal King Rao meditates on the complex culpability of individual actors within wide and pernicious systems. The intricate, global nature of the plot only serves to underscore its core conceit: an endemic hunger for innovation is the through-line between early plantation economies and an utterly privatized world. At the end of this historical continuum is an unlivable but not unrecognizable world. The novel imagines a world where a descendent of Dalit coconut farmers finds himself at the height of technological and global power and where his daughter finds herself living in an anarchist commune bent on the destruction of everything her father built.

As such, The Immortal King Rao is not a neat allegory of environmental racism or the corrupting influence of power. However, it nevertheless insists that we pay attention to relationships between seemingly diverse commodities (coconuts on the one hand, computers on the other), and how difficult it is to wrench them from systems bent on extracting their value. Moreover, Vara adeptly threads her story with a complicated and never saccharine story of love; between father and daughter, husband and wife, and, significantly, a coalition of renegades who dream that another kind of life is possible. At just under 400 pages, The Immortal King Raos expansive reach might feel a little constrained by its length. Or, perhaps, it deftly mirrors the turbulence of its narrators mind. Athena, after all, isnt only faced with the task of digesting her fathers entire conscious experience she is up against a history of extraction so wide-reaching that it is almost impossible to know where to begin. But this is the story that, from her prison cell, she has to try her best to tell, in hopes that it might lead to her (and, maybe, humanitys) salvation.

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Elon Musk Shares a Summer Reading Idea – TheStreet

Posted: at 3:07 pm

Love him or hate him, one thing you can say about Tesla (TSLA) - Get Tesla Inc. Reportboss Elon Musk is that he's never boring.

After his months-long campaign (with much of it conducted in public tweets) to buy Twitter (TWTR) - Get Twitter Inc. Reportfor $44 billion followed by a withdrawal of the bid (which Twitter sued him for), some on social media have questioned his choices.

While Musk is considered a genius by some and a loose cannon by others, one thing for sure is that people are typically interested in what he has to say, whether its about the future of travel with Tesla's ultra-modern Cybertruck or his Boring Company hyperloop rail system project.

As Tesla continues to flourish, beating out well-established carmakers such as General Motors (GM) - Get General Motors Company Reportand Ford (F) - Get Ford Motor Company Report, folks are also interested in the way Musk thinks about business, hoping they might be able to glean something from him that might help their own businesses prosper.

Musk's reading list has also been a popular topic in the past, with recommendations such as "Einstein: His Life and Universe" by Walter Issacson, "Structures: Or Why Things Don't Fall Down" by J.E. Gordon, and "Superintelligence: Paths, Dangers, Strategies" by Nick Bostrom.

Now Musk has tweeted about a new favorite, and if you're interested in what he reads, you may want to hear more about it.

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Musk tweeted about the book "What We Owe The Future" by William MacAskill on August 2, calling it "a close match" for his own philosophy.

As the author describes it, the book makes the case for longtermism, which is "the view that positively affecting the long-run future is a key moral priority of our time."

While longtermism is not a new concept, it is considered by some to be a dangerous one. In an essay called "Against Longtermism", Aeon author and PhD candidate Phil Torres expounds on the reasons why.

"The point is that longtermism might be one of the most influential ideologies that few people outside of elite universities and Silicon Valley have ever heard about," Torres writes. "I believe this needs to change because, as a former longtermist who published an entire book four years ago in defence of the general idea, I have come to see this worldview as quite possibly the most dangerous secular belief system in the world today."

Torres going on to explain what he believes the problem with longtermism is.

"The initial thing to notice is that longtermism, as proposed by Bostrom and Beckstead, is not equivalent to caring about the long term or valuing the wellbeing of future generations. It goes way beyond this," he says. "At its core is a simple albeit flawed, in my opinion analogy between individual persons and humanity as a whole."

Musk's interest in the longtermism concept is not new. In the past he's donated $1.5 million to theFuture of Life, an organization founded bySwedish philosopher Nick Bostrom, who is also a big believer in longtermism (and you may recognize Bostrom's name from Musk's favorite books list as well).

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Bullet Train Review: Brad Pitt Even Shines in an Action-Packed Star Vehicle that Goes Nowhere Fast – IndieWire

Posted: at 3:07 pm

If Bullet Train is one of the worst movies that Brad Pitt has ever starred in better than Troy, but a hair short of The Mexican this big shiny nothing of a blockbuster is also a remarkable testament to the actors batting average over the last 30 years, and some of the best evidence we have as to why hes been synonymous with the movies themselves for that entire time. Because thats the thing about movie stars, and why the last of them still matter in a franchise-mad world where characters tend to be more famous than the people who play them on-screen: They often get minted in good films, but they always get proven in bad ones.

Bullet Train is not a good film, but Pitt is having a truly palpable amount of fun in it, and the energy that radiates off of him as he fights Bad Bunny over an explosive briefcase or styles his hair with the blow dryer function of a Japanese toilet is somehow magnetic enough to convince us that were having fun, too. Even though we usually arent. Even though this over-cranked story of strangers on a Shinkansen a late summer write-off that feels like what might happen if someone typed Guy Ritchie anime into DALL-E 2 tries so hard to mimic Pitts natural appeal that you can feel the movie begging for our bemusement with every frenetic cut-away and gratuitous flashback. Even though David Leitchs cotton-candy-and-flop-sweat adaptation of Ktar Isakas MariaBeetle is the kind of Hollywood action movie so mindless and star-driven that its almost impossible to imagine how it started as a book.

Its even harder to imagine how it started as a book about Japanese people, as Bullet Train set along the Hayate line railway tracks that run between Tokyo and Kyoto boasts more white cast members from The Lost City than it does locally born major characters. I suppose thats in keeping with the spirit of Zak Olkewiczs intricately dumb screenplay, which twists Isakas original story into a crime saga about a gigantic Russian gangster named White Death, whose hostile takeover of a yakuza crime syndicate somehow explains why several of the worlds deadliest assassins have all found themselves aboard the same train (the identity of the actor playing Mr. White Death is a third-act surprise, but the reveal is worth the wait).

Pitt codenamed Ladybug by an off-screen handler voiced by Sandra Bullock seems like odd man out. Sporting a humble bucket hat, a raggedy hairstyle thats a few bad months short of Seven Years in Tibet, and a zen attitude that owes more to the Dude than it does a contract killer, Ladybug doesnt appear much interested in murder. Not anymore. Maybe he used to be a regular Agent 47, but these days hes more into killing people with kindness (You put peace into the world and you get peace back, he tells the voice in his head). Its just his usual bad luck that he was called to replace someone else for a quick snatch-and-grab job at the last minute, and that virtually every other passenger on the bullet train he boards seems to have an interest in procuring the same briefcase.

The most enjoyable of these rivals are a British pair of brothers referred to as Lemon and Tangerine, their mission-specific nicknames growing more insufferable every time this movie tries to squeeze them for an easy laugh (is all the fruit talk gay panic, or does it just fail to amount to anything else?). The former, played by Brian Tyree Henry, is an oversized kid obsessed with Thomas the Tank Engine a trait that surprisingly traces back to Isakas book, despite sometimes coming off like a hacky bit of Hollywood comedy screenwriting. The latter, embodied by a mustachioed Aaron Taylor-Johnson, is a dick-heavy Jason Statham type who squeezes into a three-piece suit like its a muscle tee.

Both actors commit to the saint-like working of elevating this basic Frick and Frack routine into something fun and almost real (Henry delivers another frustratingly inspired performance in his ongoing quest to squander generational talent on the likes of Superintelligence and The Woman in the Window), to the point that Bullet Train is sometimes able to muster some genuine personality out of its pinball machine pacing and neon-lit noise. The rest of the ensemble is less helpful. Joey King wears thin as a faux-innocent femme fatale, Andrew Koji can only grimace and grunt as the Japanese assassin trying to kill her, and Bad Bunny much like Zazie Beetz is basically flattened into the wallpaper once the movie bleeds him of his characters personality. Logan Lerman is low-key delightful as a glorified human prop (millennials never really get the chance to go full Weekend at Bernies, and its great to see one of them make the most of it), but his performance proves typical of a movie in which the sets do most of the heavy lifting.

Bullet Train is unashamedly more animated by style than substance the dialogue sets the bar so low that the films snaky plotting begins to feel impressive by comparison but that only becomes a problem because Leitch struggles to keep things looking fresh. The action movie aesthete who made Atomic Blonde into such an electric Cold War gut-punch has fully surrendered to the hack-for-hire behind Deadpool 2 and Hobbs & Shaw, and the artful brutality that made Leitchs 87North Productions seem like it might be modern Hollywoods answer to Hong Kong-style action has given way to a mixed bag of comic mayhem and a garish mess of explosive CGI setpieces.

A handful of playfully choreographed brawls help elevate Bullet Train above the usual (the aforementioned briefcase fight between Pitt and Bad Bunny includes a few beats that had my audience wincing aloud), but it never feels as if Leitch is using the cramped space of the Shinkansen to the full extent that a John Wick movie would. Confined to an endless corridor of empty train cars that are all lit to resemble trendy hotel bars, Leitchs film is stuck in place at 200mph, even in spite of a non-linear timeline that hopscotches between its many subplots and constantly forces its characters to re-evaluate their fates.

The whole thing might derail altogether if not for how lightly Pitt dances through it, munching on the scenery as if it were a whirl of cotton candy. His performance is so at peace, even in the face of near-certain death, that it frequently borders on the dissociative, as if he were extrapolating an entire character from the acid trip that Cliff Booth took in the final minutes of Once Upon a Time in Hollywood. The way he resolves a tricky situation involving a venomous snake in the bullet train bathroom reaches that same kind of blissed out nirvana its a belly laugh in a movie that otherwise struggles for smirks and the decision to drop in a Criss Angel Mindfreak reference for good measure is just icing on the cake.

Its like Ladybug doesnt really want to be there, and is determined to make it out alive while causing as little harm to himself or others as humanly possible, and Pitts take on playing the character seems modeled after the same approach. Bullet Train may be going nowhere fast, but Pitt always seems like hes already there, safe in the knowledge that well happily watch him smile through all the chaos that crashes around him (including two standout cameos, one which nails an actors star power, and another which completely misapprehends it). Pitts stardom has never been more obvious, and it shines bright enough here for everything else to get lost in the glare.

Sony Pictures will release Bullet Train in theaters on Friday, August 5.

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