Daily Archives: July 17, 2022

Ultima Genomics signs development agreement with Regeneron aimed at driving the scale of genomic information for drug discovery and development – PR…

Posted: July 17, 2022 at 9:06 am

NEWARK, Calif., July 12, 2022 /PRNewswire/ --Ultima Genomics, Inc. (the Company) has signed an agreement with Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN) to further advance Ultima Genomics' sequencing architecture. Under the terms of the agreement, Regeneron will collaborate with Ultima on the development and testing of Ultima's second-generation sequencing platform, which will build upon the advances of the Company's first instrument, the UG100anticipated to launch in 2023. In conjunction with the agreement, Regeneron, who is currently part of the early access program for the UG100, will also become an investor in Ultima. The primary objective of the collaboration between Ultima and Regeneron is to enable affordable high-throughput sequencing for large-scale genomic analysis and to accelerate insights and discoveries that will profoundly impact life sciences research around the world.

"Regeneron and Ultima share a common goal of using science to improve human health," said John Overton, Ph.D., Vice President and Chief of Sequencing and Lab Operations at the Regeneron Genetics Center (RGC). "With more than 120 active research collaborations and one of the largest whole exome sequencing reference libraries in the world, we at the RGC are keenly interested in the development of technologies that streamline the drug discovery and development process. The high cost of next-generation sequencing constrains the production of genomic information a significant bottleneck for life sciences research. With this agreement, we hope to contribute to an affordable and scalable solution that enables the rapid advance of genomic sciences, and in turn, important medicines for patients in need."

"We founded Ultima Genomics with the mission to continuously drive the scale of genomic information," said Gilad Almogy, Ultima Genomics' founder and Chief Executive Officer."While we will soon be launching our first instrument platform, the UG100, we are already hard at work developing our second platform to provide even lower cost and greater scale. We are excited to collaborate with Regeneron on this project and look forward to providing tools with the ever-increasing capability to our customers. Throughout our development, we have relied on, and are grateful for, the support, trust, and relationship with collaborators such as Regeneron, all of which are among the leading sequencers in the world."

Over the last five years, Ultima Genomics has developed a fundamentally new sequencing architecture designed to scale beyond conventional approaches and enable sequencing at a fraction of the cost of other commercially available technologies. The new architecture includes completely different approaches to flow cell engineering, sequencing chemistry, and machine learning.Ultima is currently in an early access program for the UG100, its first high throughput NGS instrument using the new technology architecture. The second-generation instrument will further increase the scale of genomic data and reduce sequencing costs beyond the first instrument. The timing of development and commercial availability of the Company's second instrument is not yet disclosed.

About Ultima Genomics

Ultima Genomics is unleashing the power of genomics at scale. The Company's mission is to continuously drive the scale of genomic information to enable unprecedented advances in biology and improvements in human health. With humanity on the cusp of a biological revolution, there is a virtually endless need for more genomic information to address biology's complexity and dynamic change and a further need to challenge conventional next-generation sequencing technologies. Ultima's revolutionary new sequencing architecture drives down the costs of sequencing to help overcome the tradeoffs that scientists and clinicians are forced to make between the breadth, depth, and frequency with which they use genomic information. The new sequencing architecture was designed to scale far beyond conventional sequencing technologies, lower the cost of genomic information and catalyze the next phase of genomics in the 21st century. To learn more, visit http://www.ultimagenomics.com

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SOURCE Ultima Genomics

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Next Generation Sequencing Market to Reach $33.73 billion By 2028 Thanks to Increased Attention Early Disease Diagnosis and High Prevalence of Cancer…

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SkyQuest Technology Consulting Pvt. Ltd.

Global next generation sequencing market was valued at $10.28 billion in 2021, and it is expected to reach a value of $33.73 billion by 2028, at a CAGR of 18.50% over the forecast period (20222028).

Westford, USA, July 13, 2022 (GLOBE NEWSWIRE) -- Next generation sequencing (NGS) is a game-changing technology that is revolutionizing how we study and understand biology. NGS allows us to sequence vast amounts of DNA or RNA much faster and more cheaply than ever before, making it possible to generate unprecedented amounts of data about the genomes of organisms. The demand for NGS services in the global next generation sequencing market has been growing rapidly in recent years, as the technology has become more affordable and accessible. A wide variety of scientific disciplines are now using NGS, including human genomics, cancer research, microbiology, evolutionary biology, agriculture, and many others. The number of publications featuring NGS data has also been increasing rapidly in recent years.

One of the key factors driving the growth of the next generation sequencing market is the ongoing need for better methods for diagnosing and treating diseases. For example, NGS can be used to detect genetic variations that may be associated with disease risk. It can also be used to identify novel drug targets and develop personalized medicines. In addition, NGS is playing an increasingly important role in basic research as scientists strive to understand the complexities of genome function.

Next Generation Sequencing: A Magic Wand for Early Diagnosis of Cancer

The global prevalence of cancer is alarmingly high, with an estimated 17 million new cases and 10 million deaths in 2020 alone. The World Health Organization (WHO) predicts that these figures will rise to 27 million new cases and 16.3 million deaths by 2040 if current trends continue. Early detection of cancer through screening programs is one of the most effective ways to reduce the burden of this disease, as it can lead to earlier diagnosis and treatment, which can improve survival rates significantly. Apart from this, more than 400,000 children develop cancer every year.

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The next generation of sequencing technology is often heralded as a magic wand for the early diagnosis of cancer. This is because it has the potential to provide rapid and accurate identification of tumors at an early stage, when they are most treatable. Next generation sequencing (NGS) technology intervenes at the level of DNA, providing information on genetic variation within a tumor. This can be used to detect early-stage cancers that may not yet have developed symptoms or detectable changes at the cellular level. The Global next generation sequencing market is also gaining demand for monitoring the progression of a cancer, and to assess how well treatments are working.

There are several reasons why NGS is seen as such a powerful tool in cancer diagnosis and treatment. First, it is extremely sensitive and can detect very small amounts of DNA from a tumor. Second, it can rapidly generate large amounts of data, which can be used to identify even rare mutations that may be associated with cancer. Finally, NGS is relatively simple and inexpensive to perform, making it widely accessible across the global next generation sequencing market from almost all strata of society, especially in developed market like the US, the UK, and Germany, among others. Despite all these advantages, there are still some challenges associated with the use of NGS in cancer diagnosis and treatment. While NGS can identify DNA alterations that may be associated with cancer.

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Next Generation Sequencing is Becoming Popular among Parents to Check Inborn Errors

As more and more parents learn about the benefits of next generation sequencing (NGS), its popularity is growing as a tool to check for inborn errors. NGS can provide a more comprehensive picture of a child's health, allowing parents to catch potential problems early and get their children the treatment they need. While NGS is not yet perfect, it is becoming more reliable and affordable as technology improves. As more parents learn about its potential, next generation sequencing market is likely to become even more popular as a way to keep children healthy and catch problems early.

As the technology for DNA sequencing gets cheaper and more sophisticated, an increasing number of parents are opting to have their child's genome sequenced at birth. This is especially true for parents who have a family history of genetic diseases. Sequencing the genome of a newborn is becoming more popular as the technology gets cheaper and more sophisticated. Inborn errors of metabolism are a group of rare genetic disorders that can cause serious health problems. Many of these disorders in the global next generation sequencing market are difficult to diagnose, and they often go undetected until something goes wrong.

According to the National Institutes of Health, about 25% of all live births in the United States each year are affected by at least one hereditary disease. However, the prevalence of these disorders varies widely, depending on the specific condition. For example, conditions like cystic fibrosis and sickle cell disease are relatively common, while others like Huntingtons disease are much rarer.

There are many different types of hereditary diseases, and they can affect any organ or system in the body. Some of the more common conditions include heart defects, respiratory problems, mental retardation, metabolic disorders, and cancer. Many of these disorders are life-threatening or cause significant disability, so it is important to be aware if any family members who have been affected by them. As a result, people are increasingly focusing getting their genome sequenced to know if they are carrying any gene that can lead to cancer.

With advancement in the next generation sequencing market, parents can now choose to have their child's genome sequenced at birth. This gives them the ability to catch these disorders early and start treatment immediately. It also allows them to make informed decisions about their child's future health. Although the cost of sequencing a genome is still relatively high, it is dropping rapidly. And as the technology continues to improve, it is expected that more parents will choose to have their child's genome sequenced at birth.

Food Industry to Offer Lucrative Opportunity for Next Generation Sequencing Market as Safety Concern Rises

The application of next generation sequencing in food safety and quality is an area of great interest and promise. The use of next generation sequencing technologies has the potential to revolutionize how we monitor food safety and quality. By providing rapid and high-throughput sequence data, next generation sequencing can be used to detect pathogens and other microorganisms in food more quickly and accurately than ever before. Additionally, the application of next generation sequencing can help us to better understand the genetic basis of food spoilage and contamination.

Growing concern about food safety has led to stricter quality control measures in the food industry. In particular, there is a greater focus on ensuring that food products are free from contaminants and meet safety standards, which is offering a lucrative opportunity for the players active in the next generation sequencing market to make most out of it. To this end, food manufacturers are increasingly adopting quality management systems such as Hazard Analysis and Critical Control Points (HACCP). These systems help to identify and control potential hazards at all stages of the food production process, from raw materials to finished products.

There are many different applications of next generation sequencing market in food safety and quality. One example is the use of next generation sequencing for pathogen detection. Pathogens are a major cause of foodborne illness, and traditional methods for detecting them often have low sensitivity or take too long to provide results. However, next generation sequencing can be used to rapidly detect pathogens in food samples with high accuracy. This information can then be used to taking steps to prevent outbreaks before they occur. In addition to pathogen detection, another important application of next generation sequencing is monitoring antibiotic resistance in bacteria present in food items. Antibiotic resistance is a growing public health concern, as it makes infections harder to treat and increases the risk of potentially deadly superbugs infection.

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AI and Accelerated Computing to Bring Down the Cost of Next Generation Sequencing to Less Than $300

AI and accelerated computing are already enabling a wide range of new applications in genomics. One such application is next generation sequencing (NGS), which is used to determine the order of nucleotides in DNA. NGS is currently used for a variety of purposes, including diagnosing genetic diseases, determining ancestry, and predicting drug response in the global next generation sequencing market. The cost of NGS has fallen dramatically in recent years, from $5.6 billion per genome in 2001 to less than $1,000 today. However, there is still room for further improvement.

AI and accelerated computing can help bring down the cost of NGS by making it more efficient. For example, AI can be used to streamline the process of sequence alignment, which is often the most time-consuming and computationally intensive step in NGS. In addition, accelerated computing can be used to speed up other parts of the NGS process, such as variant calling and read mapping. The combination of AI and accelerated computing has the potential to reduce the cost of NGS even further, to less than $300 per genome. This would make it affordable for many more people to access this important technology.

Top 10 Biologics Companies in the US Raised Over 1.65 billion in 2021, but Ultima Genomics took the Larger Piece of Pie

These companies in the global next generation sequencing market are working on developing new treatments and cures for a variety of diseases and conditions. Some of the diseases that they are targeting include cancer, Alzheimers disease, Parkinsons disease, and multiple sclerosis. The amount of money that these companies have raised shows how important it is to find new treatments for these diseases. The hope is that with this additional funding, these companies will be able to make even more progress in developing new therapies and cures. In May 2022, the company managed to raise $600 million through private equity. The company is planning to use this funding to bring down the NGS to $100 in the years to come. Apart from this, Kriya Therapeutics, Moma Therapeutics, and Aspen Neuroscience raised around $270 million, and 150 million, $147.5 million, respectively. All three of these companies are working on cutting-edge therapies that have the potential to change the lives of patients suffering from these devastating diseases. Apart from this, these company are holding major market share as they have established themselves in the market.

It is clear that biologics research is an area where there is a lot of interest and investment is coming in the global next generation sequencing market. This is good news for patients who are waiting for new treatments and cures. With more funding available, these top companies should be able to make even more progress in finding new ways to treat.

Ultima Genomics is a new biotech company that is working on cutting the cost of sequencing the human genome. Theyve created a powerful technology called named Triple X that adjusts itself by integrating new data and machine learning to bring down the cost. The first use for this companys pitch will be whole-genome sequencing, which can also be applied to other approaches like single-cell and methylation sequencing.

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Key Vendors in Next Generation Sequencing Market

PerkinElmer Inc. (US)

BGI Group (China)

Agilent Technologies Inc. (US)

Eurofins Scientific SE (Luxembourg)

Pacific Biosciences of California Inc. (US)

Oxford Nanopore Technologies (UK)

QIAGEN NV (Netherlands)

F. Hoffmann-La Roche AG (Switzerland)

GENEWIZ Inc. (US)

Psomagen, Inc. (South Korea)

10x Genomics Inc. (US)

Takara Bio (Japan)

Zymo Research (US)

NuGen Technologies (US)

Hamilton Company (US)

Beckman Coulter (US)

Becton, Dickinson, and Company (US)

Lucigen Corporation (US)

Novogene Co., Ltd. (China)

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Global Medical Tourism Market

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Next Generation Sequencing Market to Reach $33.73 billion By 2028 Thanks to Increased Attention Early Disease Diagnosis and High Prevalence of Cancer...

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Whole Genome Amplification Market Report: One Research Solution Reveal Everything You Need to Know About Key Players: Sigma-Aldrich, QIAGEN NV, GE…

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Global Whole Genome Amplification Market Forecast 2022-2028, key research on the industry condition of the Whole Genome Amplification is presented together with the best content, definition, expert opinion, SWOT analysis, meaning, and newest development around the world. The Whole Genome Amplification research includes information on industry size, sales, price, revenue, market share, gross margin, growth rate, and cross structure. The study examines the profit made from the sale of this report and technologies across a number of segments, as well as provides a comprehensive table of contents on the Market.

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Segmentation based on Key players

Sigma-Aldrich QIAGEN NV GE Healthcare LGC Group

Segmentation based on Type

Single Cell WGA Kit Complete WGA Kit WGA Reamplification Kit WGA & Chip DNA Kit Others

Segmentation based on Application

Drug Discovery & Development Disease Diagnosis Agriculture & Veterinary Research Forensics Others

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The research examines the Whole Genome Amplification market in-depth, focusing on several factors such as drivers, restraints, opportunities, and threats. Before investing, stakeholders can use this information to make informed judgments. It also enables you to conduct useful competitive research in order to generate marketing ideas for your products. When it comes to customer happiness, its critical to have a clear understanding of whats going on in the market. The general market scenario is accurately described in this research.

Impact Of Covid-19 on Whole Genome Amplification :

COVID-19 is an unprecedented global public health crisis that has impacted practically every business, and its long-term repercussions are expected to have an influence on industry growth during the forecast period. Our continuous study is enhancing our research approach to guarantee that fundamental COVID-19 concerns and potential solutions are included. The research examines COVID-19 in light of changes in consumer behavior and demand, purchasing patterns, supply chain re-routing, market dynamics, and government involvement. The updated study considers the impact of COVID-19 on the market and provides insights, analysis, projections, and forecasts.

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The following geographic segments are covered in the report:

The Whole Genome Amplification report provides information on the market area, which is divided into sub-regions and countries/regions. In addition to the market share in each country and sub-region, this chapter in this report also contains information on profit opportunities. This chapter of the report mentions the market share and growth rate for each region, country, and sub-region during the estimated period.

North America includes the United States, Canada, and Mexico

Europe includes Germany, France, UK, Italy, Spain

South America includes Colombia, Argentina, Nigeria, and Chile

The Asia Pacific includes Japan, China, Korea, India, Saudi Arabia, and Southeast Asia

When analyzing the key market participants, what aspects are taken into account?

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Whole Genome Amplification Market Report: One Research Solution Reveal Everything You Need to Know About Key Players: Sigma-Aldrich, QIAGEN NV, GE...

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Scientists Have Sequenced the DNA of a 2000-Year-Old Human From Pompeii – SciTechDaily

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The discoveries show that ancient DNA can be recovered from Pompeiian human bones, providing new insight into this historic communitys genetic history and lifestyles.

Research that was recently published in Scientific Reports presents the first human genome that has been successfully sequenced from a person who passed away in Pompeii, Italy, after Mount Vesuvius explosion in the year 79 CE. Only little segments of mitochondrial DNA from Pompeiian human and animal remains have been sequenced up to this point.

The DNA of two peoples bones that were discovered in Pompeiis House of the Craftsman was studied and extracted by Gabriele Scorrano and colleagues. The bones length, form, and structure revealed that one pair belonged to a male who was between 35 and 40 years old when he passed away, while the other set belonged to a femalewho was over 50. The authors were able to extract and sequence ancient DNA from both people, but since the sequences from the females bones had gaps in them, they could only sequence the entire genome from the males remains.

The male subjects DNA was compared to 1,030 ancient and 471 current western Eurasian subjects, and it was found that the male subjects DNA was most comparable to that of modern central Italians and other people who resided in Italy during the Roman Imperial era. However, studies of the males Y chromosome and mitochondrial DNA revealed sets of genes that are often prevalent in Sardinian people but not in other people who resided in Italy during the Roman Imperial era. This shows that the Italian Peninsula may have seen high levels of genetic diversity at the time.

Additional analyses of the male individuals skeleton and DNA identified lesions in one of the vertebrae and DNA sequences that are commonly found in Mycobacterium, the group of bacteria that the tuberculosis-causing bacteria Mycobacterium tuberculosis belongs to. This suggests that the individual may have been affected by tuberculosis prior to his death.

The authors speculate that it may have been possible to successfully recover ancient DNA from the male individuals remains as pyroclastic materials released during the eruption may have provided protection from DNA-degrading environmental factors, such as atmospheric oxygen. The findings demonstrate the possibility to retrieve ancient DNA from Pompeiian human remains and provide further insight into the genetic history and lives of this population, they add.

Reference: Bioarchaeological and palaeogenomic portrait of two Pompeians that died during the eruption of Vesuvius in 79 AD by Gabriele Scorrano, Serena Viva, Thomaz Pinotti, Pier Francesco Fabbri, Olga Rickards, and Fabio Macciardi, 26 May 2022, Scientific Reports.DOI: 10.1038/s41598-022-10899-1

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Unconventional paths: Gorzynski and the great apes – Scope

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Covered in sheep fluids, John Gorzynski climbed the stairs to his Wales apartment, exhausted. It was springtime, 2016, which for a veterinarian in rural areas of the United Kingdom means only one thing: newborn lambs, and a lot of them.

Gorzynski was his town's on-call vet. In one night, he'd performed five cesarean sections on sheep struggling to birth their lambs, and it was now 3 a.m. But before he could reach the door to his flat and have a good shower, his phone rang.

Another lamb in peril -- back to work.

"In that moment, I knew I needed a change," said Gorzynski, DVM, PhD, who is now a postdoctoral scholar at Stanford Medicine. "That lifestyle was just not sustainable for me."

He yearned to return to a research lab, where his work schedule wouldn't hinge on laboring farm animals.

The desire set Gorzynski on a path that, in 2016, brought him to the Stanford Medicine lab of biomedical data scientist and geneticist Euan Ashley, MB ChB, DPhil. During his time at Stanford, he and others have devised record-setting genome sequencing techniques, researched heart disease in great apes and deciphered genetic cardiovascular conundrums in humans.

Gorzynski grew up on a small organic farm in New York, diligently cultivated by his father. The upbringing, he said, fostered his love of animals and the outdoors. "As a kid I'd just sit up in the orchard trees, picking and snacking on cherries, apples and peaches," he said. "It's where my love of nature and animals originated."

Eventually, though, Gorzynski deviated from the family business when he chose a career in medicine. Everything was on track when he was an undergraduate at St John's University in New York -- but then he witnessed his first autopsy. "It totally put me off being a human doctor," he recalled.

His passion for medicine persisted, however, so after graduating in 2007, Gorzynski explored other options. "I hadn't considered veterinary medicine before that -- but it suddenly seemed like a clear choice," he said.

Lured by its metropolitan location and solid research reputation, Gorzynski enrolled at the University of London's Royal Veterinary College for veterinary training and joined the lab of professor of veterinary cardiology Adrian Boswood, VetMB, who researched genetic causes of cardiovascular disease in great apes, a group of primates that include chimpanzees, gorillas and bonobos.

During his time at the lab, two chimpanzees died of sudden cardiac failure at the London Zoo. Both were around 16 or 17 years old, some 35 years shy of the average lifespan of a chimpanzee in captivity. And here was the kicker: They were related. "It made me wonder if there might be a genetic component at play," Gorzynski said.

In investigating the cause of the apes' deaths, Gorzynski and others found anatomical anomalies that resembled a cardiovascular disease in humans: arrhythmogenic right ventricular cardiomyopathy, or ARVC, which interferes with proper heart rhythms. That can lead to insufficient blood supply to organs and, ultimately, sudden death.

In humans, at least 50% of this type of cardiomyopathy is due to a genetic defect. Because humans and chimpanzees share a whopping 98% of their DNA, it stands to reason that whatever we know about humans could apply to chimpanzees, and vice versa.

The disease is believed to arise from a mutation in genes associated with a structure in heart muscle cells. With DNA from the deceased chimpanzees, Gorzynski and others dug more deeply into whether the primates harbored mutations in the key genes known to cause ARVC in humans.

Expanding the research to include the rest of the zoo's chimpanzees, the researchers monitored their heart function and examined their DNA to determine whether any heart abnormalities were genetic. Eventually, using samples from wild chimpanzees from the Jane Goodall Institute, the team also investigated the incidence of ARVC in apes in their natural habitats to compare with those in captivity.

In the end, the research was inconclusive.

"We found genetic differences between captive and wild chimpanzees, but our data wasn't granular enough to see if those variants were actually causative of the disease," Gorzynski said. The technology just wasn't advanced enough. His research hit a standstill.

After his veterinary training wrapped up, Gorzynski practiced animal medicine in Four Crosses, Powys, Wales as a mixed-animal surgeon for the next 2 years.

"I just decided, 'I'm going to live my best James Herriot life,'" he said, referring to the pen name of a veterinary surgeon who chronicled his work in the book All Creatures Great and Small and its sequels. "I saw birds, dogs, cats, ferrets, sheep, cows, horses -- it was great, and fun, but it was exhausting."

After the fateful night of five sheep C-sections, when Gorzynski made up his mind to return to ape research, he began seeking graduate programs. Ashley's work -- everything from studying the biology of endurance athletes to deciphering mystery diseases -- caught Gorzynski's interest. And the intrigue went both ways.

"I remember sending him a note, and Euan responded and said, 'You know, I've been waiting for someone like you -- I have this really interesting project,'" Gorzynski said.

That project focused on Koko, a famed gorilla born in the San Francisco Zoo who wowed the world with her sign language skills. Gorzynski returned to the United States to start research as a Stanford Medicine graduate student working with Ashley, a professor of genetics, of biomedical data science and of cardiovascular medicine.

Stanford's cardiovascular team was monitoring Koko, along with other great apes at a nearby preserve where Koko had lived, for structural heart disease and saw signs of a cardiovascular condition. Powered by new, more advanced genome sequencing, Gorzynski hoped to determine if there were key genes that spurred Koko's heart ailments. Sadly, Koko died in June, 2018 of unrelated causes.

To broaden the research, Gorzynski reconnected with his collaborators at the Jane Goodall Institute to share genomic data and findings. (The specimens Gorzynski sequences are collected after a great ape dies of natural causes in a sanctuary in the Republic of the Congo that the institute supports.)

When that research was paused in 2020 by COVID-19-related travel restrictions, Gorzynski had to find new ways to round out his degree. The detour resulted in him contributing to research that set a new world record: the fastest genome sequencing technique. The process, from sequencing the genome of a patient to providing clinical information, took several hours, a big improvement from the typical timing of a few weeks.

Now that travel restrictions have loosened, Gorzynski has resumed his ape-related studies. "What we learn from our studies could inform heart disease in humans but, honestly, that's not why I'm doing this research," Gorzynski said. "My focus is the health and well-being of the animals, and my hope is that this research can teach us how to better maintain a healthy population of wild great apes."

Photo by Savory

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Global Blockchain Market Report (2022 to 2028) – Featuring Genomes, QubiTech and CiveQ Among Others – ResearchAndMarkets.com – Business Wire

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DUBLIN--(BUSINESS WIRE)--The "Global Blockchain Market, By Component, By Type, By Application, & By Region - Forecast and Analysis 2022 - 2028" report has been added to ResearchAndMarkets.com's offering.

The Global Blockchain Market was valued at USD 4.56 Billion in 2021, and it is expected to reach a value of USD 117.77 Billion by 2028, at a CAGR of more than 59.12% over the forecast period (2022 - 2028).

The global blockchain market is rapidly growing and is expected to continue to do so in the future years, due to the expanding number of innovations and consumer awareness of the benefits of employing blockchain technology is expected to propel the industry forward in the near future. The key aspects driving the growth of the global blockchain market include the adoption of blockchain technology across BFSI, healthcare, media and entertainment, and many others.

Wide acceptance of blockchain solutions for payment, digital identities, and smart contracts are also among some of the prospects that drive the industry growth during the forecast period. The increased venture capital investing in blockchain technology startups can also be attributed to the market's growth. Blockchain technology witnessed significant growth after the advent of Bitcoin, and it is now being used by various financial institutions for transactions.

In the last two to three years, blockchain technology solutions have gained in popularity for a variety of commercial applications, including payments, exchanges, documentation, and many others. Many startups such as Blockpoint, Auxesis Group, Symbiont, SpinSys, Bitfury, Neufund, Fetch.AI, Confirm, Genomes, QubiTech, and CiveQ among others have entered the market and begun developing blockchain-based solutions

Aspects covered in this report

The global blockchain market is segmented on the basis of component, type and application. Based on the component, the market is segmented as platform and services. Based on the type, the market is segmented as public, private, and hybrid. Whereas, based on the applications, the market is segmented as Food & Agriculture, Transportation & Logistics, Manufacturing, Energy & Utilities, Healthcare & Life Sciences, Media & Entertainment, BFSI, Retail & E-Commerce, IT & Telecom, and Others.

Driver

Restraint

Key Market Trends

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/e2mwxc

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The singularity of Ranveer Singh in Bollywood – Moneycontrol

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Ranveer Singh in 'Ranveer vs Wild with Bear Grylls'. He has recently started sporting a double-ponytail look, making him an all-rounder in embracing non-binary fashion fluidity, which also of course includes monochromatic suits.

At 37, Ranveer Singh is the rarest of pop confections. Before him, Bollywood hadnt seen a star whose love affair with Gucci is as intense as his role-prep routines, both of which cant parallel his effusive odes to his wife Deepika Padukone, a star as influential, talented and radiant as he, if not more.

He also aces the puttar act often, notably in his latest reality show on Netflix, Ranveer vs Wild with Bear Grylls, in which he upped his breathless susurrations of Jai Shiv Shambhu to escape the wrath of snakes with loud, anthemic repetitions of Jai Bajrang Bali to bump himself up the rappel to reach the pinnacle. All this while, during the one-hour long show, Singh relentlessly regurgitated the purpose behind this dangerous journey: to get a flower for his lady love.

In his carefully crafted high-voltage brand persona, chivalry and metrosexuality co-exista potential heartthrob for cisgender women as well as anybody on the GBTQ spectrum who likes men. He can ooze cowboy masculinity one day and daintily mimic Alia Bhatts twirls in Gangubai Kathiawadi songs the next day.

With 20 films, four Filmfare awards, a two-year-old production company named Maa Kasam Films, a record label Incink that promotes rappers from across India, and a fashionist who can inspire the best of designers and stylists, Singhs singularity in Bollywood defies categorisations.

Ranveer Singh and Alia Bhatt in episode 1 of 'Koffee with Karan Season 7'.

Im Ranveer Singh, and I am the Lamborghini of Men, Singh once announced at an awards function. The Lambo logo is a charging bullso did he mean he was a man of strength, determination and the ability or at least a desire to disrupt everything that comes in his way? If he did, he probably wasnt far off in self-estimation. He knows how to hold an audience in his roles as well as in talk shows and interviews. In the first episode of Koffee with Karan Season 7 last Sunday, Singh appeared with Alia Bhatt and mimicked Hrithik Roshan, called Uorfi Javed (a social media paparazzi-friendly personality known to wear bras made out of tarpaulin and other such fashion innovations) a fashion icon besides maintaining a perfect balance between political correctness and verbal gimmickry.

So what mountains did Singh climb to reach this pinnacle?

Born Ranveer Singh Bhavnani (he dropped his last name because, by his own admission, it wasnt that saleable and sleek a name), his grandparents moved to Bombay from Karachi, Sindh, in present-day Pakistan. His only industry bloodline is with maternal second cousin Sonam Kapoor. He studied theatre and writing in a university in Indiana, US, worked a few years in advertising as a copywriter in Mumbai, worked as an assistant director, but left it tall to pursue acting. He would go for all kinds of auditions, and refuse all minor roles. Aditya Chopra lunched him in Band Baaja Baarat in 2010, which also got him the Best Male Debut award at the Filmfare Awards. Since then, he has played a gruffy, testosterone-fuelled, bisexual villain in Padmavat (2016), a slum rapper on the cusp of success in Gully Boy (2019), and played Kapil Dev in '83 (2021). His last film, Jayeshbhai Zordaar is a standard melodramatic Bollywood message film that nails patriarchy and upholds rights of the girl child. Singh will next be in a Rohit Shetty comedy called Cirkus (possibly a fool-proof BO jangler), a Karan Johar comedy Rocky Aur Rani Ki Amar Prem Kahani opposite Alia Bhatt and a Hindi language remake of Shankars Tamil film Anniyan.

The aspirational brand credo that Singh continues to chisel and transform incessantly, especially for post-millennialsa Bollywood man who is everything and anything, and flamboyantly soensures he is always in the news. His luxury-meter is over the top: a Lamborghini Urus Pearl Capsule, Aston Martin Rapide S, Mercedes-Benz GLS, Land Rover Range Rover Vogue, and Jaguar XJ L comprise the cream of his automobile collection; his fashion tastes veer from baroque Versace shirts to customised neon-pink shararas, Franck Muller wristwatches, velvet pantsuits and a profusion of Gucci. He has recently started sporting a double-ponytail look, making him an all-rounder in embracing non-binary fashion fluidity, which also of course includes monochromatic suits.

Singh is a self-confessed fan of Govinda; he has said that Govindas character in Raja Babu is his spirit character, whatever that could mean. Id like a sea-facing villa in Goa with a swimming pool where I can cook, paint, watch movies and do yoga. And Id like to be surrounded by my many children, he recently said in an interview.

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Japan Proposes a Wild Concept for Making Artificial Gravity on the Moon – Singularity Hub

Posted: at 9:05 am

The list of challenges space explorers will face is formidable. Theyll have to produce breathable air, clean water, and food in extremely hostile environments lacking all of the above. Theyll also have to peacefully coexist with small groups of fellow explorers in tight quarters for long periods of time, all while minimizing exposure to the searing radiation thats ubiquitous virtually anywhere they go.

Assuming explorers overcome these challenges, theres another that doesnt get the love it deserves, according to researchers at Japans Kyoto University.

Long-term settlement of Earth orbit, the moon, Mars, and beyond requires explorers forsake Earths gravitythe steady downward force every Earthly animal has evolved to navigate over billions of years. Studies of astronauts spending weeks or months in microgravity have shown atrophied muscles, bone loss, vision loss, and changes to immune systems. There have, of course, been no studies of humans living on planetary bodies with low-gravity, but its likely adult explorers would contend with health issuesand how all this might affect childbirth and normal development in kids is unknown.

Assuming some kind of artificial gravity would lessen these risks considerably, Kyoto University partnered with construction company, Kajima Corp, to explore futuristic concepts that might one day offer tourists and settlers a healthy dose of good ol Earth gravity.

Their far-future vision? A towering sci-fi space cone, called the Glass, that would stand 1,312 feet (400 meters) tall and 656 feet (200 meters) across. This habitat would spin around its axis once every 20 seconds so that people living on its inner walls would enjoy Earth gravityalongside trees, grass, and a lake that would do MC Escher proud. The plans call for spinning habitats on the moon and Mars, where gravity is notably less than on Earth.

In addition to the habitat itself, the three-part proposal, outlined in a press release and video last week, also sketched out a system for transportation between Earth, Mars, and the moon called Hexatrack, which would include standardized vehicles for travel between habitats on the surface of the planet or moon and base stations in orbit.

Obviously, all this is more of a beautiful concept to solve a real problem than anything remotely practical today.

The sheer size of the endeavorakin to building the Empire State Building upside-down on the moon or Mars, spinning it like a top, and then layering water, soil, and other internal structures through its interiorwould demand huge amounts of resources and technical know-how. And without exceptional design, living in such an environment, where the ground visibly curves at your feet and the tug of local gravity is at odds with the structures artificial gravity, could be pretty disorienting. The team envisions our migration to the moon and Mars wont hit its stride until the latter half of this century, but even that timeframe for work on this scale seems optimistic.

For now, the idea is more at home among other futuristic space concepts. Though focused on off-planet living, for example, the vision for ONeill cylinders, proposed in the mid-70s, came complete with spin-based gravity, lakes, farmland, and even artificial sunshine. At the moment, though, were much closer to realizing small, private space bubbles in orbit, like those designed by Axiom Space, than we are to off-Earth megastructures such as these.

Still, as going to space on reusable rockets gets cheaper, and alternative methods of shooting stuff into orbitlike this space catapultemerge, we may hone our abilities to both build structures and also find, mine, and exploit resources out there. Theres an abundance of raw materials for sustaining our presence in space. Eventually, we may begin engineering ever bigger structures in orbit and elsewhere, and wild concepts mooted today, could look a bit more realistic.

Regardless, theres little question that bringing some extra gravity with us would help the cause. Maybe someone will build spinning conical towers on the moonor maybe therell be a better, more practical alternative by then.

In either case, its fun to dream.

Image Credit: Takuya Ono and Kajima Co. Ltd.

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Hidden MrBeast Video Sees the Popular Millionaire Put Over $50,000 on the Line for His Fans – EssentiallySports

Posted: at 9:04 am

MrBeast is known for his amazing content and mind-boggling videos that he keeps uploading on his ever-growing channel. However, coming as a surprise, the social media celebrity decided not to share his recent clip on YouTube.

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That may sound bizarre and also weird to many of his fans, but MrBeast eventually opted out to upload his newest video on the streaming platform. While the reason behind this move is unknown, the video itself is quite intriguing, to say the least. Thats because the creator and streamer did upload it on his Facebook page for the fans. Lets see whats there in this not-for-YouTube clip.

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Thanks to Facebook, we can at least have a glimpse of what is exactly there in Jimmys now forbidden video from YouTube. Apparently, the streamer went for another giveaway of lucrative prizes in this clip. But as is the case with his every video, he had some exciting challenges for the participants to win their desired items.

Starting with the first one, MrBeast literally put a case full of $10,000 inside an ice box. Yes, the case with the prize money inside it was covered in ice and the participants had to break it in order to claim this amount. The condition was to break the ice in limited attempts only.

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The first person picked number 15 between 1 and 20, and MrBeast then revealed to him that it basically meant he had fifteen swings to break the ice box with an axe. Sadly, though, this individual couldnt do it even after breaking half of the ice. Fortunately, another participant, named Felix, managed to win this challenge with just six tries and won $10,000.

In the next ultimate challenge, MrBeast revealed a wall of basketball goals. For this one, participants had to make one basket to win one item from a pool of attractive prizes like the iPad, AirPods, Nintendo Switch, Macbook, and much more.

The participants were allowed to shoot as many times as they wanted, but would risk losing all the prizes if they failed to score in any attempt. Two brothers opted to compete in this challenge. The first one managed to score a basket and claimed a Macbook Pro. His brother then took a shot and also succeeded, thus claiming an Oculus Rift.

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Unfortunately, the brother who won a Macbook decided to take another shot, for more prizes but failed to do so. As a result of that, he lost his prize along with his brothers Oculus as well.

Towards the end of the video, MrBeast is seen giving a challenge to his own crew members, namely Karl, Chris, and Chandler. He asks them to order a pizza from different stores. Whichever pizza is delivered first, were gonna tip that pizza delivery driver $10,000, said Jimmy in the clip.

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At the end of the video, Chris order manages to reach earlier than Karl and Chandlers. And as promised, MrBeast gives a massive tip of $10,000 to the delivery guy. However, the pizza that Chris tastes in ends up being not-so-delicious at all. It was quite funny actually to witness the expressions on his face.

WATCH THIS STORY: The Most Followed Female Streamers on Twitch

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Some of the internet’s most homoerotic content is on The History Channel’s YouTube? – Queerty

Posted: at 9:04 am

Screenshot: Ancient Workouts With Omar, The History Channel

Last week, we alerted you to The History Channels upcoming event docuseries,Colosseum, a perhaps unintentionally sexy look at the age of gladiators filled with ancient Roman eye candy that had us setting our DVRs to the network for the first time in ever?

Well, because were so thirsty such big history buffs, that got us wondering what else HISTORY had to offer. It only took a quick Google search to find that the networks YouTube page is rife with content that, while not overtly queer, is definitely twinged with enough homoeroticism to please the casual internet browserwere talking hours and hours of footage of strapping men recreating ancient battles in frequently very little clothing.

Related: History buffs list their favorite facts about queerness through the ages

Of course, theres a lot of other stuff to sift through. In the past decade or so, HISTORY has gotten a lot of flak for straying away from actual history, and the YouTube channel reflects that with a mind-numbing amount of sensationalist video about aliens, conspiracies, and two dudes who like to dig through trash in search of priceless antiques (wait maybe that last ones a little gay?).

With that in mind, weve assembled a handy guide to only the gayest content available on HISTORYs YouTube. Check out the below and, who knows? Maybe youll learn something! Or maybe youll just watch them on mutethats fine too, we dont judge.

Were busting out the big guns to start: To our delight, theres a whole YouTubeseries dedicated to showing you how historic warriors from around the world managed to get so buff and so strong. From the gladiators to ninjas to Medieval knights, fitness influencer Omar Isuf walks viewers through training regimens from long ago thathonestly?look exhausting. Still, we dont mind tuning in to see Isur (in the words of Gaga) serve it ancient city style.

Now, if yourereallyinto muscleswere talking big, bulking bodies of steelyoull want to check out this classic episode ofModern Marvels from 2001, which the network has uploaded in full on its YouTube. In it, experts examine the world of professional bodybuilding, tracing our present-day Strong Men and Women all the way back to the Greeks and the early days of Olympics. Its 46 full minutes of vein-bulging brawn.

Thanks to high school history class and/or Disney, youre likely well aware of the legend of Hercules, the athletic demigod who went from zero to hero. Still, you might not mind hearing his story all over again via this Greek mythology series, which has the good sense to cast a bulky, square-jawed actor to play the titular hero in various re-enactments of his 12 Labours. Hes such a beefcake that you wont even mind the shoddy CGI Hydra Not that much, at least.

One of the networks rare forays into narrative dramatic television was the Norse action epic,Vikings, which ran for six full seasons between 2013-2020. We wish we could tell you if it wasnt any good, but we simply havent seen it! Thankfully, someone over at HISTORY was looking out for the gays, editing and uploading this 90-second supercut of shirtless scenes from the series second season, complete with a sexy, swinging 70s score. Hubba, hubba! Wait, should we actually go back and watch this show?

In 2018, HISTORY revived this long-running documentary series all about mysterious phenomena and the supernatural. Now, for those in search of skin,In Search Of pales in comparison to the content above, but it does boast the handsomeand gay!Zachary Quinto as its host (following in the footsteps of his Spock predecessor, Leonard Nimoy, who hosted from 77 82). We think the series could stand to include a lot more of Quintos handsome face, but if you get your kicks from watching the actor hunt down the lost city of Atlantis, then have at it!

And, if you were hoping for real queer history, were sorry to say that HISTORY offers very little on that front (at least compared to the hours and hours of Ancient Aliens they air). The most substantial piece we could find was this 4-minute summary of the Stonewall Riots, and a quick tribute to the legendary trans activist Marsha P Johnson, but weknow there are far more stories to tell. For instance, over on Discovery+, theres a whole series dedicated to some of the most important queer stories in history.

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