Daily Archives: July 4, 2022

Identities in harmony | Penn Today – Penn Today

Posted: July 4, 2022 at 11:42 pm

As a child, geneticist Beth Burton wanted to be a music teacher. At age 6, she started playing piano and later spent years accompanying school choirs in her hometown of Wilmington, Delaware.

But in high school, she took her first biology class, and she was hooked.

More than a decade later, Burton now studies the genetic causes of Alzheimers disease as a Ph.D. candidate in the Perelman School of Medicine. But pivoting to science didnt mean abandoning her art; she earned a bachelors degree in piano and still practices often.

Now in her fourth year, Burton moves through grad school without compromising her love for music, her creativity, or any of the other traits that she says define her. In doing so, she says she hopes to inspire others as she finds her own path to success.

Not long after that first influential biology course, Burton was diagnosed with Ehlers-Danlos syndrome, a genetic disorder that affects the development and function of collagen and can lead to joint pain and digestive issues. Its a rare condition, not well understood and currently without a cure.

The diagnosis only deepened Burtons interest in biology and genetics. Alongside her degree in piano, Burton pursued a bachelors degree in biochemistry and molecular biology at Gettysburg College. Within her first year, she developed an interest in genetic research, so she applied to the Childrens Hospital of Philadelphia Research Institutes Summer Scholars Program.

There she began working with Struan Grant, a professor of pediatrics who researches the genetic causes of disease and disorder. Her experience in Grants lab the summer before sophomore year confirmed that she had made the right choice. I just loved the culture; I loved how collaborative everyone was, says Burton. I had a fantastic 10 weeks in lab.

She returned the next summer. And the summer after that.

When she finally graduated from Gettysburg in May 2018, she knew that she wanted to pursue a Ph.D. in genetics and to do it at Penn. That fall, she started at the Perelman School of Medicine. During her first year, she spent some time in the lab of Christopher Brown, a professor of genetics who, like Grant, researches how mutations in certain genes may cause disease. Together, the three of them developed a new project that would use genetics to understand the causes of Alzheimers disease.

Alzheimers is the sixth leading cause of death in the United States and the only one in the top 10 without a cure or effective treatment. By studying differences in the genes of people with and without Alzheimers, Burton wants to help change that.

In order to do so, she heads to the lab. She takes microglia, the brains immune cells, with the genetic variations for Alzheimers, then edits out a variation of interest. By observing the differences between the edited and unedited cells, Burton can determine whether the genetic variation was implicated in Alzheimers, offering potential targets for drugs and treatments in the long term.

For now, Burton is still on the hunt, narrowing her search to a few sections of DNA that she has strong evidence are associated with causing Alzheimers. Even at this stage, Grant says that the methods Burton has developed to connect genes to disease might work for all kinds of genetic health issues, from diabetes and obesity to sleep and bone disease.

What we learn from her deep dive on a particular genetic signal will really inform research beyond Alzheimers, says Grant.

Even while investigating the causes of the disease, Burton has refused to let unique aspects of herself take a back seat. In her day-to-day and on social media, Burton is vocal about her experience with Ehlers-Danlos syndrome. In part, this serves as a gentle nudge to peers in the scientific community. Scientists want to help, but it can be so easy to just talk about genetic disorders in scientific jargon and forget that were studying things that affect real people, says Burton. Im one of those real people.

Burton says she hopes that being open about her own struggles might help others believe that they have a place in science regardless of their physical limitations.

For similar reasons, Burton speaks freely about her identity as a bisexual woman. Burton says she knew from a young age that she wasnt only attracted to boys, but didnt make sense of what that meant until college, when she encountered people like her who identified as bisexual.

Seeing those people out and open with their experiences is what helped me to figure out my identity, she says. If I can be that person for someone else, that would make it all worth it.

After finishing her Ph.D., Burton plans to pursue a postdoctoral fellowship. Ultimately, she wants to become a professor in genetics and run a research lab.

While working toward her professional goals, Burton plans to enjoy the rest of her time at Penn doing what she loves: Spending time with friends, petting her rabbit, Mr. Penguin, and unwinding at the piano, a passion that influenced her time in lab, Grant says. Beth is very artistic. She cant help but bring her creativity to research.

Often, after a long day in lab, Burton goes back home and sits at the piano, where she can turn back to her first love.

At night, I can just play whatever, she says. The music has given me a lot.

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Identities in harmony | Penn Today - Penn Today

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The Global Genotyping Market size is expected to reach $30.9 billion by 2028, rising at a market growth of 14.7% CAGR during the forecast period -…

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ReportLinker

Genotyping is a technique used to detect minor genetic abnormalities that can contribute to significant phenotypic changes, such as physical distinctions that distinguish individuals from one another and pathological changes that underpin disease.

New York, July 04, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Genotyping Market Size, Share & Industry Trends Analysis Report By Product, By Application, By End Use, By Technology, By Regional Outlook and Forecast, 2022 2028" - https://www.reportlinker.com/p06289249/?utm_source=GNW It has a wide range of applications in basic science, medicine, and agriculture.

By comparing DNA sequences to other sequences, the genotyping test is a widely used method for identifying DNA sequence and genetic composition. Modern genotyping assays include several key properties, such as high efficiency, operational flexibility, and accessibility to several parameters in a single test. Increased funding by governments of various nations to promote genotyping assay methodologies, increased cases of chronic and genetic disorders around the world.

Genetic mutations such as single nucleotide variants, copy number variants, and major structural alterations in DNA can all be investigated through genotyping. On a molecular level, high-throughput genomic technologies like next-generation sequencing (NGS) and microarrays can provide a better knowledge of disease etiology. Genotyping data analysis systems may examine results for thousands of indicators and probes and identify sample abnormalities, revealing the functional implications of genetic diversity.

In the medical field, genotyping is used to diagnose to prevent the spread of tuberculosis (TB). Initially, genotyping was only used to verify tuberculosis pandemic but, with the advancement of genotyping technology, it can now accomplish much more. Due to advances in genotyping technology, it was discovered that in various tuberculosis cases, infected individuals living in the same house, were not genuinely linked. Due to socio-epidemiological aspects, universal sequencing revealed complex transmission dynamics. As a result, polymerase chain reactions (PCR) were developed, allowing for speedier tuberculosis testing. This approach of quick detection is utilized to avoid tuberculosis. Whole-genome sequencing (WGS) enabled the identification of TB strains, which could subsequently be placed on a historical cluster map.

COVID-19 Impact

Technological developments, the rising prevalence of cancer and genetic abnormalities, and increased R&D investment for precision medicine research are all contributing to the expansion. Furthermore, the COVID-19 pandemic had a favorable impact on the genotyping market, as increased demand for COVID-19 genotyping kits resulted in the pandemic. The pandemic of COVID-19 has had an enormous influence on the Genotyping business. SNP genotyping is being used to detect SARS-CoV-2 variations, which is increasing market growth. For example, Helen Harper et al. discovered that PACE (PCR Allele Competitive Extension) SNP genotyping techniques provide useful viral genotype detection for SARS-CoV-2 positive samples in a paper published in the PLOS ONE Journal in February 2021.

Market Growth Factors

DNA Sequencing Prices are Decreasing Due to Technological Advances

Miniaturization, automation, and lower total costs of DNA sequencing have all been enabled by technological improvements, as well as increased flexibility and the introduction of multi-parameter testing. This has aided in expanding the uses and accessibility of DNA sequencing, allowing clinicians to concentrate on higher-level decisions such as selecting and prioritizing therapeutic targets through various genotyping studies. This has enhanced the use of PCR, sequencing, capillary electrophoresis, and microarrays in domains including drug development and clinical research. Researchers have been able to take use of the most modern technology improvements in SNP identification due to their ability to find vast numbers of SNP markers.

Increased Genotyping Application Areas

Pharmacogenomics, diagnostic research, personalized medicine, and forensics are all potential uses for genotyping platforms. This technique is also suitable for a variety of veterinary applications, food hygiene, and atmospheric testing in distant places and industrial settings. Human diagnostics and pharmacogenomics now have substantial marker potential since these segments require large-scale genotyping analysis due to the need for better treatment choices and the high prevalence of the disease. NGS is being adapted for this purpose, with businesses like QIAGEN and Freenome (US) collaborating to create NGS-based assays for precision medicine.

Market Restraining Factors

The High Cost of Genotyping Equipment

The devices required for genotyping testing are costly, and their installation involves a large capital outlay. The qPCR systems range in price from USD 20,000 to USD 30,000, whereas dPCR systems range from USD 65,000 to USD 70,000 for manual dPCR and USD 100,000 for automated dPCR. NGS sequencers range in price from $19,900 to $1 million. The NovaSeq 5000 and NovaSeq 6000 sequencers from Illumina are priced at around USD 850,000 and USD 985,000, respectively. Genotyping instruments have a lot of advanced features and functions, hence theyre expensive. Pharmaceutical companies and research institutes require a big amount for the installation of these systems, which necessitates large investments in a large amount of high genotyping machines.

Product Outlook

Based on Product, the market is segmented into Reagents & Kits, Instruments, and Software & Services. The software & service segment recorded a substantial revenue share in the genotyping market in 2021. Due to the increased usage of software-based solutions by testing facilities and academic institutions, the software & services segment is expected to grow at a high rate. Bioinformatics enhances overall efficacy of sequencing procedures and aids in the avoidance of errors that might occur with standard sequencing methods. Agri genomics, animal livestock, human diseases, and microbes all benefit from these services.

Application Outlook

Based on Application, the market is segmented into Diagnostics & Personalized Medicine, Agricultural Biotechnology, Pharmacogenomics, Animal Genetics, and Others. The Diagnostics & Personalized segment acquired the highest revenue share in the genotyping market in 2021. It is because of the expanding usage of genotyping products for investigation and the growing need for the identification of genetic illnesses, diagnostics and personalized medicine hold the largest proportion of the genotyping market. Personalized medicine involves the integration of genetic, molecular, and environmental variability into existing approaches to knowledge and management of illnesses.

End Use Outlook

Based on End Use, the market is segmented into Diagnostics & Research Laboratories, Pharmaceutical & Biopharmaceutical Companies, Academic Institutes, and Others. The Pharmaceutical & Biopharmaceutical segment witnessed a significant revenue share in the genotyping market in 2021. Increasing importance of pharmacogenomics in drug development, as well as FDA recommendations for pharmacogenomics investigations and genotyping in the drug discovery process, Pharmacogenomics is being used by companies to produce new medications. For example, Pfizer is studying the efficacy of Talazoparib in patients with somatic BRCA mutation-resistant metastatic breast cancer in a genotyping-based clinical trial.

Technology Outlook

Based on Technology, the market is segmented into PCR, Sequencing, Capillary Electrophoresis, Microarray, Mass Spectrometry, and Others. The PCR segment garnered the highest revenue share in the genotyping market in 2021. It is due to the Adoption of advanced diagnostic techniques is developing, as is the number of CROs, forensic and research laboratories, along with the prevalence of diseases including chronic diseases and genetic disorders. The typical approach for genetic analysis, polymerase chain reaction, is used in PCR genotyping. After amplifying DNA or RNA sequences using specified primers and electrophoresis to check for size and quality, they can be isolated and purified.

Regional Outlook

Based on Regions, the market is segmented into North America, Europe, Asia Pacific, and Latin America, Middle East & Africa. The North America segment garnered the largest revenue share in the genotyping market in 2021. The growing use of advanced technologies, the presence of large pharmaceutical and biopharmaceutical businesses, proactive government policies, and advancements in healthcare infrastructure. Another important aspect contributing to the regions strong market share is the presence of big businesses and authorities investing in genotyping.

The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include F. Hoffmann-La Roche Ltd., Danaher Corporation, Agilent Technologies, Inc., Thermo Fisher Scientific, Inc., Qiagen N.V., Illumina, Inc., Bio-Rad Laboratories, Inc., Eurofins Scientific Group, and Fluidigm Corporation.

Strategies deployed in Genotyping Market

Jan-2022: Eurofins Scientific completed the acquisition of Genetic Testing Service JSC, a leading enterprise in genetic testing in Vietnam. This acquisition aimed to improve Eurofins expansion in Asia and achieve its global network of clinical diagnosis laboratories concentrated on advanced and specialized genetic testing. Additionally, Gentis has a highly effective test and product menu, which would asset from the Eurofins networks broad catalog of genomic and genetic tests and its approach to additional industries.

Jan-2022: Illumina signed a definitive co-development agreement with SomaLogic, a protein biomarker discovery and clinical diagnostics company. Through this agreement, the companies aimed to launch SomaScan Proteomics Assay within Illuminas active & future growth bandwidth next-generation sequencing platforms. Additionally, Illumina would start a multi-year advancement attempt to combine SomaLogics protein objective volume with Illuminas arranging technologies, DRAGEN, and informatics toolsets software to generate a complete end-to-end NGS functionality solution.

Aug-2021: Thermo Fisher Scientific introduced a TaqMan SARS-CoV-2 Mutation Panel to identify the Delta and Lambda strains. The advanced biosystem allows laboratories to record known mutations by choosing from more than 50 assays intended to screen for various variants. Additionally, the biosystem is extremely ascendable, permitting up to hundreds of samples to be tested to recognize one or various mutations so labs can measure observation tasks based on testing requirements.

Apr-2021: Bio-Rad Laboratories unveiled the ddPCR Assays for AAV Viral Titer and the Vericheck ddPCR Mycoplasma Detection Kit. The two assays support the production and advancement of safe and adequate cell and gene treatments. Moreover, ddPCR product offerings in the gene and cell treatment space reverse overall dedication to informing the global requirement for effective and safe healing.

Oct-2020: Bio-Rad Laboratories unveiled CFX Opus 384 and CFX Opus 96 along with BR.io, a cloud-based data management, instrument connectivity, and analysis platform. The Real-time PCR Systems portray the next generation of the enterprise CFX Real-Time PCR Systems that utilized in analysis and genomic testing along with pathogen observation and contagious disorder diagnosis.

Jan-2020: Roche teamed up with llumina, the global leader in DNA sequencing and array-based technologies. Under this collaboration, the company aimed to widen the adaptation of distributable next-generation sequencing-based testing in oncology. Additionally, Illumina would allow Roche the privilege to distribute and develop in-vitro diagnostic trails on Illuminas NextSeq 550Dx System, along with its future offering of diagnostic sequencing systems, containing the impending NovaSeqDx.

Jan-2020: Thermo Fisher Scientific introduced Axiom Propel, activated Biosystems for Genotyping workflow. The solution developed to enable laboratories to ramp up quickly by reducing the requirements for the various liquid manager and decreasing running prices through the use of recyclable allocating cassettes and minimum labware.

Dec-2018: Illumina introduced the Infinium Global Diversity Array, a new dept genotyping array. The Infinium would be a high-density chip developed to allow the accomplishment of the main genotyping focused objective of the project.

Sep-2018: Danaher Corporation completed the acquisition of Integrated DNA Technologies, a privately-held supplier of high-value consumables for genomics applications. Under this acquisition, the company aimed to expand its existence into the highly appealing genomics industry and would help play a central role in boosting consumer research and time to market as they design crucial diagnostic tests and conceivable life-saving treatments.

Mar-2018: QIAGEN joined hands with Natera, a clinical genetic testing company. This collaboration aimed to design advanced, cell-free DNA assays to utilize on QIAGENs GeneReader NGS System. Additionally, cell-free DNA assays would be advanced to leverage on the GeneReader NGS System, the first completely combined specimen to Insight NGS solution, and developed to allow tests, such as prenatal screening, for laboratories and hospitals across the world.

Scope of the Study

Market Segments covered in the Report:

By Product

Reagents & Kits

Instruments

Software & Services

By Application

Reagents & Kits

Instruments

Software & Services

By End Use

Diagnostics & Research Laboratories

Pharmaceutical & Biopharmaceutical Companies

Academic Institutes

Others

By Technology

PCR

Sequencing

Capillary Electrophoresis

Microarray

Mass Spectrometry

Others

By Geography

North America

o US

o Canada

o Mexico

o Rest of North America

Europe

o Germany

o UK

o France

o Russia

o Spain

o Italy

o Rest of Europe

Asia Pacific

o China

o Japan

o India

o South Korea

o Singapore

o Malaysia

o Rest of Asia Pacific

LAMEA

o Brazil

o Argentina

o UAE

o Saudi Arabia

o South Africa

o Nigeria

o Rest of LAMEA

Companies Profiled

F. Hoffmann-La Roche Ltd.

Danaher Corporation

Agilent Technologies, Inc.

Thermo Fisher Scientific, Inc.

Qiagen N.V.

Illumina, Inc.

Bio-Rad Laboratories, Inc.

Eurofins Scientific Group

Fluidigm Corporation

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The Global Genotyping Market size is expected to reach $30.9 billion by 2028, rising at a market growth of 14.7% CAGR during the forecast period -...

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Network TV Hasn’t Been The Same Since This Sci-Fi Drama Left The Air – Looper

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The biggest reason why "Fringe" left such a high bar is the incredibly well-written characters, who are played by a hugely talented cast. The bond between Olivia, Peter, Walter, and Astrid (Jasika Nicole) is so strong because of the horrors they face on a daily basis, and it isn't surprising that they're a dysfunctional family by the time Season 5 comes to a close. But the emotional crux of the show comes from Olivia's journey into the unknown and the secrets that are unearthed about her past because of her investigations.

She's essentially asking the question, "Who am I?" for the entire series, because of the mysteries that overlap into her own life. These quandaries involve discovering the truth about her Cortexiphan-induced powers, whether she's her own person in the face of an alternate universe, and whether she can ever feel comfortable enough to start a relationship with Peter. Anna Torv's unflinching performance is nothing short of excellent (although "Mindhunter" fans won't be surprised!), and when Olivia finally gets to be with her family by the end of the series, it's so heartwarming to see her happy and fulfilled.

Torv's performance is only enhanced by her dynamic with Joshua Jackson as Peter because their relationship never feels forced it naturally grows over the course of two seasons. But just like the idea of the alternate universe, it's incredibly rewarding for the audience to finally see them together after struggling with an evil doppelganger, plot twists about their respective histories, and saving the world from the Observers.

"Fringe" knows what audiences expect from a sci-fi drama it bravely explores its own mythology and characters with a unique edge that makes it a true treat to watch.

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The myth of ‘artificial intelligence’ – spiked – Spiked

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In his superb book, Dominion, historian Tom Holland finds parallels between the early Christians and todays judgemental theorists of gender and race. Both can be called social-justice warriors, he notes. Each sees a judgement day close at hand, and each has zealots who relish their role as judge, jury and hangman. Wokeness is just one modern mania that has a distinctly religious quality. Arguably, there are two other modern religions that eclipse wokeness in their scope and ambition: environmentalism and artificial intelligence (AI).

Environmentalism expresses a desire to subordinate human development and welfare to a new, all-encompassing mission that of reducing the atmospheric concentration of carbon dioxide. An emergency or a crisis has been declared by activists, one which supposedly requires the suspension of political and moral norms. Every aspect of our lives is recast into this new moral framework.

Karl Marx recognised how religion gives society its shape and moral order. He called religion the general theory of this world, its encyclopaedic compendium, its logic in popular form, its spiritual point dhonneur, its enthusiasm, its moral sanction, its solemn complement, and its universal basis of consolation and justification. But Marx also recognised religions devotion to the idea that human beings are exceptional and unique: It is the fantastic realisation of the human essence. Religion is a form of fetishised or estranged humanism, Marx was saying.

Environmentalism turns this celebration of humanity on its head. Human activities are measured by the harm or impacts they cause to the natural order, and all human activity is therefore sinful. We ate the forbidden fruit by burning fossil fuels and by daring to increase human welfare and now we must pay. Even the UK prime minister signals his support for this philosophical belief when he describes the Industrial Revolution as a derangement of nature, or a doomsday machine.

Equally religious, and equally anti-human, is the current infatuation with AI. We are currently in the third wave of enthusiasm for AI in 65 years, during which periods of high hopes and investment in AI have been followed by periods of derision. This time, however, belief in the transformative power of AI has penetrated the policy, media and administrative classes as thoroughly as the belief in apocalyptic climate change.

Todays AI develops an idea that has been around from the start. It uses multi-layered neural networks which calculate probabilities to find statistical regularities or patterns.

The field is rife with anthropomorphic metaphors: AI is undergoing training, for example, or deep learning. But these terms are really misdirections, for the software has acquired no knowledge or understanding of the underlying data it is processing. Instead, the software has bludgeoned its way through a task using brute force producing a statistical approximation to achieve a result.

A better name for the various activities currently undertaken by AI may be heuristic software. But then this might remind us that its guesswork, and that things can go wrong. Sometimes this guesswork can be impressive. At other times it is sufficient to be useful. Often it is not, and AIs ignorance of the real world can be painful, and hilarious.

But companies selling AI software or services claim a great deal more on AIs behalf. AI is one of the most important things humanity is working on, insists Sundar Pichai, CEO of Alphabet, Googles parent company. It is more profound than, I dunno, electricity or fire, he even claimed last year.

Our political elites accept such claims at face value, because it allows them to indulge in a little vanity. They can imagine themselves taking their place alongside the boffins, as visionaries or vanguardistas, as the future sweeps in. Five years ago, I was one of over 200 people and only three from the professional media invited to give oral evidence to a House of Lords inquiry into artificial intelligence. In advance, we were given nine points on which the lords might wish to hear our views. One of these was how we would prepare the population for the sweeping changes that were to come from new developments in AI. Apparently, as journalists we were not expected to question such improbable claims. It was taken as a given that AI would soon be a smashing success.

Five years on, the hype has reached new levels of absurdity, with artistic pastiches of models, like Open AIs GPT-3 language generator, being mistaken for human-like sentience.

The political class was promised a fourth industrial revolution, but AI is conspicuously failing to deliver tangible practical results. Yes, it is becoming another useful tool in the data-analytics toolbox. But it has failed to make an impact on other key areas, such as robotics, just as sceptical robotics scientists predicted.

Not one radiologist has been made redundant by AI, the neuroscientist and author Gary Marcus pointed out recently. Marcus has argued for some time that the current approach to AI has hit a wall, and is proving to have very little use outside the IT industry. AI remains extremely crude and dumb. For his pains, he finds himself in the same boat as so-called climate deniers. And with uncanny echoes of Climategate, the AI priesthood even refuses to allow researchers like Marcus to view or test the models themselves, in case they find something wrong with them. Nevertheless, the stunts and AI is a faith that requires regular miracles get ever more spectacular.

In fact, invoking religion or magic when flogging AI is not new. The original term was a triumph of marketing. A young professor called John McCarthy, who co-edited an obscure academic journal called the Journal of Automata Studies, decided that this new branch of mathematics could use some pizazz. Automata werent sexy enough. I invented it when we were trying to get money for a summer study, McCarthy would later admit.

The appeal of being God, of artificially giving birth, was something Professor Sir James Lighthill identified as one of AIs promises. Lighthill undertook the review that cancelled most of the funding for AI in 1973. Today, DeepMind the AI subsidiary of Alphabet is a master at evoking unexpected or creative outcomes supposedly produced by its deep-learning applications, which critics refer to as Its alive! moments. These tricks work spectacularly well with journalists, who are only too willing to suspend their scepticism. Such credulity is abundant, for example, in a long cover feature in The Economist this month, which marvels at the emergent properties of an AI that border on the uncanny.

Throughout those first and second AI summers, religious claims were never far away. During the second revival of AI in the 1980s, philosopher Mary Midgley lamented how dreary and familiar all the great claims about AI sounded to her.

They promise the human race a comprehensive miracle, a private providence, a mysterious saviour, a deliverer, a heaven, a guarantee of an endless happy future for the blessed who will put their faith in science and devoutly submit to it, she wrote in a review of a 1984 book by Professor Donald Michie, one of the leading British AI academics (Michie led one of the few departments to survive the 1970s AI winter). Is it clear why I was reminded of hymn books?, asked Midgley. Michie exhibited a crude indiscriminating euphoria, she wrote, and there is no better description of his successors 50 years later they too have a liturgical quality.

What AI shares with radical environmentalism is a longing to create an external moral arbiter. With apocalyptic climate change, the planet is judging us because we dared improve our lot. In AIs Jesuit wing transhumanism man hasnt fallen, we were just awful all along. Among transhumanists, there is a revulsion toward the physical body, which decays and defines a fixed form, and also a revulsion at what is characterised as our hopeless irrationality. We have always been inferior to the machines, they argue, but those machines just hadnt been invented yet. By submitting to the machines, we become free, as Grimes 2018 single, We Appreciate Power, articulates:

People like to say that were insaneBut AI will reward us when it reignsPledge allegiance to the worlds most powerful computerSimulation: its the future.

Here the religious overtones are explicit immortality is achieved by digitising the physical and uploading it. The deeply misanthropic idea that humans are not unique, and are in fact a bit rubbish, is not a new invention of the AI evangelists, of course. It has become commonplace in fields such as neuroscience and cognitive science to argue that consciousness is a trick of the mind, that the subjective self is an illusion or a trick of the brain circuitry. Cognitive scientist and philosopher Daniel Dennett was making this case three decades ago. A parallel, materialist view is even older: the proposition that were just poorly functioning machinery was expressed by Richard Dawkins in his 1976 bestseller, The Selfish Gene, where he wrote: You, dear human, are simply a gigantic lumbering robot.

In the early 2000s, computer pioneer and technology critic Jaron Lanier recognised these two beliefs as two cheeks of the same backside a backside he called cybernetic totalism. He was dismayed that so many highly intelligent friends of his in science and technology were sympathetic to this collection of prejudices, in part or in whole. Of the six characteristics he identified of this worldview, one was that subjective experience either doesnt exist, or is unimportant because it is some sort of ambient or peripheral effect. Subjectivity has long been unfashionable among the intelligentsia, as James Heartfield identified in The Death of the Subject Explained in 2002. Twentieth-century literary fashions like structuralism, cognitive science and more recently behavioural science merely added some intellectual respectability to these prejudices.

Two decades ago, Lanier already had an explanation for the supposedly magical and emergent properties of todays AI. To make the computers look smart, we have to make ourselves stupid, he observed. It requires a curious act of self-abasement. Unfortunately, abasing ourselves is a habit to which our elites seem strangely addicted. Hollowing out what it means to be human has cleared the path for both artificial intelligence and apocalyptic environmentalism, two of the most powerful religions of the 21st century.

Andrew Orlowski is a weekly columnist at the Daily Telegraph. Follow him on Twitter: @AndrewOrlowski.

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Fulton Sheens July 4 Declaration of Dependence – National Catholic Register

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On July 4, 1941, five months before the United States entered World War II, then-Msgr. Fulton Sheen published A Declaration of Dependence to stir Americas soul into realizing what its independence entailed and to warn Americans what they must do to keep it. This work of Sheen, a true prophet, is even more timely for today, as the world fills with more violence, irrationality, growing abandonment of God and religion, idolatry of self and much more.

A Declaration of Dependence has been reprinted and rereleased for July 4 as the saintly bishops urgent wake-up call for the United States.

Men are visited with the effects of their own sins, wrote Sheen. In other words, sin brings adversity, and such adversity is the expression of Gods chastisement of sin, brought about by the action of man himself. We are living in such a period of history now the sad hour wherein we are gathering the bitter fruits of our apostasy from God. Wars from without; class hatreds, bigotry, anti-Semitism, anti-Catholicism, atheism, and immoralities from within are the harvest of our godlessness. I know that there are many who profess belief in God, but they do not act on that belief. What recognition is given to the moral law in politics, economics, or education? How many Americans who say they believe in God went to their church or to their synagogue last Sunday or Sabbath?

His words became timeless reminders of what was already on the horizon for today.

Allan Smith, the editor of this new edition, plus other Sheen works, described to the Register how the prolific bishop wrote several books during those years as the world was engulfed in war. Sheen was really pushing hard, just to remind us and say, Were going to do World War III really quickly if you dont get this right.

It was essential to correctly understand that double aspect or meaning of Americas Declaration of Independence. As Smith explained, Sheen begins really saying to America: Remember, the Declaration of Independence means a Declaration of Dependence. He was also saying that the intentions of our Founding Fathers were that we would be a nation under God. All these men wrote this because they wanted us to say, We need God.

Sheen began his title chapter by observing, as Smith explained, how everyone talks of rights and few of duties, so that it is important for us Americans to recall that the Declaration of Independence is also a Declaration of Dependence. The Declaration of Independence asserts a double dependence: dependence on God and dependence on law as derived from God.

Quoting the opening of Americas founding document, Sheen emphasized, Notice these words: The Creator has endowed men with rights and liberties; men got them from God! In other words, we are dependent on God, and that initial dependence is the foundation of our independence. Each person has a value because God made him, not because the State recognizes him. The day we adopt in our democracy the already widespread ideas of some American jurists that right and justice depend on convention and the spirit of the times, we shall write the death warrant of our independence. He continued,

Smith pointed out that, in the books first chapter, Sheen talks about the revolutionary tempo and how its irrational. Its violent, and its atheistic. And he mentions how atheism is not so much I dont believe in God. Its like, I want to get rid of God. Its always very violent.

Indeed, as Sheen clarified, The spirit of revolution has three characteristic notes. It is: (1) irrational, (2) violent, (3) atheistic. He further explained, Irrationality developed quickly in the modern world after it lost faith in God, and it is important to note that violence follows from irrationality. When a man loses his reason, he becomes violent.

Sheen next observed,

In his book written as America celebrated its last Independence Day before entering World War II, the bishop emphasized: Mark these words: The enemy of the world in the near future is going to be Communism, which is using peace when it can and war when it must, and which is preparing, when Europe is exhausted from war, to sweep over it like a vulture to tear its flesh. When Russia falls, America will be the new seat of Communism.

Sheen always prophesied that communism would return back where it came from, the West, explained Peter Howard, president of the Fulton Sheen Institute. He reminded us that Karl Marxs philosophy came from Germany, his economics from England, and his sociology from France. It only took root in Russia because Russia, as Sheen put it, has the Asiatic soul of fire that communism needed to ignite, and then through violence spread its errors in the East.

In A Declaration of Dependence, Sheen foresaw what others did not. Howard, having received his doctorate in sacred theology focused on the work of Sheen from the Pontifical University of St. Thomas Aquinas (Angelicum), explained how communism has penetrated the West through ideological subversion.

Sheen nailed it back in 1941, when he said that the essence of todays conflict was between three philosophies of life, Howard told the Register. These philosophies revolved around the question of whether man is a useful tool of the state, as totalitarians believe; whether man is only an animal, as the materialists and secularists believe; or whether man is made in the image of God, as the Christians believe.

What is prevailing now, Howard added, are the first two philosophies, which are anti-democratic, anti-Christian, anti-Semitic and anti-human.

False prophets were saying, as seen today, Howard continued, that freedom means the right to do whatever you please; that to inculcate in the growing child a sense of right and wrong is to be unprogressive.

Smith explained that Sheen brought out in this book, as he did elsewhere, that there are two types of people: those who want to embrace the cross of Jesus Christ and those who say they dont want a cross. But when they fling off the cross of Jesus Christ, they get the cross of communism, the cross of materialism, the cross of consumerism, the cross of Marxism, Smith said.

Howard added, As Sheen put it, Communism is coming back again on the Western world because something died in the Western world namely, the strong faith of men in the God that made them.

With Europe having explicitly and implicitly abandoned its Catholic roots, America is the last force on earth that can stand between a free world and the diabolical transhumanist agenda of the totalitarian global elite, Howard explained. But America is at its weakest morally, politically and economically, and its collapse is now seen by many as imminent because many have sold out Americas foundational principles.

Still, a glimmer of hope remains, hinging on our response.

This is why America needs a new Declaration of Dependence now, Howard said, offering a Sheen solution.

It must now face and take up courageously the revolution of what Sheen calls the passive barbarism from within, while also defeating the active barbarism from without which attacks our freedom. We will only do this by rediscovering and instituting into every dimension of society Americas Christian roots (that precede 1776). This is why the Church and its saints must rise now, because we are the only ones with the fullness of that answer.

Sheen was adamant that we will never rid our nation of its political, economic and cultural problems unless we restore the Christian philosophy of life which single-handedly built Western civilization, Howard added.

Indeed, Sheen wrote,

Youth has no trouble seeing the truth in Sheens words and warnings. Jenna Drummond, a senior at The Catholic University of America who continues to focus projects and an upcoming thesis on Sheen and his development of ideas on communism beginning in his early years, finds a lot of what he says is mind-boggling because its so true now. It was true when he said it in the 1930s, in the 1940s and 1950s, and it has proven itself over and over again.

Referring to one of Sheens speeches at a Eucharistic congress before World War II, she said, He gave this really beautiful speech about communism, capitalism and Catholicism, explaining how everybody seeks liberty and equality, but what people really need is the fraternity of Catholicism, with everything rooted in God, because thats the only way that anybody will have real peace when everybody knows that theyre individually known and loved by God, she told the Register.

Drummond suggests celebrating this Independence Day in a Sheen way by spending a Holy Hour praying for our country because theres a lot going on right now, especially with the big decisions about Roe coming out, things like that, but also with the turmoil in Ukraine and Russia. As Sheen made a Holy Hour daily, people can make an Independence Day Holy Hour, she said, praising God for mercy on our country thus far, and begging for it to continue so that we can continue to celebrate Independence Day.

As Sheen wrote, Our love of God as a nation must begin with fear, for the fear of God is the beginning of all wisdom (Proverbs 9:10): first the fear of the sanctions of his justice, then the fear of betraying the blessings of mercy. He pointed to Israels history, showing how God punishes both his own people and their enemies: punitive against the Assyrians, ending in their desolation; paternal correction upon the Jews, ending in their restoration.

With all these insights and warnings throughout history, Sheen asked, Shall we go on with our godless education, our shattered family life, our class wars, our political intrigues, and our undisciplined and uncircumcised hearts, because we foolishly believe the only enemy we have is across the sea? In the name of God, let us face the facts and admit our guilt.

There are too many divisions and classes among us in America now; too many hates, too few deep loves. We will find the secret in the humblest coin of our realm, Sheen explained. So many have been interested in seeking dollars that they have quite forgotten the wisdom that is written on the penny. Take a penny into your hand: on one side you will find written the words E pluribus unum: we who are many are one. If you want to find out how the many are made one, turn the penny over, and you will find the answer: In God we trust.

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Google Says It Will Automatically Delete Abortion Clinic Visits From Users’ History – Futurism

Posted: at 11:40 pm

Good, but not good enough.Search History

Google has finally released some info about how the company will handle sensitive user data related to abortions.

Following the controversial overturn of Roe v. Wade which has already caused at least one 10-year-old child to take a risky trip across state lines to seek care the tech giant said on Friday it will delete user data that confirms a person traveled to an abortion center.

"Today, were announcing that if our systems identify that someone has visited one of these places, we will delete these entries from Location History soon after they visit," Googles senior vice president Jen Fitzpatrick wrote in a company blog post. "This change will take effect in the coming weeks."

Activists have said decisions like these could be important if the government begins seeking personal information in order to charge people who've had, sought or facilitated abortions.

In at least two states, authorities have already used search history information to prosecute women.

Just today the Washington Post said police found the phrase "buy Misopristol Abortion Pill Online" in one woman's search history after they found a deceased and possibly stillborn child in her toilet.

It's good to know Google is planning to delete location and search history data, but it's not clear what "soon" after a patient's visit means exactly, nor how many weeks it will take for the change to go into effect.

No matter what, though, it's clear online searches are no longer protected if you're pregnant. Let's hope more than a singular tech company is willing to protect citizens from a watchful government eye.

More on reproductive healthcare: People Are Stockpiling Abortion Pills and Emergency Contraceptives After Roe Reversal

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Lawyers and Doctors Struggle to Figure Out Who’s Actually Dead – Futurism

Posted: at 11:40 pm

Image by Getty / Futurism

The legal definition of death is ever-evolving.

Yesterday's Daily Beast report detailed just how hard it is to legally define death, which before 1959 was defined simply as the heart and lungs ceasing to function. But after French physicians discovered "coma dpass," which means "beyond a coma," legal clarification was written allowing doctors and hospitals to complete organ donations from these types of patients in order to save other patients' lives.

But what if brain death is reversible, or not 100 percent complete? Thaddeus Pope of the Mitchell Hamline School of Law says these conversations start to revolve around which lives are most valuable and that gets into stick territory.

"We're literally legislating what states of life are worth protecting, which is very, very similar to the abortion debate," Pope told the Beast.

Other doctors point out cases like that of a 4-year-old boy who went through a stunted kind of puberty even though he was on life support for 20 years. Puberty is a hormonal process controlled by the brain, giving credence to the idea that the person is still somewhat alive or mostly dead, depending on how you look at it.

Not all cases are created equal, though, and our legal definitions may need to expand further as we learn more about what makes a life, a life. For example, surely the creator who worked on Google's new "sentient" AI would feel significant amounts of grief if the program he believes is having a valuable personal experience were to be shut down or destroyed. But it's not clear what sorts of internal experiences make a consciousness.

Many times death is defined because hospitals and doctors need to work, whether through life-saving care or providing vital organ transplants to patients in need.

Although the legal terminology may change over time as medical advances mean more lives can be saved despite heavy brain damage or even brain death, the current standards are mostly just practical an example of the healthcare industry doing its best.

More on controversial medicine: 10-Year Old Forced to Cross State Lines By Disgusting Abortion Ban

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Scientists Say New James Webb Images Are So Powerful That It Was Emotional Just Looking at Them – Futurism

Posted: at 11:40 pm

"What I have seen moved me, as a scientist, as an engineer, and as a human being."First Light

While we await the ceremonial release of the first official images taken by NASA's uber-expensive James Webb Space Telescope, early reactions to the long-awaited shots are already sounding pretty promising.

"The images are being taken right now," NASA's scientific missions lead Thomas Zurbuchen told reporters on Wednesday. "There is already some amazing science in the can, and some others are yet to be taken as we go forward. We are in the middle of getting the history-making data down."

NASA plans to release several images on July 12, the inaugural "first light" observations from the space telescopeand a potentially groundbreaking moment for the field of astronomy.

Do you already have access to the upcoming James Webb images? If so, feel free to send them to tips@futurism.com.

It's a momentous occasion and emotions are already running high.

"What I have seen moved me, as a scientist, as an engineer, and as a human being," NASA's deputy administrator Pam Melroy told reporters.

Zurbuchen also admitted he was in his feelings over the new images.

"It's really hard to not look at the universe in a new light and not just have a moment that is deeply personal," he said at the press conference. "It's an emotional moment when you see nature suddenly releasing some of its secrets. and I would like you to imagine and look forward to that."

The images are expected to include unprecedented views of the depths of the universe and the atmosphere surrounding a distant exoplanet, potentially giving us glimpses of a habitable world other than our own.

It's the culmination of over a decade of research,and a $10 billion investment that could soon pay off in a big way.

No wonder the scientists working on the project are feeling a little sentimental.

READ MORE: NASA scientists say images from the Webb telescope nearly brought them to tears [Ars Technica]

More on the telescope: The James Webb Was Struck by a Small Meteoroid, NASA Says

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VR Company Shows Off Full-Body Suit That Electrocutes You Everywhere – Futurism

Posted: at 11:40 pm

Ever wondered what it feels like to get shot in VR?Pain Suit

Last summer, VR social platform startup Somnium and VR suit maker Teslasuit unveiled a "human-to-digital interface designed in the form of a full-body XR suit" a suit that can literally electrocute you all over the body.

And according to a recent review by TechRadar, the experience sounds absolutely wild.

The haptic suit's 90 electrodes are designed to fool its wearer into thinking they're being shot at or feeling raindrops hitting their body because,at the end of the day, who hasn't wondered what it would feel like to get blown up in combat?

According to TechRadar, the company was even able to simulate the G forces experienced by an F1 racecar driver using the suit.

"Electrical pulses fired into my arms and core, making my muscles feel heavier and I believed my body was actually being thrown around by the acceleration and deceleration caused by a moving racecar," TechRadar staff writer Hamish Hector recalls.

Hector also admitted he understandably "was terrified at the VR shooting range," but fortunately, even a virtual grenade exploding at his feet hurt "way less than you're expecting it to."

And that's probably a good thing, considering we play video games for fun and not to hurt ourselves.

Besides, the suit isn't exactly designed to be sold to the masses. At an eye-watering $20,000, it's more meant for medical rehabilitation or for training high-performance athletes.

It's not the only gadget meant to mimic the sensation of pain. There's Japanese developer and startup founder Emi Tamaki, for instance, who is working on wearables that stimulate pain "to turn the metaverse world into a real world," as she told the Financial Times back in March.

Aiming to inflict just the right amount of pain via electrodes is a fascinating frontier for VR. But whether electrical currents will really prove to be the missing puzzle piece in the hunt to make experiences more immersive than ever remains to be seen.

READ MORE: This full-body haptic suit has ruined the Oculus Quest 2 for me [TechRadar]

More on VR: Zuckerberg Shows Off VR Headsets Designed to Be "Indistinguishable From Reality"

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Someone Slipped Hundreds of Fake Articles About Things That Never Happened Onto Wikipedia – Futurism

Posted: at 11:40 pm

Incredible.Totally Made Up

A mysterious Chinese Wikipedia contributor who goes by the alias "Zhemao" spent ten years making up fictional accounts of Russian history, writing over 200 articles, and contributing to hundreds of others, Chinese English-language publication Sixth Tone reports.

Wikipedia editors have since noticed the falsified accounts after ten years of unknowingly hosting their contributions and promptly bannedthem from the online encyclopedia.

The web of lies Zhemao created is an astonishing body of work in and of itself, albeit entirely made up. Their contributions range from fictional accounts about Slavic rivalries to stories about Qing Dynasty officials a dizzying mishmash of fantastical fiction and history worthy of a series of fantasy novels. At the end of the day, you gotta respect the hustle.

It's also a colorful reminder of the fact that we can't take everything we read online for granted, particularly when it comes to often dubiously sourced Wikipedia entries.

And that's particularly relevant, given China's problematic history with controlling the historical narrative using propaganda (in fact, Sixth Tone itself is overseen by the Chinese government).

"Chinese Wikipedia entries that are more detailed than English Wikipedia and even Russian Wikipedia are all over the place," fantasy novelist Yifan, who stumbled upon Zhemao's fictional Wikipedia contributions, wrote in a Q&A online, as translated by Sixth Tone.

"Characters that dont exist in the English-Russian Wiki appear in the Chinese Wiki, and these characters are mixed together with real historical figures so that theres no telling the real from the fake," he added.

After Wikipedia noticed the ruse, Zhemao published a public apology.

"As the saying goes, in order to tell a lie, you must tell more lies," the apology reads, as translated by Sixth Tone. "I was reluctant to delete the hundreds of thousands of words I wrote, but as a result, I wound up losing millions of words, and a circle of academic friends collapsed."

The story leaves us plenty of questions: what were Zhemao's actual motives? Did the fictional narratives ever have any actual real-world consequences?

Perhaps, had Zhemao chosen a different way to disseminate their work, we'd be reading their historical fiction novels by now rather than an apology to Wikipedia.

READ MORE: She Spent a Decade Writing Fake Russian History. Wikipedia Just Noticed. [Sixth Tone]

More on Wikipedia: Russia Reportedly Arrests Man for Editing Wikipedia About Ukraine

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