Daily Archives: June 20, 2022

Amazon Will Pilot Drone Delivery in California This Year – Singularity Hub

Posted: June 20, 2022 at 3:01 pm

The number of packages people orderand the number of people ordering packagesisnt likely to go down anytime in the foreseeable future, and companies are working on ways to get those packages delivered quickly and cheaply. Too many delivery trucks cause traffic and congestion; youve doubtless seen the Amazon, FedEx, or UPS trucks take over loading zones on your block for an annoyingly long time (I sure have).

All sorts of wacky solutions have been proposed for better package delivery, from an underground hyperloop network of pipes to swarms of last-mile robots dispatched from mothership vans.

Lets not forget ever-elusive delivery drones. The widespread assumption was that Amazon would be the first to have its packages take to the skies, but as it turned out, Walmart beat them to the punch, piloting drone delivery in North Carolina in 2020.

Now Amazons catching up. The company announced this week that its starting drone delivery service in Lockeford, California later this year. South-east of Sacramento in the states hot, dry Central Valley area, the town had a population of just 3,521 as of the 2020 census. An Amazon press release says the town has historic links to the aviation industry thanks to a former resident who built and flew planes there in the early 1900s.

The company doesnt give additional details around why it chose Lockeford for the Prime Air pilot, though the towns rural location, the fact that most customers there have backyards for the drones to drop packages in, and the lack of numerous obstacles youd find in a more urban or densely-populated area likely all factored in.

Amazon has been trying to get drone delivery off the ground (pun intended) since 2013, when then-CEO Jeff Bezos went on 60 Minutes and demoed a drone he claimed could deliver packages weighing five pounds or less in under 30 minutes. Since then, the company has cycled through various iterations of delivery drones (more than two dozen, according to the press release), from a quadcopter that carried packages in its fuselage to a helicopter/airplane hybrid to its current hexagonal model, whose propellers were designed to minimized high-frequency sound waves.

The companys progress on bringing its delivery drones to market has been slow due to safety concernsincluding multiple crashesand regulatory approvals. In fact, Prime Air is still waiting for Part 135 certification from the Federal Aviation Administration, which allows companies to operate commercial delivery drones.

On the safety front, among other measures, Amazon has built what it calls an industry-leading sense-and-avoid system to keep its drones from crashing into thingsthings like other aircraft, people, pets, or unexpected obstacles (like, say, a chimney or an antenna). When a drones sensors detect objects within a certain radius of it, it automatically changes course, and as it descends to drop packages, it checks that the surrounding space is clear.

Customers in Lockeford will know when placing their Amazon orders whether a given package will arrive by drone or by truck, as specific items will be marked as Prime Air eligible. Amazon will use feedback from Lockeford residents to improve and expand the service in coming years. The company hasnt announced a specific date or month for the pilots launch yet, but says its happening before the end of the year.

Image Credit: Amazon

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An Introduction to Stanislaw Lem, the Great Polish Sci-Fi Writer, by Jonathan Lethem – Open Culture

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Who was Stanislaw Lem? The Polish science fiction writer, novelist, essayist, and polymath may best be known for his 1961 novel Solaris (adapted for the screen by Andrei Tarkosvky in 1972 and again by Steven Soderbergh in 2014). Lems science fiction appealed broadly outside of SF fandom, attracting the likes of John Updike, who called his stories marvelous and Lem a poet of scientific terminology for readers whose hearts beat faster when the Scientific American arrives each month.

Updikes characterization is but one version of Lem. There are several more, writes Jonathan Lethem in an essay for the London Review of Books, penned for Lems 100th anniversary at least five different Lems with five different literary personalities. Only the first is a hard science fiction writer, the genre originating not with Mary Shelleys Frankenstein, but in H.G. Wells technological prognostications.

Represented best in the pages of Astounding Stories and other sci-fi pulps, hard sci-fi advertises consumer goods like personal robots and flying cars. It valorizes space travel that culminates in successful, if difficult, contact with the alien life assumed to be strewn throughout the galaxies. The genre also became tied to American exceptionalist ideology, technocratic triumphalism, manifest destiny and libertarian survivalist bullshit, says Lethem.

Lem had no use for these attitudes. In his guise as a critic and reviewer he wrote, the scientific ignorance of most American science-fiction writers was as inexplicable as the abominable literary quality of their output. He admired the English H.G. Wells, comparing him to the inventor of chess, and American Philip K. Dick, whom he called a visionary among charlatans. But Lem hated most hard sci-fi, though he himself, says Lethem, was a hard sci-fi writer with visionary gifts and inexhaustible diligence when it came to the task of extrapolation.

Much of Lems work was of another kind, as Lethem explains in the short film above, a condensed version of his essay. The second Lem wrote fairy tales and folk tales of the future. The third, wrote just two novels, yet he could easily be, on the right day, ones favorite. Lem number four is the pure post-modernist, who unified his essayistic and fictional selves with a Borgesian or Nabokovian gesture.This Lem, for example, wrote the very BorgesianA Perfect Vacuum: Perfect Reviews of Nonexistent Books.

Lem number five, says Lethem, is another major figure, this one a prolific literary essayist, critic, reviewer, and non-fiction writer whose breadth is staggering. Rather than confining him with the label futurist, Lethem calls him an anythingist, a point Lem proved with his 1964Summa Technologiae, a masterwork of non-fiction, Simon Ings writes atNew Scientist, with the ambition and scope of the 13th-century Aquinas work for which its named.

This fifth and final Lem will be a fabulous shock to those who know only his science fiction, writes Ings. Only translated into English in 2014, hisSummapresages search engines, virtual reality, and technological singularity. It attempts an all encompassing discourse on evolution, commented biophysicist Peter Butko, not only of science and technology but also evolution of life, humanity, consciousness, culture, and civilization.

The last Lem makes forheady reading, but he imbues this work with the same wit and wickedly satirical voice we find in the first four. He operated, after all, as Lethem writes in his essay celebrating the Polish author at 100, in the spirit of other Iron Curtain figures who slipped below the censors radar by using forms regarded as unserious. Yet few have taken the form of science fiction more seriously.

via Aeon

Related Content:

Auteur in Space: A Video Essay on How Andrei Tarkovskys Solaris Transcends Science Fiction

Revisit Vintage Issues of Astounding Stories, the 1930s Magazine that Gave Rise to Science Fiction as We Know It

The Encyclopedia of Science Fiction: 17,500 Entries on All Things Sci-Fi Are Now Free Online

Josh Jonesis a writer and musician based in Durham, NC. Follow him at@jdmagness

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Do You Know About This Iconic Way Of Wearing Shoes By BTS V? – IWMBuzz

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Heres how BTS star V has a different style of wearing shoes which you will find hilarious but also easier.

Kim Tae-Hyung, better known as V, is a South Korean singer and songwriter. He is a member of the BTS boy band from South Korea. V was born Kim Tae-Hyung in Geochang County, South Korea. He is the oldest of three children, with two younger siblings. In elementary school, V dreamed of becoming a professional singer.

In early middle school, he began taking saxophone lessons in order to pursue a career. V has a lot of aura on stage, and his energy is contagious. Fans couldnt get enough of Vs seductive charms and flawless vocals when he performed his solo song Intro: Singularity on BTS. He has since then been a part of many hit music videos and songs.

Vs meteoric rise is surprising because his undeniable talent almost took him in a different direction. V flashed his signature good looks while driving to BTSs various pre-recordings in recent weeks. ARMY went crazy for the return of his breathtaking street style looks as he stepped out in his chic casual fashion style, complete with button-up shirts and tousled hair! He has been wearing fashionable shoes for a long time, which has enthralled fans.

Here are some pictures of the iconic way in which V wears shoes. In many of the pictures, it is noticed that he just slides his feet inside the shoes without tucking them in and is seen as not wearing socks too. And he does this to all his shoes it doesnt matter to him if they are loafers or sneakers.

Also Read: Im Always Picking Up New Techniques: BTS J-Hope On How His Rapping Style Has Improved

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John Krull column: Savoring the words, observations of a writer forever in present tense – The Herald Bulletin

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When I first encountered the writer Jim Harrison, I was not a happy man.

It was 30 years ago. I had come north to this resort community along Grand Traverse Bay to run a marathon, only to find that the intern with whom Id talked at the local chamber of commerce had given me the wrong date.

After stewing for a bit, I went for a long solo run along the water, then found my way to a bookstore.

A local weekly newspaper I picked up there featured an interview with Harrison, who lived then in this part of Michigan. I hadnt read him at that time. I knew he sometimes was labeled a kind of latter-day Hemingway because he often wrote about Michigan, hunting and fishing. I learned that it was a comparison he resisted, even resented.

I was at loose ends in those days, not feeling particularly centered in either my personal or professional lives. I wasnt sure of what I wanted or what I was supposed to do.

As I read the interview with Harrison, I was struck by his voice, authentic, honest and questing. He saw this world as a place to be experienced, to be savored, to be endured, to learn from.

Well into the interview, he delivered a short sentence that became a kind of credo for me. When I got back home, I scratched it out on an index card and taped it to the desk where I wrote.

It stayed there for years.

You cant away your life with nonsense, he said.

True then.

True now.

True always.

After I finished the interview, I headed back to the bookstore and picked up a couple of Harrisons books.

That night, I sat in a rather tired hotel room and read Jim Harrison for the first time.

His voice as a writer was raucous, relaxed, sometimes ribald, often revelatory. Although he was capable of reflection, his writers eye most often drifted outward to take note of the world and the singularity of each moment. He found great beauty in existences essential evanescence.

As I learned more about him, I discovered that he had been first and perhaps foremost a poet, which made sense. Few writers Ive read have taken more joy no, more deep satisfaction in the limber elasticities of language well used.

When I got back home, I began to acquire and work my way through a personal library of Harrisons works. Each time I read him the larger and the lesser Harrison works I found myself reminded that there are few things more powerful than truth captured and conveyed in words.

Harrison died a little more than six years ago. I never met him. Thats a regret.

I almost did, though, twice.

Once, when my wife and I took our then-infant daughter to Key West a haunt of Harrisons I stopped at another bookstore. As I was leaving, a shortish, stout older man about to enter the store opened the door for me. He looked vaguely familiar.

Only when I was in my car did I realize that it had been Harrison.

A few months later, when my wife, my daughter and I were here in Traverse City, I saw Harrison leaving a bookstore while I was searching for a parking place.

If he keeps stalking me like this, I may have to take out a restraining order, I joked to my wife.

It was a jest I think I hope Harrison would have appreciated, even laughed at.

Now, Im back in Traverse City for the first time in more than 15 years, this time as an old man, one more content with his life than the young man who tried to run through all his frustrations, a human being more attuned, one hopes, to the beauty of evanescence.

A guy still striving not to away his life with nonsense.

Im rereading Harrison while Im up here, for pleasure and because he reminds me of the power of an active mind and great writing.

He does not disappoint.

Moving water is forever in the present tense, I read as the surface of the bay nearby shifts and shimmers, a condition we rather achingly avoid.

Amen, brother.

Amen.

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ESCP Becomes an Academic Partner of the Women’s Forum – ResponseSource

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As part of its strategic commitment to the promotion of equity and inclusion, ESCP has entered into a partnership with the Women's Forum.

ESCP is committed to promoting women's leadership in the corporate world and is developing European programmes designed to address the many issues faced by women in the workplace and in leadership roles.

In line with this commitment, ESCP has initiated programmes such as its "Women in Leadership" certificate and has added content on female leadership and entrepreneurship in many of its courses. Flexibility has also been added to the delivery of the Schools EMBA in order to make continuing education more accessible for women who tend to be faced with greater caregiving responsibilities outside of work. The programme now features choice over study mode and duration, as well as a bigger menu of electives.

In parallel to its programmes, ESCP Business School offers a range of scholarships specifically dedicated to female leaders to empower them to transform companies.

According to Professor Simon Mercado, Executive Vice President for Business & External Relations: "Our partnership with the Women's Forum is a boost to ESCP's continuing efforts to encourage diversity in business and to promote gender equality in all regards. In collaborative mode we can enhance both the awareness of these issues and support women in terms of their leadership skills and advancement.

This year ESCP will intervene via the expertise of Professor Vronique Tran at Women's Forum Germany in Berlin on 20 and 21 June 2022.

Press Contacts:ESCP Emily Olyarchukeolyarchuk@escp.eu +33 (1) 49 23 24 62

BlueSky PRJamie Hosejamie@bluesky-pr.com+44 (0)1582 790 706

ABOUT ESCP BUSINESS SCHOOL

ESCP Business School was founded in 1819. The School has chosen to teach responsible leadership, open to the world and based on European multiculturalism. Six campuses in Berlin, London, Madrid, Paris, Turin and Warsaw are the stepping stones that allow students to experience this European approach to management.

Several generations of entrepreneurs and managers were thus trained in the firm belief that the business world may feed society in a positive way.This conviction and ESCPs values - excellence, singularity, creativity and plurality - daily guide our mission and build its pedagogical vision.

Every year, ESCP welcomes 8500 students and 5000 managers from 122 different nationalities. Its strength lies in its many business training programmes, both general and specialised (Bachelor, Master, MBA, Executive MBA, PhD and Executive Education), all of which include a multi-campus experience.

It all starts here.

Website: http://www.escp.eu, Follow us on Twitter: @ESCP_BS

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An unaccustomed wine | Henry Jeffreys – The Critic

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30 years ago English wine was changed forever, and a vinicultural revolution began

Among all the excitement of the Platinum Jubilee, one important anniversary seems to have been forgotten. 30 years have passed since the first harvest at Nyetimber, the Sussex estate that put English wine on the map. Rather than make pale imitations of German wine which is what most of the homegrown wine industry was doing Nyetimber aimed at the very best of Champagne. Astonishingly, it succeeded with its very first release, a 1992 Blanc des Blancs.

I was lucky enough to try a bottle last year, and after nearly three decades its still full of fruit and fizz but with a hazelnut quality like a fine old Burgundy. It came from the cellar of a Frenchman called Jerome Moisan who has a somewhat eccentric obsession with English wines, collecting old bottles and researching its history. The occasion was the launch of his business Pelegrims which makes high end toiletries from the leftovers of wine making.

Moisan thinks that first Nyetimber is every bit as important as such landmark bottles as Stags Leap Cabernet Sauvignon 1973, the wine that introduced Californian wine to the world at the Judgment of Paris tasting in 1976, or Penfolds Grange 1951, which did a similar thing for Australian wine. For him English wine is particularly fascinating because we get to witness the birth of a new wine region, a once in a generation occurrence.

As Cherie Spriggs, the estates winemaker since 2007, put it, without Nyetimber, there is no English wine industry. And we owe it all to Americans. The founders were a couple from Chicago called Stuart and Sandy Moss. He had made a fortune from manufacturing dental equipment while she was an archaeologist and antique dealer. They bought a mediaeval manor house, Nyetimber, that had previously belonged to Henry VIII.

Moisan thinks that prices at auction will top 1,000 soon

But the reason they wanted the estate was not just for the house, but for the greens and soils and warm microclimate. Their plan was audacious: to plant only Champagne varieties, chardonnay, pinot noir and pinot meunier, and only make champagne-method sparkling wine. They werent the first in England to plant these varieties, nor were they the first to make sparkling wine. But what they did bring was money and a singularity of purpose two things that were distinctly lacking in English wine when they planted vines in 1988. According to Sandy Moss, who I spoke with recently: we couldnt figure out why we couldnt do it, so we could.

The experts thought they were mad and advised them to plant apple trees, but the Mosses were vindicated with that very first vintage. Released in 1996, this all chardonnay Sussex sparkler beat the best of France in a blind tasting in Paris. As Stuart Moss put it: The gods smiled, we had the right sites, the right varieties and everything went well for us. It started a goldrush in the English wine industry with specialist sparkling wine producers like Ridgeview coming on the scene while established names like Breaky Bottom switched to champagne-style sparkling wines.

Following a run of successful releases, the Mosses sold up in 2002 to songwriter Andy Hill who you might know from hits such as Making Your Mind Up for Bucks Fizz. Its now owned by Dutch billionaire Eric Heerema who has poured an estimated 100m into the business with the aim to turn it into a global luxury brand. The wines are made by husband and wife Canadians Brad Greatrix and Cherie Spriggs. In 2018, Spriggs became the first person from outside Champagne to win Sparkling Winemaker of the Year at the International Wine Challenge.

According to Greatrix, Nyetimber doesnt have anything planned for this important anniversary, and the 92 vintage is now too rare for them to release any more for sale. Overall there are probably fewer than 100 bottles globally, and a good many of them are in the Mosss cellar in California. Nowadays, sadly, the few left have become collectors items. Moisan thinks that prices at auction will top 1,000 soon, so its unlikely Ill ever get to try it again.

But never fear, here are five other bottles to celebrate English wine week, 18-28 June, and toast those amazing Mosses. Cheers!

Westwell Wicken Foy NV (27.50)

A special cuvee launched by this small-scale Kentish producer (who supply Pelegrims with grape matter) to celebrate independent wine merchants. Its a blend of vintages from 2014 to 2019 and aged for only 18 months to accentuate the fruit. Absolutely delicious and a snazzy label, too.

Bolney Estate Cuve Ros 2018 (30.90)

Made from 100 per cent pinot noir grapes which are given a little skin contact for colour, this is a ros with guts. Its all about big red cherry fruit and herbal notes, like a light red wine, with creamy notes from maturity. Enormous fun.

Nyetimber Classic Cuvee NV (36.50)

Nyetimbers entire range is impressive but its the classic non-vintage that shows why its still the biggest name in English wine. This is creamy with lemon and orange fruit, with a subtle richness lurking in the background; impeccably balanced.

Ridgeview Blanc de Noir 2015 (50)

Ridgeview is the master of English sparkling wine, making a variety under its own label and for other producers. This is one of its high end wines and its extremely good. Made only from pinot noir and meunier, this is rich and mature with powerful dark cherry fruit, spice and tobacco.

Breaky Bottom Cuvee Koizumi Yakumo 2010 (69)

When the rest of the English wine industry switched to champagne varieties, Peter Hall persisted with seyval blanc. Tasting this you can see why its astonishingly fresh and lemony, now deeply flavoured and perfectly balanced by 12 years ageing. A cult wine thats worth every penny.

Vines in a Cold Climate: the people behind the English wine revolution by Henry Jeffreys will be published by Atlantic summer 2023.

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CLL alternative therapies and complementary treatments – Medical News Today

Posted: at 2:59 pm

Chronic lymphocytic leukemia (CLL) occurs when the bone marrow makes atypical white blood cells. These cells crowd out the healthy cells, impairing a persons immune system. Treatment involves killing the cancerous cells to stop them from spreading.

So far, the only scientifically recommended treatments that can achieve this are:

Alternative therapies for CLL involve replacing medical treatments with other forms of medication or lifestyle changes. However, there is not much evidence suggesting they are effective for treating CLL in comparison with standard treatments.

However, for many people, complementary therapies can help ease symptoms and treatment side effects and improve quality of life. Complementary therapies are methods a person uses alongside regular medical treatment.

Because people often integrate these alternative therapies with their regular medical treatments, individuals often refer to this treatment plan as integrative medicine.

In this article, we will discuss whether it is possible to treat CLL naturally, complementary therapies for CLL, and their benefits.

Currently, there is no strong evidence that natural therapies can treat or cure CLL. This includes:

However, CLL does not always need treatment right away. It can develop slowly and may show no signs or symptoms for a few years.

Therefore, in some cases, doctors may decide to monitor a persons condition without giving them any treatments to see if their signs and symptoms change. This is known as watchful waiting or observation.

If a person needs treatment, doctors may recommend one or more of the following:

Doctors do not recommend relying solely on alternative treatments as a replacement for medical intervention. That said, some alternative therapies show promise as complementary treatments, which may help a person cope with having CLL mentally or physically.

Additionally, if someone is considering alternative treatments, they should discuss this with a healthcare professional first to determine if there will be any risks.

Below are some complementary therapies for CLL.

Dietary changes may help a person with CLL:

However, the exact diet a person follows can depend on their symptoms and needs. For example, for those experiencing appetite loss or weight loss, the Leukemia and Lymphoma Society of Canada recommends:

Learn more about diets for CLL.

Curcumin is an anti-inflammatory compound present in turmeric. It also has antioxidant and anticancer properties. A 2017 review argues that this makes curcumin beneficial to take during cancer treatment, particularly in the early stages.

And while curcumin alone is not a cure for CLL, numerous laboratory and human studies have found it improves outcomes alongside conventional cancer treatment.

However, more long-term, large scale human trials are necessary to fully understand the effects of curcumin. This is because people with CLL may need to take it for long periods for it to have an effect.

According to the National Cancer Institute, some clinical trials report that acupuncture can reduce nausea and vomiting for those undergoing chemotherapy.

A 2020 literature review also found that acupuncture may be helpful in managing cancer-related fatigue among cancer survivors, helping improve their quality of life.

Furthermore, a 2021 systematic review of previous research concluded that acupuncture may be an effective and safe way to reduce pain for CLL patients in palliative care.

Receiving a diagnosis of CLL, experiencing symptoms, and undergoing cancer treatment can all be highly distressing. Some people find that complementary therapies, such as mind-body therapies, help them cope with this.

Mind-body therapies aim to promote mental and physical well-being simultaneously. They often involve mindfulness or relaxation, which in turn, may affect symptoms. People may find it helpful to try:

The National Cancer Institute says there is a lack of conclusive evidence to prove aromatherapy is an effective form of treatment to manage the symptoms of cancer. Some studies suggest it may help some people with their mood, anxiety, nausea, or pain. However, other studies have shown no change in symptoms.

If a person finds aromatherapy helpful, they may feel benefits from aromatherapy massages or diffusers.

Learn more about aromatherapy.

Cannabidiol (CBD) is a chemical compound that occurs naturally in the cannabis plant. It is not addictive, and some report that it helps with relieving the symptoms or complications of cancer, including nausea, vomiting, and depression.

However, research on CBD is still in its early stages. Therefore, more studies are necessary to confirm it works reliably for people with CLL.

Learn more about using CBD for cancer.

Before trying any alternative or complementary therapy, it is important to speak with a doctor. Some therapies, such as herbal medicine, aromatherapy, or diet changes, may affect a persons treatment. Some can also interact with medications.

People with CLL can also speak with their doctor about safely incorporating complementary therapies into their treatment plan.

Other things to consider include what someone wants to achieve with the therapy, whether they need to go to a specific location to get it, and how much it costs.

Some health insurance companies may cover certain complementary therapies for those with leukemia. It is worth contacting insurers to check this before paying.

The Leukemia and Lymphoma Society recommends that people interested in complementary therapies for CLL ask their doctor some questions, such as:

Some people turn to alternative therapies for CLL instead of doctor-recommended treatments. However, there is not much evidence to support their effectiveness compared with chemotherapy, radiation, and other conventional treatments.

However, many doctors support using complementary therapies alongside medical treatment. Acupuncture, dietary changes, and mind-body approaches may help with managing symptoms and treatment side effects.

Preliminary evidence also suggests some supplements, such as curcumin, may help enhance chemotherapy. However, more research on which therapies are most helpful is necessary.

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Complementary and Integrative Medicine for Migraine – Medscape

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This transcript has been edited for clarity.

Anna Pace, MD: Hi, everyone, and welcome. My name is Dr Anna Pace. I'm an assistant professor of neurology at the Icahn School of Medicine at Mount Sinai, and I direct the Headache Medicine Fellowship at Mount Sinai Hospital. Today, I'm lucky enough to be joined by my illustrious colleague, Dr Zhang.

Dr Zhang, would you like to introduce yourself?

Niushen Zhang, MD: Hi, Dr Pace. It's great to be here. I'm Dr Niushen Zhang. I'm a clinical assistant professor of neurology. I'm also the chief of headache medicine at Stanford University. Great to be here.

Pace: Today, we're going to be talking about complementary and integrative medicine for migraine. I think this is a topic that has sparked a lot of interest, especially on the patient side over the last couple of years. Dr Zhang, can you tell me a little bit about what exactly complementary and integrative medicine is?

Zhang: There are actually many definitions of it. What we generally think about are nonpharmaceutical treatment approaches or healthcare practices that may not be part of conventional medicine. The American Board of Integrative Medicine gives a very well-rounded definition of this, in which they say that it's a practice of medicine that focuses on the whole person, and it should be informed by evidence and make use of all of the appropriate treatment approaches that can help our patients achieve optimal health.

The name that we use to describe this field of medicine has changed over time. Initially, it was alternative medicine, then it was called complementary and alternative medicine, or CAM. The most recent term that we use is complementary and integrative medicine.

Pace: Or CIM, for short. I think CIM, based on what you're describing, sounds like it would fit well with headache medicine, in general, when we're thinking about all of the different factors that can potentially contribute to or affect a person's headache frequency. Some of the things that we always think about are lifestyle factors that can affect headaches.

Do you have any data or anything you'd like to talk about in terms of some of the different lifestyle factors that patients can work on when they are looking to try to reduce their headache frequency?

Zhang: First, we always want to think about which patients are a best fit for this type of treatment. We think about patients who may not have had adequate responses to their pharmaceutical treatments, who have poor tolerance to these treatments, or maybe some medical contraindication to medications. We also think about people who may be pregnant or lactating or planning pregnancy. These treatments can also be helpful for people who have medication overuse headache or exhibit significant stress and may not have adequate stress coping skills.

Really, the foundation is the lifestyle modifications. The way that I explain it to patients is basically your migraine brain is hypersensitive, especially to change. What it likes is a very regular and predictable schedule for eating, sleeping, and exercise.

Specifically, what we see for exercise is that about 20 minutes a day of aerobic exercise can actually decrease headache frequency and severity. This could be anything from devoted time to walking, hiking, biking, or swimming. Those can all be very helpful.

For sleep, poor sleep quality, including things like insomnia, can affect about 30% of patients with migraine. In our clinic, we always screen for any potential underlying sleep disorders, like sleep apnea. We want to make sure our patients receive appropriate evaluations and treatment for those conditions. What we find most helpful with sleep is just keeping the same bedtime and wake-up time every day, Monday through Sunday.

Of course, we get many questions about food and nutrition. The truth is the evidence is just not strong in this area at this time, for any specific dietary interventions. We always counsel our patients to keep a very regular and consistent meal schedule throughout the day and to avoid skipping meals. Patients also love to ask about food triggers, but the evidence is not strong for what foods must be avoided.

In practice, we find that food triggers are very individual for people. If someone finds that a certain food consistently triggers their migraines, then it would make sense to avoid that food, but in general, we don't encourage people to restrict their diet.

Pace: Exercise and sleep come up often in my clinic as well. Particularly for patients who find that exercise may trigger their attacks or they're hesitant to do any exercise because their attacks are so frequent, I often recommend gentler, low-impact exercises, like yoga, tai chi, or swimming, for example, which I think people find a little bit easier to warm up to or incorporate into their routine.

And really focusing on good sleep hygiene, and even things like trying to wind down before bed and having some type of routine, is really helpful. I have had a number of patients come to me and ask, "Is there anything, like vitamins or herbal supplements, that I can take to try to help prevent my attacks?" There is quite a number of them that have good evidence. What do you usually recommend for your patients?

Zhang: I'm glad you brought that up. There are, I would say, four that are evidence-based and very helpful for our patients. One of them is magnesium. That one has a level B recommendation from the American Academy of Neurology (AAN)/American Headache Society (AHS). We think it helps with calming down neuronal hyperexcitability and preventing cortical spreading depression. Some of the formulations we like are magnesium glycinate, magnesium oxide, and citrate. We do want to watch for any loose stool or diarrhea, because those are some of the common side effects that can potentially happen. The daily dosing is about 200-600 mg/d.

Other than magnesium, we also have vitamin B2 or riboflavin. That also has a level B recommendation, and it's well-tolerated. Some people do get very bright orange or yellow urine when they take it, and the dosing is around 400 mg. There's also coenzyme Q10, which has level C recommendation from AAN/AHS. It plays a role in the electron transport chain and may play an important role in sustaining mitochondrial energy stores. It's also very well-tolerated, and the daily dosing is about 300 mg.

The last one we have is something called feverfew, which is a type of chrysanthemum. This also has a level B recommendation. We think this may have some anti-inflammatory properties. Some people do get gastrointestinal (GI) side effects with that, so you do have to watch out. We don't recommend this one during pregnancy because it can cause early contractions and potentially miscarriage. The daily dosing for that is 50-300 mg.

Pace: It's great that there are so many different nutraceutical options for migraine prevention. I personally find the combination of magnesium and riboflavin to be a good one that I tend to start with. I think nutraceuticals come up quite often. I have many patients who ask me about them. Are there any patients, in particular, whom you think would benefit most from nutraceuticals?

Zhang: Similar to what we talked about before, many of our patients just don't tolerate some of the pharmaceutical treatments that we have, so this would be a good option to start with. One thing I always ask my patients to keep in mind is that the improvement can be gradual with these supplements. Really, like any preventive treatment, you want to give it up to 3 months before someone may see maximum benefit.

Pace: Agreed. I think it's hard sometimes to wait that long, but when they do, it really can help. Another type of CIM treatment that has really great evidence in migraine prevention includes the behavioral therapies, which brings to mind things like cognitive-behavioral therapy. I'm curious what your thoughts are about those and whether or not you recommend patients to utilize them?

Zhang: I think those are terrific options. Honestly, I think one of the challenges for providers is how to broach this topic without making your patients feel like you're dismissing their experience as psychiatric or psychological. I think one way to approach this is to help your patients understand that the contributors to their headaches are usually partial and additive, and that things like stress, anxiety, and mood disorders can have a significant impact on their headaches.

That's why it's really important that we find effective ways to address those. What's great is that now we have the highest level of evidence showing that specific biobehavioral treatments, such as cognitive-behavioral therapy, biofeedback, and relaxation training, are all effective preventive treatments for migraine.

Pace: As far as I understand, it sounds like patients who have migraine and who may also have anxiety and depression may benefit from these. Do you ever see patients who don't have a history of anxiety or depression utilize any of these therapies and find them helpful just for migraine?

Zhang: Absolutely. I would say relaxation training and also biofeedback. These are great because you can not only use them as a preventive treatment things that you practice on a daily basis for prevention but also reach for them as acute treatment tools when you feel that migraine escalating or the onset of migraine.

Pace: I think that sounds great, and I agree. I find that sometimes broaching this topic with patients can be a bit challenging because on the one hand, you want to be able to validate their experience, but at the same time help to target some of the potential mood components of their presentation or the anxiety that comes with having a migraine attack with aura, which I see very commonly and I'm sure you probably do as well. Using things like relaxation therapy in the moment during an aura, I think, can be incredibly useful.

One of the other things that I always get asked about is acupuncture and whether or not there is evidence for that in terms of its efficacy in helping with migraine prevention. I seem to get that question from many of my pregnant patients. Do you have any experience recommending acupuncture to patients? What do you think about the data for that?

Zhang: We are very data-driven and we want to provide evidence-based treatments for our patients. Acupuncture has pretty good evidence for its use as a preventive treatment in episodic migraine. There's still sparse evidence for using it to treat chronic migraine or to use it as an acute treatment.

When it comes to treating episodic migraine with acupuncture, there's an excellent 2016 Cochrane review that nicely summarizes the evidence for acupuncture for this treatment. They looked at 22 trials with almost 5000 patients and found that acupuncture is slightly more effective than sham in reducing frequency of headaches and at least similarly effective as some of our standard prophylactic medications.

Pace: That's great. As far as I know about the data, it seems like it would be a good option in addition to, perhaps, the traditional therapies that we are using, like oral medications. Similarly, yoga also comes up in the same conversation whether yoga can be useful. Again, many of my pregnant patients ask this question. Do you ever recommend yoga to patients?

Zhang: With yoga, I think there's still much we have to learn about in terms of how it helps our patients with migraine. At this time, we just don't have that much robust evidence for that.

There was a randomized clinical trial published in Neurology in 2020 that looked at the effect of yoga as an add-on therapy for episodic migraine. They had two groups. One was a medical therapy group, and the other underwent medical therapy for migraine treatment, as well as yoga. They had the yoga group practice a predesigned yoga intervention 3 days per week for 1 month with an instructor at a center. This was followed by, I think, 5 days per week for 2 months at home. They looked at over 100 patients for this study.

In the end, when they compared the medical therapy group with the yoga group, the yoga group showed a significant decrease in headache frequency, intensity, and some of the migraine disability scores. The conclusion was that yoga, as an add-on therapy for episodic migraine, may be superior to medical therapy alone. I think this is a very promising beginning in terms of the research, and I really hope that we get more studies like this done in the future.

Pace: Yes. I think it illustrates an important concept that I think many of us ascribe to, in that it's really important to think about the patient, what their lifestyle is like, and what they feel comfortable with in terms of a treatment regimen and how important it is to really create an individualized plan for them.

I personally use, often, a combination of pharmacologic treatment and nonpharmacologic treatments, so the fact that that study showed that yoga was great in addition to traditional migraine therapy hammers that point home for me, in terms of using even some of the other therapies that we've talked about in addition to our traditional oral or injectable therapies for migraine. Would you agree?

Zhang: I totally agree, Dr Pace. I think some of the most helpful treatment plans that we develop for our patients are those that integrate both pharmacologic tools and the nonpharmacologic tools that we have. Part of why I love headache medicine is that we actually get to personalize these treatments for our patients.

Pace: I completely agree. I think that's a good place for us to end. We thank you all very much for joining us.

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Complementary and Alternative Medicine Market Analysis 2022: Industry Overview, Growth, Trends, Opportunities and Forecast Till 2027 Designer Women -…

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According to IMARC Groups latest report, titled Complementary and Alternative Medicine Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2022-2027, the global market reached a value of US$ 100.04 Billion in 2021. Complementary and alternative medicine (CAM) represents a range of therapeutic products and diagnostic procedures that are not considered part of mainstream medical therapies. It encompasses homeopathic remedies, self-administered tools, bio-field therapy, naturopathy, acupuncture, and dietary supplements. CAM alleviates muscle tension, improves wound healing, provides relaxation, and reduces stress, pain, and anxiety. As a result, it is generally used alongside conventional medicines to treat various chronic ailments and common side effects.

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The global CAM market is primarily driven by the increasing prevalence of neurological disorders, especially amongst the geriatric population. This is further supported by shifting preferences toward natural medicines owing to their several beneficial properties. Additionally, the rising health concerns and the coronavirus disease (COVID-19) pandemic have prompted governments to invest in pharmaceutical companies to develop alternative natural drugs for treating patients, which is propelling the market growth. Other factors, such as significant improvements in the healthcare infrastructure, extensive medical tourism promotion, and ongoing research and development (R&D) activities to introduce CAM with enhanced efficacy, are contributing to the market growth. Looking forward, IMARC Group expects the global complementary and alternative medicine market to reach US$ 315.5 Billion by 2027, exhibiting a CAGR of 20.8% during 2022-2027.

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Competitive Landscape with Key Players:

Complementary and Alternative Medicine Market Segmentation:

Breakup by Type:

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Breakup by Region:

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Global Cold Pressed Sesame Oil Market To Be Driven By The Rising Uses Of The Oil In Alternative Medicine, Cooking, And Body Massage In The Forecast…

Posted: at 2:59 pm

The new report by Expert Market Research titled, Global Cold Pressed Sesame Oil Market Report and Forecast 2022-2027, gives an in-depth analysis of the globalcold pressed sesame oil market, assessing the market based on its segments like types, applications, and major regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analysing the market based on the SWOT and Porters Five Forces models.

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The key highlights of the report include:

Market Overview (2017-2027)

Forecast CAGR (2022-2027): 6.2%

The significant effect of the oil on the body and its benefits to the skin is widely popular, driving its demand in the market. The overall market demand is expected to be driven by the rising level of awareness about health and beauty around the world. Rising awareness towards a healthy lifestyle guides a large number of demands towards natural ingredients, which thrives cold-pressed sesame oil market as it makes the heart-healthy, improves skin and hair, is good for bones and is helpful in treating depression and anxiety. Additionally, the inclusion of minerals, organic compounds and vitamins generates new opportunities for the market in the pharmaceutical and food consumption segment.

Industry Definition and Major Segments

Sesame seeds are used to make sesame oil. It is used extensively in Asian cuisine as alternative medicine. Sesame seeds are pressed for oil by crushing them or roasting them over heat. Cold-pressed sesame oil is obtained by crushing sesame seeds. Sesame oil from cold-pressed seeds has a moderate and nutty flavour, and contains a larger concentration of fatty acids than sesame oil from heated seeds. Furthermore, the presence of sesamolin in cold-pressed sesame oil prevents it from oxidising, extending its shelf life.

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By type, the market is segmented into:

Organic Conventional

The major applications of the market are as follows:

Food Personal Care and Cosmetics Pharmaceuticals Others

On the basis of region, the market is segmented into:

North America Europe Asia Pacific Latin America Middle East and Africa

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Market Trends

Sesame oil use is constantly increasing over the world as consumer habits change and people become more health conscious. Consumers nowadays favour products with high nutritional value. As a result, the sesame seed oil is seeing increased demand due to its nutritious qualities, which include vitamins, minerals, fibre, good fats, and protein. Sesame oil is widely used in dressings and sauces. Easy storing capacity and longer shelf life drive its usage in these applications. Organic sesame oil has been witnessing increasing demand due to substantially higher antioxidants and very low or no pesticide traces.

Key Market Players

The major players in the market are CARE Naturkost GmbH & Co. KG, V.V.V.Anandham & Sons, Mukund Oil Mills Pvt. Ltd., Recon, and Chee Seng Oil Factory Pte Ltd, among others. The report covers the market shares, capacities, plant turnarounds, expansions, investments and mergers and acquisitions, among other latest developments of these market players.

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Global Cold Pressed Sesame Oil Market To Be Driven By The Rising Uses Of The Oil In Alternative Medicine, Cooking, And Body Massage In The Forecast...

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